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Glomerular hyaline subepithelial deposits

MedGen UID:
1784509
Concept ID:
C5539714
Finding
HPO: HP:0033602

Definition

A type of glomerular subepithelial deposit characterized by a moderately electron-dense, generally homogenous, amorphous-appearing extracellular material located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature is associated with a prominent GBM reflecting an diffuse and relatively uniform increase in thickness (subjective estimate). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular hyaline subepithelial deposits

Recent clinical studies

Etiology

Wągrowska-Danilewicz M, Danilewicz M
Pol J Pathol 2014 Oct;65(3):223-8. doi: 10.5114/pjp.2014.45786. PMID: 25372420
Orfila C, Lepert JC, Modesto A, Pipy B, Suc JM
Nephron 1996;74(1):209-13. doi: 10.1159/000189303. PMID: 8883042

Diagnosis

Terinte-Balcan G, Cinca S, Stancu S, Gherghiceanu M, Stefan G
Ultrastruct Pathol 2023 Nov 2;47(6):478-483. Epub 2023 Nov 30 doi: 10.1080/01913123.2023.2270030. PMID: 37850406
Zhang PL, Yahya TM, Prichard JW, Shaw JH 4th, Hartle JE, Lin F, Schwartzman MS
Ann Clin Lab Sci 2005 Spring;35(2):184-8. PMID: 15943183

Therapy

Kurosu M, Ando Y, Takeda S, Kusano E, Sakurai T, Kuriki K, Asano Y
Am J Kidney Dis 2001 Mar;37(3):E21. doi: 10.1053/ajkd.2001.22098. PMID: 11228198

Prognosis

Orfila C, Lepert JC, Modesto A, Pipy B, Suc JM
Nephron 1996;74(1):209-13. doi: 10.1159/000189303. PMID: 8883042

Clinical prediction guides

Wągrowska-Danilewicz M, Danilewicz M
Pol J Pathol 2014 Oct;65(3):223-8. doi: 10.5114/pjp.2014.45786. PMID: 25372420
Orfila C, Lepert JC, Modesto A, Pipy B, Suc JM
Nephron 1996;74(1):209-13. doi: 10.1159/000189303. PMID: 8883042

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