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Mesangial microfibril deposition

MedGen UID:
1778692
Concept ID:
C5539672
Finding
HPO: HP:0033546

Definition

Unbranched noncollagenous microfibrils within the mesangial matrix, composed of proteins not present within the glomerular basement membrane (GBM), most notably fibrillin-1, that attach to mesangial cells and GBM structural proteins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesangial microfibril deposition

Recent clinical studies

Etiology

Chung WY, Lee SY, Joo JE
Nephron 1995;69(1):79-82. doi: 10.1159/000188364. PMID: 7891802
Mazzucco G, Casanova S, Donini U, Rollino C, Zucchelli P, Piccoli G, Monga G
Am J Nephrol 1990;10(1):21-30. doi: 10.1159/000168049. PMID: 2111635
Bruneval P, Foidart JM, Nochy D, Camilleri JP, Bariety J
Hum Pathol 1985 May;16(5):477-84. doi: 10.1016/s0046-8177(85)80086-1. PMID: 3921452

Diagnosis

Hattori K, Shimizu R, Tanaka S, Terashima T, Hiramatsu M, Shimomura T, Ito T, Morinaga T, Terasaki M, Shimizu A, Morozumi K, Tamai H
CEN Case Rep 2022 Nov;11(4):412-416. Epub 2022 Feb 23 doi: 10.1007/s13730-022-00693-3. PMID: 35199316Free PMC Article
Chung WY, Lee SY, Joo JE
Nephron 1995;69(1):79-82. doi: 10.1159/000188364. PMID: 7891802
Bakir AA, Ainis H, Rhee HL
Am J Nephrol 1990;10(4):333-8. doi: 10.1159/000168129. PMID: 2240062
Mazzucco G, Casanova S, Donini U, Rollino C, Zucchelli P, Piccoli G, Monga G
Am J Nephrol 1990;10(1):21-30. doi: 10.1159/000168049. PMID: 2111635
Bruneval P, Foidart JM, Nochy D, Camilleri JP, Bariety J
Hum Pathol 1985 May;16(5):477-84. doi: 10.1016/s0046-8177(85)80086-1. PMID: 3921452

Therapy

Hattori K, Shimizu R, Tanaka S, Terashima T, Hiramatsu M, Shimomura T, Ito T, Morinaga T, Terasaki M, Shimizu A, Morozumi K, Tamai H
CEN Case Rep 2022 Nov;11(4):412-416. Epub 2022 Feb 23 doi: 10.1007/s13730-022-00693-3. PMID: 35199316Free PMC Article

Prognosis

Mazzucco G, Casanova S, Donini U, Rollino C, Zucchelli P, Piccoli G, Monga G
Am J Nephrol 1990;10(1):21-30. doi: 10.1159/000168049. PMID: 2111635
Kobayashi Y, Fujii K, Kurokawa A, Kamiyama M, Miyazawa H
Nephron 1988;48(1):33-9. doi: 10.1159/000184865. PMID: 3277075

Clinical prediction guides

Groma V
Nephrol Dial Transplant 1998 Feb;13(2):305-12. doi: 10.1093/oxfordjournals.ndt.a027823. PMID: 9509439
Orfila C, Meeus F, Bernadet P, Lepert JC, Suc JM
Am J Nephrol 1991;11(1):67-72. doi: 10.1159/000168276. PMID: 1904680

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