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Ureter Urothelial Carcinoma, High Grade

MedGen UID:
1794049
•Concept ID:
C5557608
•
Neoplastic Process
Synonyms: High Grade Ureter Urothelial Carcinoma; High-Grade Ureter Urothelial Carcinoma; Ureter Urothelial Carcinoma, High-Grade

Definition

Ureter urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUreter Urothelial Carcinoma, High Grade

Professional guidelines

PubMed

Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Endoscopic Treatment of Upper Tract Urothelial Carcinoma.
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485
Ureteroscopic and percutaneous management of upper tract urothelial carcinoma (UTUC): systematic review.
Cutress ML, Stewart GD, Zakikhani P, Phipps S, Thomas BG, Tolley DA
BJU Int 2012 Sep;110(5):614-28. Epub 2012 Apr 3 doi: 10.1111/j.1464-410X.2012.11068.x. PMID: 22471401

Recent clinical studies

Etiology

Contemporary Issues in Urothelial Carcinoma of Upper Urinary Tract.
Zhao J, Guo CC, Rao P
Adv Anat Pathol 2024 Mar 1;31(2):80-87. Epub 2023 Nov 27 doi: 10.1097/PAP.0000000000000421. PMID: 38009077Free PMC Article
Consultation on UTUC, Stockholm 2018: aspects of treatment.
Jung H, Giusti G, Fajkovic H, Herrmann T, Jones R, Straub M, Baard J, Osther PJS, Brehmer M
World J Urol 2019 Nov;37(11):2279-2287. Epub 2019 May 23 doi: 10.1007/s00345-019-02811-w. PMID: 31123852Free PMC Article
Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Endoscopic Treatment of Upper Tract Urothelial Carcinoma.
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485
Upper-tract transitional cell carcinoma.
Tawfiek ER, Bagley DH
Urology 1997 Sep;50(3):321-9. doi: 10.1016/S0090-4295(97)00230-6. PMID: 9301692

Diagnosis

Xanthogranulomatous Ureteritis: A Diagnostic Challenge in a Patient with Bladder Cancer.
Nova-Camacho LM, Val-Carreres Castellote A, Villafruela Mateos A
Int J Surg Pathol 2024 Feb;32(1):182-186. Epub 2023 May 4 doi: 10.1177/10668969231169049. PMID: 37143305
Muir-Torre Syndrome.
Gamret AC, Klingbeil KD, Fertig RM, Jahan-Tigh RR, Silapunt S, Uzoma M, Gaudi S, Romanelli P
Skinmed 2020;18(6):382-384. Epub 2020 Dec 1 PMID: 33397571
Femoral neuropathy following a psoas hitch vesicopexy.
Müller C, van Houwelingen EE, Huygen F
BMJ Case Rep 2018 Jul 25;2018 doi: 10.1136/bcr-2018-225158. PMID: 30049676Free PMC Article
Primary heterologous carcinosarcoma of the ureter with necrotic malignant polyps. Report of a case and review of the literature.
Johnin K, Kadowaki T, Kushima M, Ushida H, Koizumi S, Okada Y
Urol Int 2003;70(3):232-5. doi: 10.1159/000068757. PMID: 12660464
Ureteral neoplasms.
Winalski CS, Lipman JC, Tumeh SS
Radiographics 1990 Mar;10(2):271-83. doi: 10.1148/radiographics.10.2.2183298. PMID: 2183298

Therapy

Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Consultation on UTUC, Stockholm 2018: aspects of treatment.
Jung H, Giusti G, Fajkovic H, Herrmann T, Jones R, Straub M, Baard J, Osther PJS, Brehmer M
World J Urol 2019 Nov;37(11):2279-2287. Epub 2019 May 23 doi: 10.1007/s00345-019-02811-w. PMID: 31123852Free PMC Article
Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Femoral neuropathy following a psoas hitch vesicopexy.
Müller C, van Houwelingen EE, Huygen F
BMJ Case Rep 2018 Jul 25;2018 doi: 10.1136/bcr-2018-225158. PMID: 30049676Free PMC Article
Ureteroscopic and percutaneous management of upper tract urothelial carcinoma (UTUC): systematic review.
Cutress ML, Stewart GD, Zakikhani P, Phipps S, Thomas BG, Tolley DA
BJU Int 2012 Sep;110(5):614-28. Epub 2012 Apr 3 doi: 10.1111/j.1464-410X.2012.11068.x. PMID: 22471401

Prognosis

Contemporary Issues in Urothelial Carcinoma of Upper Urinary Tract.
Zhao J, Guo CC, Rao P
Adv Anat Pathol 2024 Mar 1;31(2):80-87. Epub 2023 Nov 27 doi: 10.1097/PAP.0000000000000421. PMID: 38009077Free PMC Article
Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Upper-tract transitional cell carcinoma.
Tawfiek ER, Bagley DH
Urology 1997 Sep;50(3):321-9. doi: 10.1016/S0090-4295(97)00230-6. PMID: 9301692
Development of upper tract carcinoma after cystectomy for bladder carcinoma.
Malkowicz SB, Skinner DG
Urology 1990 Jul;36(1):20-2. doi: 10.1016/0090-4295(90)80305-7. PMID: 2368226
Renal pelvic tumors.
Cummings KB, Correa RJ Jr, Gibbons RP, Stoll HM, Wheelis RF, Mason JT
J Urol 1975 Feb;113(2):158-62. doi: 10.1016/s0022-5347(17)59432-x. PMID: 1113408

Clinical prediction guides

Xanthogranulomatous Ureteritis: A Diagnostic Challenge in a Patient with Bladder Cancer.
Nova-Camacho LM, Val-Carreres Castellote A, Villafruela Mateos A
Int J Surg Pathol 2024 Feb;32(1):182-186. Epub 2023 May 4 doi: 10.1177/10668969231169049. PMID: 37143305
Discordance Between Clinical and Pathological Staging and Grading in Upper Tract Urothelial Carcinoma.
Mori K, Katayama S, Laukhtina E, Schuettfort VM, Pradere B, Quhal F, Sari Motlagh R, Mostafaei H, Grossmann NC, Rajwa P, Zimmermann K, Karakiewicz PI, Abufaraj M, Fajkovic H, Rouprêt M, Margulis V, Enikeev DV, Egawa S, Shariat SF
Clin Genitourin Cancer 2022 Feb;20(1):95.e1-95.e6. Epub 2021 Oct 10 doi: 10.1016/j.clgc.2021.10.002. PMID: 34764007
High-grade urothelial carcinoma in urine cytology: different spaces - different faces, highlighting morphologic variance.
McIntire PJ, Elsoukkary SS, Robinson BD, Siddiqui MT
J Am Soc Cytopathol 2021 Jan-Feb;10(1):36-40. Epub 2020 Aug 7 doi: 10.1016/j.jasc.2020.08.001. PMID: 32958411
Endoscopic Treatment of Upper Tract Urothelial Carcinoma.
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485
Total nephroureterectomy with ureteral intussusception and transurethral ureteral detachment and pull-through.
Clayman RV, Garske GL, Lange PH
Urology 1983 May;21(5):482-6. doi: 10.1016/0090-4295(83)90046-8. PMID: 6857887

Recent systematic reviews

Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Segmental Ureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-analysis of Comparative Studies.
Veccia A, Antonelli A, Checcucci E, Falagario U, Carrieri G, Guruli G, De Sio M, Simeone C, Porpiglia F, Autorino R
Clin Genitourin Cancer 2020 Feb;18(1):e10-e20. Epub 2019 Oct 16 doi: 10.1016/j.clgc.2019.10.015. PMID: 31704265
Distal Ureter Management During Nephroureterectomy: Evidence from a Systematic Review and Cumulative Analysis.
Lee SM, McKay A, Grimes N, Umez-Eronini N, Aboumarzouk OM
J Endourol 2019 Apr;33(4):263-273. Epub 2019 Mar 28 doi: 10.1089/end.2018.0819. PMID: 30793934
Oncologic Outcomes of Kidney-sparing Surgery Versus Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the EAU Non-muscle Invasive Bladder Cancer Guidelines Panel.
Seisen T, Peyronnet B, Dominguez-Escrig JL, Bruins HM, Yuan CY, Babjuk M, Böhle A, Burger M, Compérat EM, Cowan NC, Kaasinen E, Palou J, van Rhijn BW, Sylvester RJ, Zigeuner R, Shariat SF, Rouprêt M
Eur Urol 2016 Dec;70(6):1052-1068. Epub 2016 Jul 28 doi: 10.1016/j.eururo.2016.07.014. PMID: 27477528
Ureteroscopic and percutaneous management of upper tract urothelial carcinoma (UTUC): systematic review.
Cutress ML, Stewart GD, Zakikhani P, Phipps S, Thomas BG, Tolley DA
BJU Int 2012 Sep;110(5):614-28. Epub 2012 Apr 3 doi: 10.1111/j.1464-410X.2012.11068.x. PMID: 22471401

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