U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Loss of Chromosome 1q

MedGen UID:
1785201
Concept ID:
C5447616
Cell or Molecular Dysfunction
Synonyms: 1q Deletion; del(1q)

Definition

A cytogenetic abnormality that refers to the loss of all or part of the long arm of chromosome 1 (1q). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 1q

Professional guidelines

PubMed

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Pugh TJ, Fink JM, Lu X, Mathew S, Murata-Collins J, Willem P, Fang M; Cancer Genomics Consortium Plasma Cell Disorders Working Group
Cancer Genet 2018 Dec;228-229:184-196. Epub 2018 Oct 5 doi: 10.1016/j.cancergen.2018.07.002. PMID: 30393007
Laé M, Vincent-Salomon A, Savignoni A, Huon I, Fréneaux P, Sigal-Zafrani B, Aurias A, Sastre-Garau X, Couturier J
Mod Pathol 2007 Apr;20(4):435-44. Epub 2007 Mar 2 doi: 10.1038/modpathol.3800756. PMID: 17334353

Recent clinical studies

Etiology

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Ritzmann TA, Chapman RJ, Kilday JP, Thorp N, Modena P, Dineen RA, Macarthur D, Mallucci C, Jaspan T, Pajtler KW, Giagnacovo M, Jacques TS, Paine SML, Ellison DW, Bouffet E, Grundy RG
Neuro Oncol 2022 Jun 1;24(6):936-948. doi: 10.1093/neuonc/noac012. PMID: 35018471Free PMC Article
DeSisto J, Lucas JT Jr, Xu K, Donson A, Lin T, Sanford B, Wu G, Tran QT, Hedges D, Hsu CY, Armstrong GT, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Schüller U, Venkataraman S, Hoffman LM, Dorris K, Mulcahy Levy JM, Hankinson TC, Handler M, Liu AK, Foreman N, Vibhakar R, Jones K, Allen S, Zhang J, Baker SJ, Merchant TE, Orr BA, Green AL
Nat Commun 2021 Sep 20;12(1):5531. doi: 10.1038/s41467-021-25709-x. PMID: 34545084Free PMC Article
Szymanski JJ, Sundby RT, Jones PA, Srihari D, Earland N, Harris PK, Feng W, Qaium F, Lei H, Roberts D, Landeau M, Bell J, Huang Y, Hoffman L, Spencer M, Spraker MB, Ding L, Widemann BC, Shern JF, Hirbe AC, Chaudhuri AA
PLoS Med 2021 Aug;18(8):e1003734. Epub 2021 Aug 31 doi: 10.1371/journal.pmed.1003734. PMID: 34464388Free PMC Article
Nelson MV, van den Heuvel-Eibrink MM, Graf N, Dome JS
Curr Opin Pediatr 2021 Feb 1;33(1):40-48. Epub 2020 Dec 29 doi: 10.1097/MOP.0000000000000988. PMID: 33394739Free PMC Article

Diagnosis

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Lim KY, Lee K, Shim Y, Park JW, Kim H, Kang J, Won JK, Kim SK, Phi JH, Park CK, Chung CK, Yun H, Park SH
Brain Tumor Pathol 2022 Jan;39(1):1-13. Epub 2021 Nov 23 doi: 10.1007/s10014-021-00417-y. PMID: 34812989Free PMC Article
Szymanski JJ, Sundby RT, Jones PA, Srihari D, Earland N, Harris PK, Feng W, Qaium F, Lei H, Roberts D, Landeau M, Bell J, Huang Y, Hoffman L, Spencer M, Spraker MB, Ding L, Widemann BC, Shern JF, Hirbe AC, Chaudhuri AA
PLoS Med 2021 Aug;18(8):e1003734. Epub 2021 Aug 31 doi: 10.1371/journal.pmed.1003734. PMID: 34464388Free PMC Article
Kobayashi H, Nakai T, Nakanishi Y, Esumi M, Masuda S
Mol Med Rep 2021 Oct;24(4) Epub 2021 Aug 13 doi: 10.3892/mmr.2021.12357. PMID: 34396426Free PMC Article
Nelson MV, van den Heuvel-Eibrink MM, Graf N, Dome JS
Curr Opin Pediatr 2021 Feb 1;33(1):40-48. Epub 2020 Dec 29 doi: 10.1097/MOP.0000000000000988. PMID: 33394739Free PMC Article

Therapy

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Ritzmann TA, Chapman RJ, Kilday JP, Thorp N, Modena P, Dineen RA, Macarthur D, Mallucci C, Jaspan T, Pajtler KW, Giagnacovo M, Jacques TS, Paine SML, Ellison DW, Bouffet E, Grundy RG
Neuro Oncol 2022 Jun 1;24(6):936-948. doi: 10.1093/neuonc/noac012. PMID: 35018471Free PMC Article
Cavalli FMG, Hübner JM, Sharma T, Luu B, Sill M, Zapotocky M, Mack SC, Witt H, Lin T, Shih DJH, Ho B, Santi M, Emery L, Hukin J, Dunham C, McLendon RE, Lipp ES, Gururangan S, Grossbach A, French P, Kros JM, van Veelen MC, Rao AAN, Giannini C, Leary S, Jung S, Faria CC, Mora J, Schüller U, Alonso MM, Chan JA, Klekner A, Chambless LB, Hwang EI, Massimino M, Eberhart CG, Karajannis MA, Lu B, Liau LM, Zollo M, Ferrucci V, Carlotti C, Tirapelli DPC, Tabori U, Bouffet E, Ryzhova M, Ellison DW, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Pfister SM, Taylor MD, Aldape K, Pajtler KW, Kool M, Ramaswamy V
Acta Neuropathol 2018 Aug;136(2):227-237. Epub 2018 Jul 17 doi: 10.1007/s00401-018-1888-x. PMID: 30019219Free PMC Article
Segers H, van den Heuvel-Eibrink MM, Williams RD, van Tinteren H, Vujanic G, Pieters R, Pritchard-Jones K, Bown N; Children's Cancer and Leukaemia Group and the UK Cancer Cytogenetics Group
Genes Chromosomes Cancer 2013 Nov;52(11):1065-74. Epub 2013 Sep 4 doi: 10.1002/gcc.22101. PMID: 24038759
Varela C, Denis JA, Polentes J, Feyeux M, Aubert S, Champon B, Piétu G, Peschanski M, Lefort N
J Clin Invest 2012 Feb;122(2):569-74. Epub 2012 Jan 24 doi: 10.1172/JCI46268. PMID: 22269325Free PMC Article

Prognosis

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Ritzmann TA, Chapman RJ, Kilday JP, Thorp N, Modena P, Dineen RA, Macarthur D, Mallucci C, Jaspan T, Pajtler KW, Giagnacovo M, Jacques TS, Paine SML, Ellison DW, Bouffet E, Grundy RG
Neuro Oncol 2022 Jun 1;24(6):936-948. doi: 10.1093/neuonc/noac012. PMID: 35018471Free PMC Article
Lim KY, Lee K, Shim Y, Park JW, Kim H, Kang J, Won JK, Kim SK, Phi JH, Park CK, Chung CK, Yun H, Park SH
Brain Tumor Pathol 2022 Jan;39(1):1-13. Epub 2021 Nov 23 doi: 10.1007/s10014-021-00417-y. PMID: 34812989Free PMC Article
Nelson MV, van den Heuvel-Eibrink MM, Graf N, Dome JS
Curr Opin Pediatr 2021 Feb 1;33(1):40-48. Epub 2020 Dec 29 doi: 10.1097/MOP.0000000000000988. PMID: 33394739Free PMC Article
Tomlinson GE
Front Biosci (Elite Ed) 2012 Jan 1;4(4):1287-92. doi: 10.2741/459. PMID: 22201954

Clinical prediction guides

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Garrido Ruiz PA, González-Tablas M, Pasco Peña A, Zelaya Huerta MV, Ortiz J, Otero Á, Corchete LA, Ludeña MD, Caballero Martínez MC, Córdoba Iturriagagoitia A, Fernández IC, González-Carreró Fojón J, Hernández Laín A, Orfao A, Tabernero MD
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021116. PMID: 36674634Free PMC Article
Szymanski JJ, Sundby RT, Jones PA, Srihari D, Earland N, Harris PK, Feng W, Qaium F, Lei H, Roberts D, Landeau M, Bell J, Huang Y, Hoffman L, Spencer M, Spraker MB, Ding L, Widemann BC, Shern JF, Hirbe AC, Chaudhuri AA
PLoS Med 2021 Aug;18(8):e1003734. Epub 2021 Aug 31 doi: 10.1371/journal.pmed.1003734. PMID: 34464388Free PMC Article
Tomlinson GE
Front Biosci (Elite Ed) 2012 Jan 1;4(4):1287-92. doi: 10.2741/459. PMID: 22201954
Cryns VL, Yi SM, Tahara H, Gaz RD, Arnold A
Genes Chromosomes Cancer 1995 May;13(1):9-17. doi: 10.1002/gcc.2870130103. PMID: 7541648

Recent systematic reviews

Deng C, Dai R, Li X, Liu F
Cancer Sci 2016 May;107(5):690-9. Epub 2016 Mar 18 doi: 10.1111/cas.12910. PMID: 26892980Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...