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Abnormal myeloid leukocyte morphology

MedGen UID:
869196
•Concept ID:
C4023618
•
Cell or Molecular Dysfunction
Synonym: Abnormality of myeloid leukocytes
 
HPO: HP:0010974

Definition

An abnormality of myeloid leukocytes. [from HPO]

Professional guidelines

PubMed

Monocytic Differentiation in Acute Myeloid Leukemia Cells: Diagnostic Criteria, Biological Heterogeneity, Mitochondrial Metabolism, Resistance to and Induction by Targeted Therapies.
Bruserud Ø, Selheim F, Hernandez-Valladares M, Reikvam H
Int J Mol Sci 2024 Jun 8;25(12) doi: 10.3390/ijms25126356. PMID: 38928061Free PMC Article
Chronic myelomonocytic leukemia: 2024 update on diagnosis, risk stratification and management.
Patnaik MM, Tefferi A
Am J Hematol 2024 Jun;99(6):1142-1165. Epub 2024 Mar 7 doi: 10.1002/ajh.27271. PMID: 38450850Free PMC Article
Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2013 Feb;88(2):141-50. doi: 10.1002/ajh.23384. PMID: 23349007

Recent clinical studies

Etiology

Chronic myelomonocytic leukemia: 2024 update on diagnosis, risk stratification and management.
Patnaik MM, Tefferi A
Am J Hematol 2024 Jun;99(6):1142-1165. Epub 2024 Mar 7 doi: 10.1002/ajh.27271. PMID: 38450850Free PMC Article
Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis.
Wu X, Liu Y, Jin S, Wang M, Jiao Y, Yang B, Lu X, Ji X, Fei Y, Yang H, Zhao L, Chen H, Zhang Y, Li H, Lipsky PE, Tsokos GC, Bai F, Zhang X
Nat Commun 2021 Aug 17;12(1):4977. doi: 10.1038/s41467-021-25246-7. PMID: 34404786Free PMC Article
Molecular pathogenesis of acquired aplastic anemia.
Boddu PC, Kadia TM
Eur J Haematol 2019 Feb;102(2):103-110. Epub 2018 Dec 18 doi: 10.1111/ejh.13182. PMID: 30380171
Diagnosis, risk stratification, and response evaluation in classical myeloproliferative neoplasms.
Rumi E, Cazzola M
Blood 2017 Feb 9;129(6):680-692. Epub 2016 Dec 27 doi: 10.1182/blood-2016-10-695957. PMID: 28028026Free PMC Article
The juvenile idiopathic inflammatory myopathies: pathogenesis, clinical and autoantibody phenotypes, and outcomes.
Rider LG, Nistala K
J Intern Med 2016 Jul;280(1):24-38. Epub 2016 Mar 30 doi: 10.1111/joim.12444. PMID: 27028907Free PMC Article

Diagnosis

Chronic myelomonocytic leukemia: 2024 update on diagnosis, risk stratification and management.
Patnaik MM, Tefferi A
Am J Hematol 2024 Jun;99(6):1142-1165. Epub 2024 Mar 7 doi: 10.1002/ajh.27271. PMID: 38450850Free PMC Article
A tower of babel of acronyms? The shadowlands of MGUS/MBL/CHIP/TCUS.
Bravo-Perez C, Gurnari C
Semin Hematol 2024 Feb;61(1):43-50. Epub 2024 Jan 19 doi: 10.1053/j.seminhematol.2024.01.004. PMID: 38350765
Molecular pathogenesis of acquired aplastic anemia.
Boddu PC, Kadia TM
Eur J Haematol 2019 Feb;102(2):103-110. Epub 2018 Dec 18 doi: 10.1111/ejh.13182. PMID: 30380171
B-acute lymphoblastic leukemia/lymphoblastic lymphoma.
Loghavi S, Kutok JL, Jorgensen JL
Am J Clin Pathol 2015 Sep;144(3):393-410. doi: 10.1309/AJCPAN7BH5DNYWZB. PMID: 26276770
Eosinophilic myeloid disorders.
Noel P
Semin Hematol 2012 Apr;49(2):120-7. doi: 10.1053/j.seminhematol.2012.01.008. PMID: 22449622

Therapy

Monocytic Differentiation in Acute Myeloid Leukemia Cells: Diagnostic Criteria, Biological Heterogeneity, Mitochondrial Metabolism, Resistance to and Induction by Targeted Therapies.
Bruserud Ø, Selheim F, Hernandez-Valladares M, Reikvam H
Int J Mol Sci 2024 Jun 8;25(12) doi: 10.3390/ijms25126356. PMID: 38928061Free PMC Article
Diagnosis, risk stratification, and response evaluation in classical myeloproliferative neoplasms.
Rumi E, Cazzola M
Blood 2017 Feb 9;129(6):680-692. Epub 2016 Dec 27 doi: 10.1182/blood-2016-10-695957. PMID: 28028026Free PMC Article
Harnessing the immune system in acute myeloid leukaemia.
Austin R, Smyth MJ, Lane SW
Crit Rev Oncol Hematol 2016 Jul;103:62-77. Epub 2016 May 11 doi: 10.1016/j.critrevonc.2016.04.020. PMID: 27247119
Drug-induced agranulocytosis.
Young GA, Vincent PC
Clin Haematol 1980 Oct;9(3):483-504. PMID: 7004683
Acute promyelocytic leukemia.
Groopman J, Ellman L
Am J Hematol 1979;7(4):395-408. doi: 10.1002/ajh.2830070412. PMID: 397771

Prognosis

Monocytic Differentiation in Acute Myeloid Leukemia Cells: Diagnostic Criteria, Biological Heterogeneity, Mitochondrial Metabolism, Resistance to and Induction by Targeted Therapies.
Bruserud Ø, Selheim F, Hernandez-Valladares M, Reikvam H
Int J Mol Sci 2024 Jun 8;25(12) doi: 10.3390/ijms25126356. PMID: 38928061Free PMC Article
Diagnosis, risk stratification, and response evaluation in classical myeloproliferative neoplasms.
Rumi E, Cazzola M
Blood 2017 Feb 9;129(6):680-692. Epub 2016 Dec 27 doi: 10.1182/blood-2016-10-695957. PMID: 28028026Free PMC Article
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.
Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA
Nature 2006 Aug 17;442(7104):818-22. Epub 2006 Jul 16 doi: 10.1038/nature04980. PMID: 16862118
Chronic myelogenous leukemia.
Grignani F
Crit Rev Oncol Hematol 1985;4(1):31-66. PMID: 3902263
Acute promyelocytic leukemia.
Groopman J, Ellman L
Am J Hematol 1979;7(4):395-408. doi: 10.1002/ajh.2830070412. PMID: 397771

Clinical prediction guides

Clinical implications and genetical insights of SOX6 expression in acute myeloid leukemia.
Li Y, Jiang D, Zhang Q, Liu E, Shao H
J Cancer Res Clin Oncol 2023 Jul;149(8):4443-4453. Epub 2022 Sep 19 doi: 10.1007/s00432-022-04349-8. PMID: 36117190
Immunophenotypic changes of monocytes in myelodysplastic syndrome and clinical significance.
Li L, Yu S, Hu X, Liu Z, Tian X, Ren X, Guo X, Fu R
Clin Exp Med 2023 Jul;23(3):787-801. Epub 2022 Aug 2 doi: 10.1007/s10238-022-00856-7. PMID: 35916958Free PMC Article
Multiple Sclerosis: Microglia, Monocytes, and Macrophage-Mediated Demyelination.
Prineas JW, Parratt JDE
J Neuropathol Exp Neurol 2021 Oct 26;80(10):975-996. doi: 10.1093/jnen/nlab083. PMID: 34553215Free PMC Article
Recurrent lipoatrophic panniculitis of children.
Torrelo A, Noguera-Morel L, Hernández-Martín A, Clemente D, Barja JM, Buzón L, Azorín D, de Jesús AA, López-Robledillo JC, Colmenero I, Kutzner H, Goldbach-Mansky R, Requena L
J Eur Acad Dermatol Venereol 2017 Mar;31(3):536-543. Epub 2016 Aug 12 doi: 10.1111/jdv.13858. PMID: 27515780
Arginine and immunity.
Popovic PJ, Zeh HJ 3rd, Ochoa JB
J Nutr 2007 Jun;137(6 Suppl 2):1681S-1686S. doi: 10.1093/jn/137.6.1681S. PMID: 17513447

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