U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant Sertoli-Leydig cell tumor of ovary

MedGen UID:
1825991
•Concept ID:
C5574973
•
Neoplastic Process
Synonyms: Androblastoma; Arrhenoblastoma; malignant ovarian Sertoli-Leydig cell tumor; malignant ovarian sertoli-Leydig cell tumor; malignant ovarian Sertoli-Leydig cell tumour; malignant ovarian sertoli-Leydig cell tumour; malignant Sertoli-Leydig cell tumor of ovary; malignant Sertoli-Leydig cell tumor of the ovary; Malignant Sertoli-Leydig cell tumor of the ovary; malignant Sertoli-Leydig cell tumour of the ovary; Ovarian malignant Sertoli-Leydig cell tumor; ovarian malignant Sertoli-Leydig cell tumor; ovarian malignant Sertoli-Leydig cell tumour; Ovarian Sertoli-Leydig cell cancer; ovarian Sertoli-Leydig cell cancer; ovarian sertoli-Leydig cell tumor, malignant; ovarian Sertoli-Leydig cell tumor, malignant; Primary malignant Sertoli-Leydig cell tumor of ovary; Virilizing ovarian tumor; virilizing ovarian tumor; virilizing ovarian tumour
SNOMED CT: Primary malignant Sertoli-Leydig cell tumor of ovary (1284849005); Ovarian malignant Sertoli-Leydig cell tumor (1284849005)
 
Monarch Initiative: MONDO:0020542
Orphanet: ORPHA99916

Definition

A rare malignant sex cord stromal tumour of ovary occurring typically in young women and characterised by manifestations of androgen excess (hirsutism, hair loss, amenorrhoea, or oligomenorrhoea) when functional. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Sertoli-Leydig cell tumor of ovary

Professional guidelines

PubMed

From diagnosis to treatment of androgen-secreting ovarian tumors: a practical approach.
Rojewska P, Meczekalski B, Bala G, Luisi S, Podfigurna A
Gynecol Endocrinol 2022 Jul;38(7):537-542. Epub 2022 Jun 1 doi: 10.1080/09513590.2022.2083104. PMID: 35647677
Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430
Management of early ovarian cancer: germ cell and sex cord-stromal tumors.
Gershenson DM
Gynecol Oncol 1994 Dec;55(3 Pt 2):S62-72. PMID: 7530680

Recent clinical studies

Etiology

Review on Sertoli-Leydig Cell Tumours of the Ovary.
Muscat C, Calleja-Agius J
Discov Med 2024 Feb;36(181):234-247. doi: 10.24976/Discov.Med.202436181.22. PMID: 38409829
Sertoli-Leydig cell tumor: a clinicopathological analysis in a comprehensive, national cohort.
Bekker P, Miland-Samuelsen AR, Smerdel MP, Schnack TH, Lauszus FF, Karstensen SH
Int J Gynecol Cancer 2023 Dec 4;33(12):1921-1927. doi: 10.1136/ijgc-2023-004945. PMID: 37907261
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Gynecologic Manifestations of the DICER1 Syndrome.
Stewart CJ, Charles A, Foulkes WD
Surg Pathol Clin 2016 Jun;9(2):227-41. Epub 2016 Apr 9 doi: 10.1016/j.path.2016.01.002. PMID: 27241106
Sertoli-Leydig cell tumor.
Lantzsch T, Stoerer S, Lawrenz K, Buchmann J, Strauss HG, Koelbl H
Arch Gynecol Obstet 2001 Jan;264(4):206-8. doi: 10.1007/s004040000114. PMID: 11205710

Diagnosis

Sertoli-Leydig cell tumor: a clinicopathological analysis in a comprehensive, national cohort.
Bekker P, Miland-Samuelsen AR, Smerdel MP, Schnack TH, Lauszus FF, Karstensen SH
Int J Gynecol Cancer 2023 Dec 4;33(12):1921-1927. doi: 10.1136/ijgc-2023-004945. PMID: 37907261
Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160
Ovarian Sertoli cell tumours: practical points.
Gheorghisan-Galateanu AA, Carsote M, Terzea D, Valea A, Ghemigian A
J Pak Med Assoc 2020 Jan;70(1):129-133. doi: 10.5455/JPMA.1381. PMID: 31954037
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Therapy

INSL3 Expression in Leydig Cell Hyperplasia and Leydig Cell Tumors.
Lakis NS, Lombardo KA, Mangray S, Netto GJ, Salles D, Matoso A
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):203-209. doi: 10.1097/PAI.0000000000000567. PMID: 29084059
Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature.
Gressel GM, Buza N, Pal L
Eur J Gynaecol Oncol 2017;38(2):214-220. PMID: 29953783
Ovarian sertoli-leydig cell tumors: A multicenter long-term clinicopathological analysis of 27 patients.
Akman L, Ertas IE, Gokcu M, Terek MC, Sanci M, Sanli UA, Zekioglu O, Ozsaran AA
J Cancer Res Ther 2016 Jan-Mar;12(1):290-4. doi: 10.4103/0973-1482.158037. PMID: 27072253
Clinicopathologic features of ovarian Sertoli-Leydig cell tumors.
Zhang HY, Zhu JE, Huang W, Zhu J
Int J Clin Exp Pathol 2014;7(10):6956-64. Epub 2014 Sep 15 PMID: 25400781Free PMC Article
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database.
Bhat RA, Lim YK, Chia YN, Yam KL
J Obstet Gynaecol Res 2013 Jan;39(1):305-10. Epub 2012 Jun 13 doi: 10.1111/j.1447-0756.2012.01928.x. PMID: 22691037

Prognosis

Review on Sertoli-Leydig Cell Tumours of the Ovary.
Muscat C, Calleja-Agius J
Discov Med 2024 Feb;36(181):234-247. doi: 10.24976/Discov.Med.202436181.22. PMID: 38409829
Sertoli-Leydig cell tumor: a clinicopathological analysis in a comprehensive, national cohort.
Bekker P, Miland-Samuelsen AR, Smerdel MP, Schnack TH, Lauszus FF, Karstensen SH
Int J Gynecol Cancer 2023 Dec 4;33(12):1921-1927. doi: 10.1136/ijgc-2023-004945. PMID: 37907261
Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160
Genetics and genomics of ovarian sex cord-stromal tumors.
Fuller PJ, Leung D, Chu S
Clin Genet 2017 Feb;91(2):285-291. doi: 10.1111/cge.12917. PMID: 27813081

Clinical prediction guides

Review on Sertoli-Leydig Cell Tumours of the Ovary.
Muscat C, Calleja-Agius J
Discov Med 2024 Feb;36(181):234-247. doi: 10.24976/Discov.Med.202436181.22. PMID: 38409829
Imaging in gynecological disease (27): clinical and ultrasound characteristics of recurrent ovarian stromal cell tumors.
Moro F, Giudice MT, Bolomini G, Moruzzi MC, Mascilini F, Quagliozzi L, Ciccarone F, Scambia G, Fagotti A, Valentin L, Testa AC
Ultrasound Obstet Gynecol 2024 Mar;63(3):399-407. Epub 2024 Feb 6 doi: 10.1002/uog.27504. PMID: 37774092
Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
Imaging, clinical, and pathologic findings of Sertoli-leydig cell tumors.
Chen J, Liu Y, Zhang Y, Wang Y, Chen X, Wang Z
Sci Prog 2021 Apr-Jun;104(2):368504211009668. doi: 10.1177/00368504211009668. PMID: 33848213Free PMC Article
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...