U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Increased susceptibility to myelodysplasia

MedGen UID:
1795920
•Concept ID:
C5563710
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased susceptibility to myelodysplasia

Professional guidelines

PubMed

Therapy related leukemias: susceptibility, prevention and treatment.
Leone G, Voso MT, Sica S, Morosetti R, Pagano L
Leuk Lymphoma 2001 Apr;41(3-4):255-76. doi: 10.3109/10428190109057981. PMID: 11378539
Increased frequency of dicentric chromosomes in therapy-related MDS and AML compared to de novo disease is significantly related to previous treatment with alkylating agents and suggests a specific susceptibility to chromosome breakage at the centromere.
Andersen MK, Pedersen-Bjergaard J
Leukemia 2000 Jan;14(1):105-11. doi: 10.1038/sj.leu.2401594. PMID: 10637484

Recent clinical studies

Etiology

Hematologic malignancies and Li-Fraumeni syndrome.
Swaminathan M, Bannon SA, Routbort M, Naqvi K, Kadia TM, Takahashi K, Alvarado Y, Ravandi-Kashani F, Patel KP, Champlin R, Kantarjian H, Strong L, DiNardo CD
Cold Spring Harb Mol Case Stud 2019 Feb;5(1) Epub 2019 Feb 1 doi: 10.1101/mcs.a003210. PMID: 30709875Free PMC Article
Risk, Risk Factors, and Surveillance of Subsequent Malignant Neoplasms in Survivors of Childhood Cancer: A Review.
Turcotte LM, Neglia JP, Reulen RC, Ronckers CM, van Leeuwen FE, Morton LM, Hodgson DC, Yasui Y, Oeffinger KC, Henderson TO
J Clin Oncol 2018 Jul 20;36(21):2145-2152. Epub 2018 Jun 6 doi: 10.1200/JCO.2017.76.7764. PMID: 29874133Free PMC Article
Genetic predisposition syndromes: when should they be considered in the work-up of MDS?
Babushok DV, Bessler M
Best Pract Res Clin Haematol 2015 Mar;28(1):55-68. Epub 2014 Nov 12 doi: 10.1016/j.beha.2014.11.004. PMID: 25659730Free PMC Article
How to approach neutropenia.
Boxer LA
Hematology Am Soc Hematol Educ Program 2012;2012:174-82. doi: 10.1182/asheducation-2012.1.174. PMID: 23233578
Therapy-related leukemia and myelodysplasia: susceptibility and incidence.
Leone G, Pagano L, Ben-Yehuda D, Voso MT
Haematologica 2007 Oct;92(10):1389-98. doi: 10.3324/haematol.11034. PMID: 17768113

Diagnosis

Genetic predisposition in acute leukaemia.
Wiggins M, Stevenson W
Int J Lab Hematol 2020 Jun;42 Suppl 1:75-81. Epub 2020 Mar 2 doi: 10.1111/ijlh.13173. PMID: 32115888
Hematologic malignancies and Li-Fraumeni syndrome.
Swaminathan M, Bannon SA, Routbort M, Naqvi K, Kadia TM, Takahashi K, Alvarado Y, Ravandi-Kashani F, Patel KP, Champlin R, Kantarjian H, Strong L, DiNardo CD
Cold Spring Harb Mol Case Stud 2019 Feb;5(1) Epub 2019 Feb 1 doi: 10.1101/mcs.a003210. PMID: 30709875Free PMC Article
Risk, Risk Factors, and Surveillance of Subsequent Malignant Neoplasms in Survivors of Childhood Cancer: A Review.
Turcotte LM, Neglia JP, Reulen RC, Ronckers CM, van Leeuwen FE, Morton LM, Hodgson DC, Yasui Y, Oeffinger KC, Henderson TO
J Clin Oncol 2018 Jul 20;36(21):2145-2152. Epub 2018 Jun 6 doi: 10.1200/JCO.2017.76.7764. PMID: 29874133Free PMC Article
SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies.
Davidsson J, Puschmann A, Tedgård U, Bryder D, Nilsson L, Cammenga J
Leukemia 2018 May;32(5):1106-1115. Epub 2018 Feb 25 doi: 10.1038/s41375-018-0074-4. PMID: 29535429Free PMC Article
Genetic predisposition syndromes: when should they be considered in the work-up of MDS?
Babushok DV, Bessler M
Best Pract Res Clin Haematol 2015 Mar;28(1):55-68. Epub 2014 Nov 12 doi: 10.1016/j.beha.2014.11.004. PMID: 25659730Free PMC Article

Therapy

Genetic predisposition syndromes: when should they be considered in the work-up of MDS?
Babushok DV, Bessler M
Best Pract Res Clin Haematol 2015 Mar;28(1):55-68. Epub 2014 Nov 12 doi: 10.1016/j.beha.2014.11.004. PMID: 25659730Free PMC Article
Therapy-related leukemia and myelodysplasia: susceptibility and incidence.
Leone G, Pagano L, Ben-Yehuda D, Voso MT
Haematologica 2007 Oct;92(10):1389-98. doi: 10.3324/haematol.11034. PMID: 17768113
Does autologous transplantation directly increase the risk of secondary leukemia in lymphoma patients?
Hake CR, Graubert TA, Fenske TS
Bone Marrow Transplant 2007 Jan;39(2):59-70. Epub 2006 Dec 4 doi: 10.1038/sj.bmt.1705547. PMID: 17143301
Therapy related leukemias: susceptibility, prevention and treatment.
Leone G, Voso MT, Sica S, Morosetti R, Pagano L
Leuk Lymphoma 2001 Apr;41(3-4):255-76. doi: 10.3109/10428190109057981. PMID: 11378539
Increased frequency of dicentric chromosomes in therapy-related MDS and AML compared to de novo disease is significantly related to previous treatment with alkylating agents and suggests a specific susceptibility to chromosome breakage at the centromere.
Andersen MK, Pedersen-Bjergaard J
Leukemia 2000 Jan;14(1):105-11. doi: 10.1038/sj.leu.2401594. PMID: 10637484

Prognosis

Somatic SF3B1 mutations in myelodysplastic syndrome with ring sideroblasts and chronic lymphocytic leukaemia.
Foy A, McMullin MF
J Clin Pathol 2019 Nov;72(11):778-782. Epub 2019 Aug 31 doi: 10.1136/jclinpath-2019-205895. PMID: 31473630
Risk, Risk Factors, and Surveillance of Subsequent Malignant Neoplasms in Survivors of Childhood Cancer: A Review.
Turcotte LM, Neglia JP, Reulen RC, Ronckers CM, van Leeuwen FE, Morton LM, Hodgson DC, Yasui Y, Oeffinger KC, Henderson TO
J Clin Oncol 2018 Jul 20;36(21):2145-2152. Epub 2018 Jun 6 doi: 10.1200/JCO.2017.76.7764. PMID: 29874133Free PMC Article
Therapy-related leukemia and myelodysplasia: susceptibility and incidence.
Leone G, Pagano L, Ben-Yehuda D, Voso MT
Haematologica 2007 Oct;92(10):1389-98. doi: 10.3324/haematol.11034. PMID: 17768113
Does autologous transplantation directly increase the risk of secondary leukemia in lymphoma patients?
Hake CR, Graubert TA, Fenske TS
Bone Marrow Transplant 2007 Jan;39(2):59-70. Epub 2006 Dec 4 doi: 10.1038/sj.bmt.1705547. PMID: 17143301
Monosomy 7 and 7q--associated with myeloid malignancy.
Johnson E, Cotter FE
Blood Rev 1997 Mar;11(1):46-55. doi: 10.1016/s0268-960x(97)90006-0. PMID: 9218106

Clinical prediction guides

Risk of subsequent myeloid neoplasms after radiotherapy treatment for a solid cancer among adults in the United States, 2000-2014.
Teepen JC, Curtis RE, Dores GM, Berrington de Gonzalez A, van den Heuvel-Eibrink MM, Kremer LCM, Gilbert ES, van Leeuwen FE, Ronckers CM, Morton LM
Leukemia 2018 Dec;32(12):2580-2589. Epub 2018 May 24 doi: 10.1038/s41375-018-0149-2. PMID: 29795414
MicroRNAs and tRNA-derived fragments predict the transformation of myelodysplastic syndromes to acute myeloid leukemia.
Guo Y, Strickland SA, Mohan S, Li S, Bosompem A, Vickers KC, Zhao S, Sheng Q, Kim AS
Leuk Lymphoma 2017 Sep;58(9):1-15. Epub 2017 Jan 13 doi: 10.1080/10428194.2016.1272680. PMID: 28084850Free PMC Article
Glutathione S-transferase theta 1 gene deletion and risk of acute myeloid leukemia.
Crump C, Chen C, Appelbaum FR, Kopecky KJ, Schwartz SM, Willman CL, Slovak ML, Weiss NS
Cancer Epidemiol Biomarkers Prev 2000 May;9(5):457-60. PMID: 10815689
Increased frequency of dicentric chromosomes in therapy-related MDS and AML compared to de novo disease is significantly related to previous treatment with alkylating agents and suggests a specific susceptibility to chromosome breakage at the centromere.
Andersen MK, Pedersen-Bjergaard J
Leukemia 2000 Jan;14(1):105-11. doi: 10.1038/sj.leu.2401594. PMID: 10637484
Leukaemogenesis, gene interplay, and the role of the haemopoietic environment.
Lawler M
Radiat Oncol Investig 1997;5(3):154-7. doi: 10.1002/(sici)1520-6823(1997)5:3<154::aid-roi14>3.0.co;2-6. PMID: 9303075

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...