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EBV-Associated Smooth Muscle Tumor

MedGen UID:
1791312
•Concept ID:
C5554871
•
Neoplastic Process
Synonyms: EBV-Associated Smooth Muscle Neoplasm; Epstein-Barr Virus-Associated Smooth Muscle Neoplasm; Epstein-Barr Virus-Associated Smooth Muscle Tumor

Definition

A rare smooth muscle neoplasm of uncertain biological potential. It is associated with Epstein-Barr virus infection and seen in patients with immunodeficiency, including primary immunodeficiency, HIV/AIDS infection, and post-transplant immunosuppression. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEBV-Associated Smooth Muscle Tumor

Professional guidelines

PubMed

Treatment for leiomyosarcoma and leiomyoma in children with HIV infection.
Yin X, Wu T, Yan Y, Zhang H, Bu H
Cochrane Database Syst Rev 2010 May 12;(5):CD007665. doi: 10.1002/14651858.CD007665.pub2. PMID: 20464756

Recent clinical studies

Etiology

Useful histopathologic features for diagnosing focal liver lesions with spindle cell morphology: A clinicopathologic study.
Laohawetwanit T, Wanpiyarat N, Lerttanatum N
Ann Diagn Pathol 2022 Aug;59:151975. Epub 2022 May 10 doi: 10.1016/j.anndiagpath.2022.151975. PMID: 35576852
Multifocal EBV-associated smooth muscle tumors in a patient with cytomegalovirus infection after liver transplantation: a case report from Shiraz, Iran.
Anbardar MH, Soleimani N, Safavi D, Eshraghian A, Ayoub A
Diagn Pathol 2022 Jan 7;17(1):3. doi: 10.1186/s13000-021-01180-6. PMID: 34996501Free PMC Article
Epstein-Barr virus associated smooth muscle tumors in solid organ transplant recipients: Incidence over 31 years at a single institution and review of the literature.
Stubbins RJ, Alami Laroussi N, Peters AC, Urschel S, Dicke F, Lai RL, Zhu J, Mabilangan C, Preiksaitis JK
Transpl Infect Dis 2019 Feb;21(1):e13010. Epub 2018 Oct 25 doi: 10.1111/tid.13010. PMID: 30298678
Epstein-Barr virus-associated epithelial and mesenchymal neoplasms.
Deyrup AT
Hum Pathol 2008 Apr;39(4):473-83. doi: 10.1016/j.humpath.2007.10.030. PMID: 18342658

Diagnosis

Mesenchymal Neoplasms of the Liver.
Papke DJ Jr
Surg Pathol Clin 2023 Sep;16(3):609-634. Epub 2023 Jun 11 doi: 10.1016/j.path.2023.04.013. PMID: 37536892
EBV-Associated Smooth Muscle Tumor in the Malar Area of an HIV-Positive Patient: A Case Report.
Abidin NFZ, Rahman FA, Tuck Choon K, Tilakaratne WM
Head Neck Pathol 2023 Sep;17(3):821-825. Epub 2023 May 20 doi: 10.1007/s12105-023-01560-y. PMID: 37209302Free PMC Article
A case of Epstein-Barr virus-associated smooth muscle tumor of the posterior interosseous nerve mimicking schwannoma.
Bourhis A, Roussel-Robert V, Viard JP, Peyre M, Bielle F
Neuropathology 2022 Feb;42(1):52-57. Epub 2022 Jan 13 doi: 10.1111/neup.12774. PMID: 35026862
Multifocal EBV-associated smooth muscle tumors in a patient with cytomegalovirus infection after liver transplantation: a case report from Shiraz, Iran.
Anbardar MH, Soleimani N, Safavi D, Eshraghian A, Ayoub A
Diagn Pathol 2022 Jan 7;17(1):3. doi: 10.1186/s13000-021-01180-6. PMID: 34996501Free PMC Article
Epstein-Barr virus associated smooth muscle tumors in solid organ transplant recipients: Incidence over 31 years at a single institution and review of the literature.
Stubbins RJ, Alami Laroussi N, Peters AC, Urschel S, Dicke F, Lai RL, Zhu J, Mabilangan C, Preiksaitis JK
Transpl Infect Dis 2019 Feb;21(1):e13010. Epub 2018 Oct 25 doi: 10.1111/tid.13010. PMID: 30298678

Therapy

Treatment response with sirolimus for a pediatric patient with an EBV-associated smooth-muscle tumor after bone marrow transplantation.
Penney SW, Bishop BN, Howell DL
Pediatr Blood Cancer 2019 May;66(5):e27585. Epub 2019 Jan 6 doi: 10.1002/pbc.27585. PMID: 30614215
Epstein-Barr virus associated smooth muscle tumors in solid organ transplant recipients: Incidence over 31 years at a single institution and review of the literature.
Stubbins RJ, Alami Laroussi N, Peters AC, Urschel S, Dicke F, Lai RL, Zhu J, Mabilangan C, Preiksaitis JK
Transpl Infect Dis 2019 Feb;21(1):e13010. Epub 2018 Oct 25 doi: 10.1111/tid.13010. PMID: 30298678
Epstein-Barr virus-associated smooth muscle tumor of the cavernous sinus: a delayed complication of allogenic peripheral blood stem cell transplantation: case report.
Raheja A, Sowder A, Palmer C, Rodriguez FJ, Couldwell WT
J Neurosurg 2017 May;126(5):1479-1483. Epub 2016 Jun 24 doi: 10.3171/2016.4.JNS16290. PMID: 27341041
Epstein-Barr virus (EBV)-associated smooth-muscle tumor arising in a post-transplant patient treated successfully for two PT-EBV-associated large-cell lymphomas. Case report.
Kingma DW, Shad A, Tsokos M, Fest T, Otsuki T, Frekko K, Werner E, Werner A, Magrath I, Raffeld M, Jaffe ES
Am J Surg Pathol 1996 Dec;20(12):1511-9. doi: 10.1097/00000478-199612000-00011. PMID: 8944045

Prognosis

A case of Epstein-Barr virus-associated smooth muscle tumor of the posterior interosseous nerve mimicking schwannoma.
Bourhis A, Roussel-Robert V, Viard JP, Peyre M, Bielle F
Neuropathology 2022 Feb;42(1):52-57. Epub 2022 Jan 13 doi: 10.1111/neup.12774. PMID: 35026862
Treatment response with sirolimus for a pediatric patient with an EBV-associated smooth-muscle tumor after bone marrow transplantation.
Penney SW, Bishop BN, Howell DL
Pediatr Blood Cancer 2019 May;66(5):e27585. Epub 2019 Jan 6 doi: 10.1002/pbc.27585. PMID: 30614215
Epstein-Barr virus associated smooth muscle tumors in solid organ transplant recipients: Incidence over 31 years at a single institution and review of the literature.
Stubbins RJ, Alami Laroussi N, Peters AC, Urschel S, Dicke F, Lai RL, Zhu J, Mabilangan C, Preiksaitis JK
Transpl Infect Dis 2019 Feb;21(1):e13010. Epub 2018 Oct 25 doi: 10.1111/tid.13010. PMID: 30298678
Synchronous Epstein-Barr virus-associated skull base and adrenal smooth-muscle tumors in an 8-year-old girl with recent Epstein-Barr virus infection.
Brown DA, Deep NL, Driscoll CL, Link MJ, Jentoft ME, Daniels DJ
J Neurosurg Pediatr 2018 Sep;22(3):283-287. Epub 2018 Jun 15 doi: 10.3171/2018.3.PEDS17609. PMID: 29905497
Primary leiomyosarcoma of the pancreas: study of 9 cases and review of literature.
Zhang H, Jensen MH, Farnell MB, Smyrk TC, Zhang L
Am J Surg Pathol 2010 Dec;34(12):1849-56. doi: 10.1097/PAS.0b013e3181f97727. PMID: 21107091

Clinical prediction guides

A Novel Pathogenic Variant in CARMIL2 (RLTPR) Causing CARMIL2 Deficiency and EBV-Associated Smooth Muscle Tumors.
Yonkof JR, Gupta A, Rueda CM, Mangray S, Prince BT, Rangarajan HG, Alshahrani M, Varga E, Cripe TP, Abraham RS
Front Immunol 2020;11:884. Epub 2020 Jun 18 doi: 10.3389/fimmu.2020.00884. PMID: 32625199Free PMC Article
Epstein-Barr virus-associated smooth muscle tumour presenting as a parasagittal brain tumour.
Ibebuike KE, Pather S, Emereole O, Ndolo P, Kajee A, Gopal R, Naidoo S
J Clin Neurosci 2012 Nov;19(11):1589-91. Epub 2012 Jul 15 doi: 10.1016/j.jocn.2011.09.037. PMID: 22796272

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