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Glomerular obsolescence

MedGen UID:: 1782435
•Concept ID:: C5539514
•: Finding

HPO:	HP:0033321

Definition

Globally sclerotic glomeruli are that are small and without hyalinosis and may appear with collapse of the tuft with collagenization of the urinary space. Bowman's capsule is completely or partially absent and there is no periglomerular fibrosis and glomerular size is decreased by more than 50% compared to all other glomeruli in the same biopsy. Obsolescent glomeruli may appear to be receding into the interstitium. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGlomerular obsolescence

Abnormal renal morphology
- Abnormal nephron morphology
  - Abnormal renal corpuscle morphology
    - Abnormal renal glomerulus morphology
      - Glomerular sclerosis
        Global glomerulosclerosis
        Glomerular obsolescence

Professional guidelines

PubMed

Renal function and biopsy findings after 5 years' treatment with low-dose cyclosporin for psoriasis.

Powles AV, Cook T, Hulme B, Baker BS, Lewis HM, Thomas E, Valdimarsson H, Fry L
Br J Dermatol 1993 Feb;128(2):159-65. doi: 10.1111/j.1365-2133.1993.tb15145.x. PMID: 8457449

See all (1)

Recent clinical studies

Etiology

Urinary Vacuolar Casts Are a Unique Type of Casts in Advanced Proteinuric Glomerulopathies.

Rosenbloom S, Ramanand A, Stark A, Varghese V, Chalmers D, Au-Yeung N, Kanduri SR, Lukitsch I, Poloni JAT, Keitel E, Franz AP, Martínez-Figueroa C, Sarkar A, Alix-Arbatin MC, Fogo AB, Buchkremer F, Seltzer JR, Velez JCQ
Kidney360 2024 Feb 1;5(2):216-227. Epub 2024 Jan 19 doi: 10.34067/KID.0000000000000346. PMID: 38240639 Free PMC Article

Kidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Study.

Eadon MT, Schwantes-An TH, Phillips CL, Roberts AR, Greene CV, Hallab A, Hart KJ, Lipp SN, Perez-Ledezma C, Omar KO, Kelly KJ, Moe SM, Dagher PC, El-Achkar TM, Moorthi RN
Am J Kidney Dis 2020 Sep;76(3):350-360. Epub 2020 Apr 24 doi: 10.1053/j.ajkd.2019.12.014. PMID: 32336487 Free PMC Article

Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathy.

Inoue T, Luo Y, Seto T, Suzuki H, Okada H
Ren Fail 2019 Nov;41(1):893-898. doi: 10.1080/0886022X.2019.1665545. PMID: 31557071 Free PMC Article

A Single Center Experience With Adult Dual Kidney Transplant.

Olakkengil SA, Varatharajah K, Rao MM, Gulyani A, Hamilton M, Russ G, Russell C
Exp Clin Transplant 2015 Oct;13(5):408-12. PMID: 26450464

Renal vascular lesions in the elderly: nephrosclerosis or atheromatous renal disease?

Meyrier A
Nephrol Dial Transplant 1996;11 Suppl 9:45-52. doi: 10.1093/ndt/11.supp9.45. PMID: 9050035

See all (20)

Diagnosis

Urinary Vacuolar Casts Are a Unique Type of Casts in Advanced Proteinuric Glomerulopathies.

Role of Palatine Tonsil and Epipharyngeal Lymphoid Tissue in the Development of Glomerular Active Lesions (Glomerular vasculitis) in Immunoglobulin A Nephropathy.

Hotta O, Ieiri N, Nagai M, Tanaka A, Harabuchi Y
Int J Mol Sci 2022 Jan 10;23(2) doi: 10.3390/ijms23020727. PMID: 35054911 Free PMC Article

Kidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Study.

Focal segmental glomerulosclerosis, excluding atypical lesion, is a predictor of renal outcome in patients with membranous nephropathy: a retrospective analysis of 716 cases.

He HG, Wu CQ, Ye K, Zeng C, Huang YY, Luo SW, Yin W, Ye QR, Peng XM
BMC Nephrol 2019 Aug 22;20(1):328. doi: 10.1186/s12882-019-1498-4. PMID: 31438882 Free PMC Article

Renal biopsy in patients over 75: 131 cases.

Rollino C, Ferro M, Beltrame G, Quattrocchio G, Massara C, Quarello F, Roccatello D
Clin Nephrol 2014 Oct;82(4):225-30. doi: 10.5414/CN108258. PMID: 25161113 Free PMC Article

See all (11)

Therapy

A Single Center Experience With Adult Dual Kidney Transplant.

Olakkengil SA, Varatharajah K, Rao MM, Gulyani A, Hamilton M, Russ G, Russell C
Exp Clin Transplant 2015 Oct;13(5):408-12. PMID: 26450464

Renal biopsy in patients over 75: 131 cases.

Rollino C, Ferro M, Beltrame G, Quattrocchio G, Massara C, Quarello F, Roccatello D
Clin Nephrol 2014 Oct;82(4):225-30. doi: 10.5414/CN108258. PMID: 25161113 Free PMC Article

Predictors of poor outcomes in steroid therapy for immunoglobulin A nephropathy.

Shimizu A, Takei T, Uchida K, Tsuchiya K, Nitta K
Nephrology (Carlton) 2009 Aug;14(5):521-6. doi: 10.1111/j.1440-1797.2009.01104.x. PMID: 19674320

A clinicopathological study of IgA nephropathy in renal transplant recipients: beneficial effect of angiotensin-converting enzyme inhibitor.

Oka K, Imai E, Moriyama T, Akagi Y, Ando A, Hori M, Okuyama A, Toki K, Kyo M, Kokado Y, Takahara S
Nephrol Dial Transplant 2000 May;15(5):689-95. doi: 10.1093/ndt/15.5.689. PMID: 10809812

Cyclosporine-induced renal dysfunction in experimental animals and humans.

Remuzzi G, Perico N
Kidney Int Suppl 1995 Dec;52:S70-4. PMID: 8587288

See all (8)

Prognosis

Kidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Study.

Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathy.

Inoue T, Luo Y, Seto T, Suzuki H, Okada H
Ren Fail 2019 Nov;41(1):893-898. doi: 10.1080/0886022X.2019.1665545. PMID: 31557071 Free PMC Article

Focal segmental glomerulosclerosis, excluding atypical lesion, is a predictor of renal outcome in patients with membranous nephropathy: a retrospective analysis of 716 cases.

He HG, Wu CQ, Ye K, Zeng C, Huang YY, Luo SW, Yin W, Ye QR, Peng XM
BMC Nephrol 2019 Aug 22;20(1):328. doi: 10.1186/s12882-019-1498-4. PMID: 31438882 Free PMC Article

Renal biopsy in patients over 75: 131 cases.

Rollino C, Ferro M, Beltrame G, Quattrocchio G, Massara C, Quarello F, Roccatello D
Clin Nephrol 2014 Oct;82(4):225-30. doi: 10.5414/CN108258. PMID: 25161113 Free PMC Article

Thin GBM nephropathy: premature glomerular obsolescence is associated with hypertension and late onset renal failure.

Nieuwhof CM, de Heer F, de Leeuw P, van Breda Vriesman PJ
Kidney Int 1997 May;51(5):1596-601. doi: 10.1038/ki.1997.219. PMID: 9150478

See all (17)