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Abnormal cortical peritubular capillary morphology

MedGen UID:
1813990
•Concept ID:
C5558250
•
Anatomical Abnormality
HPO: HP:0033860

Definition

Anomalous structure of the peritubular capillaries located in the cortex of the kidney. [from HPO]

Recent clinical studies

Etiology

Tubulointerstitial fibrosis can sensitize the kidney to subsequent glomerular injury.
Lim BJ, Yang JW, Zou J, Zhong J, Matsusaka T, Pastan I, Zhang MZ, Harris RC, Yang HC, Fogo AB
Kidney Int 2017 Dec;92(6):1395-1403. Epub 2017 Jul 12 doi: 10.1016/j.kint.2017.04.010. PMID: 28709637Free PMC Article
Glomerular C4d deposits can mark structural capillary wall remodelling in thrombotic microangiopathy and transplant glomerulopathy: C4d beyond active antibody-mediated injury: a retrospective study.
Gasim AH, Chua JS, Wolterbeek R, Schmitz J, Weimer E, Singh HK, Nickeleit V
Transpl Int 2017 May;30(5):519-532. Epub 2017 Mar 23 doi: 10.1111/tri.12936. PMID: 28207978
Transplant glomerulopathy: ultrastructural abnormalities occur early in longitudinal analysis of protocol biopsies.
Wavamunno MD, O'Connell PJ, Vitalone M, Fung CL, Allen RD, Chapman JR, Nankivell BJ
Am J Transplant 2007 Dec;7(12):2757-68. Epub 2007 Oct 6 doi: 10.1111/j.1600-6143.2007.01995.x. PMID: 17924997
C-reactive protein frequently localizes in the kidney in glomerular diseases.
Nakahara C, Kanemoto K, Saito N, Oyake Y, Kamoda T, Nagata M, Matsui A
Clin Nephrol 2001 May;55(5):365-70. PMID: 11393381

Diagnosis

Glomerular C4d deposits can mark structural capillary wall remodelling in thrombotic microangiopathy and transplant glomerulopathy: C4d beyond active antibody-mediated injury: a retrospective study.
Gasim AH, Chua JS, Wolterbeek R, Schmitz J, Weimer E, Singh HK, Nickeleit V
Transpl Int 2017 May;30(5):519-532. Epub 2017 Mar 23 doi: 10.1111/tri.12936. PMID: 28207978
Fabry disease: renal biopsy-proven cases from China.
Zhang SH, Liu ZH, Zeng CH, Li SJ, Chen HP, Su J, Li LS
J Nephrol 2007 Nov-Dec;20(6):716-26. PMID: 18046674
Transplant glomerulopathy: ultrastructural abnormalities occur early in longitudinal analysis of protocol biopsies.
Wavamunno MD, O'Connell PJ, Vitalone M, Fung CL, Allen RD, Chapman JR, Nankivell BJ
Am J Transplant 2007 Dec;7(12):2757-68. Epub 2007 Oct 6 doi: 10.1111/j.1600-6143.2007.01995.x. PMID: 17924997
C4d deposition in the glomeruli and peritubular capillaries associated with transplant glomerulopathy.
Horita S, Nitta K, Kawashima M, Honda K, Onitsuka S, Tokumoto T, Tanabe K, Toma H, Nihei H, Yamaguchi Y
Clin Transplant 2003 Aug;17(4):325-30. doi: 10.1034/j.1399-0012.2003.t01-1-00014.x. PMID: 12868988
The value of electron microscopy in the diagnosis of chronic renal allograft rejection.
Ivanyi B, Kemeny E, Szederkenyi E, Marofka F, Szenohradszky P
Mod Pathol 2001 Dec;14(12):1200-8. doi: 10.1038/modpathol.3880461. PMID: 11743041

Therapy

Cell-Mediated Glomerulonephritis Without Immune Complexes in Native Kidney Biopsies: A Report of 7 Cases.
Tang X, VanBeek C, Haas M, Cook HT, Zou J, Yang H, Fogo AB
Am J Kidney Dis 2022 Sep;80(3):416-421. Epub 2021 Dec 30 doi: 10.1053/j.ajkd.2021.11.009. PMID: 34974034
Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice.
Kosugi T, Nakayama T, Li Q, Chiodo VA, Zhang L, Campbell-Thompson M, Grant M, Croker BP, Nakagawa T
Am J Physiol Renal Physiol 2010 Mar;298(3):F609-16. Epub 2009 Dec 16 doi: 10.1152/ajprenal.00377.2009. PMID: 20015944
Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathy.
Singh DK, Winocour P, Farrington K
Nat Clin Pract Nephrol 2008 Apr;4(4):216-26. Epub 2008 Feb 12 doi: 10.1038/ncpneph0757. PMID: 18268525
C4d deposition in the glomeruli and peritubular capillaries associated with transplant glomerulopathy.
Horita S, Nitta K, Kawashima M, Honda K, Onitsuka S, Tokumoto T, Tanabe K, Toma H, Nihei H, Yamaguchi Y
Clin Transplant 2003 Aug;17(4):325-30. doi: 10.1034/j.1399-0012.2003.t01-1-00014.x. PMID: 12868988
The value of electron microscopy in the diagnosis of chronic renal allograft rejection.
Ivanyi B, Kemeny E, Szederkenyi E, Marofka F, Szenohradszky P
Mod Pathol 2001 Dec;14(12):1200-8. doi: 10.1038/modpathol.3880461. PMID: 11743041

Clinical prediction guides

Glomerular C4d deposits can mark structural capillary wall remodelling in thrombotic microangiopathy and transplant glomerulopathy: C4d beyond active antibody-mediated injury: a retrospective study.
Gasim AH, Chua JS, Wolterbeek R, Schmitz J, Weimer E, Singh HK, Nickeleit V
Transpl Int 2017 May;30(5):519-532. Epub 2017 Mar 23 doi: 10.1111/tri.12936. PMID: 28207978
Fabry disease: renal biopsy-proven cases from China.
Zhang SH, Liu ZH, Zeng CH, Li SJ, Chen HP, Su J, Li LS
J Nephrol 2007 Nov-Dec;20(6):716-26. PMID: 18046674
C-reactive protein frequently localizes in the kidney in glomerular diseases.
Nakahara C, Kanemoto K, Saito N, Oyake Y, Kamoda T, Nagata M, Matsui A
Clin Nephrol 2001 May;55(5):365-70. PMID: 11393381
From segmental glomerulosclerosis to total nephron degeneration and interstitial fibrosis: a histopathological study in rat models and human glomerulopathies.
Kriz W, Hosser H, Hähnel B, Gretz N, Provoost AP
Nephrol Dial Transplant 1998 Nov;13(11):2781-98. doi: 10.1093/ndt/13.11.2781. PMID: 9829480
Three-dimensional analysis of increased vasculature around the glomerular vascular pole in diabetic nephropathy.
Min W, Yamanaka N
Virchows Arch A Pathol Anat Histopathol 1993;423(3):201-7. doi: 10.1007/BF01614771. PMID: 8236814

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