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Malignant Sertoli-Leydig cell tumor of ovary

MedGen UID:
1825991
•Concept ID:
C5574973
•
Neoplastic Process
Synonyms: Androblastoma; Arrhenoblastoma; malignant ovarian Sertoli-Leydig cell tumor; malignant ovarian sertoli-Leydig cell tumor; malignant ovarian Sertoli-Leydig cell tumour; malignant ovarian sertoli-Leydig cell tumour; malignant Sertoli-Leydig cell tumor of ovary; malignant Sertoli-Leydig cell tumor of the ovary; Malignant Sertoli-Leydig cell tumor of the ovary; malignant Sertoli-Leydig cell tumour of the ovary; Ovarian malignant Sertoli-Leydig cell tumor; ovarian malignant Sertoli-Leydig cell tumor; ovarian malignant Sertoli-Leydig cell tumour; Ovarian Sertoli-Leydig cell cancer; ovarian Sertoli-Leydig cell cancer; ovarian sertoli-Leydig cell tumor, malignant; ovarian Sertoli-Leydig cell tumor, malignant; Primary malignant Sertoli-Leydig cell tumor of ovary; Virilizing ovarian tumor; virilizing ovarian tumor; virilizing ovarian tumour
SNOMED CT: Primary malignant Sertoli-Leydig cell tumor of ovary (1284849005); Ovarian malignant Sertoli-Leydig cell tumor (1284849005)
 
Monarch Initiative: MONDO:0020542
Orphanet: ORPHA99916

Definition

A rare malignant sex cord stromal tumour of ovary occurring typically in young women and characterised by manifestations of androgen excess (hirsutism, hair loss, amenorrhoea, or oligomenorrhoea) when functional. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Sertoli-Leydig cell tumor of ovary

Professional guidelines

PubMed

From diagnosis to treatment of androgen-secreting ovarian tumors: a practical approach.
Rojewska P, Meczekalski B, Bala G, Luisi S, Podfigurna A
Gynecol Endocrinol 2022 Jul;38(7):537-542. Epub 2022 Jun 1 doi: 10.1080/09513590.2022.2083104. PMID: 35647677
Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430
Management of early ovarian cancer: germ cell and sex cord-stromal tumors.
Gershenson DM
Gynecol Oncol 1994 Dec;55(3 Pt 2):S62-72. PMID: 7530680

Recent clinical studies

Etiology

Review on Sertoli-Leydig Cell Tumours of the Ovary.
Muscat C, Calleja-Agius J
Discov Med 2024 Feb;36(181):234-247. doi: 10.24976/Discov.Med.202436181.22. PMID: 38409829
Sertoli-Leydig cell tumor: a clinicopathological analysis in a comprehensive, national cohort.
Bekker P, Miland-Samuelsen AR, Smerdel MP, Schnack TH, Lauszus FF, Karstensen SH
Int J Gynecol Cancer 2023 Dec 4;33(12):1921-1927. doi: 10.1136/ijgc-2023-004945. PMID: 37907261
Sertoli-Leydig cell tumor of the ovary: Analysis of a single institution database and review of the literature.
Durmuş Y, Kılıç Ç, Çakır C, Yüksel D, Boran N, Karalök A, Boyraz G, Turan AT
J Obstet Gynaecol Res 2019 Jul;45(7):1311-1318. Epub 2019 May 20 doi: 10.1111/jog.13977. PMID: 31106943
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature.
Gressel GM, Buza N, Pal L
Eur J Gynaecol Oncol 2017;38(2):214-220. PMID: 29953783

Diagnosis

Sertoli-Leydig cell tumor: a clinicopathological analysis in a comprehensive, national cohort.
Bekker P, Miland-Samuelsen AR, Smerdel MP, Schnack TH, Lauszus FF, Karstensen SH
Int J Gynecol Cancer 2023 Dec 4;33(12):1921-1927. doi: 10.1136/ijgc-2023-004945. PMID: 37907261
Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160
Ovarian Sertoli cell tumours: practical points.
Gheorghisan-Galateanu AA, Carsote M, Terzea D, Valea A, Ghemigian A
J Pak Med Assoc 2020 Jan;70(1):129-133. doi: 10.5455/JPMA.1381. PMID: 31954037
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Therapy

INSL3 Expression in Leydig Cell Hyperplasia and Leydig Cell Tumors.
Lakis NS, Lombardo KA, Mangray S, Netto GJ, Salles D, Matoso A
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):203-209. doi: 10.1097/PAI.0000000000000567. PMID: 29084059
Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature.
Gressel GM, Buza N, Pal L
Eur J Gynaecol Oncol 2017;38(2):214-220. PMID: 29953783
Ovarian sertoli-leydig cell tumors: A multicenter long-term clinicopathological analysis of 27 patients.
Akman L, Ertas IE, Gokcu M, Terek MC, Sanci M, Sanli UA, Zekioglu O, Ozsaran AA
J Cancer Res Ther 2016 Jan-Mar;12(1):290-4. doi: 10.4103/0973-1482.158037. PMID: 27072253
Clinicopathologic features of ovarian Sertoli-Leydig cell tumors.
Zhang HY, Zhu JE, Huang W, Zhu J
Int J Clin Exp Pathol 2014;7(10):6956-64. Epub 2014 Sep 15 PMID: 25400781Free PMC Article
Management of early ovarian cancer: germ cell and sex cord-stromal tumors.
Gershenson DM
Gynecol Oncol 1994 Dec;55(3 Pt 2):S62-72. PMID: 7530680

Prognosis

Review on Sertoli-Leydig Cell Tumours of the Ovary.
Muscat C, Calleja-Agius J
Discov Med 2024 Feb;36(181):234-247. doi: 10.24976/Discov.Med.202436181.22. PMID: 38409829
Sertoli-Leydig cell tumor: a clinicopathological analysis in a comprehensive, national cohort.
Bekker P, Miland-Samuelsen AR, Smerdel MP, Schnack TH, Lauszus FF, Karstensen SH
Int J Gynecol Cancer 2023 Dec 4;33(12):1921-1927. doi: 10.1136/ijgc-2023-004945. PMID: 37907261
Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160
Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature.
Gressel GM, Buza N, Pal L
Eur J Gynaecol Oncol 2017;38(2):214-220. PMID: 29953783

Clinical prediction guides

Review on Sertoli-Leydig Cell Tumours of the Ovary.
Muscat C, Calleja-Agius J
Discov Med 2024 Feb;36(181):234-247. doi: 10.24976/Discov.Med.202436181.22. PMID: 38409829
Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
Imaging, clinical, and pathologic findings of Sertoli-leydig cell tumors.
Chen J, Liu Y, Zhang Y, Wang Y, Chen X, Wang Z
Sci Prog 2021 Apr-Jun;104(2):368504211009668. doi: 10.1177/00368504211009668. PMID: 33848213Free PMC Article
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Expression of angiogenic factors in sclerosing stromal tumours of the ovary.
Hirakawa T, Kawano Y, Mizoguchi C, Nasu K, Narahara H
J Obstet Gynaecol 2018 Jul;38(5):682-685. Epub 2018 Feb 13 doi: 10.1080/01443615.2017.1397610. PMID: 29433373

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