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Increased non-HDL cholesterol concentration

MedGen UID:
1781215
•Concept ID:
C5539728
•
Finding
Synonym: Elevated non-HDL cholesterol concentration
 
HPO: HP:0033626

Definition

Increase above normal levels of non-HDL cholesterol in the blood. Non-HDL cholesterol is total cholesterol minus high-density lipoprotein HDL-cholesterol (high-density lipoprotein-cholesterol). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased non-HDL cholesterol concentration

Professional guidelines

PubMed

PCSK9 inhibitors on the management of primary and secondary cardiovascular prevention.
Marco-Benedí V, Sánchez-Hernández RM, Díaz JL, Jarauta E, Suárez-Tembra M, Pintó X, Morillas C, Plana N, Pedro-Botet J, Civeira F
Lipids Health Dis 2024 Sep 10;23(1):290. doi: 10.1186/s12944-024-02283-x. PMID: 39256734Free PMC Article
Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis.
Sheridan DA, Shawa IT, Thomas EL, Felmlee DJ, Bridge SH, Neely D, Cobbold JF, Holmes E, Bassendine MF, Taylor-Robinson SD
Sci Rep 2022 Apr 1;12(1):5562. doi: 10.1038/s41598-022-09588-w. PMID: 35365728Free PMC Article
Treatment of diabetic dyslipidemia.
Garg A
Am J Cardiol 1998 Feb 26;81(4A):47B-51B. doi: 10.1016/s0002-9149(98)00038-1. PMID: 9526814

Recent clinical studies

Etiology

The relationship between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and hyperuricaemia.
Wang Z, Wu M, Du R, Tang F, Xu M, Gu T, Yang Q
Lipids Health Dis 2024 Jun 21;23(1):187. doi: 10.1186/s12944-024-02171-4. PMID: 38907262Free PMC Article
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954Free PMC Article
New targets for treating hypertriglyceridemia.
Parhofer KG
Curr Opin Endocrinol Diabetes Obes 2022 Apr 1;29(2):106-111. doi: 10.1097/MED.0000000000000714. PMID: 35045528
The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial.
Xu D, Feng M, Chu Y, Wang S, Shete V, Tuohy KM, Liu F, Zhou X, Kamil A, Pan D, Liu H, Yang X, Yang C, Zhu B, Lv N, Xiong Q, Wang X, Sun J, Sun G, Yang Y
Front Immunol 2021;12:787797. Epub 2021 Dec 9 doi: 10.3389/fimmu.2021.787797. PMID: 34956218Free PMC Article
Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women.
Khaw KT, Sharp SJ, Finikarides L, Afzal I, Lentjes M, Luben R, Forouhi NG
BMJ Open 2018 Mar 6;8(3):e020167. doi: 10.1136/bmjopen-2017-020167. PMID: 29511019Free PMC Article

Diagnosis

Triglyceride-rich lipoprotein, remnant cholesterol, and apolipoproteins CII, CIII, and E in patients with schizophrenia.
Wang J, Kockx M, Bolek M, Lambert T, Sullivan D, Chow V, Kritharides L
J Lipid Res 2024 Jul;65(7):100577. Epub 2024 Jun 13 doi: 10.1016/j.jlr.2024.100577. PMID: 38879166Free PMC Article
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954Free PMC Article
The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial.
Xu D, Feng M, Chu Y, Wang S, Shete V, Tuohy KM, Liu F, Zhou X, Kamil A, Pan D, Liu H, Yang X, Yang C, Zhu B, Lv N, Xiong Q, Wang X, Sun J, Sun G, Yang Y
Front Immunol 2021;12:787797. Epub 2021 Dec 9 doi: 10.3389/fimmu.2021.787797. PMID: 34956218Free PMC Article
Trends in lipid-modifying agent use in 83 countries.
Blais JE, Wei Y, Yap KKW, Alwafi H, Ma TT, Brauer R, Lau WCY, Man KKC, Siu CW, Tan KCB, Wong ICK, Wei L, Chan EW
Atherosclerosis 2021 Jul;328:44-51. Epub 2021 May 27 doi: 10.1016/j.atherosclerosis.2021.05.016. PMID: 34091069
Fasting and nonfasting triglycerides in cardiovascular and other diseases.
Piťha J, Kovář J, Blahová T
Physiol Res 2015;64(Suppl 3):S323-30. doi: 10.33549/physiolres.933196. PMID: 26680665

Therapy

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954Free PMC Article
Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial.
Nicholls SJ, Ditmarsch M, Kastelein JJ, Rigby SP, Kling D, Curcio DL, Alp NJ, Davidson MH
Nat Med 2022 Aug;28(8):1672-1678. Epub 2022 Aug 11 doi: 10.1038/s41591-022-01936-7. PMID: 35953719
The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial.
Xu D, Feng M, Chu Y, Wang S, Shete V, Tuohy KM, Liu F, Zhou X, Kamil A, Pan D, Liu H, Yang X, Yang C, Zhu B, Lv N, Xiong Q, Wang X, Sun J, Sun G, Yang Y
Front Immunol 2021;12:787797. Epub 2021 Dec 9 doi: 10.3389/fimmu.2021.787797. PMID: 34956218Free PMC Article
Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women.
Khaw KT, Sharp SJ, Finikarides L, Afzal I, Lentjes M, Luben R, Forouhi NG
BMJ Open 2018 Mar 6;8(3):e020167. doi: 10.1136/bmjopen-2017-020167. PMID: 29511019Free PMC Article
Treatment of diabetic dyslipidemia.
Garg A
Am J Cardiol 1998 Feb 26;81(4A):47B-51B. doi: 10.1016/s0002-9149(98)00038-1. PMID: 9526814

Prognosis

Significance of lipids, lipoproteins, and apolipoproteins during the first 14-16 months of life.
Taageby Nielsen S, Mohr Lytsen R, Strandkjær N, Juul Rasmussen I, Sillesen AS, Vøgg ROB, Axelsson Raja A, Nordestgaard BG, Kamstrup PR, Iversen K, Bundgaard H, Tybjærg-Hansen A, Frikke-Schmidt R
Eur Heart J 2023 Nov 7;44(42):4408-4418. doi: 10.1093/eurheartj/ehad547. PMID: 37632410Free PMC Article
Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy.
Julve J, Rossell J, Correig E, Rojo-Lopez MI, Amigó N, Hernández M, Traveset A, Carbonell M, Alonso N, Mauricio D, Castelblanco E
Nutrients 2022 Sep 22;14(19) doi: 10.3390/nu14193932. PMID: 36235586Free PMC Article
Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial.
Nicholls SJ, Ditmarsch M, Kastelein JJ, Rigby SP, Kling D, Curcio DL, Alp NJ, Davidson MH
Nat Med 2022 Aug;28(8):1672-1678. Epub 2022 Aug 11 doi: 10.1038/s41591-022-01936-7. PMID: 35953719
New targets for treating hypertriglyceridemia.
Parhofer KG
Curr Opin Endocrinol Diabetes Obes 2022 Apr 1;29(2):106-111. doi: 10.1097/MED.0000000000000714. PMID: 35045528
Cardiovascular disease and dyslipidemia: beyond LDL.
Pöss J, Custodis F, Werner C, Weingärtner O, Böhm M, Laufs U
Curr Pharm Des 2011;17(9):861-70. doi: 10.2174/138161211795428858. PMID: 21418031

Clinical prediction guides

Avocado Consumption and Cardiometabolic Health: A Systematic Review and Meta-Analysis.
James-Martin G, Brooker PG, Hendrie GA, Stonehouse W
J Acad Nutr Diet 2024 Feb;124(2):233-248.e4. Epub 2022 Dec 21 doi: 10.1016/j.jand.2022.12.008. PMID: 36565850
Significance of lipids, lipoproteins, and apolipoproteins during the first 14-16 months of life.
Taageby Nielsen S, Mohr Lytsen R, Strandkjær N, Juul Rasmussen I, Sillesen AS, Vøgg ROB, Axelsson Raja A, Nordestgaard BG, Kamstrup PR, Iversen K, Bundgaard H, Tybjærg-Hansen A, Frikke-Schmidt R
Eur Heart J 2023 Nov 7;44(42):4408-4418. doi: 10.1093/eurheartj/ehad547. PMID: 37632410Free PMC Article
Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy.
Julve J, Rossell J, Correig E, Rojo-Lopez MI, Amigó N, Hernández M, Traveset A, Carbonell M, Alonso N, Mauricio D, Castelblanco E
Nutrients 2022 Sep 22;14(19) doi: 10.3390/nu14193932. PMID: 36235586Free PMC Article
New targets for treating hypertriglyceridemia.
Parhofer KG
Curr Opin Endocrinol Diabetes Obes 2022 Apr 1;29(2):106-111. doi: 10.1097/MED.0000000000000714. PMID: 35045528
Cardiovascular disease and dyslipidemia: beyond LDL.
Pöss J, Custodis F, Werner C, Weingärtner O, Böhm M, Laufs U
Curr Pharm Des 2011;17(9):861-70. doi: 10.2174/138161211795428858. PMID: 21418031

Recent systematic reviews

Avocado Consumption and Cardiometabolic Health: A Systematic Review and Meta-Analysis.
James-Martin G, Brooker PG, Hendrie GA, Stonehouse W
J Acad Nutr Diet 2024 Feb;124(2):233-248.e4. Epub 2022 Dec 21 doi: 10.1016/j.jand.2022.12.008. PMID: 36565850
Is non-high-density lipoprotein associated with metabolic syndrome? A systematic review and meta-analysis.
Mardi P, Abdi F, Ehsani A, Seif E, Djalalinia S, Heshmati J, Shahrestanaki E, Gorabi AM, Qorbani M
Front Endocrinol (Lausanne) 2022;13:957136. Epub 2022 Sep 13 doi: 10.3389/fendo.2022.957136. PMID: 36176470Free PMC Article
Effect of Hydroxychloroquine on Lipid Levels: A Systematic Review and Metaanalysis.
Simental-Mendía LE, Simental-Mendía M, Sánchez-García A, Linden-Torres E
Curr Pharm Des 2021;27(40):4133-4139. doi: 10.2174/1381612827666210625162612. PMID: 34176459
Serum lipid concentrations among persons with spinal cord injury - a systematic review and meta-analysis of the literature.
Gilbert O, Croffoot JR, Taylor AJ, Nash M, Schomer K, Groah S
Atherosclerosis 2014 Feb;232(2):305-12. Epub 2013 Nov 18 doi: 10.1016/j.atherosclerosis.2013.11.028. PMID: 24468143

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