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Splenic hemophagocytosis

MedGen UID:
1841575
•Concept ID:
C5826671
•
Finding
Synonym: Spleen hemophagocytosis
 
HPO: HP:0034799

Definition

Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the spleen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic hemophagocytosis

Professional guidelines

PubMed

A xenograft model of macrophage activation syndrome amenable to anti-CD33 and anti-IL-6R treatment.
Wunderlich M, Stockman C, Devarajan M, Ravishankar N, Sexton C, Kumar AR, Mizukawa B, Mulloy JC
JCI Insight 2016 Sep 22;1(15):e88181. doi: 10.1172/jci.insight.88181. PMID: 27699249Free PMC Article
Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting.
Ponzoni M, Ferreri AJ, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, Murase T, Pileri SA, Doglioni C, Zucca E, Cavalli F, Nakamura S
J Clin Oncol 2007 Jul 20;25(21):3168-73. Epub 2007 Jun 18 doi: 10.1200/JCO.2006.08.2313. PMID: 17577023
Hemophagocytic syndrome in Epstein-Barr virus-associated T-lymphoproliferative disorders: disease spectrum, pathogenesis, and management.
Su IJ, Wang CH, Cheng AL, Chen RL
Leuk Lymphoma 1995 Nov;19(5-6):401-6. doi: 10.3109/10428199509112197. PMID: 8590839

Recent clinical studies

Etiology

Postmortem Findings Associated With SARS-CoV-2: Systematic Review and Meta-analysis.
Satturwar S, Fowkes M, Farver C, Wilson AM, Eccher A, Girolami I, Pujadas E, Bryce C, Salem F, El Jamal SM, Paniz-Mondolfi A, Petersen B, Gordon RE, Reidy J, Fraggetta F, Marshall DA, Pantanowitz L
Am J Surg Pathol 2021 May 1;45(5):587-603. doi: 10.1097/PAS.0000000000001650. PMID: 33481385Free PMC Article
Hemophagocytic Lymphohistiocytosis.
Skinner J, Yankey B, Shelton BK
AACN Adv Crit Care 2019 Summer;30(2):151-164. doi: 10.4037/aacnacc2019463. PMID: 31151946
Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases.
Yaman Y, Gözmen S, Özkaya AK, Oymak Y, Apa H, Vergin C, Devrim İ
J Infect Dev Ctries 2015 Oct 29;9(10):1172-6. doi: 10.3855/jidc.6090. PMID: 26517495
Littoral cell angioma. A novel splenic vascular lesion demonstrating histiocytic differentiation.
Falk S, Stutte HJ, Frizzera G
Am J Surg Pathol 1991 Nov;15(11):1023-33. PMID: 1928554
Familial hemophagocytic lymphohistiocytosis.
Janka GE
Eur J Pediatr 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367. PMID: 6354720

Diagnosis

SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis.
Prilutskiy A, Kritselis M, Shevtsov A, Yambayev I, Vadlamudi C, Zhao Q, Kataria Y, Sarosiek SR, Lerner A, Sloan JM, Quillen K, Burks EJ
Am J Clin Pathol 2020 Sep 8;154(4):466-474. doi: 10.1093/ajcp/aqaa124. PMID: 32681166Free PMC Article
Hemophagocytic Lymphohistiocytosis.
Skinner J, Yankey B, Shelton BK
AACN Adv Crit Care 2019 Summer;30(2):151-164. doi: 10.4037/aacnacc2019463. PMID: 31151946
Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis Mimicking Lymphoma on FDG PET/CT.
Pan Q, Luo Y, Wu H, Ma Y, Li F
Clin Nucl Med 2018 Feb;43(2):125-127. doi: 10.1097/RLU.0000000000001923. PMID: 29215415
Griscelli syndrome.
Malhotra AK, Bhaskar G, Nanda M, Kabra M, Singh MK, Ramam M
J Am Acad Dermatol 2006 Aug;55(2):337-40. doi: 10.1016/j.jaad.2005.11.1056. PMID: 16844525
Familial hemophagocytic lymphohistiocytosis.
Janka GE
Eur J Pediatr 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367. PMID: 6354720

Therapy

Secondary Hemophagocytic Lymphohistocytosis in a Child With Brucellosis.
Pekpak E, Sirvan Cetin B
J Pediatr Hematol Oncol 2017 Nov;39(8):e501-e503. doi: 10.1097/MPH.0000000000000849. PMID: 28562515
Prevalence, severity, and pathogeneses of anemia in visceral leishmaniasis.
Goto Y, Cheng J, Omachi S, Morimoto A
Parasitol Res 2017 Feb;116(2):457-464. Epub 2016 Nov 7 doi: 10.1007/s00436-016-5313-x. PMID: 27822583
Unexpected thrombocytopenia and anemia in cynomolgus monkeys induced by a therapeutic human monoclonal antibody.
Everds N, Li N, Bailey K, Fort M, Stevenson R, Jawando R, Salyers K, Jawa V, Narayanan P, Stevens E, He C, Nguyen MP, Tran S, Doyle N, Poitout-Belissent F, Jolette J, Xu C, Sprugel K
Toxicol Pathol 2013;41(7):951-69. Epub 2013 Mar 7 doi: 10.1177/0192623312474727. PMID: 23475561
Hepatosplenic B-cell lymphoma associated with hemophagocytic syndrome: a case report.
Kwon SY, Lee JJ, Chung IJ, Kim HJ, Park MR, Kim HS, Park CS
J Korean Med Sci 1999 Dec;14(6):671-4. doi: 10.3346/jkms.1999.14.6.671. PMID: 10642947Free PMC Article
Familial hemophagocytic lymphohistiocytosis.
Janka GE
Eur J Pediatr 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367. PMID: 6354720

Prognosis

Pathogenesis of Autoimmune Cytopenias in Inborn Errors of Immunity Revealing Novel Therapeutic Targets.
Cortesi M, Soresina A, Dotta L, Gorio C, Cattalini M, Lougaris V, Porta F, Badolato R
Front Immunol 2022;13:846660. Epub 2022 Apr 6 doi: 10.3389/fimmu.2022.846660. PMID: 35464467Free PMC Article
SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis.
Prilutskiy A, Kritselis M, Shevtsov A, Yambayev I, Vadlamudi C, Zhao Q, Kataria Y, Sarosiek SR, Lerner A, Sloan JM, Quillen K, Burks EJ
Am J Clin Pathol 2020 Sep 8;154(4):466-474. doi: 10.1093/ajcp/aqaa124. PMID: 32681166Free PMC Article
Therapy-related pure erythroid leukemia with hepatic infiltration and hemophagocytic syndrome.
Funakoshi Y, Matsuoka H, Yamamoto K, Yakushijin K, Inui Y, Okamura A, Takeuchi M, Yokozaki H, Minami H
Intern Med 2011;50(24):3031-5. Epub 2011 Dec 15 doi: 10.2169/internalmedicine.50.6168. PMID: 22185999
Griscelli syndrome.
Malhotra AK, Bhaskar G, Nanda M, Kabra M, Singh MK, Ramam M
J Am Acad Dermatol 2006 Aug;55(2):337-40. doi: 10.1016/j.jaad.2005.11.1056. PMID: 16844525
Familial hemophagocytic lymphohistiocytosis.
Janka GE
Eur J Pediatr 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367. PMID: 6354720

Clinical prediction guides

Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice.
Maria NI, Papoin J, Raparia C, Sun Z, Josselsohn R, Lu A, Katerji H, Syeda MM, Polsky D, Paulson R, Kalfa T, Barnes BJ, Zhang W, Blanc L, Davidson A
Life Sci Alliance 2023 Oct;6(10) Epub 2023 Jul 26 doi: 10.26508/lsa.202302241. PMID: 37495396Free PMC Article
SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis.
Prilutskiy A, Kritselis M, Shevtsov A, Yambayev I, Vadlamudi C, Zhao Q, Kataria Y, Sarosiek SR, Lerner A, Sloan JM, Quillen K, Burks EJ
Am J Clin Pathol 2020 Sep 8;154(4):466-474. doi: 10.1093/ajcp/aqaa124. PMID: 32681166Free PMC Article
Prevalence, severity, and pathogeneses of anemia in visceral leishmaniasis.
Goto Y, Cheng J, Omachi S, Morimoto A
Parasitol Res 2017 Feb;116(2):457-464. Epub 2016 Nov 7 doi: 10.1007/s00436-016-5313-x. PMID: 27822583
Unexpected thrombocytopenia and anemia in cynomolgus monkeys induced by a therapeutic human monoclonal antibody.
Everds N, Li N, Bailey K, Fort M, Stevenson R, Jawando R, Salyers K, Jawa V, Narayanan P, Stevens E, He C, Nguyen MP, Tran S, Doyle N, Poitout-Belissent F, Jolette J, Xu C, Sprugel K
Toxicol Pathol 2013;41(7):951-69. Epub 2013 Mar 7 doi: 10.1177/0192623312474727. PMID: 23475561
Hepatosplenic B-cell lymphoma associated with hemophagocytic syndrome: a case report.
Kwon SY, Lee JJ, Chung IJ, Kim HJ, Park MR, Kim HS, Park CS
J Korean Med Sci 1999 Dec;14(6):671-4. doi: 10.3346/jkms.1999.14.6.671. PMID: 10642947Free PMC Article

Recent systematic reviews

Postmortem Findings Associated With SARS-CoV-2: Systematic Review and Meta-analysis.
Satturwar S, Fowkes M, Farver C, Wilson AM, Eccher A, Girolami I, Pujadas E, Bryce C, Salem F, El Jamal SM, Paniz-Mondolfi A, Petersen B, Gordon RE, Reidy J, Fraggetta F, Marshall DA, Pantanowitz L
Am J Surg Pathol 2021 May 1;45(5):587-603. doi: 10.1097/PAS.0000000000001650. PMID: 33481385Free PMC Article

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