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Anti-tissue transglutaminase antibody positivity

MedGen UID:
1787623
•Concept ID:
C5539688
•
Laboratory or Test Result
Synonym: Anti-tTG antibody positivity
 
HPO: HP:0033563

Definition

The presence of autoantibodies (immunoglobulins) in the serum that react against tissue transglutaminase. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-tissue transglutaminase antibody positivity

Professional guidelines

PubMed

Celiac disease: prevalence, diagnosis, pathogenesis and treatment.
Gujral N, Freeman HJ, Thomson AB
World J Gastroenterol 2012 Nov 14;18(42):6036-59. doi: 10.3748/wjg.v18.i42.6036. PMID: 23155333Free PMC Article
First salivary screening of celiac disease by detection of anti-transglutaminase autoantibody radioimmunoassay in 5000 Italian primary schoolchildren.
Bonamico M, Nenna R, Montuori M, Luparia RP, Turchetti A, Mennini M, Lucantoni F, Masotti D, Magliocca FM, Culasso F, Tiberti C
J Pediatr Gastroenterol Nutr 2011 Jan;52(1):17-20. doi: 10.1097/MPG.0b013e3181e6f2d0. PMID: 21057330
Utility in clinical practice of immunoglobulin a anti-tissue transglutaminase antibody for the diagnosis of celiac disease.
Abrams JA, Brar P, Diamond B, Rotterdam H, Green PH
Clin Gastroenterol Hepatol 2006 Jun;4(6):726-30. Epub 2006 Apr 19 doi: 10.1016/j.cgh.2006.02.010. PMID: 16630760

Recent systematic reviews

The Prevalence of the Celiac Disease in Patients with Dyspepsia: A Systematic Review and Meta-Analysis.
Singh AD, Ellias S, Singh P, Ahuja V, Makharia GK
Dig Dis Sci 2022 Jul;67(7):3067-3079. Epub 2021 Jul 15 doi: 10.1007/s10620-021-07142-8. PMID: 34268659
Prevalence of celiac disease in patients with short stature: A systematic review and meta-analysis.
Singh AD, Singh P, Farooqui N, Strand T, Ahuja V, Makharia GK
J Gastroenterol Hepatol 2021 Jan;36(1):44-54. Epub 2020 Aug 23 doi: 10.1111/jgh.15167. PMID: 32621396

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