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Abnormal circulating membrane cofactor protein concentration

MedGen UID:: 1841810
•Concept ID:: C5826529
•: Finding

HPO:	HP:0034618

Definition

Concentration of membrane cofactor protein in the blood circulation outside the limits of normal. Membrane cofactor protein (MCP, CD46) is a cell surface complement regulatory protein which acts as a cofactor for the factor I-mediated cleavage of the activated complement components C3b/C4b. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal circulating membrane cofactor protein concentration

Phenotypic abnormality
- Abnormality of metabolism/homeostasis
  - Abnormal circulating metabolite concentration
    - Abnormal circulating protein concentration
      - Abnormal circulating membrane cofactor protein concentration
        Decreased circulating membrane cofactor protein concentration
        Elevated circulating membrane cofactor protein concentration

Recent clinical studies

Etiology

Soluble thrombomodulin antigen in plasma is increased in patients with acute myocardial infarction treated with thrombolytic therapy.

Ohlin AK, Morser J, Ohlin H
Thromb Res 1996 May 15;82(4):313-22. doi: 10.1016/0049-3848(96)00081-3. PMID: 8743727

Therapy

Soluble thrombomodulin antigen in plasma is increased in patients with acute myocardial infarction treated with thrombolytic therapy.

Ohlin AK, Morser J, Ohlin H
Thromb Res 1996 May 15;82(4):313-22. doi: 10.1016/0049-3848(96)00081-3. PMID: 8743727

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