U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Glomerular obsolescence

MedGen UID:
1782435
Concept ID:
C5539514
Finding
HPO: HP:0033321

Definition

Globally sclerotic glomeruli are that are small and without hyalinosis and may appear with collapse of the tuft with collagenization of the urinary space. Bowman's capsule is completely or partially absent and there is no periglomerular fibrosis and glomerular size is decreased by more than 50% compared to all other glomeruli in the same biopsy. Obsolescent glomeruli may appear to be receding into the interstitium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular obsolescence

Professional guidelines

PubMed

Powles AV, Cook T, Hulme B, Baker BS, Lewis HM, Thomas E, Valdimarsson H, Fry L
Br J Dermatol 1993 Feb;128(2):159-65. doi: 10.1111/j.1365-2133.1993.tb15145.x. PMID: 8457449

Recent clinical studies

Etiology

Rosenbloom S, Ramanand A, Stark A, Varghese V, Chalmers D, Au-Yeung N, Kanduri SR, Lukitsch I, Poloni JAT, Keitel E, Franz AP, Martínez-Figueroa C, Sarkar A, Alix-Arbatin MC, Fogo AB, Buchkremer F, Seltzer JR, Velez JCQ
Kidney360 2024 Feb 1;5(2):216-227. Epub 2024 Jan 19 doi: 10.34067/KID.0000000000000346. PMID: 38240639Free PMC Article
Eadon MT, Schwantes-An TH, Phillips CL, Roberts AR, Greene CV, Hallab A, Hart KJ, Lipp SN, Perez-Ledezma C, Omar KO, Kelly KJ, Moe SM, Dagher PC, El-Achkar TM, Moorthi RN
Am J Kidney Dis 2020 Sep;76(3):350-360. Epub 2020 Apr 24 doi: 10.1053/j.ajkd.2019.12.014. PMID: 32336487Free PMC Article
Inoue T, Luo Y, Seto T, Suzuki H, Okada H
Ren Fail 2019 Nov;41(1):893-898. doi: 10.1080/0886022X.2019.1665545. PMID: 31557071Free PMC Article
Stout LC, Kumar S, Whorton EB
Hum Pathol 1994 Nov;25(11):1213-27. doi: 10.1016/0046-8177(94)90039-6. PMID: 7959667
Duffy JL, Khurana E, Susin M, Gomez-Leon G, Churg J
Am J Pathol 1983 Dec;113(3):279-90. PMID: 6359891Free PMC Article

Diagnosis

Rosenbloom S, Ramanand A, Stark A, Varghese V, Chalmers D, Au-Yeung N, Kanduri SR, Lukitsch I, Poloni JAT, Keitel E, Franz AP, Martínez-Figueroa C, Sarkar A, Alix-Arbatin MC, Fogo AB, Buchkremer F, Seltzer JR, Velez JCQ
Kidney360 2024 Feb 1;5(2):216-227. Epub 2024 Jan 19 doi: 10.34067/KID.0000000000000346. PMID: 38240639Free PMC Article
Hotta O, Ieiri N, Nagai M, Tanaka A, Harabuchi Y
Int J Mol Sci 2022 Jan 10;23(2) doi: 10.3390/ijms23020727. PMID: 35054911Free PMC Article
Eadon MT, Schwantes-An TH, Phillips CL, Roberts AR, Greene CV, Hallab A, Hart KJ, Lipp SN, Perez-Ledezma C, Omar KO, Kelly KJ, Moe SM, Dagher PC, El-Achkar TM, Moorthi RN
Am J Kidney Dis 2020 Sep;76(3):350-360. Epub 2020 Apr 24 doi: 10.1053/j.ajkd.2019.12.014. PMID: 32336487Free PMC Article
Meyrier A
Nephrol Dial Transplant 1996;11 Suppl 9:45-52. doi: 10.1093/ndt/11.supp9.45. PMID: 9050035
Andrassy K
Nephrologie 1992;13(6):279-81. PMID: 1299788

Therapy

Olakkengil SA, Varatharajah K, Rao MM, Gulyani A, Hamilton M, Russ G, Russell C
Exp Clin Transplant 2015 Oct;13(5):408-12. PMID: 26450464
Rollino C, Ferro M, Beltrame G, Quattrocchio G, Massara C, Quarello F, Roccatello D
Clin Nephrol 2014 Oct;82(4):225-30. doi: 10.5414/CN108258. PMID: 25161113Free PMC Article
Oka K, Imai E, Moriyama T, Akagi Y, Ando A, Hori M, Okuyama A, Toki K, Kyo M, Kokado Y, Takahara S
Nephrol Dial Transplant 2000 May;15(5):689-95. doi: 10.1093/ndt/15.5.689. PMID: 10809812
Remuzzi G, Perico N
Kidney Int Suppl 1995 Dec;52:S70-4. PMID: 8587288
Velosa J, Miller K, Michael AF
Am J Pathol 1976 Jul;84(1):149-62. PMID: 779494Free PMC Article

Prognosis

Rosenbloom S, Ramanand A, Stark A, Varghese V, Chalmers D, Au-Yeung N, Kanduri SR, Lukitsch I, Poloni JAT, Keitel E, Franz AP, Martínez-Figueroa C, Sarkar A, Alix-Arbatin MC, Fogo AB, Buchkremer F, Seltzer JR, Velez JCQ
Kidney360 2024 Feb 1;5(2):216-227. Epub 2024 Jan 19 doi: 10.34067/KID.0000000000000346. PMID: 38240639Free PMC Article
Eadon MT, Schwantes-An TH, Phillips CL, Roberts AR, Greene CV, Hallab A, Hart KJ, Lipp SN, Perez-Ledezma C, Omar KO, Kelly KJ, Moe SM, Dagher PC, El-Achkar TM, Moorthi RN
Am J Kidney Dis 2020 Sep;76(3):350-360. Epub 2020 Apr 24 doi: 10.1053/j.ajkd.2019.12.014. PMID: 32336487Free PMC Article
Inoue T, Luo Y, Seto T, Suzuki H, Okada H
Ren Fail 2019 Nov;41(1):893-898. doi: 10.1080/0886022X.2019.1665545. PMID: 31557071Free PMC Article
Meyrier A, Hill GS, Simon P
Kidney Int 1998 Jul;54(1):2-13. doi: 10.1046/j.1523-1755.1998.00968.x. PMID: 9648058
Nieuwhof CM, de Heer F, de Leeuw P, van Breda Vriesman PJ
Kidney Int 1997 May;51(5):1596-601. doi: 10.1038/ki.1997.219. PMID: 9150478

Clinical prediction guides

Rosenbloom S, Ramanand A, Stark A, Varghese V, Chalmers D, Au-Yeung N, Kanduri SR, Lukitsch I, Poloni JAT, Keitel E, Franz AP, Martínez-Figueroa C, Sarkar A, Alix-Arbatin MC, Fogo AB, Buchkremer F, Seltzer JR, Velez JCQ
Kidney360 2024 Feb 1;5(2):216-227. Epub 2024 Jan 19 doi: 10.34067/KID.0000000000000346. PMID: 38240639Free PMC Article
Eadon MT, Schwantes-An TH, Phillips CL, Roberts AR, Greene CV, Hallab A, Hart KJ, Lipp SN, Perez-Ledezma C, Omar KO, Kelly KJ, Moe SM, Dagher PC, El-Achkar TM, Moorthi RN
Am J Kidney Dis 2020 Sep;76(3):350-360. Epub 2020 Apr 24 doi: 10.1053/j.ajkd.2019.12.014. PMID: 32336487Free PMC Article
Inoue T, Luo Y, Seto T, Suzuki H, Okada H
Ren Fail 2019 Nov;41(1):893-898. doi: 10.1080/0886022X.2019.1665545. PMID: 31557071Free PMC Article
Araújo NC, Rioja Lda S, Rebelo MA
J Bras Nefrol 2010 Mar;32(1):27-32. PMID: 21448516
Kimura N, Yonemoto S, Machiguchi T, Li X, Kimura H, Yoshida H
Hypertens Res 2006 Aug;29(8):573-80. doi: 10.1291/hypres.29.573. PMID: 17137212

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...