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Abnormal brain glutamine level by MRS

MedGen UID:
1841685
•Concept ID:
C5826436
•
Finding
HPO: HP:0034496

Definition

A deviation from normal in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal brain glutamine level by MRS

Professional guidelines

PubMed

Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review.
Szulc A, Wiedlocha M, Waszkiewicz N, Galińska-Skok B, Marcinowicz P, Gierus J, Mosiolek A
Psychiatry Res Neuroimaging 2018 Mar 30;273:1-8. Epub 2018 Jan 17 doi: 10.1016/j.pscychresns.2018.01.001. PMID: 29414126
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Szulc A, Galinska-Skok B, Waszkiewicz N, Bibulowicz D, Konarzewska B, Tarasow E
Curr Med Chem 2013;20(3):414-27. PMID: 23157634
Brain metabolism in Rett syndrome: age, clinical, and genotype correlations.
Horská A, Farage L, Bibat G, Nagae LM, Kaufmann WE, Barker PB, Naidu S
Ann Neurol 2009 Jan;65(1):90-7. doi: 10.1002/ana.21562. PMID: 19194883Free PMC Article

Recent clinical studies

Etiology

Excitatory/Inhibitory Imbalance Underlies Hippocampal Atrophy in Individuals With 22q11.2 Deletion Syndrome With Psychotic Symptoms.
Mancini V, Saleh MG, Delavari F, Bagautdinova J, Eliez S
Biol Psychiatry 2023 Oct 1;94(7):569-579. Epub 2023 Apr 1 doi: 10.1016/j.biopsych.2023.03.021. PMID: 37011759
J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy.
Zöllner HJ, Thiel TA, Füllenbach ND, Jördens MS, Ahn S, Wilms LM, Ljimani A, Häussinger D, Butz M, Wittsack HJ, Schnitzler A, Oeltzschner G
Metab Brain Dis 2023 Apr;38(4):1221-1238. Epub 2023 Feb 2 doi: 10.1007/s11011-023-01174-x. PMID: 36729261Free PMC Article
Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) Imaging in Obsessive-Compulsive Disorder.
Biria M, Cantonas LM, Banca P
Curr Top Behav Neurosci 2021;49:231-268. doi: 10.1007/7854_2020_201. PMID: 33751502
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Brain and cognition abnormalities in long-term anabolic-androgenic steroid users.
Kaufman MJ, Janes AC, Hudson JI, Brennan BP, Kanayama G, Kerrigan AR, Jensen JE, Pope HG Jr
Drug Alcohol Depend 2015 Jul 1;152:47-56. Epub 2015 May 7 doi: 10.1016/j.drugalcdep.2015.04.023. PMID: 25986964Free PMC Article

Diagnosis

Hippocampal neurometabolic and structural changes from pre-to post-COVID-19: A case-series study.
Vints WAJ, Valatkevičienė K, Levin O, Weerasekera A, Jesmanas S, Kušleikienė S, Česnaitienė VJ, Himmelreich U, Verbunt JA, Ratai EM, Gleiznienė R, Masiulis N
Magn Reson Imaging 2024 Jun;109:249-255. Epub 2024 Mar 22 doi: 10.1016/j.mri.2024.03.032. PMID: 38521366
Spectroscopic abnormalities in the pregenual anterior cingulate cortex in obsessive-compulsive disorder using proton magnetic resonance spectroscopy: a controlled study.
Kosová E, Pajuelo D, Fajnerová I, Greguš D, Brunovský M, Stopková P, Škoch A, Fürstová P, Španiel F, Horáček J
BMC Psychiatry 2023 Oct 10;23(1):734. doi: 10.1186/s12888-023-05228-3. PMID: 37817131Free PMC Article
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Hippocampal MRS and subfield volumetry at 7T detects dysfunction not specific to seizure focus.
Voets NL, Hodgetts CJ, Sen A, Adcock JE, Emir U
Sci Rep 2017 Nov 23;7(1):16138. doi: 10.1038/s41598-017-16046-5. PMID: 29170537Free PMC Article
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Szulc A, Galinska-Skok B, Waszkiewicz N, Bibulowicz D, Konarzewska B, Tarasow E
Curr Med Chem 2013;20(3):414-27. PMID: 23157634

Therapy

Elevation of brain gamma-aminobutyric acid levels is associated with vigabatrin-associated brain abnormalities on magnetic resonance imaging.
Ikeda A, Tomiyasu M, Yamamoto A, Tsuyusaki Y, Kawai Y, Tanabe M, Tsuji M, Iai M, Aida N, Goto T
Epilepsy Res 2022 Mar;181:106881. Epub 2022 Feb 7 doi: 10.1016/j.eplepsyres.2022.106881. PMID: 35183975
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Anterior cingulate Glutamate-Glutamine cycle metabolites are altered in euthymic bipolar I disorder.
Soeiro-de-Souza MG, Henning A, Machado-Vieira R, Moreno RA, Pastorello BF, da Costa Leite C, Vallada H, Otaduy MC
Eur Neuropsychopharmacol 2015 Dec;25(12):2221-9. Epub 2015 Oct 9 doi: 10.1016/j.euroneuro.2015.09.020. PMID: 26476706
Brain and cognition abnormalities in long-term anabolic-androgenic steroid users.
Kaufman MJ, Janes AC, Hudson JI, Brennan BP, Kanayama G, Kerrigan AR, Jensen JE, Pope HG Jr
Drug Alcohol Depend 2015 Jul 1;152:47-56. Epub 2015 May 7 doi: 10.1016/j.drugalcdep.2015.04.023. PMID: 25986964Free PMC Article
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Szulc A, Galinska-Skok B, Waszkiewicz N, Bibulowicz D, Konarzewska B, Tarasow E
Curr Med Chem 2013;20(3):414-27. PMID: 23157634

Prognosis

Neurotransmitter levels in the basal ganglia are associated with intracortical circuit activity of the primary motor cortex in healthy humans.
Remahi S, Mabika M, Côté S, Iorio-Morin C, Near J, Hui SCN, Edden RAE, Théoret H, Whittingstall K, Lepage JF
Prog Neuropsychopharmacol Biol Psychiatry 2024 Feb 8;129:110892. Epub 2023 Nov 10 doi: 10.1016/j.pnpbp.2023.110892. PMID: 37952692
Glutamatergic and GABA-ergic abnormalities in First-episode depression. A 1-year follow-up 1H-MR spectroscopic study.
Draganov M, Vives-Gilabert Y, de Diego-Adeliño J, Vicent-Gil M, Puigdemont D, Portella MJ
J Affect Disord 2020 Apr 1;266:572-577. Epub 2020 Jan 26 doi: 10.1016/j.jad.2020.01.138. PMID: 32056929
Global brain atrophy and metabolic dysfunction in LGI1 encephalitis: A prospective multimodal MRI study.
Szots M, Blaabjerg M, Orsi G, Iversen P, Kondziella D, Madsen CG, Garde E, Magnusson PO, Barsi P, Nagy F, Siebner HR, Illes Z
J Neurol Sci 2017 May 15;376:159-165. Epub 2017 Mar 16 doi: 10.1016/j.jns.2017.03.020. PMID: 28431605
3T hippocampal glutamate-glutamine complex reflects verbal memory decline in aging.
Nikolova S, Stark SM, Stark CEL
Neurobiol Aging 2017 Jun;54:103-111. Epub 2017 Mar 18 doi: 10.1016/j.neurobiolaging.2017.01.026. PMID: 28363111Free PMC Article
Remote motor system metabolic profile and surgery outcome in cervical spondylotic myelopathy.
Craciunas SC, Gorgan MR, Ianosi B, Lee P, Burris J, Cirstea CM
J Neurosurg Spine 2017 Jun;26(6):668-678. Epub 2017 Mar 17 doi: 10.3171/2016.10.SPINE16479. PMID: 28304238

Clinical prediction guides

J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy.
Zöllner HJ, Thiel TA, Füllenbach ND, Jördens MS, Ahn S, Wilms LM, Ljimani A, Häussinger D, Butz M, Wittsack HJ, Schnitzler A, Oeltzschner G
Metab Brain Dis 2023 Apr;38(4):1221-1238. Epub 2023 Feb 2 doi: 10.1007/s11011-023-01174-x. PMID: 36729261Free PMC Article
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Hippocampal MRS and subfield volumetry at 7T detects dysfunction not specific to seizure focus.
Voets NL, Hodgetts CJ, Sen A, Adcock JE, Emir U
Sci Rep 2017 Nov 23;7(1):16138. doi: 10.1038/s41598-017-16046-5. PMID: 29170537Free PMC Article
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Szulc A, Galinska-Skok B, Waszkiewicz N, Bibulowicz D, Konarzewska B, Tarasow E
Curr Med Chem 2013;20(3):414-27. PMID: 23157634
Brain metabolism in Rett syndrome: age, clinical, and genotype correlations.
Horská A, Farage L, Bibat G, Nagae LM, Kaufmann WE, Barker PB, Naidu S
Ann Neurol 2009 Jan;65(1):90-7. doi: 10.1002/ana.21562. PMID: 19194883Free PMC Article

Recent systematic reviews

Nature of glutamate alterations in substance dependence: A systematic review and meta-analysis of proton magnetic resonance spectroscopy studies.
Chen T, Tan H, Lei H, Li X, Wu Q, Xu X, Ye Y, Zhong N, Du J, Jiang H, Su H, Zhao M
Psychiatry Res Neuroimaging 2021 Sep 30;315:111329. Epub 2021 Jul 7 doi: 10.1016/j.pscychresns.2021.111329. PMID: 34271295
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies.
Moriguchi S, Takamiya A, Noda Y, Horita N, Wada M, Tsugawa S, Plitman E, Sano Y, Tarumi R, ElSalhy M, Katayama N, Ogyu K, Miyazaki T, Kishimoto T, Graff-Guerrero A, Meyer JH, Blumberger DM, Daskalakis ZJ, Mimura M, Nakajima S
Mol Psychiatry 2019 Jul;24(7):952-964. Epub 2018 Oct 12 doi: 10.1038/s41380-018-0252-9. PMID: 30315224Free PMC Article
Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review.
Szulc A, Wiedlocha M, Waszkiewicz N, Galińska-Skok B, Marcinowicz P, Gierus J, Mosiolek A
Psychiatry Res Neuroimaging 2018 Mar 30;273:1-8. Epub 2018 Jan 17 doi: 10.1016/j.pscychresns.2018.01.001. PMID: 29414126
Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings.
Yildiz-Yesiloglu A, Ankerst DP
Prog Neuropsychopharmacol Biol Psychiatry 2006 Aug 30;30(6):969-95. Epub 2006 May 4 doi: 10.1016/j.pnpbp.2006.03.012. PMID: 16677749

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