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Splenic hemophagocytosis

MedGen UID:
1841575
•Concept ID:
C5826671
•
Finding
Synonym: Spleen hemophagocytosis
 
HPO: HP:0034799

Definition

Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the spleen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic hemophagocytosis

Professional guidelines

PubMed

A xenograft model of macrophage activation syndrome amenable to anti-CD33 and anti-IL-6R treatment.
Wunderlich M, Stockman C, Devarajan M, Ravishankar N, Sexton C, Kumar AR, Mizukawa B, Mulloy JC
JCI Insight 2016 Sep 22;1(15):e88181. doi: 10.1172/jci.insight.88181. PMID: 27699249Free PMC Article
Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting.
Ponzoni M, Ferreri AJ, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, Murase T, Pileri SA, Doglioni C, Zucca E, Cavalli F, Nakamura S
J Clin Oncol 2007 Jul 20;25(21):3168-73. Epub 2007 Jun 18 doi: 10.1200/JCO.2006.08.2313. PMID: 17577023
Hemophagocytic syndrome in Epstein-Barr virus-associated T-lymphoproliferative disorders: disease spectrum, pathogenesis, and management.
Su IJ, Wang CH, Cheng AL, Chen RL
Leuk Lymphoma 1995 Nov;19(5-6):401-6. doi: 10.3109/10428199509112197. PMID: 8590839

Recent clinical studies

Etiology

Infection-associated Hemophagocytic Syndrome in Critically Ill Patients with COVID-19.
Yang K, Xing MY, Jiang LY, Cai YP, Yang LL, Xie NN, Chen J, Wang WX, Wang L, Zhu JL, Zhang DY, Ruan QR, Song JX
Curr Med Sci 2021 Feb;41(1):39-45. Epub 2021 Feb 13 doi: 10.1007/s11596-021-2315-4. PMID: 33582903Free PMC Article
Flying Fox Hemolytic Fever, Description of a New Zoonosis Caused by Candidatus Mycoplasma haemohominis.
Descloux E, Mediannikov O, Gourinat AC, Colot J, Chauvet M, Mermoud I, Desoutter D, Cazorla C, Klement-Frutos E, Antonini L, Levasseur A, Bossi V, Davoust B, Merlet A, Goujart MA, Oedin M, Brescia F, Laumond S, Fournier PE, Raoult D
Clin Infect Dis 2021 Oct 5;73(7):e1445-e1453. doi: 10.1093/cid/ciaa1648. PMID: 33119064
Hemophagocytic Lymphohistiocytosis.
Skinner J, Yankey B, Shelton BK
AACN Adv Crit Care 2019 Summer;30(2):151-164. doi: 10.4037/aacnacc2019463. PMID: 31151946
Littoral cell angioma. A novel splenic vascular lesion demonstrating histiocytic differentiation.
Falk S, Stutte HJ, Frizzera G
Am J Surg Pathol 1991 Nov;15(11):1023-33. PMID: 1928554
Familial hemophagocytic lymphohistiocytosis.
Janka GE
Eur J Pediatr 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367. PMID: 6354720

Diagnosis

SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis.
Prilutskiy A, Kritselis M, Shevtsov A, Yambayev I, Vadlamudi C, Zhao Q, Kataria Y, Sarosiek SR, Lerner A, Sloan JM, Quillen K, Burks EJ
Am J Clin Pathol 2020 Sep 8;154(4):466-474. doi: 10.1093/ajcp/aqaa124. PMID: 32681166Free PMC Article
Hemophagocytic Lymphohistiocytosis.
Skinner J, Yankey B, Shelton BK
AACN Adv Crit Care 2019 Summer;30(2):151-164. doi: 10.4037/aacnacc2019463. PMID: 31151946
Prevalence, severity, and pathogeneses of anemia in visceral leishmaniasis.
Goto Y, Cheng J, Omachi S, Morimoto A
Parasitol Res 2017 Feb;116(2):457-464. Epub 2016 Nov 7 doi: 10.1007/s00436-016-5313-x. PMID: 27822583
Griscelli syndrome.
Malhotra AK, Bhaskar G, Nanda M, Kabra M, Singh MK, Ramam M
J Am Acad Dermatol 2006 Aug;55(2):337-40. doi: 10.1016/j.jaad.2005.11.1056. PMID: 16844525
Familial hemophagocytic lymphohistiocytosis.
Janka GE
Eur J Pediatr 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367. PMID: 6354720

Therapy

Hemophagocytic histiocytosis in severe SARS-CoV-2 infection: A bone marrow study.
Dandu H, Yadav G, Malhotra HS, Pandey S, Sachu R, Dubey K
Int J Lab Hematol 2021 Dec;43(6):1291-1301. Epub 2021 Jun 4 doi: 10.1111/ijlh.13619. PMID: 34086418Free PMC Article
Prevalence, severity, and pathogeneses of anemia in visceral leishmaniasis.
Goto Y, Cheng J, Omachi S, Morimoto A
Parasitol Res 2017 Feb;116(2):457-464. Epub 2016 Nov 7 doi: 10.1007/s00436-016-5313-x. PMID: 27822583
Hemophagocytic syndrome.
Al-Talag AH, Mohamed AE, Dafulla MM, Ghandour Z, Al-Karawi MA, Haleem A
Saudi Med J 2000 Oct;21(10):979-82. PMID: 11369969
B-cell lymphoma-associated hemophagocytic syndrome.
Shimazaki C, Inaba T, Nakagawa M
Leuk Lymphoma 2000 Jun;38(1-2):121-30. doi: 10.3109/10428190009060325. PMID: 10811454
Familial hemophagocytic lymphohistiocytosis.
Janka GE
Eur J Pediatr 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367. PMID: 6354720

Prognosis

Pathogenesis of Autoimmune Cytopenias in Inborn Errors of Immunity Revealing Novel Therapeutic Targets.
Cortesi M, Soresina A, Dotta L, Gorio C, Cattalini M, Lougaris V, Porta F, Badolato R
Front Immunol 2022;13:846660. Epub 2022 Apr 6 doi: 10.3389/fimmu.2022.846660. PMID: 35464467Free PMC Article
SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis.
Prilutskiy A, Kritselis M, Shevtsov A, Yambayev I, Vadlamudi C, Zhao Q, Kataria Y, Sarosiek SR, Lerner A, Sloan JM, Quillen K, Burks EJ
Am J Clin Pathol 2020 Sep 8;154(4):466-474. doi: 10.1093/ajcp/aqaa124. PMID: 32681166Free PMC Article
Understanding organ dysfunction in hemophagocytic lymphohistiocytosis.
Créput C, Galicier L, Buyse S, Azoulay E
Intensive Care Med 2008 Jul;34(7):1177-87. Epub 2008 Apr 22 doi: 10.1007/s00134-008-1111-y. PMID: 18427781
Griscelli syndrome.
Malhotra AK, Bhaskar G, Nanda M, Kabra M, Singh MK, Ramam M
J Am Acad Dermatol 2006 Aug;55(2):337-40. doi: 10.1016/j.jaad.2005.11.1056. PMID: 16844525
Familial hemophagocytic lymphohistiocytosis.
Janka GE
Eur J Pediatr 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367. PMID: 6354720

Clinical prediction guides

Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice.
Maria NI, Papoin J, Raparia C, Sun Z, Josselsohn R, Lu A, Katerji H, Syeda MM, Polsky D, Paulson R, Kalfa T, Barnes BJ, Zhang W, Blanc L, Davidson A
Life Sci Alliance 2023 Oct;6(10) Epub 2023 Jul 26 doi: 10.26508/lsa.202302241. PMID: 37495396Free PMC Article
Hemophagocytic histiocytosis in severe SARS-CoV-2 infection: A bone marrow study.
Dandu H, Yadav G, Malhotra HS, Pandey S, Sachu R, Dubey K
Int J Lab Hematol 2021 Dec;43(6):1291-1301. Epub 2021 Jun 4 doi: 10.1111/ijlh.13619. PMID: 34086418Free PMC Article
SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis.
Prilutskiy A, Kritselis M, Shevtsov A, Yambayev I, Vadlamudi C, Zhao Q, Kataria Y, Sarosiek SR, Lerner A, Sloan JM, Quillen K, Burks EJ
Am J Clin Pathol 2020 Sep 8;154(4):466-474. doi: 10.1093/ajcp/aqaa124. PMID: 32681166Free PMC Article
Prevalence, severity, and pathogeneses of anemia in visceral leishmaniasis.
Goto Y, Cheng J, Omachi S, Morimoto A
Parasitol Res 2017 Feb;116(2):457-464. Epub 2016 Nov 7 doi: 10.1007/s00436-016-5313-x. PMID: 27822583
Perivascular hemophagocytosis: report of 2 cases and review of the literature.
Valentín SM, Montalván E, Sánchez JL
Am J Dermatopathol 2010 Oct;32(7):716-9. doi: 10.1097/DAD.0b013e3181d775cf. PMID: 20859080

Recent systematic reviews

Postmortem Findings Associated With SARS-CoV-2: Systematic Review and Meta-analysis.
Satturwar S, Fowkes M, Farver C, Wilson AM, Eccher A, Girolami I, Pujadas E, Bryce C, Salem F, El Jamal SM, Paniz-Mondolfi A, Petersen B, Gordon RE, Reidy J, Fraggetta F, Marshall DA, Pantanowitz L
Am J Surg Pathol 2021 May 1;45(5):587-603. doi: 10.1097/PAS.0000000000001650. PMID: 33481385Free PMC Article

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