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Morbid obesity

MedGen UID:
18128
Concept ID:
C0028756
Disease or Syndrome
Synonym: OBESITY, SEVERE
SNOMED CT: Severe obesity (83911000119104); Morbid obesity (238136002)
 
Monarch Initiative: MONDO:0005139
OMIM®: 601487; 602044

Definition

An excess of body weight, normally defined as an individual with a body mass index greater than 35 or a body weight greater than one hundred percent of ideal body weight. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMorbid obesity

Professional guidelines

PubMed

Glueck CJ, Goldenberg N
Metabolism 2019 Mar;92:108-120. Epub 2018 Nov 13 doi: 10.1016/j.metabol.2018.11.002. PMID: 30445140
Reich-Schupke S, Schmeller W, Brauer WJ, Cornely ME, Faerber G, Ludwig M, Lulay G, Miller A, Rapprich S, Richter DF, Schacht V, Schrader K, Stücker M, Ure C
J Dtsch Dermatol Ges 2017 Jul;15(7):758-767. doi: 10.1111/ddg.13036. PMID: 28677175
Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, Toplak H; Obesity Management Task Force of the European Association for the Study of Obesity
Obes Facts 2015;8(6):402-24. Epub 2015 Dec 5 doi: 10.1159/000442721. PMID: 26641646Free PMC Article

Recent clinical studies

Etiology

Hardt K, Wappler F
Dtsch Arztebl Int 2023 Nov 17;120(46):779-785. doi: 10.3238/arztebl.m2023.0216. PMID: 37874129Free PMC Article
Opoku AA, Onifade RA, Odukoya OA
Best Pract Res Clin Obstet Gynaecol 2023 Aug;90:102379. Epub 2023 Jun 25 doi: 10.1016/j.bpobgyn.2023.102379. PMID: 37473647
Cătoi AF, Busetto L
Obes Surg 2019 Sep;29(9):2989-3000. doi: 10.1007/s11695-019-03964-8. PMID: 31273650
Persaud SR, Lieber AC, Donath E, Stingone JA, Dangayach NS, Zhang X, Mocco J, Kellner CP
Stroke 2019 Apr;50(4):999-1002. doi: 10.1161/STROKEAHA.119.024638. PMID: 30879440
Tsai A, Schumann R
Curr Opin Anaesthesiol 2016 Feb;29(1):103-8. doi: 10.1097/ACO.0000000000000279. PMID: 26595547

Diagnosis

Svanevik M, Lorentzen J, Borgeraas H, Sandbu R, Seip B, Medhus AW, Hertel JK, Kolotkin RL, Småstuen MC, Hofsø D, Hjelmesæth J
Lancet Diabetes Endocrinol 2023 Aug;11(8):555-566. Epub 2023 Jul 3 doi: 10.1016/S2213-8587(23)00127-4. PMID: 37414071
Stenberg E, Thorell A
Curr Opin Clin Nutr Metab Care 2020 Jul;23(4):255-261. doi: 10.1097/MCO.0000000000000657. PMID: 32205577
Gorodner V, Viscido G, Signorini F, Obeide L, Moser F
Updates Surg 2018 Sep;70(3):331-337. Epub 2018 Aug 24 doi: 10.1007/s13304-018-0579-4. PMID: 30143983
Ledford DK, Craig TJ
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1427-1429. doi: 10.1016/j.jaip.2018.05.009. PMID: 30033921
Wesp JA, Farrell TM
Am Surg 2018 Apr 1;84(4):501-505. PMID: 29712596

Therapy

Salminen P, Grönroos S, Helmiö M, Hurme S, Juuti A, Juusela R, Peromaa-Haavisto P, Leivonen M, Nuutila P, Ovaska J
JAMA Surg 2022 Aug 1;157(8):656-666. doi: 10.1001/jamasurg.2022.2229. PMID: 35731535Free PMC Article
Ellingjord-Dale M, Papadimitriou N, Katsoulis M, Yee C, Dimou N, Gill D, Aune D, Ong JS, MacGregor S, Elsworth B, Lewis SJ, Martin RM, Riboli E, Tsilidis KK
PLoS One 2021;16(1):e0236904. Epub 2021 Jan 19 doi: 10.1371/journal.pone.0236904. PMID: 33465101Free PMC Article
Peterli R, Wölnerhanssen BK, Peters T, Vetter D, Kröll D, Borbély Y, Schultes B, Beglinger C, Drewe J, Schiesser M, Nett P, Bueter M
JAMA 2018 Jan 16;319(3):255-265. doi: 10.1001/jama.2017.20897. PMID: 29340679Free PMC Article
Colquitt JL, Pickett K, Loveman E, Frampton GK
Cochrane Database Syst Rev 2014 Aug 8;2014(8):CD003641. doi: 10.1002/14651858.CD003641.pub4. PMID: 25105982Free PMC Article
De Miguel-Etayo P, Bueno G, Garagorri JM, Moreno LA
World Rev Nutr Diet 2013;108:98-106. Epub 2013 Sep 6 doi: 10.1159/000351493. PMID: 24029793

Prognosis

Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Kim TL, Jeong GH, Yang JW, Lee KH, Kronbichler A, van der Vliet HJ, Grosso G, Galvano F, Aune D, Kim JY, Veronese N, Stubbs B, Solmi M, Koyanagi A, Hong SH, Dragioti E, Cho E, de Rezende LFM, Giovannucci EL, Shin JI, Gamerith G
Adv Nutr 2020 Nov 16;11(6):1437-1452. doi: 10.1093/advances/nmaa077. PMID: 32667980Free PMC Article
Pincus D, Jenkinson R, Paterson M, Leroux T, Ravi B
JAMA 2020 Mar 17;323(11):1070-1076. doi: 10.1001/jama.2020.0785. PMID: 32181847Free PMC Article
Neuenschwander M, Ballon A, Weber KS, Norat T, Aune D, Schwingshackl L, Schlesinger S
BMJ 2019 Jul 3;366:l2368. doi: 10.1136/bmj.l2368. PMID: 31270064Free PMC Article
Kinlen D, Cody D, O'Shea D
QJM 2018 Jul 1;111(7):437-443. doi: 10.1093/qjmed/hcx152. PMID: 29025162

Clinical prediction guides

Tavaglione F, Jamialahmadi O, De Vincentis A, Qadri S, Mowlaei ME, Mancina RM, Ciociola E, Carotti S, Perrone G, Bruni V, Gallo IF, Tuccinardi D, Bianco C, Prati D, Manfrini S, Pozzilli P, Picardi A, Caricato M, Yki-Järvinen H, Valenti L, Vespasiani-Gentilucci U, Romeo S
Clin Gastroenterol Hepatol 2023 Jun;21(6):1523-1532.e1. Epub 2022 Apr 11 doi: 10.1016/j.cgh.2022.03.044. PMID: 35421583
Vujasinovic M, Valente R, Thorell A, Rutkowski W, Haas SL, Arnelo U, Martin L, Löhr JM
Nutrients 2017 Nov 13;9(11) doi: 10.3390/nu9111241. PMID: 29137169Free PMC Article
Marek RJ, Ben-Porath YS, Heinberg LJ
Obes Rev 2016 Feb;17(2):126-41. doi: 10.1111/obr.12356. PMID: 26783067
Shimon I
Pituitary 2015 Apr;18(2):201-5. doi: 10.1007/s11102-015-0634-9. PMID: 25578150
Cole TJ, Lobstein T
Pediatr Obes 2012 Aug;7(4):284-94. Epub 2012 Jun 19 doi: 10.1111/j.2047-6310.2012.00064.x. PMID: 22715120

Recent systematic reviews

Docimo S Jr, Aylward L, Albaugh VL, Afaneh C, El Djouzi S, Ali M, Altieri MS, Carter J; American Society for Metabolic and Bariatric Surgery Clinical Issues Committee
Surg Obes Relat Dis 2023 Nov;19(11):1205-1218. Epub 2023 Sep 16 doi: 10.1016/j.soard.2023.08.020. PMID: 37813705
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Hardt L, Mahamat-Saleh Y, Aune D, Schlesinger S
Curr Nutr Rep 2022 Dec;11(4):695-716. Epub 2022 Sep 23 doi: 10.1007/s13668-022-00440-1. PMID: 36138327Free PMC Article
Bendor CD, Bardugo A, Pinhas-Hamiel O, Afek A, Twig G
Cardiovasc Diabetol 2020 Jun 13;19(1):79. doi: 10.1186/s12933-020-01052-1. PMID: 32534575Free PMC Article
Fonseca-Junior SJ, Sá CG, Rodrigues PA, Oliveira AJ, Fernandes-Filho J
Arq Bras Cir Dig 2013;26 Suppl 1:67-73. doi: 10.1590/s0102-67202013000600015. PMID: 24463903

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