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Glomerular basement membrane amyloid spicule

MedGen UID:: 1788029
•Concept ID:: C5539643
•: Finding

HPO:	HP:0033494

Definition

Amyloid spicules are projections of typically silver-positive material from the outer aspect of the glomerular capillary wall, perpendicular to the glomerular basement membrane (GBM), most often caused by amyloidosis with the latter confirmed by additional stains. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGlomerular basement membrane amyloid spicule

Abnormal nephron morphology
- Abnormal renal corpuscle morphology
  - Abnormal renal glomerulus morphology
    - Glomerular deposits
      - Glomerular subepithelial deposits
        Abnormal glomerular basement membrane morphology
        Glomerular basement membrane amyloid spicule

Recent clinical studies

Etiology

Morphologic and clinical correlates in renal amyloidosis.

Dikman SH, Churg J, Kahn T
Hum Pathol 1981 Feb;12(2):160-9. doi: 10.1016/s0046-8177(81)80103-7. PMID: 7216218

Diagnosis

Subepithelial argyrophilic spicular structures in renal amyloidosis--an aid in diagnosis. Pathogenic considerations.

Nolting SF, Campbell WG Jr
Hum Pathol 1981 Aug;12(8):724-34. doi: 10.1016/s0046-8177(81)80174-8. PMID: 6793499

Prognosis

Morphologic and clinical correlates in renal amyloidosis.

Dikman SH, Churg J, Kahn T
Hum Pathol 1981 Feb;12(2):160-9. doi: 10.1016/s0046-8177(81)80103-7. PMID: 7216218

Clinical prediction guides

Renal involvement patterns of amyloid nephropathy: a comparison with diabetic nephropathy.

Nakamoto Y, Hamanaka S, Akihama T, Miura AB, Uesaka Y
Clin Nephrol 1984 Oct;22(4):188-94. PMID: 6509804

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ClinicalTrials.gov

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