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Increased circulating interleukin 2 concentration

MedGen UID:
1841607
•Concept ID:
C5826431
•
Finding
Synonym: IL-2 high in blood
 
HPO: HP:0034489

Definition

An increased concentration of interleukin-2 in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating interleukin 2 concentration

Professional guidelines

PubMed

Treatment of Raynaud's phenomenon with intravenous prostaglandin E1alpha-cyclodextrin improves endothelial cell injury in systemic sclerosis.
Gardinali M, Pozzi MR, Bernareggi M, Montani N, Allevi E, Catena L, Cugno M, Bottasso B, Stabilini R
J Rheumatol 2001 Apr;28(4):786-94. PMID: 11327251
Does prolonged oral treatment with sustained-release morphine tablets influence immune function?
Palm S, Lehzen S, Mignat C, Steinmann J, Leimenstoll G, Maier C
Anesth Analg 1998 Jan;86(1):166-72. doi: 10.1097/00000539-199801000-00033. PMID: 9428873
Anti-interleukin 2 receptor monoclonal antibody in the treatment of ongoing acute rejection episodes of human kidney graft--a pilot study.
Cantarovich D, Le Mauff B, Hourmant M, Giral M, Denis M, Hirn M, Jacques Y, Soulillou JP
Transplantation 1989 Mar;47(3):454-7. doi: 10.1097/00007890-198903000-00011. PMID: 2646778

Recent clinical studies

Etiology

Circulating inflammatory cytokines and psoriasis risk: A systematic review and meta-analysis.
Liu XQ, Zhou PL, Yin XY, Wang AX, Wang DH, Yang Y, Liu Q
PLoS One 2023;18(10):e0293327. Epub 2023 Oct 26 doi: 10.1371/journal.pone.0293327. PMID: 37883350Free PMC Article
Cytokine profiles in adults with imported malaria.
de Roquetaillade C, Laouenan C, Mira JP, Roy C, Thuong M, Azoulay É, Gruson D, Jacobs F, Chommeloux J, Raffi F, Hocqueloux L, Imbert P, Jeantils V, Delassus JL, Matheron S, Fitting C, Timsit JF, Bruneel F
Sci Rep 2023 Jun 26;13(1):10347. doi: 10.1038/s41598-023-36212-2. PMID: 37365194Free PMC Article
Monitoring of blood immunosuppressant concentrations and lymphocyte activation for predicting viral infections following kidney transplantation: A pilot study.
Iwamoto T, Nishikawa K
Medicine (Baltimore) 2022 Nov 18;101(46):e31783. doi: 10.1097/MD.0000000000031783. PMID: 36401367Free PMC Article
Soluble forms of intercellular adhesion molecule-1 in insulin-dependent diabetes mellitus.
Roep BO, Heidenthal E, de Vries RR, Kolb H, Martin S
Lancet 1994 Jun 25;343(8913):1590-3. doi: 10.1016/s0140-6736(94)93055-4. PMID: 7911918
Increased circulating concentrations of interleukin 2 receptor during rejection episodes in heart- or kidney-transplant recipients.
Zucchelli GC, Clerico A, De Maria R, Carmellini M, Di Stefano R, Masini S, Pilo A, Donato L
Clin Chem 1990 Dec;36(12):2106-9. PMID: 2253354

Diagnosis

Circulating inflammatory cytokines and psoriasis risk: A systematic review and meta-analysis.
Liu XQ, Zhou PL, Yin XY, Wang AX, Wang DH, Yang Y, Liu Q
PLoS One 2023;18(10):e0293327. Epub 2023 Oct 26 doi: 10.1371/journal.pone.0293327. PMID: 37883350Free PMC Article
A cross-sectional healthy-control study of serum inflammatory biomarkers interleukin (IL)-1B and IL-2R in panic disorder patients and their offspring.
Quagliato LA, Nardi AE
J Psychiatr Res 2022 May;149:260-264. Epub 2022 Mar 11 doi: 10.1016/j.jpsychires.2022.03.004. PMID: 35303615
Analysis of interleukin-2/interleukin-2 receptor system in advanced non-small-cell lung cancer.
De Vita F, Turitto G, di Grazia M, Frattolillo A, Catalano G
Tumori 1998 Jan-Feb;84(1):33-8. doi: 10.1177/030089169808400107. PMID: 9619711
Soluble forms of intercellular adhesion molecule-1 in insulin-dependent diabetes mellitus.
Roep BO, Heidenthal E, de Vries RR, Kolb H, Martin S
Lancet 1994 Jun 25;343(8913):1590-3. doi: 10.1016/s0140-6736(94)93055-4. PMID: 7911918
Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.
Chaffin KE, Beals CR, Wilkie TM, Forbush KA, Simon MI, Perlmutter RM
EMBO J 1990 Dec;9(12):3821-9. doi: 10.1002/j.1460-2075.1990.tb07600.x. PMID: 2123451Free PMC Article

Therapy

A Single Dose of Ibuprofen Impacts IL-10 Response to 164-km Road Cycling in the Heat.
Vingren JL, Boyett JC, Lee EC, Levitt DE, Luk HY, McDermott BP, Munoz CX, Ganio MS, Armstrong LE, Hill DW
Res Q Exerc Sport 2023 Jun;94(2):344-350. Epub 2022 Mar 28 doi: 10.1080/02701367.2021.1981539. PMID: 35344476
Increased levels of soluble interleukin-4 receptor in the sera of patients with visceral leishmaniasis.
Sang DK, Ouma JH, John CC, Whalen CC, King CL, Mahmoud AA, Heinzel FP
J Infect Dis 1999 Mar;179(3):743-6. doi: 10.1086/314635. PMID: 9952391
Interleukin 4 responses in acute leukaemia patients with severe chemotherapy-induced leucopenia.
Bruserud O, Ulvestad E, Halstensen A, Berentsen S, Bergheim J, Nesthus I
Eur J Haematol 1997 Nov;59(5):269-76. doi: 10.1111/j.1600-0609.1997.tb01686.x. PMID: 9414637
Recombinant interleukin-2 infusions and decreased IgG2 subclass concentrations.
Soiffer RJ, Murray C, Ritz J, Phillips N, Jacobsohn D, Chartier S, Ambrosino DM
Blood 1995 Feb 15;85(4):925-8. PMID: 7849314
Interleukin-2 initiates metabolic responses associated with critical illness in humans.
Michie HR, Eberlein TJ, Spriggs DR, Manogue KR, Cerami A, Wilmore DW
Ann Surg 1988 Oct;208(4):493-503. doi: 10.1097/00000658-198810000-00011. PMID: 2845872Free PMC Article

Prognosis

Monitoring of blood immunosuppressant concentrations and lymphocyte activation for predicting viral infections following kidney transplantation: A pilot study.
Iwamoto T, Nishikawa K
Medicine (Baltimore) 2022 Nov 18;101(46):e31783. doi: 10.1097/MD.0000000000031783. PMID: 36401367Free PMC Article
Increased serum concentration of circulating soluble receptor for interleukin-2 and its effect as a prognostic indicator in cachectic patients with gastric and colorectal cancer.
Shibata M, Takekawa M
Oncology 1999;56(1):54-8. doi: 10.1159/000011930. PMID: 9885378
Analysis of interleukin-2/interleukin-2 receptor system in advanced non-small-cell lung cancer.
De Vita F, Turitto G, di Grazia M, Frattolillo A, Catalano G
Tumori 1998 Jan-Feb;84(1):33-8. doi: 10.1177/030089169808400107. PMID: 9619711
Acute dyslipoproteinemia induced by interleukin-2: lecithin:cholesteryl acyltransferase, lipoprotein lipase, and hepatic lipase deficiencies.
Kwong LK, Ridinger DN, Bandhauer M, Ward JH, Samlowski WE, Iverius PH, Pritchard H, Wilson DE
J Clin Endocrinol Metab 1997 May;82(5):1572-81. doi: 10.1210/jcem.82.5.3937. PMID: 9141552
Administration of interleukin-2 (IL-2) results in increased plasma concentrations of IL-5 and eosinophilia in patients with cancer.
van Haelst Pisani C, Kovach JS, Kita H, Leiferman KM, Gleich GJ, Silver JE, Dennin R, Abrams JS
Blood 1991 Sep 15;78(6):1538-44. PMID: 1884020

Clinical prediction guides

Monitoring of blood immunosuppressant concentrations and lymphocyte activation for predicting viral infections following kidney transplantation: A pilot study.
Iwamoto T, Nishikawa K
Medicine (Baltimore) 2022 Nov 18;101(46):e31783. doi: 10.1097/MD.0000000000031783. PMID: 36401367Free PMC Article
A cross-sectional healthy-control study of serum inflammatory biomarkers interleukin (IL)-1B and IL-2R in panic disorder patients and their offspring.
Quagliato LA, Nardi AE
J Psychiatr Res 2022 May;149:260-264. Epub 2022 Mar 11 doi: 10.1016/j.jpsychires.2022.03.004. PMID: 35303615
Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions.
Makhseed M, Raghupathy R, Azizieh F, Farhat R, Hassan N, Bandar A
Hum Reprod 2000 Sep;15(9):2011-7. doi: 10.1093/humrep/15.9.2011. PMID: 10967006
Acute dyslipoproteinemia induced by interleukin-2: lecithin:cholesteryl acyltransferase, lipoprotein lipase, and hepatic lipase deficiencies.
Kwong LK, Ridinger DN, Bandhauer M, Ward JH, Samlowski WE, Iverius PH, Pritchard H, Wilson DE
J Clin Endocrinol Metab 1997 May;82(5):1572-81. doi: 10.1210/jcem.82.5.3937. PMID: 9141552
Interleukin-2 initiates metabolic responses associated with critical illness in humans.
Michie HR, Eberlein TJ, Spriggs DR, Manogue KR, Cerami A, Wilmore DW
Ann Surg 1988 Oct;208(4):493-503. doi: 10.1097/00000658-198810000-00011. PMID: 2845872Free PMC Article

Recent systematic reviews

Circulating inflammatory cytokines and psoriasis risk: A systematic review and meta-analysis.
Liu XQ, Zhou PL, Yin XY, Wang AX, Wang DH, Yang Y, Liu Q
PLoS One 2023;18(10):e0293327. Epub 2023 Oct 26 doi: 10.1371/journal.pone.0293327. PMID: 37883350Free PMC Article

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