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Reduced responsiveness to social cues

MedGen UID:
1841804
•Concept ID:
C5826938
•
Finding
Synonym: Abnormal social response
 
HPO: HP:5200028

Definition

A tendency to display responces to social cues that are interpreted (e.g., by family members, peers, or caregivers) as diminished compared to what would be expected based on the developmental stage and cultural context of an individual. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced responsiveness to social cues

Professional guidelines

PubMed

Disadvantage of Social Sensitivity: Interaction of Oxytocin Receptor Genotype and Child Maltreatment on Brain Structure.
Dannlowski U, Kugel H, Grotegerd D, Redlich R, Opel N, Dohm K, Zaremba D, Grögler A, Schwieren J, Suslow T, Ohrmann P, Bauer J, Krug A, Kircher T, Jansen A, Domschke K, Hohoff C, Zwitserlood P, Heinrichs M, Arolt V, Heindel W, Baune BT
Biol Psychiatry 2016 Sep 1;80(5):398-405. Epub 2015 Dec 18 doi: 10.1016/j.biopsych.2015.12.010. PMID: 26858213
Psychosocial effects of intensive care on infants and families after discharge.
Whitfield MF
Semin Neonatol 2003 Apr;8(2):185-93. doi: 10.1016/S1084-2756(02)00218-X. PMID: 15001155
Coping-skills training and cue-exposure therapy in the treatment of alcoholism.
Monti PM, Rohsenow DJ
Alcohol Res Health 1999;23(2):107-15. PMID: 10890804Free PMC Article

Recent clinical studies

Etiology

Disgust in animals and the application of disease avoidance to wildlife management and conservation.
Sarabian C, Wilkinson A, Sigaud M, Kano F, Tobajas J, Darmaillacq AS, Kalema-Zikusoka G, Plotnik JM, MacIntosh AJJ
J Anim Ecol 2023 Aug;92(8):1489-1508. Epub 2023 Mar 13 doi: 10.1111/1365-2656.13903. PMID: 36914973
Dysfunctional neurocognition in individuals with clinically significant psychopathic traits
.
Blair RJR
Dialogues Clin Neurosci 2019 Sep;21(3):291-299. doi: 10.31887/DCNS.2019.21.3/rblair. PMID: 31749653Free PMC Article
Sensory integration therapy versus usual care for sensory processing difficulties in autism spectrum disorder in children: study protocol for a pragmatic randomised controlled trial.
Randell E, McNamara R, Delport S, Busse M, Hastings RP, Gillespie D, Williams-Thomas R, Brookes-Howell L, Romeo R, Boadu J, Ahuja AS, McKigney AM, Knapp M, Smith K, Thornton J, Warren G
Trials 2019 Feb 11;20(1):113. doi: 10.1186/s13063-019-3205-y. PMID: 30744672Free PMC Article
Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation.
Belfort-DeAguiar R, Seo D
Curr Obes Rep 2018 Jun;7(2):122-129. doi: 10.1007/s13679-018-0303-1. PMID: 29619632Free PMC Article
Learning to Eat: Behavioral and Psychological Aspects.
Birch LL
Nestle Nutr Inst Workshop Ser 2016;85:125-34. Epub 2016 Apr 18 doi: 10.1159/000439503. PMID: 27088340

Diagnosis

Anhedonia in Nicotine Dependence.
Gilbert DG, Stone BM
Curr Top Behav Neurosci 2022;58:167-184. doi: 10.1007/7854_2022_320. PMID: 35507287
The developmental support hypothesis: adaptive plasticity in neural development in response to cues of social support.
Snell-Rood E, Snell-Rood C
Philos Trans R Soc Lond B Biol Sci 2020 Jul 20;375(1803):20190491. Epub 2020 Jun 1 doi: 10.1098/rstb.2019.0491. PMID: 32475336Free PMC Article
Sensory integration therapy versus usual care for sensory processing difficulties in autism spectrum disorder in children: study protocol for a pragmatic randomised controlled trial.
Randell E, McNamara R, Delport S, Busse M, Hastings RP, Gillespie D, Williams-Thomas R, Brookes-Howell L, Romeo R, Boadu J, Ahuja AS, McKigney AM, Knapp M, Smith K, Thornton J, Warren G
Trials 2019 Feb 11;20(1):113. doi: 10.1186/s13063-019-3205-y. PMID: 30744672Free PMC Article
Human threat management systems: self-protection and disease avoidance.
Neuberg SL, Kenrick DT, Schaller M
Neurosci Biobehav Rev 2011 Mar;35(4):1042-51. Epub 2010 Sep 15 doi: 10.1016/j.neubiorev.2010.08.011. PMID: 20833199Free PMC Article
Quarrelsomeness in daily life.
Moskowitz DS
J Pers 2010 Feb;78(1):39-66. doi: 10.1111/j.1467-6494.2009.00608.x. PMID: 20433612

Therapy

Targeting Insulin-Degrading Enzyme in Insulin Clearance.
Leissring MA, González-Casimiro CM, Merino B, Suire CN, Perdomo G
Int J Mol Sci 2021 Feb 24;22(5) doi: 10.3390/ijms22052235. PMID: 33668109Free PMC Article
Sensory integration therapy versus usual care for sensory processing difficulties in autism spectrum disorder in children: study protocol for a pragmatic randomised controlled trial.
Randell E, McNamara R, Delport S, Busse M, Hastings RP, Gillespie D, Williams-Thomas R, Brookes-Howell L, Romeo R, Boadu J, Ahuja AS, McKigney AM, Knapp M, Smith K, Thornton J, Warren G
Trials 2019 Feb 11;20(1):113. doi: 10.1186/s13063-019-3205-y. PMID: 30744672Free PMC Article
Erythropoietin in diabetic retinopathy.
Reid G, Lois N
Vision Res 2017 Oct;139:237-242. Epub 2017 Aug 8 doi: 10.1016/j.visres.2017.05.010. PMID: 28652140
Learning to Eat: Behavioral and Psychological Aspects.
Birch LL
Nestle Nutr Inst Workshop Ser 2016;85:125-34. Epub 2016 Apr 18 doi: 10.1159/000439503. PMID: 27088340
Quarrelsomeness in daily life.
Moskowitz DS
J Pers 2010 Feb;78(1):39-66. doi: 10.1111/j.1467-6494.2009.00608.x. PMID: 20433612

Prognosis

Disgust in animals and the application of disease avoidance to wildlife management and conservation.
Sarabian C, Wilkinson A, Sigaud M, Kano F, Tobajas J, Darmaillacq AS, Kalema-Zikusoka G, Plotnik JM, MacIntosh AJJ
J Anim Ecol 2023 Aug;92(8):1489-1508. Epub 2023 Mar 13 doi: 10.1111/1365-2656.13903. PMID: 36914973
The developmental support hypothesis: adaptive plasticity in neural development in response to cues of social support.
Snell-Rood E, Snell-Rood C
Philos Trans R Soc Lond B Biol Sci 2020 Jul 20;375(1803):20190491. Epub 2020 Jun 1 doi: 10.1098/rstb.2019.0491. PMID: 32475336Free PMC Article
Updated meta-analysis of classical fear conditioning in the anxiety disorders.
Duits P, Cath DC, Lissek S, Hox JJ, Hamm AO, Engelhard IM, van den Hout MA, Baas JM
Depress Anxiety 2015 Apr;32(4):239-53. Epub 2015 Feb 20 doi: 10.1002/da.22353. PMID: 25703487
Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse.
Breese GR, Sinha R, Heilig M
Pharmacol Ther 2011 Feb;129(2):149-71. Epub 2010 Oct 15 doi: 10.1016/j.pharmthera.2010.09.007. PMID: 20951730Free PMC Article
Quarrelsomeness in daily life.
Moskowitz DS
J Pers 2010 Feb;78(1):39-66. doi: 10.1111/j.1467-6494.2009.00608.x. PMID: 20433612

Clinical prediction guides

Disgust in animals and the application of disease avoidance to wildlife management and conservation.
Sarabian C, Wilkinson A, Sigaud M, Kano F, Tobajas J, Darmaillacq AS, Kalema-Zikusoka G, Plotnik JM, MacIntosh AJJ
J Anim Ecol 2023 Aug;92(8):1489-1508. Epub 2023 Mar 13 doi: 10.1111/1365-2656.13903. PMID: 36914973
Do cues of infectious disease shape people's affective responses to social exclusion?
Ren D, Wesselmann ED, Loh WW, van Beest I, van Leeuwen F, Sleegers WWA
Emotion 2023 Jun;23(4):997-1010. Epub 2022 Sep 1 doi: 10.1037/emo0001157. PMID: 36048032
Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorder.
Farokhnia M, Faulkner ML, Piacentino D, Lee MR, Leggio L
Physiol Behav 2019 May 15;204:49-57. Epub 2019 Feb 7 doi: 10.1016/j.physbeh.2019.02.008. PMID: 30738971
Updated meta-analysis of classical fear conditioning in the anxiety disorders.
Duits P, Cath DC, Lissek S, Hox JJ, Hamm AO, Engelhard IM, van den Hout MA, Baas JM
Depress Anxiety 2015 Apr;32(4):239-53. Epub 2015 Feb 20 doi: 10.1002/da.22353. PMID: 25703487
Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse.
Breese GR, Sinha R, Heilig M
Pharmacol Ther 2011 Feb;129(2):149-71. Epub 2010 Oct 15 doi: 10.1016/j.pharmthera.2010.09.007. PMID: 20951730Free PMC Article

Recent systematic reviews

Systematic review of randomised controlled trials of interventions that aim to reduce the risk, either directly or indirectly, of overweight and obesity in infancy and early childhood.
Redsell SA, Edmonds B, Swift JA, Siriwardena AN, Weng S, Nathan D, Glazebrook C
Matern Child Nutr 2016 Jan;12(1):24-38. Epub 2015 Apr 20 doi: 10.1111/mcn.12184. PMID: 25894857Free PMC Article

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