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Unresectable Thymic Neuroendocrine Neoplasm

MedGen UID:
1793121
•Concept ID:
C5556680
•
Neoplastic Process

Definition

A thymic neuroendocrine neoplasm that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Thymic Neuroendocrine Neoplasm

Recent clinical studies

Etiology

Capecitabine and Temozolomide as a Promising Therapy for Advanced Thymic Atypical Carcinoid.
Wang X, Li Y, Duan J, Chen Y, Yuan B, Qi Z, Tan H
Oncologist 2019 Jun;24(6):798-802. Epub 2018 Nov 9 doi: 10.1634/theoncologist.2018-0291. PMID: 30413666Free PMC Article
Capecitabine and Celecoxib as a Promising Therapy for Thymic Neoplasms.
Wood K, Byron E, Janisch L, Salgia R, Sharma MR
Am J Clin Oncol 2018 Oct;41(10):963-966. doi: 10.1097/COC.0000000000000400. PMID: 28654574Free PMC Article
Efficacy and safety of long-acting pasireotide or everolimus alone or in combination in patients with advanced carcinoids of the lung and thymus (LUNA): an open-label, multicentre, randomised, phase 2 trial.
Ferolla P, Brizzi MP, Meyer T, Mansoor W, Mazieres J, Do Cao C, Léna H, Berruti A, Damiano V, Buikhuisen W, Grønbæk H, Lombard-Bohas C, Grohé C, Minotti V, Tiseo M, De Castro J, Reed N, Gislimberti G, Singh N, Stankovic M, Öberg K, Baudin E
Lancet Oncol 2017 Dec;18(12):1652-1664. Epub 2017 Oct 23 doi: 10.1016/S1470-2045(17)30681-2. PMID: 29074099
Long-term survival after surgical management of neuroendocrine hepatic metastases.
Glazer ES, Tseng JF, Al-Refaie W, Solorzano CC, Liu P, Willborn KA, Abdalla EK, Vauthey JN, Curley SA
HPB (Oxford) 2010 Aug;12(6):427-33. doi: 10.1111/j.1477-2574.2010.00198.x. PMID: 20662794Free PMC Article
Neuroendocrine tumors of the thymus: a clinicopathological and prognostic study.
Gal AA, Kornstein MJ, Cohen C, Duarte IG, Miller JI, Mansour KA
Ann Thorac Surg 2001 Oct;72(4):1179-82. doi: 10.1016/s0003-4975(01)03032-6. PMID: 11603433

Diagnosis

Metastatic thymic carcinoid responds to chemoradiation and octreotide: A case report.
Mei Z, Wang H, Ren S, Wei J, Gu Y
Medicine (Baltimore) 2018 Nov;97(47):e13286. doi: 10.1097/MD.0000000000013286. PMID: 30461637Free PMC Article

Therapy

Capecitabine and Temozolomide as a Promising Therapy for Advanced Thymic Atypical Carcinoid.
Wang X, Li Y, Duan J, Chen Y, Yuan B, Qi Z, Tan H
Oncologist 2019 Jun;24(6):798-802. Epub 2018 Nov 9 doi: 10.1634/theoncologist.2018-0291. PMID: 30413666Free PMC Article
Metastatic thymic carcinoid responds to chemoradiation and octreotide: A case report.
Mei Z, Wang H, Ren S, Wei J, Gu Y
Medicine (Baltimore) 2018 Nov;97(47):e13286. doi: 10.1097/MD.0000000000013286. PMID: 30461637Free PMC Article
Capecitabine and Celecoxib as a Promising Therapy for Thymic Neoplasms.
Wood K, Byron E, Janisch L, Salgia R, Sharma MR
Am J Clin Oncol 2018 Oct;41(10):963-966. doi: 10.1097/COC.0000000000000400. PMID: 28654574Free PMC Article
Efficacy and safety of long-acting pasireotide or everolimus alone or in combination in patients with advanced carcinoids of the lung and thymus (LUNA): an open-label, multicentre, randomised, phase 2 trial.
Ferolla P, Brizzi MP, Meyer T, Mansoor W, Mazieres J, Do Cao C, Léna H, Berruti A, Damiano V, Buikhuisen W, Grønbæk H, Lombard-Bohas C, Grohé C, Minotti V, Tiseo M, De Castro J, Reed N, Gislimberti G, Singh N, Stankovic M, Öberg K, Baudin E
Lancet Oncol 2017 Dec;18(12):1652-1664. Epub 2017 Oct 23 doi: 10.1016/S1470-2045(17)30681-2. PMID: 29074099

Prognosis

Metastatic thymic carcinoid responds to chemoradiation and octreotide: A case report.
Mei Z, Wang H, Ren S, Wei J, Gu Y
Medicine (Baltimore) 2018 Nov;97(47):e13286. doi: 10.1097/MD.0000000000013286. PMID: 30461637Free PMC Article
Capecitabine and Celecoxib as a Promising Therapy for Thymic Neoplasms.
Wood K, Byron E, Janisch L, Salgia R, Sharma MR
Am J Clin Oncol 2018 Oct;41(10):963-966. doi: 10.1097/COC.0000000000000400. PMID: 28654574Free PMC Article
Efficacy and safety of long-acting pasireotide or everolimus alone or in combination in patients with advanced carcinoids of the lung and thymus (LUNA): an open-label, multicentre, randomised, phase 2 trial.
Ferolla P, Brizzi MP, Meyer T, Mansoor W, Mazieres J, Do Cao C, Léna H, Berruti A, Damiano V, Buikhuisen W, Grønbæk H, Lombard-Bohas C, Grohé C, Minotti V, Tiseo M, De Castro J, Reed N, Gislimberti G, Singh N, Stankovic M, Öberg K, Baudin E
Lancet Oncol 2017 Dec;18(12):1652-1664. Epub 2017 Oct 23 doi: 10.1016/S1470-2045(17)30681-2. PMID: 29074099
Long-term survival after surgical management of neuroendocrine hepatic metastases.
Glazer ES, Tseng JF, Al-Refaie W, Solorzano CC, Liu P, Willborn KA, Abdalla EK, Vauthey JN, Curley SA
HPB (Oxford) 2010 Aug;12(6):427-33. doi: 10.1111/j.1477-2574.2010.00198.x. PMID: 20662794Free PMC Article
Neuroendocrine tumors of the thymus: a clinicopathological and prognostic study.
Gal AA, Kornstein MJ, Cohen C, Duarte IG, Miller JI, Mansour KA
Ann Thorac Surg 2001 Oct;72(4):1179-82. doi: 10.1016/s0003-4975(01)03032-6. PMID: 11603433

Clinical prediction guides

Expression of mesothelin in thymic carcinoma and its potential therapeutic significance.
Thomas A, Chen Y, Berman A, Schrump DS, Giaccone G, Pastan I, Venzon DJ, Liewehr DJ, Steinberg SM, Miettinen M, Hassan R, Rajan A
Lung Cancer 2016 Nov;101:104-110. Epub 2016 Sep 28 doi: 10.1016/j.lungcan.2016.09.015. PMID: 27794397Free PMC Article

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