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Dedifferentiated Leiomyosarcoma

MedGen UID:
1791315
•Concept ID:
C5554874
•
Neoplastic Process

Definition

A pleomorphic leiomyosarcoma that lacks immunohistochemical staining for myogenic markers in the pleomorphic areas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDedifferentiated Leiomyosarcoma

Professional guidelines

PubMed

Retroperitoneal sarcomas: from diagnosis to treatment. Case series and review of the literature.
Mantas D, Garmpis N, Polychroni D, Garmpi A, Damaskos C, Liakea A, Sypsa G, Kouskos E
G Chir 2020 Jan-Feb;41(1):18-33. PMID: 32038009
Review of past and present clinical cases with a view to future treatment options.
Martín-Broto J, Reichardt P, Stacchiotti S, Blay JY
Future Oncol 2017 Jun;13(13s):11-28. Epub 2017 May 2 doi: 10.2217/fon-2017-0120. PMID: 28460536
Contemporary Management of Retroperitoneal Soft Tissue Sarcomas.
Olimpiadi Y, Song S, Hu JS, Matcuk GR, Chopra S, Eisenberg BL, Sener SF, Tseng WW
Curr Oncol Rep 2015 Aug;17(8):39. doi: 10.1007/s11912-015-0462-0. PMID: 26092408

Recent clinical studies

Etiology

Dedifferentiated leiomyosarcoma of the uterus: a clinicopathologic and immunohistochemical analysis of 23 cases.
Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
The role of miRNA-221 and miRNA-126 in patients with benign metastasizing leiomyoma of the lung: an overview with new interesting scenarios.
Ventura L, Gnetti L, Rossi M, Tiseo M, Giordano G, Corradi M, Silva M, Milanese G, Minari R, Leonetti A, Cattadori S, Ampollini L, Carbognani P, Mozzoni P
Mol Biol Rep 2021 Apr;48(4):3485-3494. Epub 2021 Apr 15 doi: 10.1007/s11033-021-06322-z. PMID: 33856606

Diagnosis

Dedifferentiated Leiomyosarcoma-morphology, Immunohistochemistry, and Molecular Findings of a Case and Review of Literature.
Kousar A, Wald AI, Heayn M, Cardillo ND, Elishaev E, Bhargava R
Int J Gynecol Pathol 2024 May 1;43(3):264-270. Epub 2023 Sep 8 doi: 10.1097/PGP.0000000000000986. PMID: 37922938
Dedifferentiated leiomyosarcoma of the uterus: a clinicopathologic and immunohistochemical analysis of 23 cases.
Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
Bilateral Hand Metastases From a Pleomorphic/Dedifferentiated Leiomyosarcoma: A Case Report.
Bubau M, Georgiu C, Fodor L
Am J Dermatopathol 2022 Feb 1;44(2):118-120. doi: 10.1097/DAD.0000000000002083. PMID: 34783705
The role of miRNA-221 and miRNA-126 in patients with benign metastasizing leiomyoma of the lung: an overview with new interesting scenarios.
Ventura L, Gnetti L, Rossi M, Tiseo M, Giordano G, Corradi M, Silva M, Milanese G, Minari R, Leonetti A, Cattadori S, Ampollini L, Carbognani P, Mozzoni P
Mol Biol Rep 2021 Apr;48(4):3485-3494. Epub 2021 Apr 15 doi: 10.1007/s11033-021-06322-z. PMID: 33856606
Uterine leiomyosarcoma with osteoclast like giant cells and long standing systemic symptoms.
Patai K, Illyes G, Varbiro S, Gidai J, Kosa L, Vajo Z
Gynecol Oncol 2006 Aug;102(2):403-5. Epub 2006 Apr 27 doi: 10.1016/j.ygyno.2006.02.030. PMID: 16643995

Prognosis

Dedifferentiated leiomyosarcoma of the uterus: a clinicopathologic and immunohistochemical analysis of 23 cases.
Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
The role of miRNA-221 and miRNA-126 in patients with benign metastasizing leiomyoma of the lung: an overview with new interesting scenarios.
Ventura L, Gnetti L, Rossi M, Tiseo M, Giordano G, Corradi M, Silva M, Milanese G, Minari R, Leonetti A, Cattadori S, Ampollini L, Carbognani P, Mozzoni P
Mol Biol Rep 2021 Apr;48(4):3485-3494. Epub 2021 Apr 15 doi: 10.1007/s11033-021-06322-z. PMID: 33856606
Pleomorphic leiomyosarcoma with a dedifferentiation-like appearance in the kidney: case report and literature review.
Tajima S, Waki M, Fukuyama M
Med Mol Morphol 2016 Dec;49(4):238-242. Epub 2015 Apr 25 doi: 10.1007/s00795-015-0103-6. PMID: 25910609
Uterine leiomyosarcoma with osteoclast like giant cells and long standing systemic symptoms.
Patai K, Illyes G, Varbiro S, Gidai J, Kosa L, Vajo Z
Gynecol Oncol 2006 Aug;102(2):403-5. Epub 2006 Apr 27 doi: 10.1016/j.ygyno.2006.02.030. PMID: 16643995

Clinical prediction guides

The role of miRNA-221 and miRNA-126 in patients with benign metastasizing leiomyoma of the lung: an overview with new interesting scenarios.
Ventura L, Gnetti L, Rossi M, Tiseo M, Giordano G, Corradi M, Silva M, Milanese G, Minari R, Leonetti A, Cattadori S, Ampollini L, Carbognani P, Mozzoni P
Mol Biol Rep 2021 Apr;48(4):3485-3494. Epub 2021 Apr 15 doi: 10.1007/s11033-021-06322-z. PMID: 33856606
Immunofluorescence analysis of DNA damage response protein p53-binding protein 1 in a case of uterine dedifferentiated leiomyosarcoma arising from leiomyoma.
Matsuda K, Akazawa Y, Yamaguchi Y, Mussazhanova Z, Kurohama H, Ueki N, Kohno M, Fukushima A, Kajimura I, Hiraki H, Matsuwaki T, Kawashita S, Kinoshita A, Nakashima M
Pathol Res Pract 2019 Nov;215(11):152640. Epub 2019 Sep 16 doi: 10.1016/j.prp.2019.152640. PMID: 31570279
Pleomorphic leiomyosarcoma with a dedifferentiation-like appearance in the kidney: case report and literature review.
Tajima S, Waki M, Fukuyama M
Med Mol Morphol 2016 Dec;49(4):238-242. Epub 2015 Apr 25 doi: 10.1007/s00795-015-0103-6. PMID: 25910609
Histological and immunohistochemical observations of dedifferentiated leiomyosarcoma of the uterus.
Fukuda T, Ohnishi Y
Acta Pathol Jpn 1991 Jun;41(6):466-72. doi: 10.1111/j.1440-1827.1991.tb03214.x. PMID: 1719742

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