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Subendothelial glomerular basement membrane electron dense deposits

MedGen UID:
1788592
•Concept ID:
C5539648
•
Finding
HPO: HP:0033500

Definition

Electron dense deposits in the glomerular basement membrane (GBM) subendothelial space associated with a prominent GBM reflecting an increase in thickness. This feature can be associated with GBM remodeling along the endothelial aspect. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubendothelial glomerular basement membrane electron dense deposits

Recent clinical studies

Etiology

Clinicopathological significance of glomerular capillary IgA deposition in childhood IgA nephropathy.
Shima Y, Nakanishi K, Mukaiyama H, Tanaka Y, Wada T, Tanaka R, Kaito H, Nozu K, Sako M, Iijima K, Yoshikawa N
Pediatr Nephrol 2021 Apr;36(4):899-908. Epub 2020 Oct 4 doi: 10.1007/s00467-020-04772-4. PMID: 33011820
Antineutrophil cytoplasmic antibody-associated glomerulonephritis with immunoglobulin deposition.
Hirose O, Itabashi M, Takei T, Honda K, Nitta K
Clin Exp Nephrol 2017 Aug;21(4):643-650. Epub 2016 Nov 9 doi: 10.1007/s10157-016-1341-1. PMID: 27830351
Clinicopathological analysis of allogeneic hematopoietic stem cell transplantation-related membranous glomerulonephritis.
Hiramatsu R, Ubara Y, Sawa N, Hasegawa E, Kawada M, Imafuku A, Sumida K, Mise K, Yamanouchi M, Ueno T, Sekine A, Hayami N, Suwabe T, Hoshino J, Takaichi K, Ohashi K, Fujii T, Wake A, Taniguchi S
Hum Pathol 2016 Apr;50:187-94. Epub 2015 Dec 29 doi: 10.1016/j.humpath.2015.12.005. PMID: 26997455
Fibronectin non-amyloid glomerulopathy.
Yong JL, Killingsworth MC, Spicer ST, Wu XJ
Int J Clin Exp Pathol 2009 Nov 20;3(2):210-6. PMID: 20126589Free PMC Article
Mesangiocapillary glomerulonephritis.
D'Amico G, Ferrario F
J Am Soc Nephrol 1992 Apr;2(10 Suppl):S159-66. doi: 10.1681/ASN.V210s159. PMID: 1534701

Diagnosis

Collagenofibrotic (Collagen Type III) glomerulopathy in association with diabetic nephropathy.
Alsaad KO, Edrees B, Rahim KA, Alanazi A, Ahmad M, Aloudah N
Saudi J Kidney Dis Transpl 2017 Jul-Aug;28(4):898-905. PMID: 28748894
Antineutrophil cytoplasmic antibody-associated glomerulonephritis with immunoglobulin deposition.
Hirose O, Itabashi M, Takei T, Honda K, Nitta K
Clin Exp Nephrol 2017 Aug;21(4):643-650. Epub 2016 Nov 9 doi: 10.1007/s10157-016-1341-1. PMID: 27830351
Clinicopathological analysis of allogeneic hematopoietic stem cell transplantation-related membranous glomerulonephritis.
Hiramatsu R, Ubara Y, Sawa N, Hasegawa E, Kawada M, Imafuku A, Sumida K, Mise K, Yamanouchi M, Ueno T, Sekine A, Hayami N, Suwabe T, Hoshino J, Takaichi K, Ohashi K, Fujii T, Wake A, Taniguchi S
Hum Pathol 2016 Apr;50:187-94. Epub 2015 Dec 29 doi: 10.1016/j.humpath.2015.12.005. PMID: 26997455
Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis.
Brackman D, Sartz L, Leh S, Kristoffersson AC, Bjerre A, Tati R, Frémeaux-Bacchi V, Karpman D
Nephrol Dial Transplant 2011 Oct;26(10):3399-403. Epub 2011 Aug 1 doi: 10.1093/ndt/gfr422. PMID: 21810760
Hereditary nephritis mimicking immune complex-mediated glomerulonephritis.
Nasr SH, Markowitz GS, Goldstein CS, Fildes RD, D'Agati VD
Hum Pathol 2006 May;37(5):547-54. doi: 10.1016/j.humpath.2005.12.017. PMID: 16647952

Therapy

Cyclosporine therapy could be considered for membranoproliferative glomerulonephritis with immunoglobulin A deposits: a case report.
Hidaka Y, Tamura H, Furuie K, Kuraoka S, Nagata H, Nakazato H
BMC Nephrol 2022 Nov 7;23(1):358. doi: 10.1186/s12882-022-02983-5. PMID: 36344919Free PMC Article
IgA nephropathy featuring massive wire loop-like deposits in two patients with alcoholic cirrhosis.
Takada D, Sumida K, Sekine A, Hazue R, Yamanouchi M, Suwabe T, Hayami N, Hoshino J, Sawa N, Takaichi K, Fujii T, Ohashi K, Ubara Y
BMC Nephrol 2017 Dec 13;18(1):362. doi: 10.1186/s12882-017-0769-1. PMID: 29237409Free PMC Article
Antineutrophil cytoplasmic antibody-associated glomerulonephritis with immunoglobulin deposition.
Hirose O, Itabashi M, Takei T, Honda K, Nitta K
Clin Exp Nephrol 2017 Aug;21(4):643-650. Epub 2016 Nov 9 doi: 10.1007/s10157-016-1341-1. PMID: 27830351
Clinicopathological analysis of allogeneic hematopoietic stem cell transplantation-related membranous glomerulonephritis.
Hiramatsu R, Ubara Y, Sawa N, Hasegawa E, Kawada M, Imafuku A, Sumida K, Mise K, Yamanouchi M, Ueno T, Sekine A, Hayami N, Suwabe T, Hoshino J, Takaichi K, Ohashi K, Fujii T, Wake A, Taniguchi S
Hum Pathol 2016 Apr;50:187-94. Epub 2015 Dec 29 doi: 10.1016/j.humpath.2015.12.005. PMID: 26997455
Immune Complex-Type Deposits in the Fischer-344 to Lewis Rat Model of Renal Transplantation and a Subset of Human Transplant Glomerulopathy.
Grau V, Zeuschner P, Immenschuh S, Bockmeyer CL, Zell S, Wittig J, Säuberlich K, Abbas M, Padberg W, Meyer-Schwesinger C, von Brandenstein M, Schlosser M, Dieplinger G, Galliford J, Clarke C, Roufosse C, Becker JU
Transplantation 2016 May;100(5):1004-14. doi: 10.1097/TP.0000000000001068. PMID: 26895216

Prognosis

Cyclosporine therapy could be considered for membranoproliferative glomerulonephritis with immunoglobulin A deposits: a case report.
Hidaka Y, Tamura H, Furuie K, Kuraoka S, Nagata H, Nakazato H
BMC Nephrol 2022 Nov 7;23(1):358. doi: 10.1186/s12882-022-02983-5. PMID: 36344919Free PMC Article
Clinicopathological significance of glomerular capillary IgA deposition in childhood IgA nephropathy.
Shima Y, Nakanishi K, Mukaiyama H, Tanaka Y, Wada T, Tanaka R, Kaito H, Nozu K, Sako M, Iijima K, Yoshikawa N
Pediatr Nephrol 2021 Apr;36(4):899-908. Epub 2020 Oct 4 doi: 10.1007/s00467-020-04772-4. PMID: 33011820
Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis.
Brackman D, Sartz L, Leh S, Kristoffersson AC, Bjerre A, Tati R, Frémeaux-Bacchi V, Karpman D
Nephrol Dial Transplant 2011 Oct;26(10):3399-403. Epub 2011 Aug 1 doi: 10.1093/ndt/gfr422. PMID: 21810760
Fibronectin non-amyloid glomerulopathy.
Yong JL, Killingsworth MC, Spicer ST, Wu XJ
Int J Clin Exp Pathol 2009 Nov 20;3(2):210-6. PMID: 20126589Free PMC Article
Renal pathology in pre-eclampsia.
Gaber LW, Spargo BH, Lindheimer MD
Baillieres Clin Obstet Gynaecol 1994 Jun;8(2):443-68. doi: 10.1016/s0950-3552(05)80330-x. PMID: 7924017

Clinical prediction guides

Clinicopathological significance of glomerular capillary IgA deposition in childhood IgA nephropathy.
Shima Y, Nakanishi K, Mukaiyama H, Tanaka Y, Wada T, Tanaka R, Kaito H, Nozu K, Sako M, Iijima K, Yoshikawa N
Pediatr Nephrol 2021 Apr;36(4):899-908. Epub 2020 Oct 4 doi: 10.1007/s00467-020-04772-4. PMID: 33011820
Antineutrophil cytoplasmic antibody-associated glomerulonephritis with immunoglobulin deposition.
Hirose O, Itabashi M, Takei T, Honda K, Nitta K
Clin Exp Nephrol 2017 Aug;21(4):643-650. Epub 2016 Nov 9 doi: 10.1007/s10157-016-1341-1. PMID: 27830351
Renal pathology in pre-eclampsia.
Gaber LW, Spargo BH, Lindheimer MD
Baillieres Clin Obstet Gynaecol 1994 Jun;8(2):443-68. doi: 10.1016/s0950-3552(05)80330-x. PMID: 7924017
Renal pathology in pre-eclampsia.
Gaber LW, Spargo BH, Lindheimer MD
Baillieres Clin Obstet Gynaecol 1987 Dec;1(4):971-95. doi: 10.1016/s0950-3552(87)80045-7. PMID: 3330496
Electron microscopic studies on IgA nephropathy.
Kimura M, Sato I, Shiratori Y, Sugawara N, Ozawa K, Yamabe H
Acta Pathol Jpn 1984 Mar;34(2):289-304. doi: 10.1111/j.1440-1827.1984.tb07557.x. PMID: 6331063

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