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Mild albuminuria

MedGen UID:
1759814
•Concept ID:
C5421582
•
Finding
HPO: HP:0033065

Definition

The presence of mildly increased concentrations of albumin in the urine, defined as an albumin-creatinine ratio (ACR) less than 30 mg/gm (less than 3.4 mg/mmol). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMild albuminuria

Professional guidelines

PubMed

Treatment of the diabetic patient: focus on cardiovascular and renal risk reduction.
Abbott KC, Bakris GL
Prog Brain Res 2002;139:289-98. doi: 10.1016/s0079-6123(02)39025-3. PMID: 12436944

Recent clinical studies

Etiology

CKD Biomarkers, Cognitive Impairment, and Incident Dementia in an Older Healthy Cohort.
Murray AM, Thao LTP, Ryan J, Wolfe R, Wetmore JB, Woods RL, Polkinghorne KR
Kidney360 2022 Mar 31;3(3):435-445. Epub 2021 Dec 7 doi: 10.34067/KID.0005672021. PMID: 35582189Free PMC Article
Accounting for Age in the Definition of Chronic Kidney Disease.
Liu P, Quinn RR, Lam NN, Elliott MJ, Xu Y, James MT, Manns B, Ravani P
JAMA Intern Med 2021 Oct 1;181(10):1359-1366. doi: 10.1001/jamainternmed.2021.4813. PMID: 34459844Free PMC Article
Chronic kidney disease 10 years on: what have we learned?
Taal MW
Curr Opin Nephrol Hypertens 2012 Nov;21(6):607-11. doi: 10.1097/MNH.0b013e328358a30e. PMID: 23010759
Combined association of albuminuria and cystatin C-based estimated GFR with mortality, coronary heart disease, and heart failure outcomes: the Atherosclerosis Risk in Communities (ARIC) Study.
Waheed S, Matsushita K, Sang Y, Hoogeveen R, Ballantyne C, Coresh J, Astor BC
Am J Kidney Dis 2012 Aug;60(2):207-16. Epub 2012 Apr 25 doi: 10.1053/j.ajkd.2012.03.011. PMID: 22537422Free PMC Article
Treatment of the diabetic patient: focus on cardiovascular and renal risk reduction.
Abbott KC, Bakris GL
Prog Brain Res 2002;139:289-98. doi: 10.1016/s0079-6123(02)39025-3. PMID: 12436944

Diagnosis

CKD Biomarkers, Cognitive Impairment, and Incident Dementia in an Older Healthy Cohort.
Murray AM, Thao LTP, Ryan J, Wolfe R, Wetmore JB, Woods RL, Polkinghorne KR
Kidney360 2022 Mar 31;3(3):435-445. Epub 2021 Dec 7 doi: 10.34067/KID.0005672021. PMID: 35582189Free PMC Article
Accounting for Age in the Definition of Chronic Kidney Disease.
Liu P, Quinn RR, Lam NN, Elliott MJ, Xu Y, James MT, Manns B, Ravani P
JAMA Intern Med 2021 Oct 1;181(10):1359-1366. doi: 10.1001/jamainternmed.2021.4813. PMID: 34459844Free PMC Article
Hypoadiponectinemia as a marker of increased cardiovascular risk in patients with non-alcoholic fatty liver disease: correlation with albumin/creatinine ratio.
Assem M, Amin M, Khalafallah O, Hussien A, Saif A, Mousa S
Arch Endocrinol Metab 2021 Nov 1;65(1):93-97. Epub 2020 Nov 9 doi: 10.20945/2359-3997000000307. PMID: 33166436Free PMC Article
Association between the occurrence of albuminuria and the risk of early dementia among older people upon health examination: a community-based cohort study in Taiwan.
Tseng TJ, Yen YT, Yang YH, Chen YH, Chan TC
BMJ Open 2020 Dec 8;10(12):e041664. doi: 10.1136/bmjopen-2020-041664. PMID: 33293399Free PMC Article
Chronic kidney disease 10 years on: what have we learned?
Taal MW
Curr Opin Nephrol Hypertens 2012 Nov;21(6):607-11. doi: 10.1097/MNH.0b013e328358a30e. PMID: 23010759

Therapy

Sodium-glucose co-transporter-2 inhibitors are associated with kidney benefits at all degrees of albuminuria: A retrospective cohort study of adults with diabetes.
Fujita KK, Ye F, Collister D, Klarenbach S, Campbell DJT, Chew DS, Quinn AE, Ronksley P, Lau D
Diabetes Obes Metab 2024 Feb;26(2):699-709. Epub 2023 Nov 23 doi: 10.1111/dom.15361. PMID: 37997302
Treatment of the diabetic patient: focus on cardiovascular and renal risk reduction.
Abbott KC, Bakris GL
Prog Brain Res 2002;139:289-98. doi: 10.1016/s0079-6123(02)39025-3. PMID: 12436944

Prognosis

Accounting for Age in the Definition of Chronic Kidney Disease.
Liu P, Quinn RR, Lam NN, Elliott MJ, Xu Y, James MT, Manns B, Ravani P
JAMA Intern Med 2021 Oct 1;181(10):1359-1366. doi: 10.1001/jamainternmed.2021.4813. PMID: 34459844Free PMC Article
Chronic Kidney Disease and Risk for Gastrointestinal Bleeding in the Community: The Atherosclerosis Risk in Communities (ARIC) Study.
Ishigami J, Grams ME, Naik RP, Coresh J, Matsushita K
Clin J Am Soc Nephrol 2016 Oct 7;11(10):1735-1743. Epub 2016 Aug 11 doi: 10.2215/CJN.02170216. PMID: 27515592Free PMC Article
Non-Alcoholic Fatty Liver Disease Is a Risk Factor for the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus.
Jia G, Di F, Wang Q, Shao J, Gao L, Wang L, Li Q, Li N
PLoS One 2015;10(11):e0142808. Epub 2015 Nov 13 doi: 10.1371/journal.pone.0142808. PMID: 26566287Free PMC Article
Chronic kidney disease 10 years on: what have we learned?
Taal MW
Curr Opin Nephrol Hypertens 2012 Nov;21(6):607-11. doi: 10.1097/MNH.0b013e328358a30e. PMID: 23010759
Combined association of albuminuria and cystatin C-based estimated GFR with mortality, coronary heart disease, and heart failure outcomes: the Atherosclerosis Risk in Communities (ARIC) Study.
Waheed S, Matsushita K, Sang Y, Hoogeveen R, Ballantyne C, Coresh J, Astor BC
Am J Kidney Dis 2012 Aug;60(2):207-16. Epub 2012 Apr 25 doi: 10.1053/j.ajkd.2012.03.011. PMID: 22537422Free PMC Article

Clinical prediction guides

CKD Biomarkers, Cognitive Impairment, and Incident Dementia in an Older Healthy Cohort.
Murray AM, Thao LTP, Ryan J, Wolfe R, Wetmore JB, Woods RL, Polkinghorne KR
Kidney360 2022 Mar 31;3(3):435-445. Epub 2021 Dec 7 doi: 10.34067/KID.0005672021. PMID: 35582189Free PMC Article
Chronic Kidney Disease and Risk for Gastrointestinal Bleeding in the Community: The Atherosclerosis Risk in Communities (ARIC) Study.
Ishigami J, Grams ME, Naik RP, Coresh J, Matsushita K
Clin J Am Soc Nephrol 2016 Oct 7;11(10):1735-1743. Epub 2016 Aug 11 doi: 10.2215/CJN.02170216. PMID: 27515592Free PMC Article
Chronic kidney disease 10 years on: what have we learned?
Taal MW
Curr Opin Nephrol Hypertens 2012 Nov;21(6):607-11. doi: 10.1097/MNH.0b013e328358a30e. PMID: 23010759
Combined association of albuminuria and cystatin C-based estimated GFR with mortality, coronary heart disease, and heart failure outcomes: the Atherosclerosis Risk in Communities (ARIC) Study.
Waheed S, Matsushita K, Sang Y, Hoogeveen R, Ballantyne C, Coresh J, Astor BC
Am J Kidney Dis 2012 Aug;60(2):207-16. Epub 2012 Apr 25 doi: 10.1053/j.ajkd.2012.03.011. PMID: 22537422Free PMC Article
Implications for kidney disease in obese children and adolescents.
Savino A, Pelliccia P, Giannini C, de Giorgis T, Cataldo I, Chiarelli F, Mohn A
Pediatr Nephrol 2011 May;26(5):749-58. Epub 2011 Feb 11 doi: 10.1007/s00467-010-1659-y. PMID: 21308381

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