U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant rhabdoid tumor of the bladder

MedGen UID:
1841816
•Concept ID:
C5826479
•
Neoplastic Process
HPO: HP:0034560

Definition

A rhabdoid tumor (a rare aggressive malignancies in infants and young children with a poor prognosis) originating in the urinary bladder. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant rhabdoid tumor of the bladder

Recent clinical studies

Etiology

SWI/SNF-deficient neoplasms of the genitourinary tract.
Sirohi D MD, Ohe C, Smith SC, Amin MB
Semin Diagn Pathol 2021 May;38(3):212-221. Epub 2021 Apr 3 doi: 10.1053/j.semdp.2021.03.007. PMID: 33840529
Sarcomatoid urothelial carcinoma of the bladder: a contemporary clinicopathologic analysis of 37 cases.
Fatima N, Canter DJ, Carthon BC, Kucuk O, Master VA, Nieh PT, Ogan K, Osunkoya AO
Can J Urol 2015 Jun;22(3):7783-7. PMID: 26068625
Molecularly confirmed primary malignant rhabdoid tumor of the urinary bladder: implications of accurate diagnosis.
Savage N, Linn D, McDonough C, Donohoe JM, Franco A, Reuter V, Biddinger PW, Eaton KW, Biegel JA, Sharma S
Ann Diagn Pathol 2012 Dec;16(6):504-7. Epub 2011 Jul 19 doi: 10.1016/j.anndiagpath.2011.04.008. PMID: 21775180Free PMC Article

Diagnosis

TROP-2, NECTIN-4 and predictive biomarkers in sarcomatoid and rhabdoid bladder urothelial carcinoma.
Brunelli M, Gobbo S, Malpeli G, Sirgiovanni G, Caserta C, Munari E, Francesconi S, Caliò A, Martignoni G, Cimadamore A, Veccia A, Antonelli A, Tucci M, Pierconti F, Hattab IM, Eccher A, Ascani S, Milella M, Buffoni L, Cheng L, Bracarda S
Pathologica 2024 Feb;116(1):55-61. doi: 10.32074/1591-951X-937. PMID: 38482675Free PMC Article
SWI/SNF-deficient neoplasms of the genitourinary tract.
Sirohi D MD, Ohe C, Smith SC, Amin MB
Semin Diagn Pathol 2021 May;38(3):212-221. Epub 2021 Apr 3 doi: 10.1053/j.semdp.2021.03.007. PMID: 33840529
Isolated Pure Malignant Rhabdoid Tumor (MRT) of the Bladder: Case Report and Lessons Learned.
Hecht SL, Walker JP, Treece AL, Cost NG
Urology 2020 Mar;137:164-167. Epub 2019 Nov 14 doi: 10.1016/j.urology.2019.10.023. PMID: 31733273
GATA3 expression in sarcomatoid urothelial carcinoma of the bladder.
Fatima N, Osunkoya AO
Hum Pathol 2014 Aug;45(8):1625-9. Epub 2014 Apr 13 doi: 10.1016/j.humpath.2014.03.015. PMID: 24824028
Molecularly confirmed primary malignant rhabdoid tumor of the urinary bladder: implications of accurate diagnosis.
Savage N, Linn D, McDonough C, Donohoe JM, Franco A, Reuter V, Biddinger PW, Eaton KW, Biegel JA, Sharma S
Ann Diagn Pathol 2012 Dec;16(6):504-7. Epub 2011 Jul 19 doi: 10.1016/j.anndiagpath.2011.04.008. PMID: 21775180Free PMC Article

Therapy

Marked Response to Nivolumab by a Patient With SMARCA4-Deficient Undifferentiated Urothelial Carcinoma Showing High PD-L1 Expression: A Case Report.
Arihara Y, Omori G, Kobayashi K, Sugita S, Murase K, Kubo T, Idogawa M, Hasegawa T, Takada K
Cancer Rep (Hoboken) 2024 Jun;7(6):e2127. doi: 10.1002/cnr2.2127. PMID: 38923369Free PMC Article
Isolated Pure Malignant Rhabdoid Tumor (MRT) of the Bladder: Case Report and Lessons Learned.
Hecht SL, Walker JP, Treece AL, Cost NG
Urology 2020 Mar;137:164-167. Epub 2019 Nov 14 doi: 10.1016/j.urology.2019.10.023. PMID: 31733273
Malignant rhabdoid tumor of the bladder and ganglioglioma in a 14 year-old male with a germline 22q11.2 deletion.
Bosse KR, Shukla AR, Pawel B, Chikwava KR, Santi M, Tooke L, Castagna K, Biegel JA, Bagatell R
Cancer Genet 2014 Sep;207(9):415-9. Epub 2014 May 21 doi: 10.1016/j.cancergen.2014.05.007. PMID: 25018128Free PMC Article
A rare case of primary rhabdoid melanoma of the urinary bladder treated with ipilimumab, an anti-CTLA 4 monoclonal antibody.
Schindler K, Schicher N, Kunstfeld R, Pehamberger H, Toepker M, Haitel A, Hoeller C, Harmankaya K
Melanoma Res 2012 Aug;22(4):320-5. doi: 10.1097/CMR.0b013e32835566c0. PMID: 22713795

Prognosis

TROP-2, NECTIN-4 and predictive biomarkers in sarcomatoid and rhabdoid bladder urothelial carcinoma.
Brunelli M, Gobbo S, Malpeli G, Sirgiovanni G, Caserta C, Munari E, Francesconi S, Caliò A, Martignoni G, Cimadamore A, Veccia A, Antonelli A, Tucci M, Pierconti F, Hattab IM, Eccher A, Ascani S, Milella M, Buffoni L, Cheng L, Bracarda S
Pathologica 2024 Feb;116(1):55-61. doi: 10.32074/1591-951X-937. PMID: 38482675Free PMC Article
SWI/SNF-deficient neoplasms of the genitourinary tract.
Sirohi D MD, Ohe C, Smith SC, Amin MB
Semin Diagn Pathol 2021 May;38(3):212-221. Epub 2021 Apr 3 doi: 10.1053/j.semdp.2021.03.007. PMID: 33840529
Pure Bladder Malignant Rhabdoid Tumor Successfully Treated With Partial Cystectomy, Radiation, and Chemotherapy: A Case Report and Review of the Literature.
Assadi A, Alzubaidi A, Lesmana H, Brennan RC, Saad A, Ortiz-Hernández V, Gleason JM
J Pediatr Hematol Oncol 2021 Nov 1;43(8):e1214-e1216. doi: 10.1097/MPH.0000000000001963. PMID: 33031160
Isolated Pure Malignant Rhabdoid Tumor (MRT) of the Bladder: Case Report and Lessons Learned.
Hecht SL, Walker JP, Treece AL, Cost NG
Urology 2020 Mar;137:164-167. Epub 2019 Nov 14 doi: 10.1016/j.urology.2019.10.023. PMID: 31733273
Nestin in gastrointestinal and other cancers: effects on cells and tumor angiogenesis.
Ishiwata T, Matsuda Y, Naito Z
World J Gastroenterol 2011 Jan 28;17(4):409-18. doi: 10.3748/wjg.v17.i4.409. PMID: 21274370Free PMC Article

Clinical prediction guides

TROP-2, NECTIN-4 and predictive biomarkers in sarcomatoid and rhabdoid bladder urothelial carcinoma.
Brunelli M, Gobbo S, Malpeli G, Sirgiovanni G, Caserta C, Munari E, Francesconi S, Caliò A, Martignoni G, Cimadamore A, Veccia A, Antonelli A, Tucci M, Pierconti F, Hattab IM, Eccher A, Ascani S, Milella M, Buffoni L, Cheng L, Bracarda S
Pathologica 2024 Feb;116(1):55-61. doi: 10.32074/1591-951X-937. PMID: 38482675Free PMC Article
SWI/SNF-deficient neoplasms of the genitourinary tract.
Sirohi D MD, Ohe C, Smith SC, Amin MB
Semin Diagn Pathol 2021 May;38(3):212-221. Epub 2021 Apr 3 doi: 10.1053/j.semdp.2021.03.007. PMID: 33840529
Pure Bladder Malignant Rhabdoid Tumor Successfully Treated With Partial Cystectomy, Radiation, and Chemotherapy: A Case Report and Review of the Literature.
Assadi A, Alzubaidi A, Lesmana H, Brennan RC, Saad A, Ortiz-Hernández V, Gleason JM
J Pediatr Hematol Oncol 2021 Nov 1;43(8):e1214-e1216. doi: 10.1097/MPH.0000000000001963. PMID: 33031160
GATA3 expression in sarcomatoid urothelial carcinoma of the bladder.
Fatima N, Osunkoya AO
Hum Pathol 2014 Aug;45(8):1625-9. Epub 2014 Apr 13 doi: 10.1016/j.humpath.2014.03.015. PMID: 24824028
Molecularly confirmed primary malignant rhabdoid tumor of the urinary bladder: implications of accurate diagnosis.
Savage N, Linn D, McDonough C, Donohoe JM, Franco A, Reuter V, Biddinger PW, Eaton KW, Biegel JA, Sharma S
Ann Diagn Pathol 2012 Dec;16(6):504-7. Epub 2011 Jul 19 doi: 10.1016/j.anndiagpath.2011.04.008. PMID: 21775180Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...