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Elevated circulating phosphoethanolamine concentration

MedGen UID:
1781503
•Concept ID:
C5539567
•
Finding
Synonym: Elevated circulating o-phosphoethanolamine concentration
 
HPO: HP:0033406

Definition

An increased concentration of o-phosphoethanolamine in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating phosphoethanolamine concentration

Professional guidelines

PubMed

Hypophosphatasia - aetiology, nosology, pathogenesis, diagnosis and treatment.
Whyte MP
Nat Rev Endocrinol 2016 Apr;12(4):233-46. Epub 2016 Feb 19 doi: 10.1038/nrendo.2016.14. PMID: 26893260

Recent clinical studies

Etiology

Lipidomics profiling and circulating triglyceride concentrations in sub-Saharan African individuals.
Bentley AR, Doumatey AP, Zhou J, Lei L, Meeks KAC, Heuston EF, Rotimi CN, Adeyemo AA
Sci Rep 2024 Sep 6;14(1):20834. doi: 10.1038/s41598-024-71734-3. PMID: 39251667Free PMC Article
Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B(6) metabolism.
Whyte MP, Zhang F, Mack KE, Wenkert D, Gottesman GS, Ericson KL, Cole JT, Coburn SP
Bone 2024 Apr;181:117033. Epub 2024 Feb 1 doi: 10.1016/j.bone.2024.117033. PMID: 38307176
Plasma glycerophospholipid profile, erythrocyte n-3 PUFAs, and metabolic syndrome incidence: a prospective study in Chinese men and women.
Chen S, Wu Q, Zhu L, Zong G, Li H, Zheng H, Zeng R, Lin X, Sun L
Am J Clin Nutr 2021 Jul 1;114(1):143-153. doi: 10.1093/ajcn/nqab050. PMID: 33829226
Hypophosphatasia - aetiology, nosology, pathogenesis, diagnosis and treatment.
Whyte MP
Nat Rev Endocrinol 2016 Apr;12(4):233-46. Epub 2016 Feb 19 doi: 10.1038/nrendo.2016.14. PMID: 26893260
Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy.
Whyte MP, Landt M, Ryan LM, Mulivor RA, Henthorn PS, Fedde KN, Mahuren JD, Coburn SP
J Clin Invest 1995 Apr;95(4):1440-5. doi: 10.1172/JCI117814. PMID: 7706447Free PMC Article

Diagnosis

Hypophosphatasia - aetiology, nosology, pathogenesis, diagnosis and treatment.
Whyte MP
Nat Rev Endocrinol 2016 Apr;12(4):233-46. Epub 2016 Feb 19 doi: 10.1038/nrendo.2016.14. PMID: 26893260
Nanohybrid liposomal cerasomes with good physiological stability and rapid temperature responsiveness for high intensity focused ultrasound triggered local chemotherapy of cancer.
Liang X, Gao J, Jiang L, Luo J, Jing L, Li X, Jin Y, Dai Z
ACS Nano 2015 Feb 24;9(2):1280-93. Epub 2015 Jan 22 doi: 10.1021/nn507482w. PMID: 25599568
Adult hypophosphatasia.
Sorensen E, Flodgaard H
Acta Med Scand 1975 May;197(5):357-60. doi: 10.1111/j.0954-6820.1975.tb04934.x. PMID: 167553

Therapy

Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates.
Lefever E, Witters P, Gielen E, Vanclooster A, Meersseman W, Morava E, Cassiman D, Laurent MR
J Clin Densitom 2020 Jul-Sep;23(3):340-348. Epub 2018 Dec 21 doi: 10.1016/j.jocd.2018.12.006. PMID: 30655187
Nanohybrid liposomal cerasomes with good physiological stability and rapid temperature responsiveness for high intensity focused ultrasound triggered local chemotherapy of cancer.
Liang X, Gao J, Jiang L, Luo J, Jing L, Li X, Jin Y, Dai Z
ACS Nano 2015 Feb 24;9(2):1280-93. Epub 2015 Jan 22 doi: 10.1021/nn507482w. PMID: 25599568
Enhanced tumor delivery of gemcitabine via PEG-DSPE/TPGS mixed micelles.
Wang Y, Fan W, Dai X, Katragadda U, Mckinley D, Teng Q, Tan C
Mol Pharm 2014 Apr 7;11(4):1140-50. Epub 2014 Mar 10 doi: 10.1021/mp4005904. PMID: 24579673Free PMC Article
Formulation, antileukemia mechanism, pharmacokinetics, and biodistribution of a novel liposomal emodin.
Wang T, Yin X, Lu Y, Shan W, Xiong S
Int J Nanomedicine 2012;7:2325-37. Epub 2012 May 8 doi: 10.2147/IJN.S31029. PMID: 22661889Free PMC Article
Adult hypophosphatasia.
Sorensen E, Flodgaard H
Acta Med Scand 1975 May;197(5):357-60. doi: 10.1111/j.0954-6820.1975.tb04934.x. PMID: 167553

Clinical prediction guides

Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B(6) metabolism.
Whyte MP, Zhang F, Mack KE, Wenkert D, Gottesman GS, Ericson KL, Cole JT, Coburn SP
Bone 2024 Apr;181:117033. Epub 2024 Feb 1 doi: 10.1016/j.bone.2024.117033. PMID: 38307176
Formulation, antileukemia mechanism, pharmacokinetics, and biodistribution of a novel liposomal emodin.
Wang T, Yin X, Lu Y, Shan W, Xiong S
Int J Nanomedicine 2012;7:2325-37. Epub 2012 May 8 doi: 10.2147/IJN.S31029. PMID: 22661889Free PMC Article

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