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Lymphoplasmacytic lymphoma without IgM production

MedGen UID:
1814446
Concept ID:
C5680061
Neoplastic Process
Synonyms: Lymphoplasmacytic lymphoma without IgM (immunoglobulin M) production; lymphoplasmacytic lymphoma without IgM production; Lymphoplasmacytic lymphoma without immunoglobulin M production; Lymphoplasmacytic lymphoma without Immunoglobulin M production; lymphoplasmacytic lymphoma without Immunoglobulin M production
SNOMED CT: Lymphoplasmacytic lymphoma without IgM production (1255270006); Lymphoplasmacytic lymphoma without IgM (immunoglobulin M) production (1255270006); Lymphoplasmacytic lymphoma without immunoglobulin M production (1255270006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018621
Orphanet: ORPHA443159

Definition

A rare B-cell non-Hodgkin lymphoma characterised by the presence of small B-lymphocytes, plasmacytoid lymphocytes and plasma cells, and either non-secreting or secreting IgG or IgA paraproteins. The disease usually involves the bone marrow and sometimes also the spleen or lymph nodes. Patients typically present with symptoms related to anaemia. Hyperviscosity, autoimmune phenomena and B symptoms may also be observed. Mortality is higher as compared to Waldenström macroglobulinaemia. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphoplasmacytic lymphoma without IgM production

Professional guidelines

PubMed

Gertz MA
Hematol Oncol Clin North Am 2022 Apr;36(2):341-352. Epub 2022 Mar 11 doi: 10.1016/j.hoc.2021.11.001. PMID: 35282954Free PMC Article
Chakraborty R, Kapoor P, Ansell SM, Gertz MA
Expert Rev Hematol 2015 Oct;8(5):569-79. Epub 2015 Jul 2 doi: 10.1586/17474086.2015.1061427. PMID: 26138997
Dimopoulos MA, Anagnostopoulos A
Curr Treat Options Oncol 2007 Apr;8(2):144-53. doi: 10.1007/s11864-007-0016-2. PMID: 17634838

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma, 2023

Recent clinical studies

Etiology

McMaster ML
Semin Hematol 2023 Mar;60(2):65-72. Epub 2023 Mar 31 doi: 10.1053/j.seminhematol.2023.03.008. PMID: 37099032Free PMC Article
Viera S, Ludek P, Zdeněk A, Marta K, Martin Š, Sabina Š, Zdeněk K
Klin Onkol 2018 Summer;31(4):270-276. doi: 10.14735/amko2018270. PMID: 30541309
Kwaan HC
Clin Hemorheol Microcirc 2013;55(1):75-83. doi: 10.3233/CH-131691. PMID: 23455837
Morel P, Merlini G
Expert Rev Hematol 2012 Apr;5(2):187-99. doi: 10.1586/ehm.11.82. PMID: 22475287
Herrinton LJ, Weiss NS
Blood 1993 Nov 15;82(10):3148-50. PMID: 8219203

Diagnosis

McMaster ML
Semin Hematol 2023 Mar;60(2):65-72. Epub 2023 Mar 31 doi: 10.1053/j.seminhematol.2023.03.008. PMID: 37099032Free PMC Article
Gertz MA
Hematol Oncol Clin North Am 2022 Apr;36(2):341-352. Epub 2022 Mar 11 doi: 10.1016/j.hoc.2021.11.001. PMID: 35282954Free PMC Article
Viera S, Ludek P, Zdeněk A, Marta K, Martin Š, Sabina Š, Zdeněk K
Klin Onkol 2018 Summer;31(4):270-276. doi: 10.14735/amko2018270. PMID: 30541309
Sahin I, Leblebjian H, Treon SP, Ghobrial IM
Expert Rev Hematol 2014 Feb;7(1):157-68. Epub 2014 Jan 3 doi: 10.1586/17474086.2014.871494. PMID: 24405328
Morel P, Merlini G
Expert Rev Hematol 2012 Apr;5(2):187-99. doi: 10.1586/ehm.11.82. PMID: 22475287

Therapy

Gertz MA
Hematol Oncol Clin North Am 2022 Apr;36(2):341-352. Epub 2022 Mar 11 doi: 10.1016/j.hoc.2021.11.001. PMID: 35282954Free PMC Article
D'Aloiso BD, Rupchak SS, Gettle KJ, Lima C, Rush RD
J Extra Corpor Technol 2018 Jun;50(2):120-123. PMID: 29921992Free PMC Article
Novak J, Havrda M, Gaherova L, Spicka J, Kozak T
Immunopharmacol Immunotoxicol 2017 Aug;39(4):251-252. Epub 2017 May 19 doi: 10.1080/08923973.2017.1318912. PMID: 28523957
Sahin I, Leblebjian H, Treon SP, Ghobrial IM
Expert Rev Hematol 2014 Feb;7(1):157-68. Epub 2014 Jan 3 doi: 10.1586/17474086.2014.871494. PMID: 24405328
Morel P, Merlini G
Expert Rev Hematol 2012 Apr;5(2):187-99. doi: 10.1586/ehm.11.82. PMID: 22475287

Prognosis

McMaster ML
Semin Hematol 2023 Mar;60(2):65-72. Epub 2023 Mar 31 doi: 10.1053/j.seminhematol.2023.03.008. PMID: 37099032Free PMC Article
Viera S, Ludek P, Zdeněk A, Marta K, Martin Š, Sabina Š, Zdeněk K
Klin Onkol 2018 Summer;31(4):270-276. doi: 10.14735/amko2018270. PMID: 30541309
Morel P, Merlini G
Expert Rev Hematol 2012 Apr;5(2):187-99. doi: 10.1586/ehm.11.82. PMID: 22475287
Dimopoulos MA, Galani E, Matsouka C
Hematol Oncol Clin North Am 1999 Dec;13(6):1351-66. doi: 10.1016/s0889-8588(05)70130-1. PMID: 10626154
Herrinton LJ, Weiss NS
Blood 1993 Nov 15;82(10):3148-50. PMID: 8219203

Clinical prediction guides

Viera S, Ludek P, Zdeněk A, Marta K, Martin Š, Sabina Š, Zdeněk K
Klin Onkol 2018 Summer;31(4):270-276. doi: 10.14735/amko2018270. PMID: 30541309
Novak J, Havrda M, Gaherova L, Spicka J, Kozak T
Immunopharmacol Immunotoxicol 2017 Aug;39(4):251-252. Epub 2017 May 19 doi: 10.1080/08923973.2017.1318912. PMID: 28523957
Castillo JJ, Ghobrial IM, Treon SP
Cancer Treat Res 2015;165:177-95. doi: 10.1007/978-3-319-13150-4_7. PMID: 25655610
Hammarstróm L, Smith CI, Pettersson D, Mellstedt H, Holm G
Clin Exp Immunol 1981 Jan;43(1):157-64. PMID: 6788412Free PMC Article
Lough J, Shuster J
Hum Pathol 1975 Mar;6(2):251-5. doi: 10.1016/s0046-8177(75)80178-x. PMID: 807515

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma, 2023

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