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HTLV-1-associated myelopathy-tropical spastic paraparesis(HAM)

MedGen UID:
18298
Concept ID:
C0030481
Disease or Syndrome
Synonyms: FAMILIAL SPASTIC PARAPARESIS, HTLV-1-ASSOCIATED; HAM; Human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis; MYELOPATHY, HTLV-1-ASSOCIATED; Paraparesis, Tropical Spastic; Tropical spastic paraparesis (formerly)
SNOMED CT: Tropical spastic paraplegia (714279000); HTLV-I-associated myelopathy (714279000); Tropical spastic paraparesis (714279000); Human T-cell lymphotropic virus 1-associated myelopathy (714279000); Myelopathy caused by Human T-lymphotropic virus 1 (714279000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0008039
OMIM®: 159580
Orphanet: ORPHA289326

Definition

A progressive chronic inflammatory disease of the central nervous system with the aetiologic agent Human T cell lymphotropic virus type I (HTLV-I), the disease is characterised by unremitting myelopathic symptoms such as spastic paraparesis, bowel and/or bladder dysfunction and sensory changes of the lower limbs. [from SNOMEDCT_US]

Clinical features

From HPO
Spastic paraparesis
MedGen UID:
52432
Concept ID:
C0037771
Sign or Symptom
Mild or moderate loss of motor function accompanied by spasticity in the lower extremities. This condition is a manifestation of CENTRAL NERVOUS SYSTEM DISEASES that cause injury to the motor cortex or descending motor pathways.
Myelopathy
MedGen UID:
11550
Concept ID:
C0037928
Disease or Syndrome
A non neoplastic or neoplastic disorder that affects the spinal cord.
Abnormal pyramidal sign
MedGen UID:
68582
Concept ID:
C0234132
Sign or Symptom
Functional neurological abnormalities related to dysfunction of the pyramidal tract.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHTLV-1-associated myelopathy-tropical spastic paraparesis
Follow this link to review classifications for HTLV-1-associated myelopathy-tropical spastic paraparesis in Orphanet.

Professional guidelines

PubMed

Mashkani B, Jalili Nik M, Rezaee SA, Boostani R
Expert Rev Neurother 2023 Jul-Dec;23(12):1233-1248. Epub 2023 Dec 15 doi: 10.1080/14737175.2023.2272639. PMID: 37933802
Meyerowitz EA, Mukerji SS, Kyle Harrold G, Erdil RM, Chen ST, Rudmann EA, Tsibris A, Venna N, Robbins GK
Clin Infect Dis 2023 Sep 18;77(6):851-856. doi: 10.1093/cid/ciad281. PMID: 37157862Free PMC Article
Afonso PV, Mekaouche M, Mortreux F, Toulza F, Moriceau A, Wattel E, Gessain A, Bangham CR, Dubreuil G, Plumelle Y, Hermine O, Estaquier J, Mahieux R
Blood 2010 Nov 11;116(19):3802-8. Epub 2010 Jun 29 doi: 10.1182/blood-2010-02-270751. PMID: 20587783

Recent clinical studies

Etiology

Kamrani M, Saryazdi S, Zemorshidi F, Khadem-Rezaiyan M, Behravan G
J Neurovirol 2023 Aug;29(4):416-424. Epub 2023 May 19 doi: 10.1007/s13365-023-01139-x. PMID: 37204651
Sato T, Yamauchi J, Yagishita N, Araya N, Takao N, Ohta Y, Inoue E, Takahashi M, Yamagishi M, Suzuki Y, Uchimaru K, Matsumoto N, Hasegawa Y, Yamano Y
Brain 2023 Aug 1;146(8):3181-3191. doi: 10.1093/brain/awad139. PMID: 37093965
Sales M, de Almeida Scaldaferri GB, Barbosa Dos Santos JI, Melo A, da Silva Ribeiro NM
J Neurovirol 2021 Dec;27(6):857-863. Epub 2020 Oct 6 doi: 10.1007/s13365-020-00911-7. PMID: 33021698
Vallinoto AC, Santana BB, Sá KS, Ferreira TC, Sousa RC, Azevedo VN, Feitosa RN, Machado LF, Ishak MO, Ishak R
Mediators Inflamm 2015;2015:804167. Epub 2015 Nov 1 doi: 10.1155/2015/804167. PMID: 26609200Free PMC Article
Douglas JN, Gardner LA, Lee S, Shin Y, Groover CJ, Levin MC
J Vis Exp 2012 Sep 26;(67) doi: 10.3791/4154. PMID: 23051967Free PMC Article

Diagnosis

Kamrani M, Saryazdi S, Zemorshidi F, Khadem-Rezaiyan M, Behravan G
J Neurovirol 2023 Aug;29(4):416-424. Epub 2023 May 19 doi: 10.1007/s13365-023-01139-x. PMID: 37204651
Meyerowitz EA, Mukerji SS, Kyle Harrold G, Erdil RM, Chen ST, Rudmann EA, Tsibris A, Venna N, Robbins GK
Clin Infect Dis 2023 Sep 18;77(6):851-856. doi: 10.1093/cid/ciad281. PMID: 37157862Free PMC Article
Terada Y, Miyata K, Shoji N, Mochizuki M
Ocul Immunol Inflamm 2023 Sep;31(7):1416-1424. Epub 2023 Feb 21 doi: 10.1080/09273948.2023.2175697. PMID: 36803501
Sales M, de Almeida Scaldaferri GB, Barbosa Dos Santos JI, Melo A, da Silva Ribeiro NM
J Neurovirol 2021 Dec;27(6):857-863. Epub 2020 Oct 6 doi: 10.1007/s13365-020-00911-7. PMID: 33021698
Khan MY, Khan IN, Farman M, Al Karim S, Qadri I, Kamal MA, Al Ghamdi K, Harakeh S
Curr Top Med Chem 2017;17(12):1320-1330. doi: 10.2174/1568026616666161222141318. PMID: 28017149

Therapy

Sato T, Yamauchi J, Yagishita N, Araya N, Takao N, Ohta Y, Inoue E, Takahashi M, Yamagishi M, Suzuki Y, Uchimaru K, Matsumoto N, Hasegawa Y, Yamano Y
Brain 2023 Aug 1;146(8):3181-3191. doi: 10.1093/brain/awad139. PMID: 37093965
Nozuma S, Kubota R, Jacobson S
J Neurovirol 2020 Oct;26(5):652-663. Epub 2020 Jul 23 doi: 10.1007/s13365-020-00881-w. PMID: 32705480Free PMC Article
Enose-Akahata Y, Jacobson S
Retrovirology 2019 Nov 29;16(1):35. doi: 10.1186/s12977-019-0499-5. PMID: 31783764Free PMC Article
Sato T, Coler-Reilly ALG, Yagishita N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y, Yamano Y
N Engl J Med 2018 Feb 8;378(6):529-538. doi: 10.1056/NEJMoa1704827. PMID: 29414279
Khan MY, Khan IN, Farman M, Al Karim S, Qadri I, Kamal MA, Al Ghamdi K, Harakeh S
Curr Top Med Chem 2017;17(12):1320-1330. doi: 10.2174/1568026616666161222141318. PMID: 28017149

Prognosis

Terada Y, Miyata K, Shoji N, Mochizuki M
Ocul Immunol Inflamm 2023 Sep;31(7):1416-1424. Epub 2023 Feb 21 doi: 10.1080/09273948.2023.2175697. PMID: 36803501
Clauze A, Enose-Akahata Y, Jacobson S
Front Immunol 2022;13:984274. Epub 2022 Sep 15 doi: 10.3389/fimmu.2022.984274. PMID: 36189294Free PMC Article
Sarkis S, Galli V, Moles R, Yurick D, Khoury G, Purcell DFJ, Franchini G, Pise-Masison CA
Retrovirology 2019 Dec 18;16(1):43. doi: 10.1186/s12977-019-0502-1. PMID: 31852543Free PMC Article
Martin F, Castro H, Gabriel C, Adonis A, Fedina A, Harrison L, Brodnicki L, Demontis MA, Babiker AG, Weber JN, Bangham CR, Taylor GP
PLoS Negl Trop Dis 2012;6(6):e1675. Epub 2012 Jun 12 doi: 10.1371/journal.pntd.0001675. PMID: 22720101Free PMC Article
Goncalves DU, Proietti FA, Barbosa-Stancioli EF, Martins ML, Ribas JG, Martins-Filho OA, Teixeira-Carvalho A, Peruhype-Magalhães V, Carneiro-Proietti AB
Inflamm Allergy Drug Targets 2008 Jun;7(2):98-107. doi: 10.2174/187152808785107642. PMID: 18691139

Clinical prediction guides

Kamrani M, Saryazdi S, Zemorshidi F, Khadem-Rezaiyan M, Behravan G
J Neurovirol 2023 Aug;29(4):416-424. Epub 2023 May 19 doi: 10.1007/s13365-023-01139-x. PMID: 37204651
Sato T, Yamauchi J, Yagishita N, Araya N, Takao N, Ohta Y, Inoue E, Takahashi M, Yamagishi M, Suzuki Y, Uchimaru K, Matsumoto N, Hasegawa Y, Yamano Y
Brain 2023 Aug 1;146(8):3181-3191. doi: 10.1093/brain/awad139. PMID: 37093965
Zarei-Ghobadi M, Sheikhi M, Teymoori-Rad M, Yaslianifard S, Norouzi M, Yaslianifard S, Faraji R, Farahmand M, Bayat S, Jafari M, Mozhgani SH
BMC Res Notes 2021 Mar 23;14(1):109. doi: 10.1186/s13104-021-05521-y. PMID: 33757561Free PMC Article
Sato T, Coler-Reilly ALG, Yagishita N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y, Yamano Y
N Engl J Med 2018 Feb 8;378(6):529-538. doi: 10.1056/NEJMoa1704827. PMID: 29414279
Pillat MM, Bauer ME, de Oliveira AC, Ulrich H, Casseb J
Cent Nerv Syst Agents Med Chem 2011 Dec 1;11(4):239-45. doi: 10.2174/1871524911106040239. PMID: 22300227

Recent systematic reviews

Bastos Ferreira AP, do Nascimento ADFS, Sampaio Rocha-Filho PA
J Neurovirol 2022 Feb;28(1):1-16. Epub 2022 Jan 3 doi: 10.1007/s13365-021-01043-2. PMID: 34981435
Bastos Ferreira AP, Cassilhas APP, Moura P, Sampaio Rocha-Filho PA
Viral Immunol 2021 Jul-Aug;34(6):380-391. Epub 2021 Jan 19 doi: 10.1089/vim.2020.0131. PMID: 33470891
Ngoma AM, Omokoko MD, Mutombo PB, Mvika ES, Muwonga JM, Nollet KE, Ohto H
Trop Med Int Health 2019 Nov;24(11):1277-1290. Epub 2019 Sep 30 doi: 10.1111/tmi.13305. PMID: 31465629
Fani M, Rezayi M, Meshkat Z, Rezaee SA, Makvandi M, Abouzari-Lotf E, Ferns GA
J Cell Physiol 2019 Aug;234(8):12433-12441. Epub 2019 Jan 11 doi: 10.1002/jcp.28087. PMID: 30633358
Oliveira PD, Kachimarek AC, Bittencourt AL
J Trop Pediatr 2018 Apr 1;64(2):151-161. doi: 10.1093/tropej/fmx039. PMID: 28582585

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