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Increased circulating apolipoprotein circulation

MedGen UID:
1786792
•Concept ID:
C5539612
•
Finding
HPO: HP:0033460

Definition

Elevated concentration in the blood circulation of a lipid-transport protein (apoliprotein). [from HPO]

Professional guidelines

PubMed

Medium-chain fatty acids for the prevention or treatment of Alzheimer's disease: a systematic review and meta-analysis.
Castro CB, Dias CB, Hillebrandt H, Sohrabi HR, Chatterjee P, Shah TM, Fuller SJ, Garg ML, Martins RN
Nutr Rev 2023 Aug 10;81(9):1144-1162. doi: 10.1093/nutrit/nuac104. PMID: 36633304
Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association.
Skulas-Ray AC, Wilson PWF, Harris WS, Brinton EA, Kris-Etherton PM, Richter CK, Jacobson TA, Engler MB, Miller M, Robinson JG, Blum CB, Rodriguez-Leyva D, de Ferranti SD, Welty FK; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology
Circulation 2019 Sep 17;140(12):e673-e691. Epub 2019 Aug 19 doi: 10.1161/CIR.0000000000000709. PMID: 31422671
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

Recent clinical studies

Etiology

Destabilization of Atherosclerotic Plaque by Bilirubin Deficiency.
Chen W, Tumanov S, Stanley CP, Kong SMY, Nadel J, Vigder N, Newington DL, Wang XS, Dunn LL, Stocker R
Circ Res 2023 Mar 31;132(7):812-827. Epub 2023 Mar 6 doi: 10.1161/CIRCRESAHA.122.322418. PMID: 36876485
The effects of exercise training on lipid metabolism and coronary heart disease.
Muscella A, Stefàno E, Marsigliante S
Am J Physiol Heart Circ Physiol 2020 Jul 1;319(1):H76-H88. Epub 2020 May 22 doi: 10.1152/ajpheart.00708.2019. PMID: 32442027
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
Antisense Oligonucleotides Targeting Lipoprotein(a).
Langsted A, Nordestgaard BG
Curr Atheroscler Rep 2019 May 20;21(8):30. doi: 10.1007/s11883-019-0792-8. PMID: 31111240
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.
Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV
Nature 2012 May 16;485(7399):512-6. doi: 10.1038/nature11087. PMID: 22622580Free PMC Article

Diagnosis

ApoA-I and Diabetes.
King TW, Cochran BJ, Rye KA
Arterioscler Thromb Vasc Biol 2023 Aug;43(8):1362-1368. Epub 2023 Jun 29 doi: 10.1161/ATVBAHA.123.318267. PMID: 37381981
Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women.
Ko SH, Kim HS
Nutrients 2020 Jan 13;12(1) doi: 10.3390/nu12010202. PMID: 31941004Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Circulating biomarkers.
Badimon L, Romero JC, Cubedo J, Borrell-Pagès M
Thromb Res 2012 Oct;130 Suppl 1:S12-5. doi: 10.1016/j.thromres.2012.08.262. PMID: 23026650

Therapy

Obesity and risk of gestational diabetes mellitus: A two-sample Mendelian randomization study.
Song X, Wang C, Wang T, Zhang S, Qin J
Diabetes Res Clin Pract 2023 Mar;197:110561. Epub 2023 Feb 3 doi: 10.1016/j.diabres.2023.110561. PMID: 36738839
HDL in the 21st Century: A Multifunctional Roadmap for Future HDL Research.
Rohatgi A, Westerterp M, von Eckardstein A, Remaley A, Rye KA
Circulation 2021 Jun 8;143(23):2293-2309. Epub 2021 Jun 7 doi: 10.1161/CIRCULATIONAHA.120.044221. PMID: 34097448Free PMC Article
The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study.
Johnson KE, Siewert KM, Klarin D, Damrauer SM; VA Million Veteran Program, Chang KM, Tsao PS, Assimes TL, Maxwell KN, Voight BF
PLoS Med 2020 Sep;17(9):e1003302. Epub 2020 Sep 11 doi: 10.1371/journal.pmed.1003302. PMID: 32915777Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

Prognosis

Obesity and risk of gestational diabetes mellitus: A two-sample Mendelian randomization study.
Song X, Wang C, Wang T, Zhang S, Qin J
Diabetes Res Clin Pract 2023 Mar;197:110561. Epub 2023 Feb 3 doi: 10.1016/j.diabres.2023.110561. PMID: 36738839
Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH.
Larsson SC, Michaëlsson K, Mola-Caminal M, Höijer J, Mantzoros CS
Metabolism 2022 Dec;137:155329. Epub 2022 Oct 5 doi: 10.1016/j.metabol.2022.155329. PMID: 36208799
HDL in the 21st Century: A Multifunctional Roadmap for Future HDL Research.
Rohatgi A, Westerterp M, von Eckardstein A, Remaley A, Rye KA
Circulation 2021 Jun 8;143(23):2293-2309. Epub 2021 Jun 7 doi: 10.1161/CIRCULATIONAHA.120.044221. PMID: 34097448Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

Clinical prediction guides

Obesity and risk of gestational diabetes mellitus: A two-sample Mendelian randomization study.
Song X, Wang C, Wang T, Zhang S, Qin J
Diabetes Res Clin Pract 2023 Mar;197:110561. Epub 2023 Feb 3 doi: 10.1016/j.diabres.2023.110561. PMID: 36738839
Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH.
Larsson SC, Michaëlsson K, Mola-Caminal M, Höijer J, Mantzoros CS
Metabolism 2022 Dec;137:155329. Epub 2022 Oct 5 doi: 10.1016/j.metabol.2022.155329. PMID: 36208799
HDL in the 21st Century: A Multifunctional Roadmap for Future HDL Research.
Rohatgi A, Westerterp M, von Eckardstein A, Remaley A, Rye KA
Circulation 2021 Jun 8;143(23):2293-2309. Epub 2021 Jun 7 doi: 10.1161/CIRCULATIONAHA.120.044221. PMID: 34097448Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
Circulating biomarkers.
Badimon L, Romero JC, Cubedo J, Borrell-Pagès M
Thromb Res 2012 Oct;130 Suppl 1:S12-5. doi: 10.1016/j.thromres.2012.08.262. PMID: 23026650

Recent systematic reviews

Medium-chain fatty acids for the prevention or treatment of Alzheimer's disease: a systematic review and meta-analysis.
Castro CB, Dias CB, Hillebrandt H, Sohrabi HR, Chatterjee P, Shah TM, Fuller SJ, Garg ML, Martins RN
Nutr Rev 2023 Aug 10;81(9):1144-1162. doi: 10.1093/nutrit/nuac104. PMID: 36633304
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Differential effects of medium- and long-chain saturated fatty acids on blood lipid profile: a systematic review and meta-analysis.
Panth N, Abbott KA, Dias CB, Wynne K, Garg ML
Am J Clin Nutr 2018 Oct 1;108(4):675-687. doi: 10.1093/ajcn/nqy167. PMID: 30239550
Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals.
Khan TA, Shah T, Prieto D, Zhang W, Price J, Fowkes GR, Cooper J, Talmud PJ, Humphries SE, Sundstrom J, Hubacek JA, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Abdollahi MR, Slooter AJ, Szolnoki Z, Sandhu M, Wareham N, Frikke-Schmidt R, Tybjærg-Hansen A, Fillenbaum G, Heijmans BT, Katsuya T, Gromadzka G, Singleton A, Ferrucci L, Hardy J, Worrall B, Rich SS, Matarin M, Whittaker J, Gaunt TR, Whincup P, Morris R, Deanfield J, Donald A, Davey Smith G, Kivimaki M, Kumari M, Smeeth L, Khaw KT, Nalls M, Meschia J, Sun K, Hui R, Day I, Hingorani AD, Casas JP
Int J Epidemiol 2013 Apr;42(2):475-92. doi: 10.1093/ije/dyt034. PMID: 23569189Free PMC Article
Neuroimaging and APOE genotype: a systematic qualitative review.
Cherbuin N, Leach LS, Christensen H, Anstey KJ
Dement Geriatr Cogn Disord 2007;24(5):348-62. Epub 2007 Oct 2 doi: 10.1159/000109150. PMID: 17911980

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