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Glomerular amyloid subepithelial deposits

MedGen UID:
1786705
•Concept ID:
C5539711
•
Finding
HPO: HP:0033599

Definition

A type of fibrillar glomerular subepithelial deposit characterized by extracellular aggregates composed of fine, randomly oriented, non-branching fibrils 8-12 nm in diameter, often forming a cottony mass. This feature is associated with a prominent glomerular basement membrane (GBM) reflecting an diffuse and relatively uniform increase in thickness (subjective estimate). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular amyloid subepithelial deposits

Recent clinical studies

Etiology

Fibronectin non-amyloid glomerulopathy.
Yong JL, Killingsworth MC, Spicer ST, Wu XJ
Int J Clin Exp Pathol 2009 Nov 20;3(2):210-6. PMID: 20126589Free PMC Article
Resolution of renal amyloidosis secondary to rheumatoid arthritis.
Falck HM, Törnroth T, Skrifvars B, Wegelius O
Acta Med Scand 1979;205(7):651-6. doi: 10.1111/j.0954-6820.1979.tb06121.x. PMID: 474195

Diagnosis

Direct observation of epoxy resin blocks for renal biopsy by low-vacuum scanning electron microscopy.
Tojo A, Abe M, Matsuyama KI
Med Mol Morphol 2023 Sep;56(3):206-216. Epub 2023 May 10 doi: 10.1007/s00795-023-00356-x. PMID: 37165248Free PMC Article
Serum amyloid P deposition is a sensitive and specific feature of membranous-like glomerulopathy with masked IgG kappa deposits.
Larsen CP, Sharma SG, Caza TN, Kenan DJ, Storey AJ, Edmondson RD, Herzog C, Arthur JM
Kidney Int 2020 Mar;97(3):602-608. Epub 2019 Nov 9 doi: 10.1016/j.kint.2019.10.026. PMID: 32001064Free PMC Article
A large-sized bubbling appearance of the glomerular basement membrane in a patient with pulmonary limited AL amyloidosis and a past history of lupus nephritis.
Suga N, Miura N, Uemura Y, Nakamura T, Morita H, Banno S, Imai H
Clin Exp Nephrol 2011 Dec;15(6):970-5. Epub 2011 Aug 30 doi: 10.1007/s10157-011-0528-8. PMID: 21874627
Combined treatment with cyclophosphamide and prednisolone can induce remission of nephrotic syndrome in a patient with renal amyloidosis, associated with rheumatoid arthritis.
Maezawa A, Hiromura K, Mitsuhashi H, Tsukada Y, Kanai H, Yano S, Naruse T
Clin Nephrol 1994 Jul;42(1):30-2. PMID: 7923963

Therapy

ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage.
Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch R, Lichtenthaler SF, Saftig P, Meyer-Schwesinger C
J Am Soc Nephrol 2021 Jun 1;32(6):1389-1408. Epub 2021 Mar 30 doi: 10.1681/ASN.2020081213. PMID: 33785583Free PMC Article
Combined treatment with cyclophosphamide and prednisolone can induce remission of nephrotic syndrome in a patient with renal amyloidosis, associated with rheumatoid arthritis.
Maezawa A, Hiromura K, Mitsuhashi H, Tsukada Y, Kanai H, Yano S, Naruse T
Clin Nephrol 1994 Jul;42(1):30-2. PMID: 7923963
Resolution of renal amyloidosis secondary to rheumatoid arthritis.
Falck HM, Törnroth T, Skrifvars B, Wegelius O
Acta Med Scand 1979;205(7):651-6. doi: 10.1111/j.0954-6820.1979.tb06121.x. PMID: 474195

Prognosis

ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage.
Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch R, Lichtenthaler SF, Saftig P, Meyer-Schwesinger C
J Am Soc Nephrol 2021 Jun 1;32(6):1389-1408. Epub 2021 Mar 30 doi: 10.1681/ASN.2020081213. PMID: 33785583Free PMC Article
Fibronectin non-amyloid glomerulopathy.
Yong JL, Killingsworth MC, Spicer ST, Wu XJ
Int J Clin Exp Pathol 2009 Nov 20;3(2):210-6. PMID: 20126589Free PMC Article
Renal amyloidosis. Correlations between morphology, chemical types of amyloid protein and clinical features.
Shiiki H, Shimokama T, Yoshikawa Y, Toyoshima H, Kitamoto T, Watanabe T
Virchows Arch A Pathol Anat Histopathol 1988;412(3):197-204. doi: 10.1007/BF00737143. PMID: 3124341
Resolution of renal amyloidosis secondary to rheumatoid arthritis.
Falck HM, Törnroth T, Skrifvars B, Wegelius O
Acta Med Scand 1979;205(7):651-6. doi: 10.1111/j.0954-6820.1979.tb06121.x. PMID: 474195

Clinical prediction guides

Direct observation of epoxy resin blocks for renal biopsy by low-vacuum scanning electron microscopy.
Tojo A, Abe M, Matsuyama KI
Med Mol Morphol 2023 Sep;56(3):206-216. Epub 2023 May 10 doi: 10.1007/s00795-023-00356-x. PMID: 37165248Free PMC Article
A large-sized bubbling appearance of the glomerular basement membrane in a patient with pulmonary limited AL amyloidosis and a past history of lupus nephritis.
Suga N, Miura N, Uemura Y, Nakamura T, Morita H, Banno S, Imai H
Clin Exp Nephrol 2011 Dec;15(6):970-5. Epub 2011 Aug 30 doi: 10.1007/s10157-011-0528-8. PMID: 21874627
Immunotactoid glomerulopathy and cutaneous vasculitis.
Orfila C, Meeus F, Bernadet P, Lepert JC, Suc JM
Am J Nephrol 1991;11(1):67-72. doi: 10.1159/000168276. PMID: 1904680
Renal immunopathology in renal cell carcinoma.
Beaufils H, Patte R, Aubert P, Camey M, Kuss R, Barbagelatta M, Chomette G
Virchows Arch A Pathol Anat Histopathol 1984;404(1):87-97. doi: 10.1007/BF00704253. PMID: 6236602
Diabetic glomerulonephropathy: histopathologic, immunofluorescent, and ultrastructural studies of 16 cases.
Ainsworth SK, Hirsch HZ, Brackett NC Jr, Brissie RM, Williams AV Jr, Hennigar GR
Hum Pathol 1982 May;13(5):470-8. doi: 10.1016/s0046-8177(82)80030-0. PMID: 7042531

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