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Morbid obesity

MedGen UID:
18128
•Concept ID:
C0028756
•
Disease or Syndrome
Synonym: OBESITY, SEVERE
SNOMED CT: Severe obesity (83911000119104); Morbid obesity (238136002)
 
Monarch Initiative: MONDO:0005139
OMIM®: 601487; 602044

Definition

An excess of body weight, normally defined as an individual with a body mass index greater than 35 or a body weight greater than one hundred percent of ideal body weight. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMorbid obesity

Professional guidelines

PubMed

Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics.
Glueck CJ, Goldenberg N
Metabolism 2019 Mar;92:108-120. Epub 2018 Nov 13 doi: 10.1016/j.metabol.2018.11.002. PMID: 30445140
Consensus document. Management of non-alcoholic fatty liver disease (NAFLD). Clinical practice guideline.
Aller R, Fernández-Rodríguez C, Lo Iacono O, Bañares R, Abad J, Carrión JA, García-Monzón C, Caballería J, Berenguer M, Rodríguez-Perálvarez M, Miranda JL, Vilar-Gómez E, Crespo J, García-Cortés M, Reig M, Navarro JM, Gallego R, Genescà J, Arias-Loste MT, Pareja MJ, Albillos A, Muntané J, Jorquera F, Solà E, Hernández-Guerra M, Rojo MÁ, Salmerón J, Caballería L, Diago M, Molina E, Bataller R, Romero-Gómez M
Gastroenterol Hepatol 2018 May;41(5):328-349. Epub 2018 Apr 7 doi: 10.1016/j.gastrohep.2017.12.003. PMID: 29631866
European Guidelines for Obesity Management in Adults.
Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, Toplak H; Obesity Management Task Force of the European Association for the Study of Obesity
Obes Facts 2015;8(6):402-24. Epub 2015 Dec 5 doi: 10.1159/000442721. PMID: 26641646Free PMC Article

Recent clinical studies

Etiology

Surgery for morbidly obese patients?
Irtun Ø
Tidsskr Nor Laegeforen 2023 Nov 7;143(16) Epub 2023 Nov 6 doi: 10.4045/tidsskr.23.0696. PMID: 37938007
Anesthesia for Morbidly Obese Patients.
Hardt K, Wappler F
Dtsch Arztebl Int 2023 Nov 17;120(46):779-785. doi: 10.3238/arztebl.m2023.0216. PMID: 37874129Free PMC Article
Pharmacokinetics and Dosing Regimens of Direct Oral Anticoagulants in Morbidly Obese Patients: An Updated Literature Review.
Zhao Y, Guo M, Li D, Xu W, Pan C, He C, Cui X
Clin Appl Thromb Hemost 2023 Jan-Dec;29:10760296231153638. doi: 10.1177/10760296231153638. PMID: 36760080Free PMC Article
Laparoscopic sleeve gastrectomy and gastroesophageal reflux.
Stenard F, Iannelli A
World J Gastroenterol 2015 Sep 28;21(36):10348-57. doi: 10.3748/wjg.v21.i36.10348. PMID: 26420961Free PMC Article
Surgical treatment of morbid obesity.
Crookes PF
Annu Rev Med 2006;57:243-64. doi: 10.1146/annurev.med.56.062904.144928. PMID: 16409148

Diagnosis

Recurrent Angioedema.
Ledford DK, Craig TJ
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1427-1429. doi: 10.1016/j.jaip.2018.05.009. PMID: 30033921
Understanding the role of psychopathology in bariatric surgery outcomes.
Marek RJ, Ben-Porath YS, Heinberg LJ
Obes Rev 2016 Feb;17(2):126-41. doi: 10.1111/obr.12356. PMID: 26783067
Laparoscopic sleeve gastrectomy and gastroesophageal reflux.
Stenard F, Iannelli A
World J Gastroenterol 2015 Sep 28;21(36):10348-57. doi: 10.3748/wjg.v21.i36.10348. PMID: 26420961Free PMC Article
Nonalcoholic fatty liver disease and bariatric surgery in adolescents.
Holterman A, Gurria J, Tanpure S, DiSomma N
Semin Pediatr Surg 2014 Feb;23(1):49-57. Epub 2013 Oct 31 doi: 10.1053/j.sempedsurg.2013.10.016. PMID: 24491369
Treating morbid obesity.
Pettit E
RN 2009 Feb;72(2):30-4; quiz 35. PMID: 19283941

Therapy

Effect of Laparoscopic Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass on Weight Loss, Comorbidities, and Reflux at 10 Years in Adult Patients With Obesity: The SLEEVEPASS Randomized Clinical Trial.
Salminen P, Grönroos S, Helmiö M, Hurme S, Juuti A, Juusela R, Peromaa-Haavisto P, Leivonen M, Nuutila P, Ovaska J
JAMA Surg 2022 Aug 1;157(8):656-666. doi: 10.1001/jamasurg.2022.2229. PMID: 35731535Free PMC Article
Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid Obesity: The SM-BOSS Randomized Clinical Trial.
Peterli R, Wölnerhanssen BK, Peters T, Vetter D, Kröll D, Borbély Y, Schultes B, Beglinger C, Drewe J, Schiesser M, Nett P, Bueter M
JAMA 2018 Jan 16;319(3):255-265. doi: 10.1001/jama.2017.20897. PMID: 29340679Free PMC Article
Naltrexone/bupropion for obesity.
Drug Ther Bull 2017 Nov;55(11):126-129. doi: 10.1136/dtb.2017.11.0550. PMID: 29117992
Interventions for treating obesity in children.
De Miguel-Etayo P, Bueno G, Garagorri JM, Moreno LA
World Rev Nutr Diet 2013;108:98-106. Epub 2013 Sep 6 doi: 10.1159/000351493. PMID: 24029793
Pharmacology and obesity.
Lemmens HJ, Ingrande J
Int Anesthesiol Clin 2013 Summer;51(3):52-66. doi: 10.1097/AIA.0b013e31829a4d56. PMID: 23797645

Prognosis

Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Current status of gastroesophageal reflux disease after sleeve gastrectomy: Still a long way to go.
Tian P, Fu J, Liu Y, Bian S, Li M, Zhang M, Liu J, Jin L, Zhang Z, Zhang P
Biosci Trends 2021 Nov 21;15(5):305-312. Epub 2021 Aug 10 doi: 10.5582/bst.2021.01288. PMID: 34373428
Complications of obesity.
Kinlen D, Cody D, O'Shea D
QJM 2018 Jul 1;111(7):437-443. doi: 10.1093/qjmed/hcx152. PMID: 29025162
Obesity and cancer: at the crossroads of cellular metabolism and proliferation.
O'Rourke RW
Surg Obes Relat Dis 2014 Nov-Dec;10(6):1208-19. Epub 2014 Aug 27 doi: 10.1016/j.soard.2014.08.012. PMID: 25264328Free PMC Article
NAFLD, obesity, and bariatric surgery.
Angulo P
Gastroenterology 2006 May;130(6):1848-52. doi: 10.1053/j.gastro.2006.03.041. PMID: 16697746

Clinical prediction guides

Sleeve Gastrectomy and Diabetes: Is Cure Possible?
Andalib A, Aminian A
Adv Surg 2017 Sep;51(1):29-40. Epub 2017 Jun 2 doi: 10.1016/j.yasu.2017.03.003. PMID: 28797344
Understanding the role of psychopathology in bariatric surgery outcomes.
Marek RJ, Ben-Porath YS, Heinberg LJ
Obes Rev 2016 Feb;17(2):126-41. doi: 10.1111/obr.12356. PMID: 26783067
Self-care predictors for success post-bariatric surgery: a literature review.
Wykowski K, Krouse HJ
Gastroenterol Nurs 2013 Mar-Apr;36(2):129-35. doi: 10.1097/SGA.0b013e3182891295. PMID: 23549216
Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity.
Cole TJ, Lobstein T
Pediatr Obes 2012 Aug;7(4):284-94. Epub 2012 Jun 19 doi: 10.1111/j.2047-6310.2012.00064.x. PMID: 22715120
The electrocardiogram in morbid obesity.
Alpert MA, Terry BE, Cohen MV, Fan TM, Painter JA, Massey CV
Am J Cardiol 2000 Apr 1;85(7):908-10, A10. doi: 10.1016/s0002-9149(99)00894-2. PMID: 10758940

Recent systematic reviews

Endoscopic sleeve gastroplasty and its role in the treatment of obesity: a systematic review.
Docimo S Jr, Aylward L, Albaugh VL, Afaneh C, El Djouzi S, Ali M, Altieri MS, Carter J; American Society for Metabolic and Bariatric Surgery Clinical Issues Committee
Surg Obes Relat Dis 2023 Nov;19(11):1205-1218. Epub 2023 Sep 16 doi: 10.1016/j.soard.2023.08.020. PMID: 37813705
Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Plant-Based Diets and Cancer Prognosis: a Review of Recent Research.
Hardt L, Mahamat-Saleh Y, Aune D, Schlesinger S
Curr Nutr Rep 2022 Dec;11(4):695-716. Epub 2022 Sep 23 doi: 10.1007/s13668-022-00440-1. PMID: 36138327Free PMC Article
Treatment Options for Weight Regain or Insufficient Weight Loss After Sleeve Gastrectomy: a Systematic Review and Meta-analysis.
Franken RJ, Sluiter NR, Franken J, de Vries R, Souverein D, Gerdes VEA, de Brauw M
Obes Surg 2022 Jun;32(6):2035-2046. Epub 2022 Apr 2 doi: 10.1007/s11695-022-06020-0. PMID: 35366738
Physical exercise and morbid obesity: a systematic review.
Fonseca-Junior SJ, Sá CG, Rodrigues PA, Oliveira AJ, Fernandes-Filho J
Arq Bras Cir Dig 2013;26 Suppl 1:67-73. doi: 10.1590/s0102-67202013000600015. PMID: 24463903

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    Related information

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