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Cervical Mucoepidermoid Carcinoma

MedGen UID:
1793125
•Concept ID:
C5556684
•
Neoplastic Process

Definition

A rare carcinoma that arises from the cervix. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Mucoepidermoid Carcinoma

Professional guidelines

PubMed

Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry.
Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
The Evaluation and Management of Carcinoma of the Minor Salivary Glands.
Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489
Impact of phenotype on treatment and prognosis of laryngeal malignancies.
Ferlito A, Rinaldo A, Devaney KO, Devaney SL, Milroy CM
J Laryngol Otol 1998 Aug;112(8):710-4. doi: 10.1017/s0022215100141556. PMID: 9850312

Recent clinical studies

Etiology

A molecular guide to systemic therapy in salivary gland carcinoma.
Weaver AN, Lakritz S, Mandair D, Ulanja MB, Bowles DW
Head Neck 2023 May;45(5):1315-1326. Epub 2023 Mar 1 doi: 10.1002/hed.27307. PMID: 36859797
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
The Evaluation and Management of Carcinoma of the Minor Salivary Glands.
Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489
Outpatient Parotidectomy: A Retrospective Series.
Michel MC, Mulcahy CF, Benito DA, Patel S, Badger C, Kane S, Li NW, Goodman JF, Thakkar PG, Joshi AS
Ann Otol Rhinol Laryngol 2021 Mar;130(3):254-261. Epub 2020 Jul 16 doi: 10.1177/0003489420938101. PMID: 32672069
Sinonasal carcinomas: epidemiology, pathology, and management.
Haerle SK, Gullane PJ, Witterick IJ, Zweifel C, Gentili F
Neurosurg Clin N Am 2013 Jan;24(1):39-49. Epub 2012 Sep 10 doi: 10.1016/j.nec.2012.08.004. PMID: 23174356

Diagnosis

Molecular Mechanisms of Carcinogenesis in Pediatric Airways Tumors.
Soloperto D, Gazzini S, Cerullo R
Int J Mol Sci 2023 Jan 22;24(3) doi: 10.3390/ijms24032195. PMID: 36768522Free PMC Article
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
2021 Update on Diagnostic Markers and Translocation in Salivary Gland Tumors.
Meyer MT, Watermann C, Dreyer T, Ergün S, Karnati S
Int J Mol Sci 2021 Jun 24;22(13) doi: 10.3390/ijms22136771. PMID: 34202474Free PMC Article
The Evaluation and Management of Carcinoma of the Minor Salivary Glands.
Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489
Salivary gland malignancies in children.
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Therapy

Iodine-125 brachytherapy for the treatment of central mucoepidermoid carcinoma of the jaw in a pre-teen.
Chen Z, Liu G, Geng Y, Wu H
Int J Oral Maxillofac Surg 2022 Oct;51(10):1273-1278. Epub 2022 Feb 1 doi: 10.1016/j.ijom.2022.01.015. PMID: 35120787
Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease.
Schvartsman G, Pinto NA, Bell D, Ferrarotto R
Head Neck 2019 Jan;41(1):239-247. Epub 2018 Dec 15 doi: 10.1002/hed.25468. PMID: 30552848
Multidrug resistance in mucoepidermoid carcinoma of the parotid gland--immunohistochemical investigations of P-glycoprotein expression.
Furusaka T, Sasaki CT, Matsuda A, Susaki Y, Matsuda H, Ikeda M
Acta Otolaryngol 2013 May;133(5):552-7. Epub 2013 Jan 28 doi: 10.3109/00016489.2012.749521. PMID: 23350593
Sinonasal carcinomas: epidemiology, pathology, and management.
Haerle SK, Gullane PJ, Witterick IJ, Zweifel C, Gentili F
Neurosurg Clin N Am 2013 Jan;24(1):39-49. Epub 2012 Sep 10 doi: 10.1016/j.nec.2012.08.004. PMID: 23174356
Mucoepidermoid carcinoma of the parotid as a secondary malignancy after chemotherapy in a child with neuroblastoma.
Blatt J, Zdanski C, Scanga L, Rao KW, Morris DE, Shockley WW
J Pediatr Hematol Oncol 2013 Jul;35(5):399-401. doi: 10.1097/MPH.0b013e3182468c55. PMID: 22469948

Prognosis

Update on the Treatment of Salivary Gland Carcinomas.
Gillard DM, Farzal Z, Ryan WR
Surg Oncol Clin N Am 2024 Oct;33(4):747-760. Epub 2024 Jul 16 doi: 10.1016/j.soc.2024.04.008. PMID: 39244292
Molecular Mechanisms of Carcinogenesis in Pediatric Airways Tumors.
Soloperto D, Gazzini S, Cerullo R
Int J Mol Sci 2023 Jan 22;24(3) doi: 10.3390/ijms24032195. PMID: 36768522Free PMC Article
Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease.
Schvartsman G, Pinto NA, Bell D, Ferrarotto R
Head Neck 2019 Jan;41(1):239-247. Epub 2018 Dec 15 doi: 10.1002/hed.25468. PMID: 30552848
Primary Intraosseous Mucoepidermoid Carcinoma of the Maxilla.
Nallamilli SM, Tatapudi R, Reddy RS, Ravikanth M, Rajesh N
Ghana Med J 2015 Jun;49(2):120-3. doi: 10.4314/gmj.v49i2.10. PMID: 26339097Free PMC Article
Salivary gland malignancies in children.
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Clinical prediction guides

Iodine-125 brachytherapy for the treatment of central mucoepidermoid carcinoma of the jaw in a pre-teen.
Chen Z, Liu G, Geng Y, Wu H
Int J Oral Maxillofac Surg 2022 Oct;51(10):1273-1278. Epub 2022 Feb 1 doi: 10.1016/j.ijom.2022.01.015. PMID: 35120787
Rare Epididymal-Derived Myoepithelial Carcinoma: A Case Report and Review of Literature.
Wang K, Shi H, Mao W, Li W, Wu Z, Wang G, Yin L, Xie J, Peng B
Ann Clin Lab Sci 2020 May;50(3):391-396. PMID: 32581032
Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland.
Niu X, Fang Q, Liu F
BMC Cancer 2019 May 3;19(1):417. doi: 10.1186/s12885-019-5637-x. PMID: 31053107Free PMC Article
Salivary gland malignancies in children.
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197
The pathology of head and neck tumors: salivary glands, part 2.
Batsakis JG, Chinn E, Regezi JA, Repola DA
Head Neck Surg 1978 Nov-Dec;1(2):167-80. doi: 10.1002/hed.2890010211. PMID: 755809

Recent systematic reviews

Diagnostic Reliability of CRTC1/3::MAML2 Gene Fusion Transcripts in Discriminating Histologically Similar Intraosseous Mucoepidermoid Carcinoma from Glandular Odontogenic Cyst: A Systematic Review and Meta-analysis.
Keerthika R, Devi A, Kamboj M, Sivakumar N, Vijayakumar G, Narwal A, Girdhar A
Head Neck Pathol 2023 Mar;17(1):233-245. Epub 2022 Nov 10 doi: 10.1007/s12105-022-01494-x. PMID: 36357765Free PMC Article
Clinicopathological Predictors of Survival for Parotid Mucoepidermoid Carcinoma: A Systematic Review.
Cheng EY, Kim JH, Grose EM, Philteos J, Levin M, de Almeida J, Goldstein D
Otolaryngol Head Neck Surg 2023 Apr;168(4):611-618. Epub 2023 Feb 5 doi: 10.1177/01945998221086845. PMID: 35316125
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Clinicopathological analysis and survival outcomes of primary salivary gland tumors in pediatric patients: A systematic review.
Louredo BVR, Santos-Silva AR, Vargas PA, Ajudarte Lopes M, Martins MD, Guerra ENDS, Prado Ribeiro AC, Brandão TB, de Mendonça RMH, Kowalski LP, Speight PM, Khurram SA, Pérez-de-Oliveira ME
J Oral Pathol Med 2021 May;50(5):435-443. Epub 2021 Jan 8 doi: 10.1111/jop.13151. PMID: 33314344
Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta-analysis.
Zamani M, Grønhøj C, Schmidt Jensen J, von Buchwald C, Charabi BW, Hjuler T
Pediatr Blood Cancer 2019 Mar;66(3):e27543. Epub 2018 Oct 30 doi: 10.1002/pbc.27543. PMID: 30378272

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