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Abnormal renal tubular resorption

MedGen UID:
869158
•Concept ID:
C4023578
•
Pathologic Function
Synonyms: Abnormal renal resorption; Abnormality of renal resorption
 
HPO: HP:0011038

Definition

An abnormality of renal absorption. [from HPO]

Professional guidelines

PubMed

Bone morphogenetic protein 7: a novel treatment for chronic renal and bone disease.
Li T, Surendran K, Zawaideh MA, Mathew S, Hruska KA
Curr Opin Nephrol Hypertens 2004 Jul;13(4):417-22. doi: 10.1097/01.mnh.0000133974.24935.fe. PMID: 15199292
Effect of vitamin D treatment in hypoparathyroid patients: a study on calcium, phosphate and magnesium homeostasis.
Mortensen L, Hyldstrup L, Charles P
Eur J Endocrinol 1997 Jan;136(1):52-60. doi: 10.1530/eje.0.1360052. PMID: 9037127
Management of hypercalcemia in relation to pathophysiology.
Bonjour JP, Rizzoli R, Hirschel-Scholz S, Caverzasio J
Bone 1987;8 Suppl 1:S29-33. PMID: 2825740

Recent clinical studies

Etiology

Non-crystalline light chain proximal tubulopathy, a morphologically protean entity.
Kousios A, Blakey S, Moran L, Atta M, Charif R, Duncan N, Smith A, Tam FWK, Levy JB, Chaidos A, Roufosse C
Nephrol Dial Transplant 2023 Oct 31;38(11):2576-2588. doi: 10.1093/ndt/gfad085. PMID: 37120733Free PMC Article
Spectrum of renal dysfunction after curative parathyroidectomy in symptomatic primary hyperparathyroidism.
Gosavi V, Lila A, Memon SS, Sarathi V, Goroshi M, Jamale T, Thakare S, Phadte A, Patil V, Bandgar T
Ann Endocrinol (Paris) 2023 Feb;84(1):14-20. Epub 2022 Dec 20 doi: 10.1016/j.ando.2022.10.015. PMID: 36563936
Abnormalities in biomarkers of mineral and bone metabolism in kidney donors.
Kasiske BL, Kumar R, Kimmel PL, Pesavento TE, Kalil RS, Kraus ES, Rabb H, Posselt AM, Anderson-Haag TL, Steffes MW, Israni AK, Snyder JJ, Singh RJ, Weir MR
Kidney Int 2016 Oct;90(4):861-8. Epub 2016 Jun 28 doi: 10.1016/j.kint.2016.05.012. PMID: 27370408Free PMC Article
Bone mineral density decline according to renal tubular dysfunction and phosphaturia in tenofovir-exposed HIV-infected patients.
Casado JL, Santiuste C, Vazquez M, Bañón S, Rosillo M, Gomez A, Perez-Elías MJ, Caballero C, Rey JM, Moreno S
AIDS 2016 Jun 1;30(9):1423-31. doi: 10.1097/QAD.0000000000001067. PMID: 26919733
Autosomal dominant polycystic kidney disease (ADPKD)--mechanisms of cyst formation and renal failure.
Ritz E, Zeier M, Geberth S, Waldherr R
Aust N Z J Med 1993 Feb;23(1):35-41. doi: 10.1111/j.1445-5994.1993.tb00535.x. PMID: 8460972

Diagnosis

Non-crystalline light chain proximal tubulopathy, a morphologically protean entity.
Kousios A, Blakey S, Moran L, Atta M, Charif R, Duncan N, Smith A, Tam FWK, Levy JB, Chaidos A, Roufosse C
Nephrol Dial Transplant 2023 Oct 31;38(11):2576-2588. doi: 10.1093/ndt/gfad085. PMID: 37120733Free PMC Article
Spectrum of renal dysfunction after curative parathyroidectomy in symptomatic primary hyperparathyroidism.
Gosavi V, Lila A, Memon SS, Sarathi V, Goroshi M, Jamale T, Thakare S, Phadte A, Patil V, Bandgar T
Ann Endocrinol (Paris) 2023 Feb;84(1):14-20. Epub 2022 Dec 20 doi: 10.1016/j.ando.2022.10.015. PMID: 36563936
The idiopathic hypercalciuria reviewed. Metabolic abnormality or disease?
García Nieto VM, Luis Yanes MI, Tejera Carreño P, Perez Suarez G, Moraleda Mesa T
Nefrologia (Engl Ed) 2019 Nov-Dec;39(6):592-602. Epub 2019 May 31 doi: 10.1016/j.nefro.2019.02.011. PMID: 31160051
Osteomalacic and hyperparathyroid changes in fibrous dysplasia of bone: core biopsy studies and clinical correlations.
Corsi A, Collins MT, Riminucci M, Howell PG, Boyde A, Robey PG, Bianco P
J Bone Miner Res 2003 Jul;18(7):1235-46. doi: 10.1359/jbmr.2003.18.7.1235. PMID: 12854833
Autosomal dominant polycystic kidney disease (ADPKD)--mechanisms of cyst formation and renal failure.
Ritz E, Zeier M, Geberth S, Waldherr R
Aust N Z J Med 1993 Feb;23(1):35-41. doi: 10.1111/j.1445-5994.1993.tb00535.x. PMID: 8460972

Therapy

Spectrum of renal dysfunction after curative parathyroidectomy in symptomatic primary hyperparathyroidism.
Gosavi V, Lila A, Memon SS, Sarathi V, Goroshi M, Jamale T, Thakare S, Phadte A, Patil V, Bandgar T
Ann Endocrinol (Paris) 2023 Feb;84(1):14-20. Epub 2022 Dec 20 doi: 10.1016/j.ando.2022.10.015. PMID: 36563936
Treatment of Human Immunodeficiency Virus Infection With Tenofovir Disoproxil Fumarate-Containing Antiretrovirals Maintains Low Bone Formation Rate, But Increases Osteoid Volume on Bone Histomorphometry.
Ramalho J, Martins CSW, Galvão J, Furukawa LN, Domingues WV, Oliveira IB, Dos Reis LM, Pereira RM, Nickolas TL, Yin MT, Eira M, Jorgetti V, Moyses RM
J Bone Miner Res 2019 Sep;34(9):1574-1584. Epub 2019 Jul 3 doi: 10.1002/jbmr.3751. PMID: 31269294Free PMC Article
Abnormalities in biomarkers of mineral and bone metabolism in kidney donors.
Kasiske BL, Kumar R, Kimmel PL, Pesavento TE, Kalil RS, Kraus ES, Rabb H, Posselt AM, Anderson-Haag TL, Steffes MW, Israni AK, Snyder JJ, Singh RJ, Weir MR
Kidney Int 2016 Oct;90(4):861-8. Epub 2016 Jun 28 doi: 10.1016/j.kint.2016.05.012. PMID: 27370408Free PMC Article
Bone mineral density decline according to renal tubular dysfunction and phosphaturia in tenofovir-exposed HIV-infected patients.
Casado JL, Santiuste C, Vazquez M, Bañón S, Rosillo M, Gomez A, Perez-Elías MJ, Caballero C, Rey JM, Moreno S
AIDS 2016 Jun 1;30(9):1423-31. doi: 10.1097/QAD.0000000000001067. PMID: 26919733
Management of hypercalcemia in relation to pathophysiology.
Bonjour JP, Rizzoli R, Hirschel-Scholz S, Caverzasio J
Bone 1987;8 Suppl 1:S29-33. PMID: 2825740

Prognosis

The utility of (99m)Tc-DMSA and Tc(99m)-EC scintigraphy for early diagnosis of ifosfamide induced nephrotoxicity.
Caglar M, Yarís N, Akyuz C
Nucl Med Commun 2001 Dec;22(12):1325-32. doi: 10.1097/00006231-200112000-00008. PMID: 11711903
Technetium-99m dimercaptosuccinic acid and ifosfamide tubular dysfunction in children with cancer.
Anninga JK, Valdés Olmos RA, de Kraker J, van Tinteren H, Hoefnagel CA, van Royen EA
Eur J Nucl Med 1994 Jul;21(7):658-62. doi: 10.1007/BF00285589. PMID: 7957353
Autosomal dominant polycystic kidney disease (ADPKD)--mechanisms of cyst formation and renal failure.
Ritz E, Zeier M, Geberth S, Waldherr R
Aust N Z J Med 1993 Feb;23(1):35-41. doi: 10.1111/j.1445-5994.1993.tb00535.x. PMID: 8460972

Clinical prediction guides

The idiopathic hypercalciuria reviewed. Metabolic abnormality or disease?
García Nieto VM, Luis Yanes MI, Tejera Carreño P, Perez Suarez G, Moraleda Mesa T
Nefrologia (Engl Ed) 2019 Nov-Dec;39(6):592-602. Epub 2019 May 31 doi: 10.1016/j.nefro.2019.02.011. PMID: 31160051
Bone mineral density decline according to renal tubular dysfunction and phosphaturia in tenofovir-exposed HIV-infected patients.
Casado JL, Santiuste C, Vazquez M, Bañón S, Rosillo M, Gomez A, Perez-Elías MJ, Caballero C, Rey JM, Moreno S
AIDS 2016 Jun 1;30(9):1423-31. doi: 10.1097/QAD.0000000000001067. PMID: 26919733
Osteomalacic and hyperparathyroid changes in fibrous dysplasia of bone: core biopsy studies and clinical correlations.
Corsi A, Collins MT, Riminucci M, Howell PG, Boyde A, Robey PG, Bianco P
J Bone Miner Res 2003 Jul;18(7):1235-46. doi: 10.1359/jbmr.2003.18.7.1235. PMID: 12854833
Recent developments in the understanding of the pathophysiology of osteopetrosis.
Felix R, Hofstetter W, Cecchini MG
Eur J Endocrinol 1996 Feb;134(2):143-56. doi: 10.1530/eje.0.1340143. PMID: 8630510
Evaluation of bone resorption and renal tubular reabsorption of calcium and phosphate in malignant and nonmalignant hypercalcemia.
Buchs B, Rizzoli R, Bonjour JP
Bone 1991;12(1):47-56. doi: 10.1016/8756-3282(91)90055-n. PMID: 2054236

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