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Impaired renal tubular reabsorption of glucose

MedGen UID:
1815094
Concept ID:
C5706188
Pathologic Function
HPO: HP:0034357

Definition

Increased fractional excretion (FE) of glucose in the urine. The FE of glucose is the percentage of the glucose filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine glucose, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired renal tubular reabsorption of glucose

Professional guidelines

PubMed

Mou L, Zhu L, Chen X, Hu Y, Zhu H, Xu Y
Mol Diagn Ther 2024 Jan;28(1):87-99. Epub 2023 Nov 16 doi: 10.1007/s40291-023-00683-w. PMID: 37971623

Recent clinical studies

Etiology

Packer M
Eur Heart J 2023 Dec 21;44(48):5027-5035. doi: 10.1093/eurheartj/ehad235. PMID: 37086098Free PMC Article
Kumari M, Sharma R, Pandey G, Ecelbarger CM, Mishra P, Tiwari S
J Cell Biochem 2019 Jun;120(6):10688-10696. Epub 2019 Jan 15 doi: 10.1002/jcb.28359. PMID: 30644120
Claverie-Martin F, Trujillo-Suarez J, Gonzalez-Acosta H, Aparicio C, Justa Roldan ML, Stiburkova B, Ichida K, Martín-Gomez MA, Herrero Goñi M, Carrasco Hidalgo-Barquero M, Iñigo V, Enriquez R, Cordoba-Lanus E, Garcia-Nieto VM; RenalTube Group
Clin Chim Acta 2018 Jun;481:83-89. Epub 2018 Feb 24 doi: 10.1016/j.cca.2018.02.030. PMID: 29486147
Fioretto P, Zambon A, Rossato M, Busetto L, Vettor R
Diabetes Care 2016 Aug;39 Suppl 2:S165-71. doi: 10.2337/dcS15-3006. PMID: 27440829
Pabico RC, McKenna BA, Freeman RB
Urology 1998 May;51(5A Suppl):156-60. doi: 10.1016/s0090-4295(98)00081-8. PMID: 9610573

Diagnosis

Claverie-Martin F, Trujillo-Suarez J, Gonzalez-Acosta H, Aparicio C, Justa Roldan ML, Stiburkova B, Ichida K, Martín-Gomez MA, Herrero Goñi M, Carrasco Hidalgo-Barquero M, Iñigo V, Enriquez R, Cordoba-Lanus E, Garcia-Nieto VM; RenalTube Group
Clin Chim Acta 2018 Jun;481:83-89. Epub 2018 Feb 24 doi: 10.1016/j.cca.2018.02.030. PMID: 29486147
Sebesta I, Stiburkova B, Bartl J, Ichida K, Hosoyamada M, Taylor J, Marinaki A
Nucleosides Nucleotides Nucleic Acids 2011 Dec;30(12):1112-6. doi: 10.1080/15257770.2011.611483. PMID: 22132965
Esler M, Rumantir M, Wiesner G, Kaye D, Hastings J, Lambert G
Am J Hypertens 2001 Nov;14(11 Pt 2):304S-309S. doi: 10.1016/s0895-7061(01)02236-1. PMID: 11721888
Turner G, Coates P, Warren S, Woodhead JS, Peters JR
Acta Diabetol 1997 Mar;34(1):27-32. doi: 10.1007/s005920050061. PMID: 9134054
Rossi R, Gödde A, Kleinebrand A, Riepenhausen M, Boos J, Ritter J, Jürgens H
J Clin Oncol 1994 Jan;12(1):159-65. doi: 10.1200/JCO.1994.12.1.159. PMID: 8270973

Therapy

Packer M
Diabetes Obes Metab 2020 May;22(5):734-742. Epub 2020 Feb 20 doi: 10.1111/dom.13961. PMID: 31916329
Fioretto P, Zambon A, Rossato M, Busetto L, Vettor R
Diabetes Care 2016 Aug;39 Suppl 2:S165-71. doi: 10.2337/dcS15-3006. PMID: 27440829
Kadokura T, Zhang W, Krauwinkel W, Leeflang S, Keirns J, Taniuchi Y, Nakajo I, Smulders R
Clin Pharmacokinet 2014 Nov;53(11):975-88. doi: 10.1007/s40262-014-0180-z. PMID: 25316572
Esler M, Rumantir M, Wiesner G, Kaye D, Hastings J, Lambert G
Am J Hypertens 2001 Nov;14(11 Pt 2):304S-309S. doi: 10.1016/s0895-7061(01)02236-1. PMID: 11721888
Rossi R, Gödde A, Kleinebrand A, Riepenhausen M, Boos J, Ritter J, Jürgens H
J Clin Oncol 1994 Jan;12(1):159-65. doi: 10.1200/JCO.1994.12.1.159. PMID: 8270973

Prognosis

Zeni L, Norden AGW, Cancarini G, Unwin RJ
J Nephrol 2017 Dec;30(6):701-717. Epub 2017 Aug 24 doi: 10.1007/s40620-017-0423-9. PMID: 28840540Free PMC Article
Manoharan M, Schwille PO
Clin Chem Lab Med 2002 Mar;40(3):266-77. doi: 10.1515/CCLM.2002.043. PMID: 12005217
Rossi R, Pleyer J, Schäfers P, Kuhn N, Kleta R, Deufel T, Jürgens H
Med Pediatr Oncol 1999 Mar;32(3):177-82. doi: 10.1002/(sici)1096-911x(199903)32:3<177::aid-mpo3>3.0.co;2-h. PMID: 10064184
Turner G, Coates P, Warren S, Woodhead JS, Peters JR
Acta Diabetol 1997 Mar;34(1):27-32. doi: 10.1007/s005920050061. PMID: 9134054
Rossi R, Helmchen U, Schellong G
Eur J Pediatr 1992 May;151(5):384-7. doi: 10.1007/BF02113264. PMID: 1396897

Clinical prediction guides

Packer M
Eur Heart J 2023 Dec 21;44(48):5027-5035. doi: 10.1093/eurheartj/ehad235. PMID: 37086098Free PMC Article
Kumari M, Sharma R, Pandey G, Ecelbarger CM, Mishra P, Tiwari S
J Cell Biochem 2019 Jun;120(6):10688-10696. Epub 2019 Jan 15 doi: 10.1002/jcb.28359. PMID: 30644120
Zeni L, Norden AGW, Cancarini G, Unwin RJ
J Nephrol 2017 Dec;30(6):701-717. Epub 2017 Aug 24 doi: 10.1007/s40620-017-0423-9. PMID: 28840540Free PMC Article
Kadokura T, Zhang W, Krauwinkel W, Leeflang S, Keirns J, Taniuchi Y, Nakajo I, Smulders R
Clin Pharmacokinet 2014 Nov;53(11):975-88. doi: 10.1007/s40262-014-0180-z. PMID: 25316572
Turner G, Coates P, Warren S, Woodhead JS, Peters JR
Acta Diabetol 1997 Mar;34(1):27-32. doi: 10.1007/s005920050061. PMID: 9134054

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