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Reduced circulating interleukin 21 concentration

MedGen UID:
1814329
•Concept ID:
C5676760
•
Finding
HPO: HP:0034165

Definition

An abnormally decreased concentration of interleukin 21 in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating interleukin 21 concentration

Conditions with this feature

Immunodeficiency 89 and autoimmunity
MedGen UID:
1794237
•Concept ID:
C5562027
•
Disease or Syndrome
Immunodeficiency-89 and autoimmunity (IMD89) is an autosomal recessive immune disorder characterized by adult onset of recurrent infections, allergies, microcytic anemia, and Crohn disease (see 266600) (Yang et al., 2020).
See: Condition Record
Immunodeficiency 89 and autoimmunity

Recent clinical studies

Etiology

Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC(+) CD4(+) cell levels: a surrogate marker candidate of HIV-induced intestinal damage.
Ploquin MJ, Casrouge A, Madec Y, Noël N, Jacquelin B, Huot N, Duffy D, Jochems SP, Micci L, Lécuroux C, Boufassa F, Booiman T, Garcia-Tellez T, Ghislain M, Grand RL, Lambotte O, Kootstra N, Meyer L, Goujard C, Paiardini M, Albert ML, Müller-Trutwin M
J Int AIDS Soc 2018 Jul;21(7):e25144. doi: 10.1002/jia2.25144. PMID: 29987877Free PMC Article

Diagnosis

Increased frequency of PD-1(hi)CXCR5(-) T cells and B cells in patients with newly diagnosed IgA nephropathy.
Wang X, Li T, Si R, Chen J, Qu Z, Jiang Y
Sci Rep 2020 Jan 16;10(1):492. doi: 10.1038/s41598-019-57324-8. PMID: 31949193Free PMC Article

Therapy

Long-Term Suppression of Circulating Proinflammatory Cytokines in Multiple Sclerosis Patients Following Autologous Haematopoietic Stem Cell Transplantation.
Hendrawan K, Khoo MLM, Visweswaran M, Massey JC, Withers B, Sutton I, Ma DDF, Moore JJ
Front Immunol 2021;12:782935. Epub 2022 Jan 19 doi: 10.3389/fimmu.2021.782935. PMID: 35126353Free PMC Article
Increased frequency of PD-1(hi)CXCR5(-) T cells and B cells in patients with newly diagnosed IgA nephropathy.
Wang X, Li T, Si R, Chen J, Qu Z, Jiang Y
Sci Rep 2020 Jan 16;10(1):492. doi: 10.1038/s41598-019-57324-8. PMID: 31949193Free PMC Article

Prognosis

The functional potency of natural killer cells in response to IL-2/IL-15/IL-21 stimulation is limited by a concurrent upregulation of Tim-3 in bladder cancer.
Zhang W, Feng H, Chen Q, Lu X, Ge J
Exp Cell Res 2018 Nov 15;372(2):92-98. Epub 2018 Sep 20 doi: 10.1016/j.yexcr.2018.09.013. PMID: 30243902
Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC(+) CD4(+) cell levels: a surrogate marker candidate of HIV-induced intestinal damage.
Ploquin MJ, Casrouge A, Madec Y, Noël N, Jacquelin B, Huot N, Duffy D, Jochems SP, Micci L, Lécuroux C, Boufassa F, Booiman T, Garcia-Tellez T, Ghislain M, Grand RL, Lambotte O, Kootstra N, Meyer L, Goujard C, Paiardini M, Albert ML, Müller-Trutwin M
J Int AIDS Soc 2018 Jul;21(7):e25144. doi: 10.1002/jia2.25144. PMID: 29987877Free PMC Article

Clinical prediction guides

Long-Term Suppression of Circulating Proinflammatory Cytokines in Multiple Sclerosis Patients Following Autologous Haematopoietic Stem Cell Transplantation.
Hendrawan K, Khoo MLM, Visweswaran M, Massey JC, Withers B, Sutton I, Ma DDF, Moore JJ
Front Immunol 2021;12:782935. Epub 2022 Jan 19 doi: 10.3389/fimmu.2021.782935. PMID: 35126353Free PMC Article
Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC(+) CD4(+) cell levels: a surrogate marker candidate of HIV-induced intestinal damage.
Ploquin MJ, Casrouge A, Madec Y, Noël N, Jacquelin B, Huot N, Duffy D, Jochems SP, Micci L, Lécuroux C, Boufassa F, Booiman T, Garcia-Tellez T, Ghislain M, Grand RL, Lambotte O, Kootstra N, Meyer L, Goujard C, Paiardini M, Albert ML, Müller-Trutwin M
J Int AIDS Soc 2018 Jul;21(7):e25144. doi: 10.1002/jia2.25144. PMID: 29987877Free PMC Article
Elevated circulating Th17 and follicular helper CD4(+) T cells in patients with rheumatoid arthritis.
Zhang Y, Li Y, Lv TT, Yin ZJ, Wang XB
APMIS 2015 Aug;123(8):659-66. Epub 2015 Apr 27 doi: 10.1111/apm.12399. PMID: 25912557

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