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Organic personality disorder

MedGen UID:
18195
•Concept ID:
C0029233
•
Mental or Behavioral Dysfunction
Synonyms: Organic personality syndrome; Organic Personality Syndrome
SNOMED CT: Organic personality syndrome (36217008); Organic personality disorder (36217008)

Definition

A mental disorder caused by intrinsic disease which is characterized by persistent alteration of a known behavioral pattern. Changes in emotional stability, motivation, judgment or impulse control are usually noted. It is broadly classified as a personality change due to a general medical condition. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrganic personality disorder

Professional guidelines

PubMed

Differential diagnosis between borderline personality disorder and organic personality disorder following traumatic brain injury.
Gagnon J, Bouchard MA, Rainville C
Bull Menninger Clin 2006 Winter;70(1):1-28. doi: 10.1521/bumc.2006.70.1.1. PMID: 16545030
Management of the behavioral manifestations of dementia.
Yeager BF, Farnett LE, Ruzicka SA
Arch Intern Med 1995 Feb 13;155(3):250-60. PMID: 7832596

Recent clinical studies

Etiology

Similarities and differences in borderline and organic personality disorder.
Mathiesen BB, Simonsen E, Soegaard U, Kvist K
Cogn Neuropsychiatry 2014;19(1):1-16. Epub 2013 May 28 doi: 10.1080/13546805.2013.776494. PMID: 23710758
Prader-Willi Syndrome: clinical concerns for the orthopaedic surgeon.
Kroonen LT, Herman M, Pizzutillo PD, Macewen GD
J Pediatr Orthop 2006 Sep-Oct;26(5):673-9. doi: 10.1097/01.bpo.0000226282.01202.4f. PMID: 16932110
Organic personality disorder after traumatic brain injury: cognitive, anatomic and psychosocial factors. A 6 month follow-up.
Franulic A, Horta E, Maturana R, Scherpenisse J, Carbonell C
Brain Inj 2000 May;14(5):431-9. doi: 10.1080/026990500120538. PMID: 10834338
Antidepressant drugs and the emergence of suicidal tendencies.
Teicher MH, Glod CA, Cole JO
Drug Saf 1993 Mar;8(3):186-212. doi: 10.2165/00002018-199308030-00002. PMID: 8452661
Organic personality disorder in dementia syndromes: an inventory approach.
Cummings JL, Petry S, Dian L, Shapira J, Hill MA
J Neuropsychiatry Clin Neurosci 1990 Summer;2(3):261-7. doi: 10.1176/jnp.2.3.261. PMID: 2136084

Diagnosis

Real-world experience of assessing antibodies against the N-methyl-D-aspartate receptor (NMDAR-IgG) in psychiatric patients. A retrospective single-centre study.
Ariño H, Coutinho E, Pollak TA, Stewart R
Brain Behav Immun 2021 Nov;98:330-336. Epub 2021 Sep 1 doi: 10.1016/j.bbi.2021.08.233. PMID: 34480989
Similarities and differences in borderline and organic personality disorder.
Mathiesen BB, Simonsen E, Soegaard U, Kvist K
Cogn Neuropsychiatry 2014;19(1):1-16. Epub 2013 May 28 doi: 10.1080/13546805.2013.776494. PMID: 23710758
Differential diagnosis between borderline personality disorder and organic personality disorder following traumatic brain injury.
Gagnon J, Bouchard MA, Rainville C
Bull Menninger Clin 2006 Winter;70(1):1-28. doi: 10.1521/bumc.2006.70.1.1. PMID: 16545030
Organic personality disorder after traumatic brain injury: cognitive, anatomic and psychosocial factors. A 6 month follow-up.
Franulic A, Horta E, Maturana R, Scherpenisse J, Carbonell C
Brain Inj 2000 May;14(5):431-9. doi: 10.1080/026990500120538. PMID: 10834338
Organic personality disorder in dementia syndromes: an inventory approach.
Cummings JL, Petry S, Dian L, Shapira J, Hill MA
J Neuropsychiatry Clin Neurosci 1990 Summer;2(3):261-7. doi: 10.1176/jnp.2.3.261. PMID: 2136084

Therapy

Auditory hallucinations associated with nitrofurantoin use: case report and review of the literature.
Štuhec M
Wien Klin Wochenschr 2014 Sep;126(17-18):549-52. Epub 2014 Aug 15 doi: 10.1007/s00508-014-0577-6. PMID: 25123143
Organic personality disorder after traumatic brain injury: cognitive, anatomic and psychosocial factors. A 6 month follow-up.
Franulic A, Horta E, Maturana R, Scherpenisse J, Carbonell C
Brain Inj 2000 May;14(5):431-9. doi: 10.1080/026990500120538. PMID: 10834338
Management of the behavioral manifestations of dementia.
Yeager BF, Farnett LE, Ruzicka SA
Arch Intern Med 1995 Feb 13;155(3):250-60. PMID: 7832596
Antidepressant drugs and the emergence of suicidal tendencies.
Teicher MH, Glod CA, Cole JO
Drug Saf 1993 Mar;8(3):186-212. doi: 10.2165/00002018-199308030-00002. PMID: 8452661
The expression of bipolar affective disorders in brain injured patients.
Zwil AS, McAllister TW, Raimo E
Int J Psychiatry Med 1992;22(4):377-95. doi: 10.2190/J71J-FTML-JY1E-RKKG. PMID: 1363419

Prognosis

Real-world experience of assessing antibodies against the N-methyl-D-aspartate receptor (NMDAR-IgG) in psychiatric patients. A retrospective single-centre study.
Ariño H, Coutinho E, Pollak TA, Stewart R
Brain Behav Immun 2021 Nov;98:330-336. Epub 2021 Sep 1 doi: 10.1016/j.bbi.2021.08.233. PMID: 34480989
Psychiatric lifetime diagnoses are associated with a reduced chance of seizure freedom after temporal lobe surgery.
Koch-Stoecker SC, Bien CG, Schulz R, May TW
Epilepsia 2017 Jun;58(6):983-993. Epub 2017 Apr 5 doi: 10.1111/epi.13736. PMID: 28378900
Impact of psychiatric and neuropsychological sequelae of traumatic brain injury on the duration of legal time periods.
Quemada JI, de Francisco ML, Echeburúa E, Bulbena A
Actas Esp Psiquiatr 2010 Mar-Apr;38(2):101-7. Epub 2010 Mar 1 PMID: 20976639
Prader-Willi Syndrome: clinical concerns for the orthopaedic surgeon.
Kroonen LT, Herman M, Pizzutillo PD, Macewen GD
J Pediatr Orthop 2006 Sep-Oct;26(5):673-9. doi: 10.1097/01.bpo.0000226282.01202.4f. PMID: 16932110
Organic personality disorder after traumatic brain injury: cognitive, anatomic and psychosocial factors. A 6 month follow-up.
Franulic A, Horta E, Maturana R, Scherpenisse J, Carbonell C
Brain Inj 2000 May;14(5):431-9. doi: 10.1080/026990500120538. PMID: 10834338

Clinical prediction guides

Real-world experience of assessing antibodies against the N-methyl-D-aspartate receptor (NMDAR-IgG) in psychiatric patients. A retrospective single-centre study.
Ariño H, Coutinho E, Pollak TA, Stewart R
Brain Behav Immun 2021 Nov;98:330-336. Epub 2021 Sep 1 doi: 10.1016/j.bbi.2021.08.233. PMID: 34480989
Prader-Willi Syndrome: clinical concerns for the orthopaedic surgeon.
Kroonen LT, Herman M, Pizzutillo PD, Macewen GD
J Pediatr Orthop 2006 Sep-Oct;26(5):673-9. doi: 10.1097/01.bpo.0000226282.01202.4f. PMID: 16932110
Organic personality disorder after traumatic brain injury: cognitive, anatomic and psychosocial factors. A 6 month follow-up.
Franulic A, Horta E, Maturana R, Scherpenisse J, Carbonell C
Brain Inj 2000 May;14(5):431-9. doi: 10.1080/026990500120538. PMID: 10834338
Antidepressant drugs and the emergence of suicidal tendencies.
Teicher MH, Glod CA, Cole JO
Drug Saf 1993 Mar;8(3):186-212. doi: 10.2165/00002018-199308030-00002. PMID: 8452661
Organic personality disorder in dementia syndromes: an inventory approach.
Cummings JL, Petry S, Dian L, Shapira J, Hill MA
J Neuropsychiatry Clin Neurosci 1990 Summer;2(3):261-7. doi: 10.1176/jnp.2.3.261. PMID: 2136084

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