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Decreased circulating membrane cofactor protein concentration

MedGen UID:
1841661
•Concept ID:
C5826530
•
Finding
Synonyms: Decreased circulating CD46 concentration; MCP (membrane cofactor protein) low in blood
 
HPO: HP:0034619

Definition

Concentration of membrane cofactor protein in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating membrane cofactor protein concentration

Recent clinical studies

Diagnosis

Thermodynamic and kinetic characterization of the protein Z-dependent protease inhibitor (ZPI)-protein Z interaction reveals an unexpected role for ZPI Lys-239.
Huang X, Zhou J, Zhou A, Olson ST
J Biol Chem 2015 Apr 10;290(15):9906-18. Epub 2015 Feb 20 doi: 10.1074/jbc.M114.633479. PMID: 25713144Free PMC Article

Therapy

Bioenergetic and antioxidant properties of coenzyme Q10: recent developments.
Littarru GP, Tiano L
Mol Biotechnol 2007 Sep;37(1):31-7. doi: 10.1007/s12033-007-0052-y. PMID: 17914161

Clinical prediction guides

Scott syndrome erythrocytes contain a membrane protein capable of mediating Ca2+-dependent transbilayer migration of membrane phospholipids.
Stout JG, Bassé F, Luhm RA, Weiss HJ, Wiedmer T, Sims PJ
J Clin Invest 1997 May 1;99(9):2232-8. doi: 10.1172/JCI119397. PMID: 9151796Free PMC Article

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