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Morbid obesity

MedGen UID:
18128
Concept ID:
C0028756
Disease or Syndrome
Synonym: OBESITY, SEVERE
SNOMED CT: Severe obesity (83911000119104); Morbid obesity (238136002)
 
Monarch Initiative: MONDO:0005139
OMIM®: 601487; 602044

Definition

An excess of body weight, normally defined as an individual with a body mass index greater than 35 or a body weight greater than one hundred percent of ideal body weight. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMorbid obesity

Professional guidelines

PubMed

Glueck CJ, Goldenberg N
Metabolism 2019 Mar;92:108-120. Epub 2018 Nov 13 doi: 10.1016/j.metabol.2018.11.002. PMID: 30445140
Aller R, Fernández-Rodríguez C, Lo Iacono O, Bañares R, Abad J, Carrión JA, García-Monzón C, Caballería J, Berenguer M, Rodríguez-Perálvarez M, Miranda JL, Vilar-Gómez E, Crespo J, García-Cortés M, Reig M, Navarro JM, Gallego R, Genescà J, Arias-Loste MT, Pareja MJ, Albillos A, Muntané J, Jorquera F, Solà E, Hernández-Guerra M, Rojo MÁ, Salmerón J, Caballería L, Diago M, Molina E, Bataller R, Romero-Gómez M
Gastroenterol Hepatol 2018 May;41(5):328-349. Epub 2018 Apr 7 doi: 10.1016/j.gastrohep.2017.12.003. PMID: 29631866
Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, Toplak H; Obesity Management Task Force of the European Association for the Study of Obesity
Obes Facts 2015;8(6):402-24. Epub 2015 Dec 5 doi: 10.1159/000442721. PMID: 26641646Free PMC Article

Recent clinical studies

Etiology

Hardt K, Wappler F
Dtsch Arztebl Int 2023 Nov 17;120(46):779-785. doi: 10.3238/arztebl.m2023.0216. PMID: 37874129Free PMC Article
Purcell S, Hossain I, Evans B, Porter G, Richardson G, Ellsmere J
J Gastrointest Surg 2022 Jul;26(7):1388-1393. Epub 2022 Feb 24 doi: 10.1007/s11605-022-05272-6. PMID: 35211834Free PMC Article
Cătoi AF, Busetto L
Obes Surg 2019 Sep;29(9):2989-3000. doi: 10.1007/s11695-019-03964-8. PMID: 31273650
Tsai A, Schumann R
Curr Opin Anaesthesiol 2016 Feb;29(1):103-8. doi: 10.1097/ACO.0000000000000279. PMID: 26595547
Dumon KR, Murayama KM
Surg Clin North Am 2011 Dec;91(6):1313-38, x. doi: 10.1016/j.suc.2011.08.014. PMID: 22054156

Diagnosis

Stenberg E, Thorell A
Curr Opin Clin Nutr Metab Care 2020 Jul;23(4):255-261. doi: 10.1097/MCO.0000000000000657. PMID: 32205577
Gorodner V, Viscido G, Signorini F, Obeide L, Moser F
Updates Surg 2018 Sep;70(3):331-337. Epub 2018 Aug 24 doi: 10.1007/s13304-018-0579-4. PMID: 30143983
Ledford DK, Craig TJ
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1427-1429. doi: 10.1016/j.jaip.2018.05.009. PMID: 30033921
Wesp JA, Farrell TM
Am Surg 2018 Apr 1;84(4):501-505. PMID: 29712596
Lim CH, Jahansouz C, Abraham AA, Leslie DB, Ikramuddin S
Expert Rev Gastroenterol Hepatol 2016 Jul;10(7):777-84. Epub 2016 Apr 6 doi: 10.1586/17474124.2016.1169921. PMID: 27027414

Therapy

Salminen P, Grönroos S, Helmiö M, Hurme S, Juuti A, Juusela R, Peromaa-Haavisto P, Leivonen M, Nuutila P, Ovaska J
JAMA Surg 2022 Aug 1;157(8):656-666. doi: 10.1001/jamasurg.2022.2229. PMID: 35731535Free PMC Article
Peterli R, Wölnerhanssen BK, Peters T, Vetter D, Kröll D, Borbély Y, Schultes B, Beglinger C, Drewe J, Schiesser M, Nett P, Bueter M
JAMA 2018 Jan 16;319(3):255-265. doi: 10.1001/jama.2017.20897. PMID: 29340679Free PMC Article
Drug Ther Bull 2017 Nov;55(11):126-129. doi: 10.1136/dtb.2017.11.0550. PMID: 29117992
Colquitt JL, Pickett K, Loveman E, Frampton GK
Cochrane Database Syst Rev 2014 Aug 8;2014(8):CD003641. doi: 10.1002/14651858.CD003641.pub4. PMID: 25105982Free PMC Article
De Miguel-Etayo P, Bueno G, Garagorri JM, Moreno LA
World Rev Nutr Diet 2013;108:98-106. Epub 2013 Sep 6 doi: 10.1159/000351493. PMID: 24029793

Prognosis

Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Kim TL, Jeong GH, Yang JW, Lee KH, Kronbichler A, van der Vliet HJ, Grosso G, Galvano F, Aune D, Kim JY, Veronese N, Stubbs B, Solmi M, Koyanagi A, Hong SH, Dragioti E, Cho E, de Rezende LFM, Giovannucci EL, Shin JI, Gamerith G
Adv Nutr 2020 Nov 16;11(6):1437-1452. doi: 10.1093/advances/nmaa077. PMID: 32667980Free PMC Article
Pincus D, Jenkinson R, Paterson M, Leroux T, Ravi B
JAMA 2020 Mar 17;323(11):1070-1076. doi: 10.1001/jama.2020.0785. PMID: 32181847Free PMC Article
Neuenschwander M, Ballon A, Weber KS, Norat T, Aune D, Schwingshackl L, Schlesinger S
BMJ 2019 Jul 3;366:l2368. doi: 10.1136/bmj.l2368. PMID: 31270064Free PMC Article
Kinlen D, Cody D, O'Shea D
QJM 2018 Jul 1;111(7):437-443. doi: 10.1093/qjmed/hcx152. PMID: 29025162

Clinical prediction guides

Meneses D, Olveira A, Corripio R, Méndez MDC, Romero M, Calvo-Viñuelas I, Herranz L, Vicent D, de-Cos-Blanco AI
Endocrinol Diabetes Nutr (Engl Ed) 2022 Mar;69(3):178-188. doi: 10.1016/j.endien.2022.02.017. PMID: 35396116
Belligoli A, Bettini S, Segato G, Busetto L
Curr Obes Rep 2020 Sep;9(3):373-379. doi: 10.1007/s13679-020-00390-1. PMID: 32542590
Vujasinovic M, Valente R, Thorell A, Rutkowski W, Haas SL, Arnelo U, Martin L, Löhr JM
Nutrients 2017 Nov 13;9(11) doi: 10.3390/nu9111241. PMID: 29137169Free PMC Article
Shimon I
Pituitary 2015 Apr;18(2):201-5. doi: 10.1007/s11102-015-0634-9. PMID: 25578150
Cole TJ, Lobstein T
Pediatr Obes 2012 Aug;7(4):284-94. Epub 2012 Jun 19 doi: 10.1111/j.2047-6310.2012.00064.x. PMID: 22715120

Recent systematic reviews

Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Hardt L, Mahamat-Saleh Y, Aune D, Schlesinger S
Curr Nutr Rep 2022 Dec;11(4):695-716. Epub 2022 Sep 23 doi: 10.1007/s13668-022-00440-1. PMID: 36138327Free PMC Article
Bendor CD, Bardugo A, Pinhas-Hamiel O, Afek A, Twig G
Cardiovasc Diabetol 2020 Jun 13;19(1):79. doi: 10.1186/s12933-020-01052-1. PMID: 32534575Free PMC Article
Kolotkin RL, Andersen JR
Clin Obes 2017 Oct;7(5):273-289. Epub 2017 Jul 10 doi: 10.1111/cob.12203. PMID: 28695722Free PMC Article
Fonseca-Junior SJ, Sá CG, Rodrigues PA, Oliveira AJ, Fernandes-Filho J
Arq Bras Cir Dig 2013;26 Suppl 1:67-73. doi: 10.1590/s0102-67202013000600015. PMID: 24463903

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