U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal circulating apolipoprotein concentration

MedGen UID:
1369272
•Concept ID:
C4476649
•
Finding
Synonym: Abnormal apolipoprotein level
 
HPO: HP:0025201

Definition

A deviation from the normal concentration in blood of an apolipoprotein, i.e., of a protein that binds lipids to form lipoprotein and is thereby responsible for the transport of lipids in the blood and lymph circulation. [from HPO]

Professional guidelines

PubMed

Reconstituted HDL (Milano) Treatment Efficaciously Reverses Heart Failure with Preserved Ejection Fraction in Mice.
Mishra M, Muthuramu I, Aboumsallem JP, Kempen H, De Geest B
Int J Mol Sci 2018 Oct 30;19(11) doi: 10.3390/ijms19113399. PMID: 30380754Free PMC Article
Effects of treatment of secondary hyperparathyroidism on the lipid profile in patients on hemodialysis.
Lim PS, Hung TS, Yeh CH, Yu MH
Blood Purif 1998;16(1):22-9. doi: 10.1159/000014309. PMID: 9513759

Recent clinical studies

Etiology

Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease.
Amaya-Garrido A, Brunet M, Buffin-Meyer B, Piedrafita A, Grzesiak L, Agbegbo E, Del Bello A, Ferrandiz I, Ardeleanu S, Bermudez-Lopez M, Fedou C, Camus M, Burlet-Schiltz O, Massines J, Buléon M, Feuillet G, Alves M, Neau E, Casemayou A, Breuil B, Saulnier-Blache JS, Denis C, Voelkl J, Glorieux G, Hobson S, Arefin S, Rahman A, Kublickiene K, Stenvinkel P, Bascands JL, Faguer S, Valdivielso JM, Schanstra JP, Klein J
Sci Transl Med 2023 Sep 6;15(712):eabn5939. doi: 10.1126/scitranslmed.abn5939. PMID: 37672568
Higher in vivo muscarinic-2 receptor distribution volumes in aging subjects with an apolipoprotein E-epsilon4 allele.
Cohen RM, Podruchny TA, Bokde AL, Carson RE, Herscovitch P, Kiesewetter DO, Eckelman WC, Sunderland T
Synapse 2003 Sep 1;49(3):150-6. doi: 10.1002/syn.10225. PMID: 12774299
Mechanisms of hepatic chylomicron remnant clearance.
Willnow TE
Diabet Med 1997 Aug;14 Suppl 3:S75-80. doi: 10.1002/(sici)1096-9136(199708)14:3+<s75::aid-dia449>3.3.co;2-0. PMID: 9272618
Lipids, risk factors and ischaemic heart disease.
Castelli WP
Atherosclerosis 1996 Jul;124 Suppl:S1-9. doi: 10.1016/0021-9150(96)05851-0. PMID: 8831910
Metabolic basis of primary hypercholesterolemia.
Vega GL, Denke MA, Grundy SM
Circulation 1991 Jul;84(1):118-28. doi: 10.1161/01.cir.84.1.118. PMID: 2060088

Diagnosis

Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis.
Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG
Hepatology 2022 Apr;75(4):968-982. Epub 2021 Dec 7 doi: 10.1002/hep.32203. PMID: 34662439Free PMC Article
Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents.
Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1781-97. doi: 10.1210/clinem/dgz161. PMID: 31845996Free PMC Article
Lack of association of apoE ε4 allele with insulin resistance.
Ragogna F, Lattuada G, Ruotolo G, Luzi L, Perseghin G
Acta Diabetol 2012 Feb;49(1):25-32. Epub 2011 Feb 3 doi: 10.1007/s00592-011-0255-3. PMID: 21290252
Portal vein and systemic adiponectin concentrations are closely linked with hepatic glucose and lipoprotein kinetics in extremely obese subjects.
Magkos F, Fabbrini E, Patterson BW, Eagon JC, Klein S
Metabolism 2011 Nov;60(11):1641-8. Epub 2011 May 31 doi: 10.1016/j.metabol.2011.03.019. PMID: 21632078Free PMC Article
Antiphospholipid antibodies: discovery, definitions, detection and disease.
McIntyre JA, Wagenknecht DR, Faulk WP
Prog Lipid Res 2003 May;42(3):176-237. doi: 10.1016/s0163-7827(02)00048-6. PMID: 12689618

Therapy

Reconstituted HDL (Milano) Treatment Efficaciously Reverses Heart Failure with Preserved Ejection Fraction in Mice.
Mishra M, Muthuramu I, Aboumsallem JP, Kempen H, De Geest B
Int J Mol Sci 2018 Oct 30;19(11) doi: 10.3390/ijms19113399. PMID: 30380754Free PMC Article
Antiatherogenic small, dense HDL--guardian angel of the arterial wall?
Kontush A, Chapman MJ
Nat Clin Pract Cardiovasc Med 2006 Mar;3(3):144-53. doi: 10.1038/ncpcardio0500. PMID: 16505860
Lipids, risk factors and ischaemic heart disease.
Castelli WP
Atherosclerosis 1996 Jul;124 Suppl:S1-9. doi: 10.1016/0021-9150(96)05851-0. PMID: 8831910
Improvement of plasma lipoprotein profiles during high-flux dialysis.
Seres DS, Strain GW, Hashim SA, Goldberg IJ, Levin NW
J Am Soc Nephrol 1993 Jan;3(7):1409-15. doi: 10.1681/ASN.V371409. PMID: 8439653
Metabolic basis of primary hypercholesterolemia.
Vega GL, Denke MA, Grundy SM
Circulation 1991 Jul;84(1):118-28. doi: 10.1161/01.cir.84.1.118. PMID: 2060088

Prognosis

Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis.
Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG
Hepatology 2022 Apr;75(4):968-982. Epub 2021 Dec 7 doi: 10.1002/hep.32203. PMID: 34662439Free PMC Article
Dyslipidemia, Insulin Resistance, Ectopic Lipid Accumulation, and Vascular Function in Resistance to Thyroid Hormone β.
Moran C, McEniery CM, Schoenmakers N, Mitchell C, Sleigh A, Watson L, Lyons G, Burling K, Barker P, Chatterjee K
J Clin Endocrinol Metab 2021 Apr 23;106(5):e2005-e2014. doi: 10.1210/clinem/dgab002. PMID: 33524107Free PMC Article
Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents.
Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1781-97. doi: 10.1210/clinem/dgz161. PMID: 31845996Free PMC Article
Acute dyslipoproteinemia induced by interleukin-2: lecithin:cholesteryl acyltransferase, lipoprotein lipase, and hepatic lipase deficiencies.
Kwong LK, Ridinger DN, Bandhauer M, Ward JH, Samlowski WE, Iverius PH, Pritchard H, Wilson DE
J Clin Endocrinol Metab 1997 May;82(5):1572-81. doi: 10.1210/jcem.82.5.3937. PMID: 9141552
Lipoprotein(a) and apolipoproteins B and A-1 in children and coronary vascular events in their grandparents.
Wilcken DE, Wang XL, Greenwood J, Lynch J
J Pediatr 1993 Oct;123(4):519-26. doi: 10.1016/s0022-3476(05)80944-8. PMID: 8410502

Clinical prediction guides

Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease.
Amaya-Garrido A, Brunet M, Buffin-Meyer B, Piedrafita A, Grzesiak L, Agbegbo E, Del Bello A, Ferrandiz I, Ardeleanu S, Bermudez-Lopez M, Fedou C, Camus M, Burlet-Schiltz O, Massines J, Buléon M, Feuillet G, Alves M, Neau E, Casemayou A, Breuil B, Saulnier-Blache JS, Denis C, Voelkl J, Glorieux G, Hobson S, Arefin S, Rahman A, Kublickiene K, Stenvinkel P, Bascands JL, Faguer S, Valdivielso JM, Schanstra JP, Klein J
Sci Transl Med 2023 Sep 6;15(712):eabn5939. doi: 10.1126/scitranslmed.abn5939. PMID: 37672568
Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis.
Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG
Hepatology 2022 Apr;75(4):968-982. Epub 2021 Dec 7 doi: 10.1002/hep.32203. PMID: 34662439Free PMC Article
Antiphospholipid antibodies: discovery, definitions, detection and disease.
McIntyre JA, Wagenknecht DR, Faulk WP
Prog Lipid Res 2003 May;42(3):176-237. doi: 10.1016/s0163-7827(02)00048-6. PMID: 12689618
Fasting and postprandial lipid abnormalities in hypopituitary women receiving conventional replacement therapy.
al-Shoumer KA, Cox KH, Hughes CL, Richmond W, Johnston DG
J Clin Endocrinol Metab 1997 Aug;82(8):2653-9. doi: 10.1210/jcem.82.8.4129. PMID: 9253349
Genetic predisposition to hyperlipidaemia in diabetes: the end of the beginning?
Wilson DE, Kwong LK, Elbein SC, Lalouel JM
J Intern Med Suppl 1994;736:53-61. PMID: 7986310

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...