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Fungal bloodstream infection

MedGen UID:
1841672
•Concept ID:
C5826638
•
Disease or Syndrome
Synonym: Fungi in blood
 
HPO: HP:0034749

Definition

Detection of a fungal organism (such as candida or coccidioides) in the blood stream. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFungal bloodstream infection

Professional guidelines

PubMed

Epidemiology, management and outcome of candidaemia in patients with diabetes.
Preece G, Bhola S, Davidson A, Collier A, Bal AM
J R Coll Physicians Edinb 2022 Dec;52(4):292-297. Epub 2022 Nov 24 doi: 10.1177/14782715221137451. PMID: 36420755
Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality.
Morrell M, Fraser VJ, Kollef MH
Antimicrob Agents Chemother 2005 Sep;49(9):3640-5. doi: 10.1128/AAC.49.9.3640-3645.2005. PMID: 16127033Free PMC Article

Recent clinical studies

Etiology

Epidemiology, management and outcome of candidaemia in patients with diabetes.
Preece G, Bhola S, Davidson A, Collier A, Bal AM
J R Coll Physicians Edinb 2022 Dec;52(4):292-297. Epub 2022 Nov 24 doi: 10.1177/14782715221137451. PMID: 36420755
A multi-center outbreak of Candida tropicalis bloodstream infections associated with contaminated hemodialysis machine prime buckets.
Boyce JM, Dumigan DG, Havill NL, Hollis RJ, Pfaller MA, Moore BA
Am J Infect Control 2021 Aug;49(8):1008-1013. Epub 2021 Feb 22 doi: 10.1016/j.ajic.2021.02.014. PMID: 33631306
Analysis of fungal bloodstream infection in intensive care units in the Meizhou region of China: species distribution and resistance and the risk factors for patient mortality.
Xiao G, Liao W, Zhang Y, Luo X, Zhang C, Li G, Yang Y, Xu Y
BMC Infect Dis 2020 Aug 14;20(1):599. doi: 10.1186/s12879-020-05291-1. PMID: 32795259Free PMC Article
Diagnostic efficacy of serum cytokines and chemokines in fungal bloodstream infection in febrile patients.
Wang Q, Yang M, Wang C, Cui J, Li X, Wang C
J Clin Lab Anal 2020 Apr;34(4):e23149. Epub 2020 Jan 23 doi: 10.1002/jcla.23149. PMID: 31971308Free PMC Article
Etiology of Severe Febrile Illness in Low- and Middle-Income Countries: A Systematic Review.
Prasad N, Murdoch DR, Reyburn H, Crump JA
PLoS One 2015;10(6):e0127962. Epub 2015 Jun 30 doi: 10.1371/journal.pone.0127962. PMID: 26126200Free PMC Article

Diagnosis

Invasive para-aortic Candida glabrata: a multidisciplinary management challenge.
Miller R, Harris S, Porter R, Burnett H
BMJ Case Rep 2021 Jun 17;14(6) doi: 10.1136/bcr-2020-240710. PMID: 34140325Free PMC Article
Analysis of fungal bloodstream infection in intensive care units in the Meizhou region of China: species distribution and resistance and the risk factors for patient mortality.
Xiao G, Liao W, Zhang Y, Luo X, Zhang C, Li G, Yang Y, Xu Y
BMC Infect Dis 2020 Aug 14;20(1):599. doi: 10.1186/s12879-020-05291-1. PMID: 32795259Free PMC Article
Diagnostic efficacy of serum cytokines and chemokines in fungal bloodstream infection in febrile patients.
Wang Q, Yang M, Wang C, Cui J, Li X, Wang C
J Clin Lab Anal 2020 Apr;34(4):e23149. Epub 2020 Jan 23 doi: 10.1002/jcla.23149. PMID: 31971308Free PMC Article
Etiology of Severe Febrile Illness in Low- and Middle-Income Countries: A Systematic Review.
Prasad N, Murdoch DR, Reyburn H, Crump JA
PLoS One 2015;10(6):e0127962. Epub 2015 Jun 30 doi: 10.1371/journal.pone.0127962. PMID: 26126200Free PMC Article
Bloodstream infections by Malassezia and Candida species in critical care patients.
Iatta R, Cafarchia C, Cuna T, Montagna O, Laforgia N, Gentile O, Rizzo A, Boekhout T, Otranto D, Montagna MT
Med Mycol 2014 Apr;52(3):264-9. Epub 2013 Dec 22 doi: 10.1093/mmy/myt004. PMID: 24576998

Therapy

Universal antifungal prophylaxis effectively prevents fungal bloodstream infection in pediatric liver transplant recipients: a retrospective real-world study.
Wang W, Wang Y, Zhang Y, Zhang W, Bai X, Zhang Q, Liang T
Int J Infect Dis 2024 Jun;143:107003. Epub 2024 Mar 21 doi: 10.1016/j.ijid.2024.107003. PMID: 38521451
Epidemiology, management and outcome of candidaemia in patients with diabetes.
Preece G, Bhola S, Davidson A, Collier A, Bal AM
J R Coll Physicians Edinb 2022 Dec;52(4):292-297. Epub 2022 Nov 24 doi: 10.1177/14782715221137451. PMID: 36420755
A multi-center outbreak of Candida tropicalis bloodstream infections associated with contaminated hemodialysis machine prime buckets.
Boyce JM, Dumigan DG, Havill NL, Hollis RJ, Pfaller MA, Moore BA
Am J Infect Control 2021 Aug;49(8):1008-1013. Epub 2021 Feb 22 doi: 10.1016/j.ajic.2021.02.014. PMID: 33631306
Analysis of fungal bloodstream infection in intensive care units in the Meizhou region of China: species distribution and resistance and the risk factors for patient mortality.
Xiao G, Liao W, Zhang Y, Luo X, Zhang C, Li G, Yang Y, Xu Y
BMC Infect Dis 2020 Aug 14;20(1):599. doi: 10.1186/s12879-020-05291-1. PMID: 32795259Free PMC Article
Bloodstream infections by Malassezia and Candida species in critical care patients.
Iatta R, Cafarchia C, Cuna T, Montagna O, Laforgia N, Gentile O, Rizzo A, Boekhout T, Otranto D, Montagna MT
Med Mycol 2014 Apr;52(3):264-9. Epub 2013 Dec 22 doi: 10.1093/mmy/myt004. PMID: 24576998

Prognosis

Successful heart transplantation from a donor with bacterial and fungal bloodstream infection: Case report of donor optimization strategy.
Alghamdi AA, Hussain A, Bosaeed M, Selimovic N, Zaibag MA
J Card Surg 2022 Aug;37(8):2440-2442. Epub 2022 May 9 doi: 10.1111/jocs.16609. PMID: 35535367
Association of preoperative infections, nasal Staphylococcus aureus colonization and gut microbiota with left ventricular assist device outcomes.
Yuzefpolskaya M, Lumish HS, Javaid A, Cagliostro B, Mondellini GM, Bohn B, Sweat A, Onat D, Braghieri L, Takeda K, Naka Y, Sayer GT, Uriel N, Aaron JG, Montassier E, Demmer RT, Colombo PC
Eur J Heart Fail 2021 Aug;23(8):1404-1415. Epub 2021 May 31 doi: 10.1002/ejhf.2215. PMID: 33964186Free PMC Article
Analysis of fungal bloodstream infection in intensive care units in the Meizhou region of China: species distribution and resistance and the risk factors for patient mortality.
Xiao G, Liao W, Zhang Y, Luo X, Zhang C, Li G, Yang Y, Xu Y
BMC Infect Dis 2020 Aug 14;20(1):599. doi: 10.1186/s12879-020-05291-1. PMID: 32795259Free PMC Article
Epidemiological features of nosocomial candidaemia in neonates, infants and children: A multicentre study in Iran.
Ahangarkani F, Shokohi T, Rezai MS, Ilkit M, Mahmoodi Nesheli H, Karami H, Tamaddoni A, Alizadeh-Navaei R, Khodavaisy S, Meis JF, Badali H
Mycoses 2020 Apr;63(4):382-394. doi: 10.1111/myc.13053. PMID: 31985076
Mixed bloodstream infection with Staphylococcus aureus and Penicillium chrysogenum in an immunocompromised patient: case report and review of the literature.
Swoboda-Kopec E, Wroblewska MM, Rokosz A, Luczak M
Clin Microbiol Infect 2003 Nov;9(11):1116-7. doi: 10.1046/j.1469-0691.2003.00718.x. PMID: 14616728

Clinical prediction guides

A multi-center outbreak of Candida tropicalis bloodstream infections associated with contaminated hemodialysis machine prime buckets.
Boyce JM, Dumigan DG, Havill NL, Hollis RJ, Pfaller MA, Moore BA
Am J Infect Control 2021 Aug;49(8):1008-1013. Epub 2021 Feb 22 doi: 10.1016/j.ajic.2021.02.014. PMID: 33631306
Analysis of fungal bloodstream infection in intensive care units in the Meizhou region of China: species distribution and resistance and the risk factors for patient mortality.
Xiao G, Liao W, Zhang Y, Luo X, Zhang C, Li G, Yang Y, Xu Y
BMC Infect Dis 2020 Aug 14;20(1):599. doi: 10.1186/s12879-020-05291-1. PMID: 32795259Free PMC Article
Epidemiological features of nosocomial candidaemia in neonates, infants and children: A multicentre study in Iran.
Ahangarkani F, Shokohi T, Rezai MS, Ilkit M, Mahmoodi Nesheli H, Karami H, Tamaddoni A, Alizadeh-Navaei R, Khodavaisy S, Meis JF, Badali H
Mycoses 2020 Apr;63(4):382-394. doi: 10.1111/myc.13053. PMID: 31985076
A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans.
Jaeger M, Matzaraki V, Aguirre-Gamboa R, Gresnigt MS, Chu X, Johnson MD, Oosting M, Smeekens SP, Withoff S, Jonkers I, Perfect JR, van de Veerdonk FL, Kullberg BJ, Joosten LAB, Li Y, Wijmenga C, Netea MG, Kumar V
J Infect Dis 2019 Jul 31;220(5):862-872. doi: 10.1093/infdis/jiz206. PMID: 31241743Free PMC Article
Increased presepsin levels are associated with the severity of fungal bloodstream infections.
Bamba Y, Moro H, Aoki N, Koizumi T, Ohshima Y, Watanabe S, Sakagami T, Koya T, Takada T, Kikuchi T
PLoS One 2018;13(10):e0206089. Epub 2018 Oct 31 doi: 10.1371/journal.pone.0206089. PMID: 30379880Free PMC Article

Recent systematic reviews

Etiology of Severe Febrile Illness in Low- and Middle-Income Countries: A Systematic Review.
Prasad N, Murdoch DR, Reyburn H, Crump JA
PLoS One 2015;10(6):e0127962. Epub 2015 Jun 30 doi: 10.1371/journal.pone.0127962. PMID: 26126200Free PMC Article

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