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Decreased dendritic spine number

MedGen UID:
1814113
•Concept ID:
C5558378
•
Finding
HPO: HP:0034005

Definition

An abnormal reduction in the amount of spines on a given dendrite. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased dendritic spine number

Professional guidelines

PubMed

Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer's amyloidosis.
Maiti P, Bowers Z, Bourcier-Schultz A, Morse J, Dunbar GL
Alzheimers Res Ther 2021 Feb 8;13(1):37. doi: 10.1186/s13195-021-00769-9. PMID: 33557949Free PMC Article
PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment.
Pérez-González M, Mendioroz M, Badesso S, Sucunza D, Roldan M, Espelosín M, Ursua S, Luján R, Cuadrado-Tejedor M, Garcia-Osta A
Prog Neurobiol 2020 Aug;191:101818. Epub 2020 May 5 doi: 10.1016/j.pneurobio.2020.101818. PMID: 32380223
Levodopa treatment and dendritic spine pathology.
Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414Free PMC Article

Recent clinical studies

Etiology

Endogenous PTEN-Induced Kinase 1 Regulates Dendritic Architecture and Spinogenesis.
Otero PA, Fricklas G, Nigam A, Lizama BN, Wills ZP, Johnson JW, Chu CT
J Neurosci 2022 Oct 12;42(41):7848-7860. Epub 2022 Sep 7 doi: 10.1523/JNEUROSCI.0785-22.2022. PMID: 36414008Free PMC Article
Etiology-related Degree of Sprouting of Parvalbumin-immunoreactive Axons in the Human Dentate Gyrus in Temporal Lobe Epilepsy.
Ábrahám H, Molnár JE, Sóki N, Gyimesi C, Horváth Z, Janszky J, Dóczi T, Seress L
Neuroscience 2020 Nov 10;448:55-70. Epub 2020 Sep 12 doi: 10.1016/j.neuroscience.2020.09.018. PMID: 32931846
PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment.
Pérez-González M, Mendioroz M, Badesso S, Sucunza D, Roldan M, Espelosín M, Ursua S, Luján R, Cuadrado-Tejedor M, Garcia-Osta A
Prog Neurobiol 2020 Aug;191:101818. Epub 2020 May 5 doi: 10.1016/j.pneurobio.2020.101818. PMID: 32380223
Autism spectrum disorder: neuropathology and animal models.
Varghese M, Keshav N, Jacot-Descombes S, Warda T, Wicinski B, Dickstein DL, Harony-Nicolas H, De Rubeis S, Drapeau E, Buxbaum JD, Hof PR
Acta Neuropathol 2017 Oct;134(4):537-566. Epub 2017 Jun 5 doi: 10.1007/s00401-017-1736-4. PMID: 28584888Free PMC Article
Decreased numbers of dendritic spines on cortical pyramidal neurons in human chronic alcoholism.
Ferrer I, Fábregues I, Rairiz J, Galofré E
Neurosci Lett 1986 Aug 15;69(1):115-9. doi: 10.1016/0304-3940(86)90425-8. PMID: 3748463

Diagnosis

Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer's dementia.
Byman E, Nägga K, Gustavsson AM; Netherlands Brain Bank, Andersson-Assarsson J, Hansson O, Sonestedt E, Wennström M
Alzheimers Res Ther 2020 Nov 21;12(1):158. doi: 10.1186/s13195-020-00726-y. PMID: 33220711Free PMC Article
Autism spectrum disorder: neuropathology and animal models.
Varghese M, Keshav N, Jacot-Descombes S, Warda T, Wicinski B, Dickstein DL, Harony-Nicolas H, De Rubeis S, Drapeau E, Buxbaum JD, Hof PR
Acta Neuropathol 2017 Oct;134(4):537-566. Epub 2017 Jun 5 doi: 10.1007/s00401-017-1736-4. PMID: 28584888Free PMC Article
When cortical development goes wrong: schizophrenia as a neurodevelopmental disease of microcircuits.
Garey L
J Anat 2010 Oct;217(4):324-33. doi: 10.1111/j.1469-7580.2010.01231.x. PMID: 20408906Free PMC Article
Neurons and their dendrites in frontotemporal dementia.
Ferrer I
Dement Geriatr Cogn Disord 1999;10 Suppl 1:55-60. doi: 10.1159/000051214. PMID: 10436342
Decreased numbers of dendritic spines on cortical pyramidal neurons in dementia. A quantitative Golgi study on biopsy samples.
Catalá I, Ferrer I, Galofré E, Fábregues I
Hum Neurobiol 1988;6(4):255-9. PMID: 3350705

Therapy

Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity.
Du Y, Li Y, Zhao X, Yao Y, Wang B, Zhang L, Wang G
Chin Med J (Engl) 2023 Dec 20;136(24):2983-2992. Epub 2023 Mar 30 doi: 10.1097/CM9.0000000000002647. PMID: 37000971Free PMC Article
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Hum Mol Genet 2018 Jul 15;27(14):2502-2516. doi: 10.1093/hmg/ddy154. PMID: 29701781Free PMC Article
Levodopa treatment and dendritic spine pathology.
Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414Free PMC Article
Synapse formation in the brain can be enhanced by co-administering three specific nutrients.
Wurtman RJ
Eur J Pharmacol 2017 Dec 15;817:20-21. Epub 2017 Oct 12 doi: 10.1016/j.ejphar.2017.09.038. PMID: 29031899
p38 MAP kinase inhibitors as potential therapeutic drugs for neural diseases.
Yasuda S, Sugiura H, Tanaka H, Takigami S, Yamagata K
Cent Nerv Syst Agents Med Chem 2011 Mar 1;11(1):45-59. doi: 10.2174/187152411794961040. PMID: 20812905

Prognosis

Excess Neuronal Branching Allows for Local Innervation of Specific Dendritic Compartments in Mature Cortex.
Bird AD, Deters LH, Cuntz H
Cereb Cortex 2021 Jan 5;31(2):1008-1031. doi: 10.1093/cercor/bhaa271. PMID: 33078188
PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment.
Pérez-González M, Mendioroz M, Badesso S, Sucunza D, Roldan M, Espelosín M, Ursua S, Luján R, Cuadrado-Tejedor M, Garcia-Osta A
Prog Neurobiol 2020 Aug;191:101818. Epub 2020 May 5 doi: 10.1016/j.pneurobio.2020.101818. PMID: 32380223
Stress induced neural reorganization: A conceptual framework linking depression and Alzheimer's disease.
Ross JA, Gliebus G, Van Bockstaele EJ
Prog Neuropsychopharmacol Biol Psychiatry 2018 Jul 13;85:136-151. Epub 2017 Aug 10 doi: 10.1016/j.pnpbp.2017.08.004. PMID: 28803923Free PMC Article
Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease.
Akram A, Christoffel D, Rocher AB, Bouras C, Kövari E, Perl DP, Morrison JH, Herrmann FR, Haroutunian V, Giannakopoulos P, Hof PR
Neurobiol Aging 2008 Sep;29(9):1296-307. Epub 2007 Apr 8 doi: 10.1016/j.neurobiolaging.2007.03.007. PMID: 17420070Free PMC Article
Different dendrite and dendritic spine alterations in basal and apical arbors in mutant human amyloid precursor protein transgenic mice.
Alpár A, Ueberham U, Brückner MK, Seeger G, Arendt T, Gärtner U
Brain Res 2006 Jul 12;1099(1):189-98. Epub 2006 Jun 15 doi: 10.1016/j.brainres.2006.04.109. PMID: 16781686

Clinical prediction guides

MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity.
Naulé L, Mancini A, Pereira SA, Gassaway BM, Lydeard JR, Magnotto JC, Kim HK, Liang J, Matos C, Gygi SP, Merkle FT, Carroll RS, Abreu AP, Kaiser UB
JCI Insight 2023 Apr 24;8(8) doi: 10.1172/jci.insight.164178. PMID: 37092553Free PMC Article
Etiology-related Degree of Sprouting of Parvalbumin-immunoreactive Axons in the Human Dentate Gyrus in Temporal Lobe Epilepsy.
Ábrahám H, Molnár JE, Sóki N, Gyimesi C, Horváth Z, Janszky J, Dóczi T, Seress L
Neuroscience 2020 Nov 10;448:55-70. Epub 2020 Sep 12 doi: 10.1016/j.neuroscience.2020.09.018. PMID: 32931846
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Hum Mol Genet 2018 Jul 15;27(14):2502-2516. doi: 10.1093/hmg/ddy154. PMID: 29701781Free PMC Article
The neurotrophin receptor p75 mediates gp120-induced loss of synaptic spines in aging mice.
Bachis A, Wenzel E, Boelk A, Becker J, Mocchetti I
Neurobiol Aging 2016 Oct;46:160-8. Epub 2016 Jul 13 doi: 10.1016/j.neurobiolaging.2016.07.001. PMID: 27498053Free PMC Article
Regulation of synaptic stability by AMPA receptor reverse signaling.
Ripley B, Otto S, Tiglio K, Williams ME, Ghosh A
Proc Natl Acad Sci U S A 2011 Jan 4;108(1):367-72. Epub 2010 Dec 20 doi: 10.1073/pnas.1015163108. PMID: 21173224Free PMC Article

Recent systematic reviews

Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies.
Berdenis van Berlekom A, Muflihah CH, Snijders GJLJ, MacGillavry HD, Middeldorp J, Hol EM, Kahn RS, de Witte LD
Schizophr Bull 2020 Feb 26;46(2):374-386. doi: 10.1093/schbul/sbz060. PMID: 31192350Free PMC Article
Use of human amniotic epithelial cells in mouse models of bleomycin-induced lung fibrosis: A systematic review and meta-analysis.
He F, Zhou A, Feng S
PLoS One 2018;13(5):e0197658. Epub 2018 May 17 doi: 10.1371/journal.pone.0197658. PMID: 29772024Free PMC Article

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