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Cervical Mucoepidermoid Carcinoma

MedGen UID:: 1793125
•Concept ID:: C5556684
•: Neoplastic Process

Definition

A rare carcinoma that arises from the cervix. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCervical Mucoepidermoid Carcinoma

Reproductive system disorder
- Female reproductive system disorder
  - Female reproductive system neoplasm
    - Female reproductive organ cancer
      - Female Reproductive System Carcinoma
        Carcinoma of cervix
        Cervical Mucoepidermoid Carcinoma

Professional guidelines

PubMed

The Evaluation and Management of Carcinoma of the Minor Salivary Glands.

Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489

Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.

Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669 Free PMC Article

The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.

Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877

See all (58)

Recent clinical studies

Etiology

A molecular guide to systemic therapy in salivary gland carcinoma.

Weaver AN, Lakritz S, Mandair D, Ulanja MB, Bowles DW
Head Neck 2023 May;45(5):1315-1326. Epub 2023 Mar 1 doi: 10.1002/hed.27307. PMID: 36859797

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.

Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980 Free PMC Article

Clear Cell Neoplasms of Salivary Glands: A Diagnostic Challenge.

Skalova A, Leivo I, Hellquist H, Simpson RHW, Vander Poorten V, Willems SM, Mosaieby E, Slouka D, Ferlito A
Adv Anat Pathol 2022 Jul 1;29(4):217-226. Epub 2022 Mar 7 doi: 10.1097/PAP.0000000000000339. PMID: 35249992

The Evaluation and Management of Carcinoma of the Minor Salivary Glands.

Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489

Mucoepidermoid carcinoma of the head and neck in children.

Dombrowski ND, Wolter NE, Irace AL, Cunningham MJ, Mack JW, Marcus KJ, Vargas SO, Perez-Atayde AR, Robson CD, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 May;120:93-99. Epub 2019 Feb 10 doi: 10.1016/j.ijporl.2019.02.020. PMID: 30772619

See all (440)

Diagnosis

Top Ten Oncocytic Head and Neck Lesions to Contemplate.

Bullock MJ, Jiang XS
Head Neck Pathol 2023 Mar;17(1):53-65. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01520-y. PMID: 36928735 Free PMC Article

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.

Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980 Free PMC Article

Mucoepidermoid carcinoma of the head and neck in children.

Salivary mucoepidermoid carcinoma revisited.

Coca-Pelaz A, Rodrigo JP, Triantafyllou A, Hunt JL, Rinaldo A, Strojan P, Haigentz M Jr, Mendenhall WM, Takes RP, Vander Poorten V, Ferlito A
Eur Arch Otorhinolaryngol 2015 Apr;272(4):799-819. Epub 2014 Apr 26 doi: 10.1007/s00405-014-3053-z. PMID: 24771140

Mucoepidermoid carcinoma.

Devaraju R, Gantala R, Aitha H, Gotoor SG
BMJ Case Rep 2014 Aug 1;2014:bcr-2013-202776. doi: 10.1136/bcr-2013-202776. PMID: 25085946 Free PMC Article

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Therapy

In Vitro Carbon Ion Beam and Gemcitabine Chemoradiation in a Mucoepidermoid Carcinoma Cell Line.

Schneider T, Zwicker F, Huber PE, Debus J, Hauswald H
In Vivo 2023 Sep-Oct;37(5):1951-1959. doi: 10.21873/invivo.13291. PMID: 37652498 Free PMC Article

Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease.

Schvartsman G, Pinto NA, Bell D, Ferrarotto R
Head Neck 2019 Jan;41(1):239-247. Epub 2018 Dec 15 doi: 10.1002/hed.25468. PMID: 30552848

Systemic therapy in non-conventional cancers of the larynx.

Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903

Expanding primary cells from mucoepidermoid and other salivary gland neoplasms for genetic and chemosensitivity testing.

Alamri AM, Liu X, Blancato JK, Haddad BR, Wang W, Zhong X, Choudhary S, Krawczyk E, Kallakury BV, Davidson BJ, Furth PA
Dis Model Mech 2018 Jan 29;11(1) doi: 10.1242/dmm.031716. PMID: 29419396 Free PMC Article

Sinonasal carcinomas: epidemiology, pathology, and management.

Haerle SK, Gullane PJ, Witterick IJ, Zweifel C, Gentili F
Neurosurg Clin N Am 2013 Jan;24(1):39-49. Epub 2012 Sep 10 doi: 10.1016/j.nec.2012.08.004. PMID: 23174356

See all (82)

Prognosis

Clinicopathological characteristics of four major histological types of high-grade parotid carcinoma.

Kawata R, Kinoshita I, Jinnin T, Higashino M, Terada T, Kurisu Y, Hirose Y, Tochizawa T
Int J Clin Oncol 2023 Dec;28(12):1597-1606. Epub 2023 Oct 13 doi: 10.1007/s10147-023-02416-9. PMID: 37831230

Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical and Recurrence Biopsy Specimens.

Yamanaka S, Suzuki S, Ito H, Sivasundaram K, Hanamura I, Okubo I, Yoshikawa K, Ono S, Takahara T, Satou A, Tsuzuki T, Ueda R, Ogawa T, Fujimoto Y
Int J Mol Sci 2023 Jan 15;24(2) doi: 10.3390/ijms24021722. PMID: 36675234 Free PMC Article

Mucoepidermoid carcinoma of the head and neck: CRTC1/3 MAML 2 translocation and its prognosticators.

van Weert S, Lissenberg-Witte BI, Bloemena E, Leemans CR
Eur Arch Otorhinolaryngol 2022 May;279(5):2573-2581. Epub 2021 Aug 17 doi: 10.1007/s00405-021-07039-2. PMID: 34405264 Free PMC Article

Mucoepidermoid carcinoma of the head and neck in children.

Salivary mucoepidermoid carcinoma revisited.

See all (436)

Clinical prediction guides

Influence of Grading on Management and Outcome in Mucoepidermoid Carcinoma of the Parotid-A Multi-institutional Analysis.

Grasl S, Janik S, Faisal M, Grasl MC, Pammer J, Weinreb I, Fischer G, Kim J, Hosni A, de Almeida JR, Goldstein DP, Erovic BM
Laryngoscope 2023 Jan;133(1):124-132. Epub 2022 Apr 27 doi: 10.1002/lary.30135. PMID: 35475580

The evolving role of molecular pathology in the diagnosis of salivary gland tumours with potential pitfalls.

Kaur K, Mehta S, Vanik S, Trivedi P, Banerjee N, Dhar H, Datta S, Karanjai S
Eur Arch Otorhinolaryngol 2022 Aug;279(8):3769-3783. Epub 2022 Mar 10 doi: 10.1007/s00405-022-07326-6. PMID: 35267084

Apoptotic signaling in salivary mucoepidermoid carcinoma.

da Silva GM, Saavedra V, Ianez RCF, de Sousa EA, Gomes ÁN, Kelner N, Nagai MA, Kowalski LP, Soares FA, Lourenço SV, Coutinho-Camillo CM
Head Neck 2019 Sep;41(9):2904-2913. Epub 2019 Apr 9 doi: 10.1002/hed.25763. PMID: 30968512

Intraosseous mucoepidermoid carcinoma: Outcome review.

Merna C, Kita A, Wester J, Diaz-Aguilar D, Goldstein JD, Palma Diaz F, Blackwell K, St John MA
Laryngoscope 2018 May;128(5):1083-1092. Epub 2017 Aug 22 doi: 10.1002/lary.26832. PMID: 28833169

Salivary gland malignancies in children.

Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

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Recent systematic reviews

Diagnostic Reliability of CRTC1/3::MAML2 Gene Fusion Transcripts in Discriminating Histologically Similar Intraosseous Mucoepidermoid Carcinoma from Glandular Odontogenic Cyst: A Systematic Review and Meta-analysis.

Keerthika R, Devi A, Kamboj M, Sivakumar N, Vijayakumar G, Narwal A, Girdhar A
Head Neck Pathol 2023 Mar;17(1):233-245. Epub 2022 Nov 10 doi: 10.1007/s12105-022-01494-x. PMID: 36357765 Free PMC Article

Clinicopathological Predictors of Survival for Parotid Mucoepidermoid Carcinoma: A Systematic Review.

Cheng EY, Kim JH, Grose EM, Philteos J, Levin M, de Almeida J, Goldstein D
Otolaryngol Head Neck Surg 2023 Apr;168(4):611-618. Epub 2023 Feb 5 doi: 10.1177/01945998221086845. PMID: 35316125

Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.

Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810

Clinicopathological analysis and survival outcomes of primary salivary gland tumors in pediatric patients: A systematic review.

Louredo BVR, Santos-Silva AR, Vargas PA, Ajudarte Lopes M, Martins MD, Guerra ENDS, Prado Ribeiro AC, Brandão TB, de Mendonça RMH, Kowalski LP, Speight PM, Khurram SA, Pérez-de-Oliveira ME
J Oral Pathol Med 2021 May;50(5):435-443. Epub 2021 Jan 8 doi: 10.1111/jop.13151. PMID: 33314344

Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta-analysis.

Zamani M, Grønhøj C, Schmidt Jensen J, von Buchwald C, Charabi BW, Hjuler T
Pediatr Blood Cancer 2019 Mar;66(3):e27543. Epub 2018 Oct 30 doi: 10.1002/pbc.27543. PMID: 30378272

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Cervical Mucoepidermoid Carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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