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Peripheral lung neovascularity

MedGen UID:
1785553
•Concept ID:
C5539692
•
Finding
HPO: HP:0033571

Definition

The presence of small, tortuous, micronodular, serpiginous intrapulmonary vessels often in the subpleural lung or in proximity to centrilobular arterioles, coursing in directions inconsistent with known arteriolar anatomy. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeripheral lung neovascularity

Professional guidelines

PubMed

Value of ddPCR in the Preoperative Diagnosis of Solitary Pulmonary Nodules Based on the Observation of Virtual Reality Images of Smart Medical Treatment.
Mou X, Sun G, Shi Y, Zhang L, Li R, Yu S, Liu S
J Healthc Eng 2021;2021:9920617. Epub 2021 Aug 12 doi: 10.1155/2021/9920617. PMID: 34422251Free PMC Article
Fibroblast growth factor-mediated angiogenesis for the treatment of ischemia. Lessons learned from experimental models and early human experience.
Gonçalves LM
Rev Port Cardiol 1998 Oct;17 Suppl 2:II11-20. PMID: 9835778

Recent clinical studies

Therapy

Mesenchymal Stem Cell Extracellular Vesicles Reverse Sugen/Hypoxia Pulmonary Hypertension in Rats.
Klinger JR, Pereira M, Del Tatto M, Brodsky AS, Wu KQ, Dooner MS, Borgovan T, Wen S, Goldberg LR, Aliotta JM, Ventetuolo CE, Quesenberry PJ, Liang OD
Am J Respir Cell Mol Biol 2020 May;62(5):577-587. doi: 10.1165/rcmb.2019-0154OC. PMID: 31721618Free PMC Article
Blood-based biomarkers for monitoring antiangiogenic therapy in non-small cell lung cancer.
Rodríguez Garzotto A, Díaz-García CV, Agudo-López A, Prieto García E, Ponce S, López-Martín JA, Paz-Ares L, Iglesias L, Agulló-Ortuño MT
Med Oncol 2016 Oct;33(10):105. Epub 2016 Aug 27 doi: 10.1007/s12032-016-0824-y. PMID: 27568331
Evaluation of Lung Radiofrequency Ablation With Dual-Energy Computed Tomography: Analysis of Tumor Composition and Lung Perfusion.
Tomita K, Hiraki T, Gobara H, Fujiwara H, Iguchi T, Matsui Y, Kanazawa S
J Comput Assist Tomogr 2016 Sep-Oct;40(5):752-6. doi: 10.1097/RCT.0000000000000422. PMID: 27224234
The evaluation of MDCT and quantitative first-pass perfusion in lung cancers.
Yildirim IO, Baysal T, Celik MR
Eur Rev Med Pharmacol Sci 2013 Sep;17(17):2390-5. PMID: 24065234
Peripheral lung cancer: relationship between multi-slice spiral CT perfusion imaging and tumor angiogenesis and cyclin D1 expression.
Ma SH, Xu K, Xiao ZW, Wu M, Sun ZY, Wang ZX, Hu ZG, Dai X, Han MJ, Li YG
Clin Imaging 2007 May-Jun;31(3):165-77. doi: 10.1016/j.clinimag.2007.01.011. PMID: 17449377

Prognosis

Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction.
Marei I, Chidiac O, Thomas B, Pasquier J, Dargham S, Robay A, Vakayil M, Jameesh M, Triggle C, Rafii A, Jayyousi A, Al Suwaidi J, Abi Khalil C
Cardiovasc Diabetol 2022 Feb 2;21(1):17. doi: 10.1186/s12933-022-01449-0. PMID: 35109843Free PMC Article
Incidence of Proliferative Diabetic Retinopathy and Other Neovascular Sequelae at 5 Years Following Diagnosis of Type 2 Diabetes.
Gange WS, Lopez J, Xu BY, Lung K, Seabury SA, Toy BC
Diabetes Care 2021 Nov;44(11):2518-2526. Epub 2021 Sep 2 doi: 10.2337/dc21-0228. PMID: 34475031Free PMC Article
Blood-based biomarkers for monitoring antiangiogenic therapy in non-small cell lung cancer.
Rodríguez Garzotto A, Díaz-García CV, Agudo-López A, Prieto García E, Ponce S, López-Martín JA, Paz-Ares L, Iglesias L, Agulló-Ortuño MT
Med Oncol 2016 Oct;33(10):105. Epub 2016 Aug 27 doi: 10.1007/s12032-016-0824-y. PMID: 27568331
Circulating tumour cells and lung microvascular tumour cell retention in patients with metastatic breast and cervical cancer.
Peeters DJ, Brouwer A, Van den Eynden GG, Rutten A, Onstenk W, Sieuwerts AM, Van Laere SJ, Huget P, Pauwels P, Peeters M, Vermeulen PB, Dirix LY
Cancer Lett 2015 Jan 28;356(2 Pt B):872-9. Epub 2014 Nov 4 doi: 10.1016/j.canlet.2014.10.039. PMID: 25449778
Circulating endothelial cells and endothelial progenitor cells in obstructive sleep apnea.
Martin K, Stanchina M, Kouttab N, Harrington EO, Rounds S
Lung 2008 May-Jun;186(3):145-150. Epub 2008 Apr 10 doi: 10.1007/s00408-008-9073-y. PMID: 18401642Free PMC Article

Clinical prediction guides

Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction.
Marei I, Chidiac O, Thomas B, Pasquier J, Dargham S, Robay A, Vakayil M, Jameesh M, Triggle C, Rafii A, Jayyousi A, Al Suwaidi J, Abi Khalil C
Cardiovasc Diabetol 2022 Feb 2;21(1):17. doi: 10.1186/s12933-022-01449-0. PMID: 35109843Free PMC Article
Dual-Energy CT Perfusion of Invasive Tumor Front in Non-Small Cell Lung Cancers.
Dewaguet J, Copin MC, Duhamel A, Faivre JB, Deken V, Sedlmair M, Flohr T, Schmidt B, Cortot A, Wasielewski E, Remy J, Remy-Jardin M
Radiology 2022 Feb;302(2):448-456. Epub 2021 Nov 16 doi: 10.1148/radiol.2021210600. PMID: 34783594
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.
Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D
N Engl J Med 2020 Jul 9;383(2):120-128. Epub 2020 May 21 doi: 10.1056/NEJMoa2015432. PMID: 32437596Free PMC Article
Circulating Tumor Cells from Different Vascular Sites Exhibit Spatial Heterogeneity in Epithelial and Mesenchymal Composition and Distinct Clinical Significance in Hepatocellular Carcinoma.
Sun YF, Guo W, Xu Y, Shi YH, Gong ZJ, Ji Y, Du M, Zhang X, Hu B, Huang A, Chen GG, Lai PBS, Cao Y, Qiu SJ, Zhou J, Yang XR, Fan J
Clin Cancer Res 2018 Feb 1;24(3):547-559. Epub 2017 Oct 25 doi: 10.1158/1078-0432.CCR-17-1063. PMID: 29070526
Von Willebrand factor and angiogenesis: basic and applied issues.
Randi AM, Laffan MA
J Thromb Haemost 2017 Jan;15(1):13-20. doi: 10.1111/jth.13551. PMID: 27778439

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