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Reduced circulating interleukin 23 concentration

MedGen UID:
1814335
•Concept ID:
C5676766
•
Finding
HPO: HP:0034171

Definition

An abnormally decreased concentration of interleukin 23 in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating interleukin 23 concentration

Conditions with this feature

Immunodeficiency 89 and autoimmunity
MedGen UID:
1794237
•Concept ID:
C5562027
•
Disease or Syndrome
Immunodeficiency-89 and autoimmunity (IMD89) is an autosomal recessive immune disorder characterized by adult onset of recurrent infections, allergies, microcytic anemia, and Crohn disease (see 266600) (Yang et al., 2020).
See: Condition Record
Immunodeficiency 89 and autoimmunity

Recent clinical studies

Etiology

Microcirculation and neutrophil-related cytokine concentrations are not altered around narrow diameter implants in T2DM patients during wound healing.
Diehl D, Kaner D, Bockholt A, Bilhan H, Friedmann A
Clin Oral Investig 2023 Mar;27(3):1167-1175. Epub 2022 Oct 13 doi: 10.1007/s00784-022-04731-3. PMID: 36229741Free PMC Article

Diagnosis

Microcirculation and neutrophil-related cytokine concentrations are not altered around narrow diameter implants in T2DM patients during wound healing.
Diehl D, Kaner D, Bockholt A, Bilhan H, Friedmann A
Clin Oral Investig 2023 Mar;27(3):1167-1175. Epub 2022 Oct 13 doi: 10.1007/s00784-022-04731-3. PMID: 36229741Free PMC Article
CD40 agonist-induced IL-12p40 potentiates hepatotoxicity.
Bonnans C, Thomas G, He W, Jung B, Chen W, Liao M, Heyen J, Buetow B, Pillai S, Matsumoto D, Chaparro-Riggers J, Salek-Ardakani S, Qu Y
J Immunother Cancer 2020 May;8(1) doi: 10.1136/jitc-2020-000624. PMID: 32474414Free PMC Article

Therapy

Ustekinumab Inhibits T Follicular Helper Cell Differentiation in Patients With Crohn's Disease.
Globig AM, Sommer NP, Wild K, Schardey J, Zoldan K, Thomann AK, Schulte LA, Schreiner R, Reindl W, Klaus J, Schempp CM, Hofmann M, Thimme R, Boettler T, Hasselblatt P
Cell Mol Gastroenterol Hepatol 2021;11(1):1-12. Epub 2020 Jul 15 doi: 10.1016/j.jcmgh.2020.07.005. PMID: 32679193Free PMC Article
CD40 agonist-induced IL-12p40 potentiates hepatotoxicity.
Bonnans C, Thomas G, He W, Jung B, Chen W, Liao M, Heyen J, Buetow B, Pillai S, Matsumoto D, Chaparro-Riggers J, Salek-Ardakani S, Qu Y
J Immunother Cancer 2020 May;8(1) doi: 10.1136/jitc-2020-000624. PMID: 32474414Free PMC Article

Prognosis

Microcirculation and neutrophil-related cytokine concentrations are not altered around narrow diameter implants in T2DM patients during wound healing.
Diehl D, Kaner D, Bockholt A, Bilhan H, Friedmann A
Clin Oral Investig 2023 Mar;27(3):1167-1175. Epub 2022 Oct 13 doi: 10.1007/s00784-022-04731-3. PMID: 36229741Free PMC Article
Effect of inhibition of interleukin-12/23 by ustekinumab on the expression of leptin and leptin receptor in human THP-1 macrophages.
Voloshyna I, Mounessa J, Carsons SE, Reiss AB
Clin Exp Dermatol 2016 Apr;41(3):308-11. Epub 2015 Jun 20 doi: 10.1111/ced.12699. PMID: 26095599Free PMC Article

Clinical prediction guides

Microcirculation and neutrophil-related cytokine concentrations are not altered around narrow diameter implants in T2DM patients during wound healing.
Diehl D, Kaner D, Bockholt A, Bilhan H, Friedmann A
Clin Oral Investig 2023 Mar;27(3):1167-1175. Epub 2022 Oct 13 doi: 10.1007/s00784-022-04731-3. PMID: 36229741Free PMC Article

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