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Impaired renal tubular reabsorption of glucose

MedGen UID:
1815094
•Concept ID:
C5706188
•
Pathologic Function
HPO: HP:0034357

Definition

Increased fractional excretion (FE) of glucose in the urine. The FE of glucose is the percentage of the glucose filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine glucose, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired renal tubular reabsorption of glucose

Professional guidelines

PubMed

Evaluation and Management of Hyponatremia in Heart Failure.
Mondellini GM, Verbrugge FH
Curr Heart Fail Rep 2024 Jun;21(3):252-261. Epub 2024 Feb 27 doi: 10.1007/s11897-024-00651-3. PMID: 38411885
Genotype and Phenotype of Renal Hypouricemia: A Single-Center Study from China.
Mou L, Zhu L, Chen X, Hu Y, Zhu H, Xu Y
Mol Diagn Ther 2024 Jan;28(1):87-99. Epub 2023 Nov 16 doi: 10.1007/s40291-023-00683-w. PMID: 37971623

Recent clinical studies

Etiology

METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
Yang J, Jiang T, Lu X, Li X, Zhou X, Guo X, Ma C, Xie X, Li D, Yu S, An J, Zhao B, Li H
Int Immunopharmacol 2024 Dec 25;143(Pt 1):113308. Epub 2024 Oct 10 doi: 10.1016/j.intimp.2024.113308. PMID: 39393275
Mechanisms of enhanced renal and hepatic erythropoietin synthesis by sodium-glucose cotransporter 2 inhibitors.
Packer M
Eur Heart J 2023 Dec 21;44(48):5027-5035. doi: 10.1093/eurheartj/ehad235. PMID: 37086098Free PMC Article
Deletion of insulin receptor in the proximal tubule and fasting augment albumin excretion.
Kumari M, Sharma R, Pandey G, Ecelbarger CM, Mishra P, Tiwari S
J Cell Biochem 2019 Jun;120(6):10688-10696. Epub 2019 Jan 15 doi: 10.1002/jcb.28359. PMID: 30644120
URAT1 and GLUT9 mutations in Spanish patients with renal hypouricemia.
Claverie-Martin F, Trujillo-Suarez J, Gonzalez-Acosta H, Aparicio C, Justa Roldan ML, Stiburkova B, Ichida K, Martín-Gomez MA, Herrero Goñi M, Carrasco Hidalgo-Barquero M, Iñigo V, Enriquez R, Cordoba-Lanus E, Garcia-Nieto VM; RenalTube Group
Clin Chim Acta 2018 Jun;481:83-89. Epub 2018 Feb 24 doi: 10.1016/j.cca.2018.02.030. PMID: 29486147
SGLT2 Inhibitors and the Diabetic Kidney.
Fioretto P, Zambon A, Rossato M, Busetto L, Vettor R
Diabetes Care 2016 Aug;39 Suppl 2:S165-71. doi: 10.2337/dcS15-3006. PMID: 27440829

Diagnosis

METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
Yang J, Jiang T, Lu X, Li X, Zhou X, Guo X, Ma C, Xie X, Li D, Yu S, An J, Zhao B, Li H
Int Immunopharmacol 2024 Dec 25;143(Pt 1):113308. Epub 2024 Oct 10 doi: 10.1016/j.intimp.2024.113308. PMID: 39393275
URAT1 and GLUT9 mutations in Spanish patients with renal hypouricemia.
Claverie-Martin F, Trujillo-Suarez J, Gonzalez-Acosta H, Aparicio C, Justa Roldan ML, Stiburkova B, Ichida K, Martín-Gomez MA, Herrero Goñi M, Carrasco Hidalgo-Barquero M, Iñigo V, Enriquez R, Cordoba-Lanus E, Garcia-Nieto VM; RenalTube Group
Clin Chim Acta 2018 Jun;481:83-89. Epub 2018 Feb 24 doi: 10.1016/j.cca.2018.02.030. PMID: 29486147
Diagnostic tests for primary renal hypouricemia.
Sebesta I, Stiburkova B, Bartl J, Ichida K, Hosoyamada M, Taylor J, Marinaki A
Nucleosides Nucleotides Nucleic Acids 2011 Dec;30(12):1112-6. doi: 10.1080/15257770.2011.611483. PMID: 22132965
Sympathetic nervous system and insulin resistance: from obesity to diabetes.
Esler M, Rumantir M, Wiesner G, Kaye D, Hastings J, Lambert G
Am J Hypertens 2001 Nov;14(11 Pt 2):304S-309S. doi: 10.1016/s0895-7061(01)02236-1. PMID: 11721888
Proximal tubular reabsorption of growth hormone and sodium/fluid in normo- and microalbuminuric insulin-dependent diabetes mellitus.
Turner G, Coates P, Warren S, Woodhead JS, Peters JR
Acta Diabetol 1997 Mar;34(1):27-32. doi: 10.1007/s005920050061. PMID: 9134054

Therapy

METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
Yang J, Jiang T, Lu X, Li X, Zhou X, Guo X, Ma C, Xie X, Li D, Yu S, An J, Zhao B, Li H
Int Immunopharmacol 2024 Dec 25;143(Pt 1):113308. Epub 2024 Oct 10 doi: 10.1016/j.intimp.2024.113308. PMID: 39393275
Evaluation and Management of Hyponatremia in Heart Failure.
Mondellini GM, Verbrugge FH
Curr Heart Fail Rep 2024 Jun;21(3):252-261. Epub 2024 Feb 27 doi: 10.1007/s11897-024-00651-3. PMID: 38411885
Interplay of adenosine monophosphate-activated protein kinase/sirtuin-1 activation and sodium influx inhibition mediates the renal benefits of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes: A novel conceptual framework.
Packer M
Diabetes Obes Metab 2020 May;22(5):734-742. Epub 2020 Feb 20 doi: 10.1111/dom.13961. PMID: 31916329
SGLT2 Inhibitors and the Diabetic Kidney.
Fioretto P, Zambon A, Rossato M, Busetto L, Vettor R
Diabetes Care 2016 Aug;39 Suppl 2:S165-71. doi: 10.2337/dcS15-3006. PMID: 27440829
Clinical pharmacokinetics and pharmacodynamics of the novel SGLT2 inhibitor ipragliflozin.
Kadokura T, Zhang W, Krauwinkel W, Leeflang S, Keirns J, Taniuchi Y, Nakajo I, Smulders R
Clin Pharmacokinet 2014 Nov;53(11):975-88. doi: 10.1007/s40262-014-0180-z. PMID: 25316572

Prognosis

A more tubulocentric view of diabetic kidney disease.
Zeni L, Norden AGW, Cancarini G, Unwin RJ
J Nephrol 2017 Dec;30(6):701-717. Epub 2017 Aug 24 doi: 10.1007/s40620-017-0423-9. PMID: 28840540Free PMC Article
Oxypurines, protein, glucose and the functional state of blood vasculature are markers of renal calcium stone-forming processes? Observations in men with idiopathic recurrent calcium urolithiasis.
Manoharan M, Schwille PO
Clin Chem Lab Med 2002 Mar;40(3):266-77. doi: 10.1515/CCLM.2002.043. PMID: 12005217
Development of ifosfamide-induced nephrotoxicity: prospective follow-up in 75 patients.
Rossi R, Pleyer J, Schäfers P, Kuhn N, Kleta R, Deufel T, Jürgens H
Med Pediatr Oncol 1999 Mar;32(3):177-82. doi: 10.1002/(sici)1096-911x(199903)32:3<177::aid-mpo3>3.0.co;2-h. PMID: 10064184
Proximal tubular reabsorption of growth hormone and sodium/fluid in normo- and microalbuminuric insulin-dependent diabetes mellitus.
Turner G, Coates P, Warren S, Woodhead JS, Peters JR
Acta Diabetol 1997 Mar;34(1):27-32. doi: 10.1007/s005920050061. PMID: 9134054
Tubular function and histological findings in ifosfamide-induced renal Fanconi syndrome--a report of two cases.
Rossi R, Helmchen U, Schellong G
Eur J Pediatr 1992 May;151(5):384-7. doi: 10.1007/BF02113264. PMID: 1396897

Clinical prediction guides

Mechanisms of enhanced renal and hepatic erythropoietin synthesis by sodium-glucose cotransporter 2 inhibitors.
Packer M
Eur Heart J 2023 Dec 21;44(48):5027-5035. doi: 10.1093/eurheartj/ehad235. PMID: 37086098Free PMC Article
Deletion of insulin receptor in the proximal tubule and fasting augment albumin excretion.
Kumari M, Sharma R, Pandey G, Ecelbarger CM, Mishra P, Tiwari S
J Cell Biochem 2019 Jun;120(6):10688-10696. Epub 2019 Jan 15 doi: 10.1002/jcb.28359. PMID: 30644120
A more tubulocentric view of diabetic kidney disease.
Zeni L, Norden AGW, Cancarini G, Unwin RJ
J Nephrol 2017 Dec;30(6):701-717. Epub 2017 Aug 24 doi: 10.1007/s40620-017-0423-9. PMID: 28840540Free PMC Article
Clinical pharmacokinetics and pharmacodynamics of the novel SGLT2 inhibitor ipragliflozin.
Kadokura T, Zhang W, Krauwinkel W, Leeflang S, Keirns J, Taniuchi Y, Nakajo I, Smulders R
Clin Pharmacokinet 2014 Nov;53(11):975-88. doi: 10.1007/s40262-014-0180-z. PMID: 25316572
Proximal tubular reabsorption of growth hormone and sodium/fluid in normo- and microalbuminuric insulin-dependent diabetes mellitus.
Turner G, Coates P, Warren S, Woodhead JS, Peters JR
Acta Diabetol 1997 Mar;34(1):27-32. doi: 10.1007/s005920050061. PMID: 9134054

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