Warning: The NCBI web site requires JavaScript to function. more...

Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Reduced epidermal plectin protein expression

MedGen UID:: 1841648
•Concept ID:: C5826495
•: Finding

Synonym:	Skin biopsy: plectin antibody staining abnormal or absent

HPO:	HP:0034580

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVReduced epidermal plectin protein expression

Phenotypic abnormality
- Abnormality of the integument
  - Abnormality of the skin
    - Abnormal skin morphology
      - Abnormal epidermal morphology
        Abnormal epidermal protein expression
        Reduced epidermal plectin protein expression

Recent clinical studies

Diagnosis

PKD2 and RSK1 Regulate Integrin β4 Phosphorylation at Threonine 1736.

Te Molder L, Sonnenberg A
PLoS One 2015;10(11):e0143357. Epub 2015 Nov 18 doi: 10.1371/journal.pone.0143357. PMID: 26580203 Free PMC Article

Therapy

MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway.

Jang TH, Huang WC, Tung SL, Lin SC, Chen PM, Cho CY, Yang YY, Yen TC, Lo GH, Chuang SE, Wang LH
J Biomed Sci 2022 Jun 15;29(1):42. doi: 10.1186/s12929-022-00824-z. PMID: 35706019 Free PMC Article

Clinical prediction guides

MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway.

Jang TH, Huang WC, Tung SL, Lin SC, Chen PM, Cho CY, Yang YY, Yen TC, Lo GH, Chuang SE, Wang LH
J Biomed Sci 2022 Jun 15;29(1):42. doi: 10.1186/s12929-022-00824-z. PMID: 35706019 Free PMC Article

Cultured keratinocytes from plectin/HD1-deficient epidermolysis bullosa simplex showed altered ability of adhesion to the matrix.

Kurose K, Mori O, Hachisuka H, Shimizu H, Owaribe K, Hashimoto T
J Dermatol Sci 2000 Dec;24(3):184-9. doi: 10.1016/s0923-1811(00)00100-6. PMID: 11084300

Supplemental Content

Table of contents

Clinical resources

ClinicalTrials.gov

Consumer resources

MedlinePlus

Reviews

Related information

PMC Articles
Related information in PubMed Central Links
PubMed
Related literature resources in PubMed

Recent activity

Clear Turn Off Turn On

Reduced epidermal plectin protein expression
Reduced epidermal plectin protein expression

MedGen
Epidermolysis bullosa simplex due to plakophilin deficiency
Epidermolysis bullosa simplex due to plakophilin deficiency

MedGen
Scleroderma Renal Crisis
Scleroderma Renal Crisis

MedGen
Paralytic ileus
Paralytic ileus

MedGen

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...