U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pleural cobblestoning

MedGen UID:
1785780
•Concept ID:
C5539530
•
Finding
HPO: HP:0033344

Definition

A pleural cobblestone appearance characterized by irregular bumps surrounded by depressed lines in open lung biopsy. Caused by underlying scarring causing retraction of the interlobular septa where they insert on the pleura. [from HPO]

Recent clinical studies

Etiology

Oxidized regenerated cellulose induces pleural thickening in patients with pneumothorax: possible involvement of the mesothelial-mesenchymal transition.
Ebana H, Hayashi T, Mitani K, Kobayashi E, Kumasaka T, Mizobuchi T, Kurihara M, Takahashi F, Takahashi K, Seyama K
Surg Today 2018 Apr;48(4):462-472. Epub 2017 Oct 12 doi: 10.1007/s00595-017-1597-4. PMID: 29027010

Diagnosis

The Cobblestone Heart.
Tan WJ, Suz CS, Azza O, Zuki M
Med J Malaysia 2021 Mar;76(2):241-244. PMID: 33742636
Establishment and preliminary characterization of human malignant mesothelioma cell lines.
de Cupis A, Pirani P, Favoni RE
Monaldi Arch Chest Dis 1998 Apr;53(2):188-92. PMID: 9689807
Establishment and characterization of five human malignant mesothelioma cell lines derived from pleural effusions.
Manning LS, Whitaker D, Murch AR, Garlepp MJ, Davis MR, Musk AW, Robinson BW
Int J Cancer 1991 Jan 21;47(2):285-90. doi: 10.1002/ijc.2910470219. PMID: 1703129

Therapy

Establishment and preliminary characterization of human malignant mesothelioma cell lines.
de Cupis A, Pirani P, Favoni RE
Monaldi Arch Chest Dis 1998 Apr;53(2):188-92. PMID: 9689807
Establishment and characterization of five human malignant mesothelioma cell lines derived from pleural effusions.
Manning LS, Whitaker D, Murch AR, Garlepp MJ, Davis MR, Musk AW, Robinson BW
Int J Cancer 1991 Jan 21;47(2):285-90. doi: 10.1002/ijc.2910470219. PMID: 1703129

Clinical prediction guides

Establishment and characterization of five human malignant mesothelioma cell lines derived from pleural effusions.
Manning LS, Whitaker D, Murch AR, Garlepp MJ, Davis MR, Musk AW, Robinson BW
Int J Cancer 1991 Jan 21;47(2):285-90. doi: 10.1002/ijc.2910470219. PMID: 1703129

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...