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Increased non-HDL cholesterol concentration

MedGen UID:
1781215
•Concept ID:
C5539728
•
Finding
Synonym: Elevated non-HDL cholesterol concentration
 
HPO: HP:0033626

Definition

Increase above normal levels of non-HDL cholesterol in the blood. Non-HDL cholesterol is total cholesterol minus high-density lipoprotein HDL-cholesterol (high-density lipoprotein-cholesterol). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased non-HDL cholesterol concentration

Professional guidelines

PubMed

Glucose and lipid-related biomarkers and the antidepressant response to infliximab in patients with treatment-resistant depression.
Bekhbat M, Chu K, Le NA, Woolwine BJ, Haroon E, Miller AH, Felger JC
Psychoneuroendocrinology 2018 Dec;98:222-229. Epub 2018 Sep 6 doi: 10.1016/j.psyneuen.2018.09.004. PMID: 30249443Free PMC Article
Advances in lipid testing and management in patients with diabetes mellitus.
Vasudevan MM, Ballantyne CM
Endocr Pract 2009 Sep-Oct;15(6):641-52. doi: 10.4158/EP09190.RA. PMID: 19625239
Treatment of diabetic dyslipidemia.
Garg A
Am J Cardiol 1998 Feb 26;81(4A):47B-51B. doi: 10.1016/s0002-9149(98)00038-1. PMID: 9526814

Recent clinical studies

Etiology

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954
Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial.
Nicholls SJ, Ditmarsch M, Kastelein JJ, Rigby SP, Kling D, Curcio DL, Alp NJ, Davidson MH
Nat Med 2022 Aug;28(8):1672-1678. Epub 2022 Aug 11 doi: 10.1038/s41591-022-01936-7. PMID: 35953719
The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial.
Xu D, Feng M, Chu Y, Wang S, Shete V, Tuohy KM, Liu F, Zhou X, Kamil A, Pan D, Liu H, Yang X, Yang C, Zhu B, Lv N, Xiong Q, Wang X, Sun J, Sun G, Yang Y
Front Immunol 2021;12:787797. Epub 2021 Dec 9 doi: 10.3389/fimmu.2021.787797. PMID: 34956218Free PMC Article
Dietary habits, lipoprotein metabolism and cardiovascular disease: From individual foods to dietary patterns.
Gomez-Delgado F, Katsiki N, Lopez-Miranda J, Perez-Martinez P
Crit Rev Food Sci Nutr 2021;61(10):1651-1669. Epub 2020 Jun 9 doi: 10.1080/10408398.2020.1764487. PMID: 32515660
Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women.
Khaw KT, Sharp SJ, Finikarides L, Afzal I, Lentjes M, Luben R, Forouhi NG
BMJ Open 2018 Mar 6;8(3):e020167. doi: 10.1136/bmjopen-2017-020167. PMID: 29511019Free PMC Article

Diagnosis

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954
Effects of long-term vitamin D supplementation on metabolic profile in middle-aged and elderly patients with type 2 diabetes.
Hu Z, Zhi X, Li J, Li B, Wang J, Zhu J, Zhang Z
J Steroid Biochem Mol Biol 2023 Jan;225:106198. Epub 2022 Sep 29 doi: 10.1016/j.jsbmb.2022.106198. PMID: 36181990
The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial.
Xu D, Feng M, Chu Y, Wang S, Shete V, Tuohy KM, Liu F, Zhou X, Kamil A, Pan D, Liu H, Yang X, Yang C, Zhu B, Lv N, Xiong Q, Wang X, Sun J, Sun G, Yang Y
Front Immunol 2021;12:787797. Epub 2021 Dec 9 doi: 10.3389/fimmu.2021.787797. PMID: 34956218Free PMC Article
Inflammation and atherosclerosis.
Poledne R, Lesná IK
Vnitr Lek 2019 Winter;64(12):1142-1146. PMID: 30704248
Fasting and nonfasting triglycerides in cardiovascular and other diseases.
Piťha J, Kovář J, Blahová T
Physiol Res 2015;64(Suppl 3):S323-30. doi: 10.33549/physiolres.933196. PMID: 26680665

Therapy

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954
Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial.
Nicholls SJ, Ditmarsch M, Kastelein JJ, Rigby SP, Kling D, Curcio DL, Alp NJ, Davidson MH
Nat Med 2022 Aug;28(8):1672-1678. Epub 2022 Aug 11 doi: 10.1038/s41591-022-01936-7. PMID: 35953719
The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial.
Xu D, Feng M, Chu Y, Wang S, Shete V, Tuohy KM, Liu F, Zhou X, Kamil A, Pan D, Liu H, Yang X, Yang C, Zhu B, Lv N, Xiong Q, Wang X, Sun J, Sun G, Yang Y
Front Immunol 2021;12:787797. Epub 2021 Dec 9 doi: 10.3389/fimmu.2021.787797. PMID: 34956218Free PMC Article
Subclinical Hyperthyroidism: Status of the Cholesterol Transfers to HDL and Other Parameters Related to Lipoprotein Metabolism in Patients Submitted to Thyroidectomy for Thyroid Cancer.
Sigal GA, Tavoni TM, Silva BMO, Khalil-Filho R, Brandão LG, Baracat EC, Maranhão RC
Front Endocrinol (Lausanne) 2020;11:176. Epub 2020 Apr 2 doi: 10.3389/fendo.2020.00176. PMID: 32300332Free PMC Article
Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women.
Khaw KT, Sharp SJ, Finikarides L, Afzal I, Lentjes M, Luben R, Forouhi NG
BMJ Open 2018 Mar 6;8(3):e020167. doi: 10.1136/bmjopen-2017-020167. PMID: 29511019Free PMC Article

Prognosis

Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial.
Nicholls SJ, Ditmarsch M, Kastelein JJ, Rigby SP, Kling D, Curcio DL, Alp NJ, Davidson MH
Nat Med 2022 Aug;28(8):1672-1678. Epub 2022 Aug 11 doi: 10.1038/s41591-022-01936-7. PMID: 35953719
New targets for treating hypertriglyceridemia.
Parhofer KG
Curr Opin Endocrinol Diabetes Obes 2022 Apr 1;29(2):106-111. doi: 10.1097/MED.0000000000000714. PMID: 35045528
Is measurement of non-HDL cholesterol an effective way to identify the metabolic syndrome?
Liu A, Reaven GM
Nutr Metab Cardiovasc Dis 2013 Nov;23(11):1122-7. Epub 2013 Jan 24 doi: 10.1016/j.numecd.2012.12.001. PMID: 23352957Free PMC Article
Cholesteryl ester transfer protein inhibition as a strategy to reduce cardiovascular risk.
Barter PJ, Rye KA
J Lipid Res 2012 Sep;53(9):1755-66. Epub 2012 May 22 doi: 10.1194/jlr.R024075. PMID: 22550134Free PMC Article
High-density lipoprotein cholesterol and triglycerides as therapeutic targets for preventing and treating coronary artery disease.
Gotto AM Jr
Am Heart J 2002 Dec;144(6 Suppl):S33-42. doi: 10.1067/mhj.2002.130301. PMID: 12486414

Clinical prediction guides

Improvement in cardiometabolic risk markers following an oatmeal diet is associated with gut microbiota in mildly hypercholesterolemic individuals.
Xu D, Pan D, Liu H, Yang C, Yang X, Wang X, Liu F, Feng M, Wu Q, Shen Y, Yang L, Wang S, Sun G
Food Res Int 2022 Oct;160:111701. Epub 2022 Jul 26 doi: 10.1016/j.foodres.2022.111701. PMID: 36076452
Efficacy and Safety of K-877 (Pemafibrate), a Selective PPARα Modulator, in European Patients on Statin Therapy.
Ginsberg HN, Hounslow NJ, Senko Y, Suganami H, Bogdanski P, Ceska R, Kalina A, Libis RA, Supryadkina TV, Hovingh GK
Diabetes Care 2022 Apr 1;45(4):898-908. doi: 10.2337/dc21-1288. PMID: 35238894
New targets for treating hypertriglyceridemia.
Parhofer KG
Curr Opin Endocrinol Diabetes Obes 2022 Apr 1;29(2):106-111. doi: 10.1097/MED.0000000000000714. PMID: 35045528
Subclinical Hyperthyroidism: Status of the Cholesterol Transfers to HDL and Other Parameters Related to Lipoprotein Metabolism in Patients Submitted to Thyroidectomy for Thyroid Cancer.
Sigal GA, Tavoni TM, Silva BMO, Khalil-Filho R, Brandão LG, Baracat EC, Maranhão RC
Front Endocrinol (Lausanne) 2020;11:176. Epub 2020 Apr 2 doi: 10.3389/fendo.2020.00176. PMID: 32300332Free PMC Article
Aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: A randomized, double-blind, placebo-controlled clinical trial.
Xu C, Mathews AE, Rodrigues C, Eudy BJ, Rowe CA, O'Donoughue A, Percival SS
Clin Nutr ESPEN 2018 Apr;24:148-155. Epub 2018 Jan 3 doi: 10.1016/j.clnesp.2017.11.010. PMID: 29576354

Recent systematic reviews

Is non-high-density lipoprotein associated with metabolic syndrome? A systematic review and meta-analysis.
Mardi P, Abdi F, Ehsani A, Seif E, Djalalinia S, Heshmati J, Shahrestanaki E, Gorabi AM, Qorbani M
Front Endocrinol (Lausanne) 2022;13:957136. Epub 2022 Sep 13 doi: 10.3389/fendo.2022.957136. PMID: 36176470Free PMC Article
Effect of Hydroxychloroquine on Lipid Levels: A Systematic Review and Metaanalysis.
Simental-Mendía LE, Simental-Mendía M, Sánchez-García A, Linden-Torres E
Curr Pharm Des 2021;27(40):4133-4139. doi: 10.2174/1381612827666210625162612. PMID: 34176459
Serum lipid concentrations among persons with spinal cord injury - a systematic review and meta-analysis of the literature.
Gilbert O, Croffoot JR, Taylor AJ, Nash M, Schomer K, Groah S
Atherosclerosis 2014 Feb;232(2):305-12. Epub 2013 Nov 18 doi: 10.1016/j.atherosclerosis.2013.11.028. PMID: 24468143

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