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Dedifferentiated Leiomyosarcoma

MedGen UID:
1791315
Concept ID:
C5554874
Neoplastic Process

Definition

A pleomorphic leiomyosarcoma that lacks immunohistochemical staining for myogenic markers in the pleomorphic areas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDedifferentiated Leiomyosarcoma

Professional guidelines

PubMed

Apte SS, Mor E, Mitchell C, Gyorki DE
Curr Oncol 2023 Jun 21;30(7):5953-5972. doi: 10.3390/curroncol30070445. PMID: 37504306Free PMC Article
Mantas D, Garmpis N, Polychroni D, Garmpi A, Damaskos C, Liakea A, Sypsa G, Kouskos E
G Chir 2020 Jan-Feb;41(1):18-33. PMID: 32038009
Martín-Broto J, Reichardt P, Stacchiotti S, Blay JY
Future Oncol 2017 Jun;13(13s):11-28. Epub 2017 May 2 doi: 10.2217/fon-2017-0120. PMID: 28460536

Recent clinical studies

Etiology

Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
Ventura L, Gnetti L, Rossi M, Tiseo M, Giordano G, Corradi M, Silva M, Milanese G, Minari R, Leonetti A, Cattadori S, Ampollini L, Carbognani P, Mozzoni P
Mol Biol Rep 2021 Apr;48(4):3485-3494. Epub 2021 Apr 15 doi: 10.1007/s11033-021-06322-z. PMID: 33856606

Diagnosis

Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
Bubau M, Georgiu C, Fodor L
Am J Dermatopathol 2022 Feb 1;44(2):118-120. doi: 10.1097/DAD.0000000000002083. PMID: 34783705
Ventura L, Gnetti L, Rossi M, Tiseo M, Giordano G, Corradi M, Silva M, Milanese G, Minari R, Leonetti A, Cattadori S, Ampollini L, Carbognani P, Mozzoni P
Mol Biol Rep 2021 Apr;48(4):3485-3494. Epub 2021 Apr 15 doi: 10.1007/s11033-021-06322-z. PMID: 33856606
Patai K, Illyes G, Varbiro S, Gidai J, Kosa L, Vajo Z
Gynecol Oncol 2006 Aug;102(2):403-5. Epub 2006 Apr 27 doi: 10.1016/j.ygyno.2006.02.030. PMID: 16643995

Prognosis

Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
Ventura L, Gnetti L, Rossi M, Tiseo M, Giordano G, Corradi M, Silva M, Milanese G, Minari R, Leonetti A, Cattadori S, Ampollini L, Carbognani P, Mozzoni P
Mol Biol Rep 2021 Apr;48(4):3485-3494. Epub 2021 Apr 15 doi: 10.1007/s11033-021-06322-z. PMID: 33856606
Tajima S, Waki M, Fukuyama M
Med Mol Morphol 2016 Dec;49(4):238-242. Epub 2015 Apr 25 doi: 10.1007/s00795-015-0103-6. PMID: 25910609
Patai K, Illyes G, Varbiro S, Gidai J, Kosa L, Vajo Z
Gynecol Oncol 2006 Aug;102(2):403-5. Epub 2006 Apr 27 doi: 10.1016/j.ygyno.2006.02.030. PMID: 16643995

Clinical prediction guides

Ventura L, Gnetti L, Rossi M, Tiseo M, Giordano G, Corradi M, Silva M, Milanese G, Minari R, Leonetti A, Cattadori S, Ampollini L, Carbognani P, Mozzoni P
Mol Biol Rep 2021 Apr;48(4):3485-3494. Epub 2021 Apr 15 doi: 10.1007/s11033-021-06322-z. PMID: 33856606
Matsuda K, Akazawa Y, Yamaguchi Y, Mussazhanova Z, Kurohama H, Ueki N, Kohno M, Fukushima A, Kajimura I, Hiraki H, Matsuwaki T, Kawashita S, Kinoshita A, Nakashima M
Pathol Res Pract 2019 Nov;215(11):152640. Epub 2019 Sep 16 doi: 10.1016/j.prp.2019.152640. PMID: 31570279
Tajima S, Waki M, Fukuyama M
Med Mol Morphol 2016 Dec;49(4):238-242. Epub 2015 Apr 25 doi: 10.1007/s00795-015-0103-6. PMID: 25910609
Fukuda T, Ohnishi Y
Acta Pathol Jpn 1991 Jun;41(6):466-72. doi: 10.1111/j.1440-1827.1991.tb03214.x. PMID: 1719742

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