U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Elevated myocardial native T2

MedGen UID:
1788876
•Concept ID:
C5539855
•
Finding
HPO: HP:4000003

Definition

Increased duration of myocardial T2 time without gadolinium contrast. Elevated T2, which can detect myocardial edema. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated myocardial native T2

Professional guidelines

PubMed

CMR imaging biosignature of cardiac involvement due to cancer-related treatment by T1 and T2 mapping.
Haslbauer JD, Lindner S, Valbuena-Lopez S, Zainal H, Zhou H, D'Angelo T, Pathan F, Arendt CA, Bug G, Serve H, Vogl TJ, Zeiher AM, Carr-White G, Nagel E, Puntmann VO
Int J Cardiol 2019 Jan 15;275:179-186. Epub 2018 Oct 11 doi: 10.1016/j.ijcard.2018.10.023. PMID: 30360992

Recent clinical studies

Etiology

Cardiovascular Magnetic Resonance Imaging in Patients With Ibrutinib-Associated Cardiotoxicity.
Buck B, Chum AP, Patel M, Carter R, Nawaz H, Yildiz V, Ruz P, Wiczer T, Rogers KA, Awan FT, Bhat S, Guha A, Kittai AS, Simonetti OP, Raman SV, Wallace G, Sanchez R, Bonsu JM, Gambril J, Haddad D, Mann J, Wei L, Kola-Kehinde O, Byrd JC, Woyach JA, Addison D
JAMA Oncol 2023 Apr 1;9(4):552-555. doi: 10.1001/jamaoncol.2022.6869. PMID: 36729480Free PMC Article
Cardiac MRI to Visualize Myocardial Damage after ST-Segment Elevation Myocardial Infarction: A Review of Its Histologic Validation.
Beijnink CWH, van der Hoeven NW, Konijnenberg LSF, Kim RJ, Bekkers SCAM, Kloner RA, Everaars H, El Messaoudi S, van Rossum AC, van Royen N, Nijveldt R
Radiology 2021 Oct;301(1):4-18. Epub 2021 Aug 24 doi: 10.1148/radiol.2021204265. PMID: 34427461
Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination.
Kim HW, Jenista ER, Wendell DC, Azevedo CF, Campbell MJ, Darty SN, Parker MA, Kim RJ
JAMA Cardiol 2021 Oct 1;6(10):1196-1201. doi: 10.1001/jamacardio.2021.2828. PMID: 34185046Free PMC Article
Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients With Immune Checkpoint Inhibitor-Associated Myocarditis.
Thavendiranathan P, Zhang L, Zafar A, Drobni ZD, Mahmood SS, Cabral M, Awadalla M, Nohria A, Zlotoff DA, Thuny F, Heinzerling LM, Barac A, Sullivan RJ, Chen CL, Gupta D, Kirchberger MC, Hartmann SE, Weinsaft JW, Gilman HK, Rizvi MA, Kovacina B, Michel C, Sahni G, González-Mansilla A, Calles A, Fernández-Avilés F, Mahmoudi M, Reynolds KL, Ganatra S, Gavira JJ, González NS, García de Yébenes Castro M, Kwong RY, Jerosch-Herold M, Coelho-Filho OR, Afilalo J, Zataraín-Nicolás E, Baksi AJ, Wintersperger BJ, Calvillo-Arguelles O, Ederhy S, Yang EH, Lyon AR, Fradley MG, Neilan TG
J Am Coll Cardiol 2021 Mar 30;77(12):1503-1516. doi: 10.1016/j.jacc.2021.01.050. PMID: 33766256Free PMC Article
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article

Diagnosis

Cardiovascular Magnetic Resonance Imaging in Patients With Ibrutinib-Associated Cardiotoxicity.
Buck B, Chum AP, Patel M, Carter R, Nawaz H, Yildiz V, Ruz P, Wiczer T, Rogers KA, Awan FT, Bhat S, Guha A, Kittai AS, Simonetti OP, Raman SV, Wallace G, Sanchez R, Bonsu JM, Gambril J, Haddad D, Mann J, Wei L, Kola-Kehinde O, Byrd JC, Woyach JA, Addison D
JAMA Oncol 2023 Apr 1;9(4):552-555. doi: 10.1001/jamaoncol.2022.6869. PMID: 36729480Free PMC Article
Cardiac MRI to Visualize Myocardial Damage after ST-Segment Elevation Myocardial Infarction: A Review of Its Histologic Validation.
Beijnink CWH, van der Hoeven NW, Konijnenberg LSF, Kim RJ, Bekkers SCAM, Kloner RA, Everaars H, El Messaoudi S, van Rossum AC, van Royen N, Nijveldt R
Radiology 2021 Oct;301(1):4-18. Epub 2021 Aug 24 doi: 10.1148/radiol.2021204265. PMID: 34427461
Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination.
Kim HW, Jenista ER, Wendell DC, Azevedo CF, Campbell MJ, Darty SN, Parker MA, Kim RJ
JAMA Cardiol 2021 Oct 1;6(10):1196-1201. doi: 10.1001/jamacardio.2021.2828. PMID: 34185046Free PMC Article
Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients With Immune Checkpoint Inhibitor-Associated Myocarditis.
Thavendiranathan P, Zhang L, Zafar A, Drobni ZD, Mahmood SS, Cabral M, Awadalla M, Nohria A, Zlotoff DA, Thuny F, Heinzerling LM, Barac A, Sullivan RJ, Chen CL, Gupta D, Kirchberger MC, Hartmann SE, Weinsaft JW, Gilman HK, Rizvi MA, Kovacina B, Michel C, Sahni G, González-Mansilla A, Calles A, Fernández-Avilés F, Mahmoudi M, Reynolds KL, Ganatra S, Gavira JJ, González NS, García de Yébenes Castro M, Kwong RY, Jerosch-Herold M, Coelho-Filho OR, Afilalo J, Zataraín-Nicolás E, Baksi AJ, Wintersperger BJ, Calvillo-Arguelles O, Ederhy S, Yang EH, Lyon AR, Fradley MG, Neilan TG
J Am Coll Cardiol 2021 Mar 30;77(12):1503-1516. doi: 10.1016/j.jacc.2021.01.050. PMID: 33766256Free PMC Article
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article

Therapy

Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination.
Kim HW, Jenista ER, Wendell DC, Azevedo CF, Campbell MJ, Darty SN, Parker MA, Kim RJ
JAMA Cardiol 2021 Oct 1;6(10):1196-1201. doi: 10.1001/jamacardio.2021.2828. PMID: 34185046Free PMC Article
Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients With Immune Checkpoint Inhibitor-Associated Myocarditis.
Thavendiranathan P, Zhang L, Zafar A, Drobni ZD, Mahmood SS, Cabral M, Awadalla M, Nohria A, Zlotoff DA, Thuny F, Heinzerling LM, Barac A, Sullivan RJ, Chen CL, Gupta D, Kirchberger MC, Hartmann SE, Weinsaft JW, Gilman HK, Rizvi MA, Kovacina B, Michel C, Sahni G, González-Mansilla A, Calles A, Fernández-Avilés F, Mahmoudi M, Reynolds KL, Ganatra S, Gavira JJ, González NS, García de Yébenes Castro M, Kwong RY, Jerosch-Herold M, Coelho-Filho OR, Afilalo J, Zataraín-Nicolás E, Baksi AJ, Wintersperger BJ, Calvillo-Arguelles O, Ederhy S, Yang EH, Lyon AR, Fradley MG, Neilan TG
J Am Coll Cardiol 2021 Mar 30;77(12):1503-1516. doi: 10.1016/j.jacc.2021.01.050. PMID: 33766256Free PMC Article
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article
Myocardial Storage, Inflammation, and Cardiac Phenotype in Fabry Disease After One Year of Enzyme Replacement Therapy.
Nordin S, Kozor R, Vijapurapu R, Augusto JB, Knott KD, Captur G, Treibel TA, Ramaswami U, Tchan M, Geberhiwot T, Steeds RP, Hughes DA, Moon JC
Circ Cardiovasc Imaging 2019 Dec;12(12):e009430. Epub 2019 Dec 12 doi: 10.1161/CIRCIMAGING.119.009430. PMID: 31826677Free PMC Article
Performance of native and contrast-enhanced T1 mapping to detect myocardial damage in patients with suspected myocarditis: a head-to-head comparison of different cardiovascular magnetic resonance techniques.
Nadjiri J, Nieberler H, Hendrich E, Greiser A, Will A, Martinoff S, Hadamitzky M
Int J Cardiovasc Imaging 2017 Apr;33(4):539-547. Epub 2016 Nov 23 doi: 10.1007/s10554-016-1029-3. PMID: 27878700

Prognosis

Cardiovascular Magnetic Resonance Imaging in Patients With Ibrutinib-Associated Cardiotoxicity.
Buck B, Chum AP, Patel M, Carter R, Nawaz H, Yildiz V, Ruz P, Wiczer T, Rogers KA, Awan FT, Bhat S, Guha A, Kittai AS, Simonetti OP, Raman SV, Wallace G, Sanchez R, Bonsu JM, Gambril J, Haddad D, Mann J, Wei L, Kola-Kehinde O, Byrd JC, Woyach JA, Addison D
JAMA Oncol 2023 Apr 1;9(4):552-555. doi: 10.1001/jamaoncol.2022.6869. PMID: 36729480Free PMC Article
Cardiac MRI to Visualize Myocardial Damage after ST-Segment Elevation Myocardial Infarction: A Review of Its Histologic Validation.
Beijnink CWH, van der Hoeven NW, Konijnenberg LSF, Kim RJ, Bekkers SCAM, Kloner RA, Everaars H, El Messaoudi S, van Rossum AC, van Royen N, Nijveldt R
Radiology 2021 Oct;301(1):4-18. Epub 2021 Aug 24 doi: 10.1148/radiol.2021204265. PMID: 34427461
Differences in native T1 and native T2 mapping between patients on hemodialysis and control subjects.
Graham-Brown MPM, Gulsin GS, Poli F, Parke K, Burton JO, McCann GP
Eur J Radiol 2021 Jul;140:109748. Epub 2021 May 1 doi: 10.1016/j.ejrad.2021.109748. PMID: 33962255
Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients With Immune Checkpoint Inhibitor-Associated Myocarditis.
Thavendiranathan P, Zhang L, Zafar A, Drobni ZD, Mahmood SS, Cabral M, Awadalla M, Nohria A, Zlotoff DA, Thuny F, Heinzerling LM, Barac A, Sullivan RJ, Chen CL, Gupta D, Kirchberger MC, Hartmann SE, Weinsaft JW, Gilman HK, Rizvi MA, Kovacina B, Michel C, Sahni G, González-Mansilla A, Calles A, Fernández-Avilés F, Mahmoudi M, Reynolds KL, Ganatra S, Gavira JJ, González NS, García de Yébenes Castro M, Kwong RY, Jerosch-Herold M, Coelho-Filho OR, Afilalo J, Zataraín-Nicolás E, Baksi AJ, Wintersperger BJ, Calvillo-Arguelles O, Ederhy S, Yang EH, Lyon AR, Fradley MG, Neilan TG
J Am Coll Cardiol 2021 Mar 30;77(12):1503-1516. doi: 10.1016/j.jacc.2021.01.050. PMID: 33766256Free PMC Article
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article

Clinical prediction guides

Cardiovascular Magnetic Resonance Imaging in Patients With Ibrutinib-Associated Cardiotoxicity.
Buck B, Chum AP, Patel M, Carter R, Nawaz H, Yildiz V, Ruz P, Wiczer T, Rogers KA, Awan FT, Bhat S, Guha A, Kittai AS, Simonetti OP, Raman SV, Wallace G, Sanchez R, Bonsu JM, Gambril J, Haddad D, Mann J, Wei L, Kola-Kehinde O, Byrd JC, Woyach JA, Addison D
JAMA Oncol 2023 Apr 1;9(4):552-555. doi: 10.1001/jamaoncol.2022.6869. PMID: 36729480Free PMC Article
Differences in native T1 and native T2 mapping between patients on hemodialysis and control subjects.
Graham-Brown MPM, Gulsin GS, Poli F, Parke K, Burton JO, McCann GP
Eur J Radiol 2021 Jul;140:109748. Epub 2021 May 1 doi: 10.1016/j.ejrad.2021.109748. PMID: 33962255
Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients With Immune Checkpoint Inhibitor-Associated Myocarditis.
Thavendiranathan P, Zhang L, Zafar A, Drobni ZD, Mahmood SS, Cabral M, Awadalla M, Nohria A, Zlotoff DA, Thuny F, Heinzerling LM, Barac A, Sullivan RJ, Chen CL, Gupta D, Kirchberger MC, Hartmann SE, Weinsaft JW, Gilman HK, Rizvi MA, Kovacina B, Michel C, Sahni G, González-Mansilla A, Calles A, Fernández-Avilés F, Mahmoudi M, Reynolds KL, Ganatra S, Gavira JJ, González NS, García de Yébenes Castro M, Kwong RY, Jerosch-Herold M, Coelho-Filho OR, Afilalo J, Zataraín-Nicolás E, Baksi AJ, Wintersperger BJ, Calvillo-Arguelles O, Ederhy S, Yang EH, Lyon AR, Fradley MG, Neilan TG
J Am Coll Cardiol 2021 Mar 30;77(12):1503-1516. doi: 10.1016/j.jacc.2021.01.050. PMID: 33766256Free PMC Article
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article
Clinical impact of native T1 mapping for detecting myocardial impairment in takotsubo cardiomyopathy.
Aikawa Y, Noguchi T, Morita Y, Tateishi E, Kono A, Miura H, Komori Y, Asaumi Y, Fukuda T, Yasuda S
Eur Heart J Cardiovasc Imaging 2019 Oct 1;20(10):1147-1155. doi: 10.1093/ehjci/jez034. PMID: 30879048

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...