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Increased circulating interleukin 27 concentration

MedGen UID:
1814339
•Concept ID:
C5676770
•
Finding
HPO: HP:0034175

Definition

An abnormally increased concentration of interleukin 27 in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating interleukin 27 concentration

Recent clinical studies

Etiology

Clinical characteristics and prognosis of patients with heart failure and high concentrations of interleukin-17D.
Baumhove L, Bomer N, Tromp J, van Essen BJ, Dickstein K, Cleland JG, Lang CC, Ng LL, Samani NJ, Anker SD, Metra M, van Veldhuisen DJ, van der Meer P, Voors AA
Int J Cardiol 2024 Feb 1;396:131384. Epub 2023 Sep 21 doi: 10.1016/j.ijcard.2023.131384. PMID: 37739044
Serum IL-27 levels increase in subjects with hypothyroidism and are negatively correlated with the occurrence of nonalcoholic fatty liver disease.
Wen Y, Zhang H, Yang N, Gao X, Chen Z, Liu J, Wang G
Front Endocrinol (Lausanne) 2023;14:1173826. Epub 2023 Aug 2 doi: 10.3389/fendo.2023.1173826. PMID: 37600722Free PMC Article
Interleukin 38 Protects Against Lethal Sepsis.
Xu F, Lin S, Yan X, Wang C, Tu H, Yin Y, Cao J
J Infect Dis 2018 Aug 24;218(7):1175-1184. doi: 10.1093/infdis/jiy289. PMID: 29762676
Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip.
Lind L, Siegbahn A, Lindahl B, Stenemo M, Sundström J, Ärnlöv J
Stroke 2015 Dec;46(12):3340-7. Epub 2015 Nov 5 doi: 10.1161/STROKEAHA.115.010829. PMID: 26542692

Diagnosis

Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip.
Lind L, Siegbahn A, Lindahl B, Stenemo M, Sundström J, Ärnlöv J
Stroke 2015 Dec;46(12):3340-7. Epub 2015 Nov 5 doi: 10.1161/STROKEAHA.115.010829. PMID: 26542692
Concentration of serum interleukin-27 increase in patients with lymph node metastatic gastroesophageal cancer.
Diakowska D, Lewandowski A, Markocka-Mączka K, Grabowski K
Adv Clin Exp Med 2013 Sep-Oct;22(5):683-91. PMID: 24285453

Therapy

Interleukin 38 Protects Against Lethal Sepsis.
Xu F, Lin S, Yan X, Wang C, Tu H, Yin Y, Cao J
J Infect Dis 2018 Aug 24;218(7):1175-1184. doi: 10.1093/infdis/jiy289. PMID: 29762676

Prognosis

Clinical characteristics and prognosis of patients with heart failure and high concentrations of interleukin-17D.
Baumhove L, Bomer N, Tromp J, van Essen BJ, Dickstein K, Cleland JG, Lang CC, Ng LL, Samani NJ, Anker SD, Metra M, van Veldhuisen DJ, van der Meer P, Voors AA
Int J Cardiol 2024 Feb 1;396:131384. Epub 2023 Sep 21 doi: 10.1016/j.ijcard.2023.131384. PMID: 37739044
Serum IL-27 levels increase in subjects with hypothyroidism and are negatively correlated with the occurrence of nonalcoholic fatty liver disease.
Wen Y, Zhang H, Yang N, Gao X, Chen Z, Liu J, Wang G
Front Endocrinol (Lausanne) 2023;14:1173826. Epub 2023 Aug 2 doi: 10.3389/fendo.2023.1173826. PMID: 37600722Free PMC Article
Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip.
Lind L, Siegbahn A, Lindahl B, Stenemo M, Sundström J, Ärnlöv J
Stroke 2015 Dec;46(12):3340-7. Epub 2015 Nov 5 doi: 10.1161/STROKEAHA.115.010829. PMID: 26542692

Clinical prediction guides

Serum IL-27 levels increase in subjects with hypothyroidism and are negatively correlated with the occurrence of nonalcoholic fatty liver disease.
Wen Y, Zhang H, Yang N, Gao X, Chen Z, Liu J, Wang G
Front Endocrinol (Lausanne) 2023;14:1173826. Epub 2023 Aug 2 doi: 10.3389/fendo.2023.1173826. PMID: 37600722Free PMC Article
Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip.
Lind L, Siegbahn A, Lindahl B, Stenemo M, Sundström J, Ärnlöv J
Stroke 2015 Dec;46(12):3340-7. Epub 2015 Nov 5 doi: 10.1161/STROKEAHA.115.010829. PMID: 26542692
Decreased expression of IL-27 and its correlation with Th1 and Th17 cells in progressive multiple sclerosis.
Tang SC, Fan XH, Pan QM, Sun QS, Liu Y
J Neurol Sci 2015 Jan 15;348(1-2):174-80. Epub 2014 Dec 3 doi: 10.1016/j.jns.2014.11.035. PMID: 25498842

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