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Ureter Urothelial Carcinoma, High Grade

MedGen UID:
1794049
•Concept ID:
C5557608
•
Neoplastic Process
Synonyms: High Grade Ureter Urothelial Carcinoma; High-Grade Ureter Urothelial Carcinoma; Ureter Urothelial Carcinoma, High-Grade

Definition

Ureter urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUreter Urothelial Carcinoma, High Grade

Professional guidelines

PubMed

Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Endoscopic Treatment of Upper Tract Urothelial Carcinoma.
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485
Ureteroscopic and percutaneous management of upper tract urothelial carcinoma (UTUC): systematic review.
Cutress ML, Stewart GD, Zakikhani P, Phipps S, Thomas BG, Tolley DA
BJU Int 2012 Sep;110(5):614-28. Epub 2012 Apr 3 doi: 10.1111/j.1464-410X.2012.11068.x. PMID: 22471401

Recent clinical studies

Etiology

Discordance Between Clinical and Pathological Staging and Grading in Upper Tract Urothelial Carcinoma.
Mori K, Katayama S, Laukhtina E, Schuettfort VM, Pradere B, Quhal F, Sari Motlagh R, Mostafaei H, Grossmann NC, Rajwa P, Zimmermann K, Karakiewicz PI, Abufaraj M, Fajkovic H, Rouprêt M, Margulis V, Enikeev DV, Egawa S, Shariat SF
Clin Genitourin Cancer 2022 Feb;20(1):95.e1-95.e6. Epub 2021 Oct 10 doi: 10.1016/j.clgc.2021.10.002. PMID: 34764007
Upper urothelial tract high-grade carcinoma: comparison of urine cytology and DNA methylation analysis in urinary samples.
Pierconti F, Martini M, Fiorentino V, Cenci T, Racioppi M, Foschi N, Di Gianfrancesco L, Sacco E, Rossi E, Larocca LM, Bassi PF
Hum Pathol 2021 Dec;118:42-48. Epub 2021 Sep 25 doi: 10.1016/j.humpath.2021.09.007. PMID: 34582934
Consultation on UTUC, Stockholm 2018: aspects of treatment.
Jung H, Giusti G, Fajkovic H, Herrmann T, Jones R, Straub M, Baard J, Osther PJS, Brehmer M
World J Urol 2019 Nov;37(11):2279-2287. Epub 2019 May 23 doi: 10.1007/s00345-019-02811-w. PMID: 31123852Free PMC Article
Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Endoscopic Treatment of Upper Tract Urothelial Carcinoma.
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485

Diagnosis

Upper urothelial tract high-grade carcinoma: comparison of urine cytology and DNA methylation analysis in urinary samples.
Pierconti F, Martini M, Fiorentino V, Cenci T, Racioppi M, Foschi N, Di Gianfrancesco L, Sacco E, Rossi E, Larocca LM, Bassi PF
Hum Pathol 2021 Dec;118:42-48. Epub 2021 Sep 25 doi: 10.1016/j.humpath.2021.09.007. PMID: 34582934
High-grade urothelial carcinoma in urine cytology: different spaces - different faces, highlighting morphologic variance.
McIntire PJ, Elsoukkary SS, Robinson BD, Siddiqui MT
J Am Soc Cytopathol 2021 Jan-Feb;10(1):36-40. Epub 2020 Aug 7 doi: 10.1016/j.jasc.2020.08.001. PMID: 32958411
Muir-Torre Syndrome.
Gamret AC, Klingbeil KD, Fertig RM, Jahan-Tigh RR, Silapunt S, Uzoma M, Gaudi S, Romanelli P
Skinmed 2020;18(6):382-384. Epub 2020 Dec 1 PMID: 33397571
Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Ureteral neoplasms.
Winalski CS, Lipman JC, Tumeh SS
Radiographics 1990 Mar;10(2):271-83. doi: 10.1148/radiographics.10.2.2183298. PMID: 2183298

Therapy

Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Consultation on UTUC, Stockholm 2018: aspects of treatment.
Jung H, Giusti G, Fajkovic H, Herrmann T, Jones R, Straub M, Baard J, Osther PJS, Brehmer M
World J Urol 2019 Nov;37(11):2279-2287. Epub 2019 May 23 doi: 10.1007/s00345-019-02811-w. PMID: 31123852Free PMC Article
Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Shao IH, Chang YH, Pang ST
Int J Urol 2019 Feb;26(2):148-159. Epub 2018 Oct 29 doi: 10.1111/iju.13826. PMID: 30372791
Ureteroscopic and percutaneous management of upper tract urothelial carcinoma (UTUC): systematic review.
Cutress ML, Stewart GD, Zakikhani P, Phipps S, Thomas BG, Tolley DA
BJU Int 2012 Sep;110(5):614-28. Epub 2012 Apr 3 doi: 10.1111/j.1464-410X.2012.11068.x. PMID: 22471401

Prognosis

Annular-shaped stenosis in the ureter: Caution should be taken.
Ming J, Wang Y, Su Z, Wang C
Urol Oncol 2022 Jun;40(6):274.e7-274.e14. Epub 2022 Mar 29 doi: 10.1016/j.urolonc.2022.01.015. PMID: 35365415
Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Discordance Between Clinical and Pathological Staging and Grading in Upper Tract Urothelial Carcinoma.
Mori K, Katayama S, Laukhtina E, Schuettfort VM, Pradere B, Quhal F, Sari Motlagh R, Mostafaei H, Grossmann NC, Rajwa P, Zimmermann K, Karakiewicz PI, Abufaraj M, Fajkovic H, Rouprêt M, Margulis V, Enikeev DV, Egawa S, Shariat SF
Clin Genitourin Cancer 2022 Feb;20(1):95.e1-95.e6. Epub 2021 Oct 10 doi: 10.1016/j.clgc.2021.10.002. PMID: 34764007
High-grade urothelial carcinoma in urine cytology: different spaces - different faces, highlighting morphologic variance.
McIntire PJ, Elsoukkary SS, Robinson BD, Siddiqui MT
J Am Soc Cytopathol 2021 Jan-Feb;10(1):36-40. Epub 2020 Aug 7 doi: 10.1016/j.jasc.2020.08.001. PMID: 32958411
Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554

Clinical prediction guides

Discordance Between Clinical and Pathological Staging and Grading in Upper Tract Urothelial Carcinoma.
Mori K, Katayama S, Laukhtina E, Schuettfort VM, Pradere B, Quhal F, Sari Motlagh R, Mostafaei H, Grossmann NC, Rajwa P, Zimmermann K, Karakiewicz PI, Abufaraj M, Fajkovic H, Rouprêt M, Margulis V, Enikeev DV, Egawa S, Shariat SF
Clin Genitourin Cancer 2022 Feb;20(1):95.e1-95.e6. Epub 2021 Oct 10 doi: 10.1016/j.clgc.2021.10.002. PMID: 34764007
Upper urothelial tract high-grade carcinoma: comparison of urine cytology and DNA methylation analysis in urinary samples.
Pierconti F, Martini M, Fiorentino V, Cenci T, Racioppi M, Foschi N, Di Gianfrancesco L, Sacco E, Rossi E, Larocca LM, Bassi PF
Hum Pathol 2021 Dec;118:42-48. Epub 2021 Sep 25 doi: 10.1016/j.humpath.2021.09.007. PMID: 34582934
High-grade urothelial carcinoma in urine cytology: different spaces - different faces, highlighting morphologic variance.
McIntire PJ, Elsoukkary SS, Robinson BD, Siddiqui MT
J Am Soc Cytopathol 2021 Jan-Feb;10(1):36-40. Epub 2020 Aug 7 doi: 10.1016/j.jasc.2020.08.001. PMID: 32958411
Preoperative multiplex nomogram for prediction of high-risk nonorgan-confined upper-tract urothelial carcinoma.
Petros FG, Qiao W, Singla N, Clinton TN, Robyak H, Raman JD, Margulis V, Matin SF
Urol Oncol 2019 Apr;37(4):292.e1-292.e9. Epub 2018 Dec 22 doi: 10.1016/j.urolonc.2018.12.002. PMID: 30584035
Endoscopic Treatment of Upper Tract Urothelial Carcinoma.
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485

Recent systematic reviews

Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Management of the Distal Ureter in Radical Laparoscopic Nephroureterectomy for Upper Tract Urothelial Carcinoma.
Whiting D, Sriprasad S
J Laparoendosc Adv Surg Tech A 2021 Jun;31(6):610-620. Epub 2020 Jul 23 doi: 10.1089/lap.2020.0420. PMID: 32716832
Segmental Ureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-analysis of Comparative Studies.
Veccia A, Antonelli A, Checcucci E, Falagario U, Carrieri G, Guruli G, De Sio M, Simeone C, Porpiglia F, Autorino R
Clin Genitourin Cancer 2020 Feb;18(1):e10-e20. Epub 2019 Oct 16 doi: 10.1016/j.clgc.2019.10.015. PMID: 31704265
Distal Ureter Management During Nephroureterectomy: Evidence from a Systematic Review and Cumulative Analysis.
Lee SM, McKay A, Grimes N, Umez-Eronini N, Aboumarzouk OM
J Endourol 2019 Apr;33(4):263-273. Epub 2019 Mar 28 doi: 10.1089/end.2018.0819. PMID: 30793934
Ureteroscopic and percutaneous management of upper tract urothelial carcinoma (UTUC): systematic review.
Cutress ML, Stewart GD, Zakikhani P, Phipps S, Thomas BG, Tolley DA
BJU Int 2012 Sep;110(5):614-28. Epub 2012 Apr 3 doi: 10.1111/j.1464-410X.2012.11068.x. PMID: 22471401

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