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Subepithelial glomerular basement membrane electron dense deposits

MedGen UID:
1786324
•Concept ID:
C5539649
•
Finding
HPO: HP:0033501

Definition

Prominent glomerular basement membrane (GBM) reflecting a diffuse and relatively uniform increase in thickness (subjective estimate) with exogenous material deposited between the outer (epithelial) aspect of the GBM and the visceral epithelial cell, with varying degrees of incorporation into the GBM. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubepithelial glomerular basement membrane electron dense deposits

Recent clinical studies

Etiology

Clinicopathological significance of glomerular capillary IgA deposition in childhood IgA nephropathy.
Shima Y, Nakanishi K, Mukaiyama H, Tanaka Y, Wada T, Tanaka R, Kaito H, Nozu K, Sako M, Iijima K, Yoshikawa N
Pediatr Nephrol 2021 Apr;36(4):899-908. Epub 2020 Oct 4 doi: 10.1007/s00467-020-04772-4. PMID: 33011820
Antineutrophil cytoplasmic antibody-associated glomerulonephritis with immunoglobulin deposition.
Hirose O, Itabashi M, Takei T, Honda K, Nitta K
Clin Exp Nephrol 2017 Aug;21(4):643-650. Epub 2016 Nov 9 doi: 10.1007/s10157-016-1341-1. PMID: 27830351
Clinicopathological analysis of allogeneic hematopoietic stem cell transplantation-related membranous glomerulonephritis.
Hiramatsu R, Ubara Y, Sawa N, Hasegawa E, Kawada M, Imafuku A, Sumida K, Mise K, Yamanouchi M, Ueno T, Sekine A, Hayami N, Suwabe T, Hoshino J, Takaichi K, Ohashi K, Fujii T, Wake A, Taniguchi S
Hum Pathol 2016 Apr;50:187-94. Epub 2015 Dec 29 doi: 10.1016/j.humpath.2015.12.005. PMID: 26997455
Fibronectin non-amyloid glomerulopathy.
Yong JL, Killingsworth MC, Spicer ST, Wu XJ
Int J Clin Exp Pathol 2009 Nov 20;3(2):210-6. PMID: 20126589Free PMC Article
Type 3 membranoproliferative glomerulonephritis: clinicopathologic correlations and long-term follow-up in nine patients.
Abreo K, Moorthy AV
Arch Pathol Lab Med 1982 Aug;106(8):413-7. PMID: 6896632

Diagnosis

German Shorthaired Pointer dogs with exfoliative cutaneous lupus erythematosus develop immune-complex membranous glomerulonephropathy.
Amerman HK, Cianciolo RE, Casal ML, Mauldin E
Vet Pathol 2023 Nov;60(6):843-848. Epub 2023 May 24 doi: 10.1177/03009858231173362. PMID: 37222157Free PMC Article
Direct observation of epoxy resin blocks for renal biopsy by low-vacuum scanning electron microscopy.
Tojo A, Abe M, Matsuyama KI
Med Mol Morphol 2023 Sep;56(3):206-216. Epub 2023 May 10 doi: 10.1007/s00795-023-00356-x. PMID: 37165248Free PMC Article
Coexistence of Anti-Glomerular Basement Membrane Glomerulonephritis and Membranous Nephropathy in a Female Patient with Preserved Renal Function.
Ogawara A, Harada M, Ichikawa T, Fujii K, Ehara T, Kobayashi M
Tohoku J Exp Med 2017 Dec;243(4):335-341. doi: 10.1620/tjem.243.335. PMID: 29269610
Antineutrophil cytoplasmic antibody-associated glomerulonephritis with immunoglobulin deposition.
Hirose O, Itabashi M, Takei T, Honda K, Nitta K
Clin Exp Nephrol 2017 Aug;21(4):643-650. Epub 2016 Nov 9 doi: 10.1007/s10157-016-1341-1. PMID: 27830351
Clinicopathological analysis of allogeneic hematopoietic stem cell transplantation-related membranous glomerulonephritis.
Hiramatsu R, Ubara Y, Sawa N, Hasegawa E, Kawada M, Imafuku A, Sumida K, Mise K, Yamanouchi M, Ueno T, Sekine A, Hayami N, Suwabe T, Hoshino J, Takaichi K, Ohashi K, Fujii T, Wake A, Taniguchi S
Hum Pathol 2016 Apr;50:187-94. Epub 2015 Dec 29 doi: 10.1016/j.humpath.2015.12.005. PMID: 26997455

Therapy

Cyclosporine therapy could be considered for membranoproliferative glomerulonephritis with immunoglobulin A deposits: a case report.
Hidaka Y, Tamura H, Furuie K, Kuraoka S, Nagata H, Nakazato H
BMC Nephrol 2022 Nov 7;23(1):358. doi: 10.1186/s12882-022-02983-5. PMID: 36344919Free PMC Article
Antineutrophil cytoplasmic antibody-associated glomerulonephritis with immunoglobulin deposition.
Hirose O, Itabashi M, Takei T, Honda K, Nitta K
Clin Exp Nephrol 2017 Aug;21(4):643-650. Epub 2016 Nov 9 doi: 10.1007/s10157-016-1341-1. PMID: 27830351
Clinicopathological analysis of allogeneic hematopoietic stem cell transplantation-related membranous glomerulonephritis.
Hiramatsu R, Ubara Y, Sawa N, Hasegawa E, Kawada M, Imafuku A, Sumida K, Mise K, Yamanouchi M, Ueno T, Sekine A, Hayami N, Suwabe T, Hoshino J, Takaichi K, Ohashi K, Fujii T, Wake A, Taniguchi S
Hum Pathol 2016 Apr;50:187-94. Epub 2015 Dec 29 doi: 10.1016/j.humpath.2015.12.005. PMID: 26997455
Neonatal Fc receptor promotes immune complex-mediated glomerular disease.
Olaru F, Luo W, Suleiman H, St John PL, Ge L, Mezo AR, Shaw AS, Abrahamson DR, Miner JH, Borza DB
J Am Soc Nephrol 2014 May;25(5):918-25. Epub 2013 Dec 19 doi: 10.1681/ASN.2013050498. PMID: 24357670Free PMC Article
Renal biopsy pathology in Wegener's granulomatosis.
Horn RG, Fauci AS, Rosenthal AS, Wolff SM
Am J Pathol 1974 Mar;74(3):423-40. PMID: 4592552Free PMC Article

Prognosis

Clinicopathological significance of glomerular capillary IgA deposition in childhood IgA nephropathy.
Shima Y, Nakanishi K, Mukaiyama H, Tanaka Y, Wada T, Tanaka R, Kaito H, Nozu K, Sako M, Iijima K, Yoshikawa N
Pediatr Nephrol 2021 Apr;36(4):899-908. Epub 2020 Oct 4 doi: 10.1007/s00467-020-04772-4. PMID: 33011820
Coexistence of Anti-Glomerular Basement Membrane Glomerulonephritis and Membranous Nephropathy in a Female Patient with Preserved Renal Function.
Ogawara A, Harada M, Ichikawa T, Fujii K, Ehara T, Kobayashi M
Tohoku J Exp Med 2017 Dec;243(4):335-341. doi: 10.1620/tjem.243.335. PMID: 29269610
Fibronectin non-amyloid glomerulopathy.
Yong JL, Killingsworth MC, Spicer ST, Wu XJ
Int J Clin Exp Pathol 2009 Nov 20;3(2):210-6. PMID: 20126589Free PMC Article
Lysis of the glomerular basement membrane in children with IgA nephropathy and Henoch-Shönlein nephritis.
Yoshikawa N, Yoshiara S, Yoshiya K, Matsuo T, Okada S
J Pathol 1986 Oct;150(2):119-26. doi: 10.1002/path.1711500206. PMID: 3794864
Type 3 membranoproliferative glomerulonephritis: clinicopathologic correlations and long-term follow-up in nine patients.
Abreo K, Moorthy AV
Arch Pathol Lab Med 1982 Aug;106(8):413-7. PMID: 6896632

Clinical prediction guides

Direct observation of epoxy resin blocks for renal biopsy by low-vacuum scanning electron microscopy.
Tojo A, Abe M, Matsuyama KI
Med Mol Morphol 2023 Sep;56(3):206-216. Epub 2023 May 10 doi: 10.1007/s00795-023-00356-x. PMID: 37165248Free PMC Article
Clinicopathological significance of glomerular capillary IgA deposition in childhood IgA nephropathy.
Shima Y, Nakanishi K, Mukaiyama H, Tanaka Y, Wada T, Tanaka R, Kaito H, Nozu K, Sako M, Iijima K, Yoshikawa N
Pediatr Nephrol 2021 Apr;36(4):899-908. Epub 2020 Oct 4 doi: 10.1007/s00467-020-04772-4. PMID: 33011820
Antineutrophil cytoplasmic antibody-associated glomerulonephritis with immunoglobulin deposition.
Hirose O, Itabashi M, Takei T, Honda K, Nitta K
Clin Exp Nephrol 2017 Aug;21(4):643-650. Epub 2016 Nov 9 doi: 10.1007/s10157-016-1341-1. PMID: 27830351
Lysis of the glomerular basement membrane in children with IgA nephropathy and Henoch-Shönlein nephritis.
Yoshikawa N, Yoshiara S, Yoshiya K, Matsuo T, Okada S
J Pathol 1986 Oct;150(2):119-26. doi: 10.1002/path.1711500206. PMID: 3794864
Renal biopsy pathology in Wegener's granulomatosis.
Horn RG, Fauci AS, Rosenthal AS, Wolff SM
Am J Pathol 1974 Mar;74(3):423-40. PMID: 4592552Free PMC Article

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