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Increased circulating apolipoprotein circulation

MedGen UID:
1786792
•Concept ID:
C5539612
•
Finding
HPO: HP:0033460

Definition

Elevated concentration in the blood circulation of a lipid-transport protein (apoliprotein). [from HPO]

Professional guidelines

PubMed

Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association.
Skulas-Ray AC, Wilson PWF, Harris WS, Brinton EA, Kris-Etherton PM, Richter CK, Jacobson TA, Engler MB, Miller M, Robinson JG, Blum CB, Rodriguez-Leyva D, de Ferranti SD, Welty FK; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology
Circulation 2019 Sep 17;140(12):e673-e691. Epub 2019 Aug 19 doi: 10.1161/CIR.0000000000000709. PMID: 31422671
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Lipoprotein apheresis for the treatment of elevated circulating levels of lipoprotein(a): a critical literature review.
Franchini M, Capuzzo E, Liumbruno GM
Blood Transfus 2016 Sep;14(5):413-8. Epub 2015 Dec 22 doi: 10.2450/2015.0163-15. PMID: 26710351Free PMC Article

Recent clinical studies

Etiology

The current state of apolipoprotein E in dyslipidemia.
Rasmussen KL, Frikke-Schmidt R
Curr Opin Lipidol 2024 Apr 1;35(2):78-84. Epub 2023 Dec 6 doi: 10.1097/MOL.0000000000000915. PMID: 38054895
ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE-/- mice.
Yu H, Jiao X, Yang Y, Lv Q, Du Z, Li L, Hu C, Du Y, Zhang J, Li F, Sun Q, Wang Y, Chen D, Zhang X, Qin Y
Clin Sci (Lond) 2023 Jun 28;137(12):979-993. doi: 10.1042/CS20230031. PMID: 37294581Free PMC Article
Managing of Dyslipidaemia Characterized by Accumulation of Triglyceride-Rich Lipoproteins.
Visser J, van Zwol W, Kuivenhoven JA
Curr Atheroscler Rep 2022 Jan;24(1):1-12. Epub 2022 Feb 2 doi: 10.1007/s11883-022-00979-y. PMID: 35107764Free PMC Article
APOL1 Renal Risk Variants: Fertile Soil for HIV-Associated Nephropathy.
Kopp JB, Heymann J, Winkler CA
Semin Nephrol 2017 Nov;37(6):514-519. doi: 10.1016/j.semnephrol.2017.07.004. PMID: 29110758Free PMC Article
Lipoprotein metabolism: an overview.
Shepherd J
Ann Acad Med Singap 1992 Jan;21(1):106-13. PMID: 1590643

Diagnosis

S-nitrosylation of AMPKγ impairs coronary collateral circulation and disrupts VSMC reprogramming.
Bai W, Guo T, Wang H, Li B, Sun Q, Wu W, Zhang J, Zhou J, Luo J, Zhu M, Lu J, Li P, Dong B, Han S, Pang X, Zhang G, Bai Y, Wang S
EMBO Rep 2024 Jan;25(1):128-143. Epub 2023 Dec 18 doi: 10.1038/s44319-023-00015-3. PMID: 38177907Free PMC Article
ApoA-I and Diabetes.
King TW, Cochran BJ, Rye KA
Arterioscler Thromb Vasc Biol 2023 Aug;43(8):1362-1368. Epub 2023 Jun 29 doi: 10.1161/ATVBAHA.123.318267. PMID: 37381981
Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women.
Ko SH, Kim HS
Nutrients 2020 Jan 13;12(1) doi: 10.3390/nu12010202. PMID: 31941004Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

Therapy

Molecular Therapies in Cardiovascular Diseases: Small Interfering RNA in Atherosclerosis, Heart Failure, and Hypertension.
Sarzani R, Spannella F, Di Pentima C, Giulietti F, Landolfo M, Allevi M
Int J Mol Sci 2023 Dec 26;25(1) doi: 10.3390/ijms25010328. PMID: 38203499Free PMC Article
How to Handle Elevated Triglycerides: Life after PROMINENT.
Pirillo A, Catapano AL
Curr Atheroscler Rep 2023 Dec;25(12):921-929. Epub 2023 Dec 20 doi: 10.1007/s11883-023-01175-2. PMID: 38114852
ApoA-I and Diabetes.
King TW, Cochran BJ, Rye KA
Arterioscler Thromb Vasc Biol 2023 Aug;43(8):1362-1368. Epub 2023 Jun 29 doi: 10.1161/ATVBAHA.123.318267. PMID: 37381981
Clinical Pharmacokinetics and Pharmacodynamics of CSL112.
Ortega-Paz L, Giordano S, Capodanno D, Mehran R, Gibson CM, Angiolillo DJ
Clin Pharmacokinet 2023 Apr;62(4):541-558. Epub 2023 Mar 16 doi: 10.1007/s40262-023-01224-8. PMID: 36928983Free PMC Article
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

Prognosis

Obesity and risk of gestational diabetes mellitus: A two-sample Mendelian randomization study.
Song X, Wang C, Wang T, Zhang S, Qin J
Diabetes Res Clin Pract 2023 Mar;197:110561. Epub 2023 Feb 3 doi: 10.1016/j.diabres.2023.110561. PMID: 36738839
HDL in the 21st Century: A Multifunctional Roadmap for Future HDL Research.
Rohatgi A, Westerterp M, von Eckardstein A, Remaley A, Rye KA
Circulation 2021 Jun 8;143(23):2293-2309. Epub 2021 Jun 7 doi: 10.1161/CIRCULATIONAHA.120.044221. PMID: 34097448Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Osteopontin - a multi-modal marker and mediator in atherosclerotic vascular disease.
Wolak T
Atherosclerosis 2014 Oct;236(2):327-37. Epub 2014 Jul 29 doi: 10.1016/j.atherosclerosis.2014.07.004. PMID: 25128758

Clinical prediction guides

The current state of apolipoprotein E in dyslipidemia.
Rasmussen KL, Frikke-Schmidt R
Curr Opin Lipidol 2024 Apr 1;35(2):78-84. Epub 2023 Dec 6 doi: 10.1097/MOL.0000000000000915. PMID: 38054895
HDL in the 21st Century: A Multifunctional Roadmap for Future HDL Research.
Rohatgi A, Westerterp M, von Eckardstein A, Remaley A, Rye KA
Circulation 2021 Jun 8;143(23):2293-2309. Epub 2021 Jun 7 doi: 10.1161/CIRCULATIONAHA.120.044221. PMID: 34097448Free PMC Article
Remnant lipoproteins: are they equal to or more atherogenic than LDL?
Salinas CAA, Chapman MJ
Curr Opin Lipidol 2020 Jun;31(3):132-139. doi: 10.1097/MOL.0000000000000682. PMID: 32332433
High-density lipoprotein subfractions--what the clinicians need to know.
Pirillo A, Norata GD, Catapano AL
Cardiology 2013;124(2):116-25. Epub 2013 Feb 20 doi: 10.1159/000346463. PMID: 23428644
Apolipoprotein D--an atypical apolipoprotein.
Weech PK, Provost P, Tremblay NM, Camato RN, Milne RW, Marcel YL, Rassart E
Prog Lipid Res 1991;30(2-3):259-66. doi: 10.1016/0163-7827(91)90023-x. PMID: 1823944

Recent systematic reviews

Effect of proanthocyanidins on blood lipids: A systematic review and meta-analysis.
Wang P, Liu XL, Jiang ZZ, Long Y, Gao CL, Huang W, Tan XZ, Ma XM, Xu Y
Phytother Res 2024 May;38(5):2154-2164. Epub 2024 Feb 23 doi: 10.1002/ptr.8162. PMID: 38391003
Medium-chain fatty acids for the prevention or treatment of Alzheimer's disease: a systematic review and meta-analysis.
Castro CB, Dias CB, Hillebrandt H, Sohrabi HR, Chatterjee P, Shah TM, Fuller SJ, Garg ML, Martins RN
Nutr Rev 2023 Aug 10;81(9):1144-1162. doi: 10.1093/nutrit/nuac104. PMID: 36633304
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals.
Khan TA, Shah T, Prieto D, Zhang W, Price J, Fowkes GR, Cooper J, Talmud PJ, Humphries SE, Sundstrom J, Hubacek JA, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Abdollahi MR, Slooter AJ, Szolnoki Z, Sandhu M, Wareham N, Frikke-Schmidt R, Tybjærg-Hansen A, Fillenbaum G, Heijmans BT, Katsuya T, Gromadzka G, Singleton A, Ferrucci L, Hardy J, Worrall B, Rich SS, Matarin M, Whittaker J, Gaunt TR, Whincup P, Morris R, Deanfield J, Donald A, Davey Smith G, Kivimaki M, Kumari M, Smeeth L, Khaw KT, Nalls M, Meschia J, Sun K, Hui R, Day I, Hingorani AD, Casas JP
Int J Epidemiol 2013 Apr;42(2):475-92. doi: 10.1093/ije/dyt034. PMID: 23569189Free PMC Article
Neuroimaging and APOE genotype: a systematic qualitative review.
Cherbuin N, Leach LS, Christensen H, Anstey KJ
Dement Geriatr Cogn Disord 2007;24(5):348-62. Epub 2007 Oct 2 doi: 10.1159/000109150. PMID: 17911980

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