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Focal necrotic thalamus lesion

MedGen UID:
1841892
•Concept ID:
C5826815
•
Finding
HPO: HP:0034988

Definition

A localized area of cell death, often accompanied by infiltration of inflammatory cells, in the thalamus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal necrotic thalamus lesion

Professional guidelines

PubMed

Percheron artery syndrome: variability in presentation and differential diagnosis.
de la Cruz-Cosme C, Márquez-Martínez M, Aguilar-Cuevas R, Romero-Acebal M, Valdivielso-Felices P
Rev Neurol 2011 Aug 16;53(4):193-200. PMID: 21780071
Dual phase FDG-PET imaging of brain metastases provides superior assessment of recurrence versus post-treatment necrosis.
Horky LL, Hsiao EM, Weiss SE, Drappatz J, Gerbaudo VH
J Neurooncol 2011 May;103(1):137-46. Epub 2010 Sep 14 doi: 10.1007/s11060-010-0365-8. PMID: 20838854

Recent clinical studies

Etiology

Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts.
Weaver NA, Kuijf HJ, Aben HP, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Del C Valdés-Hernández M, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biesbroek JM, Biessels GJ
Lancet Neurol 2021 Jun;20(6):448-459. Epub 2021 Apr 23 doi: 10.1016/S1474-4422(21)00060-0. PMID: 33901427
Dystonia and tremor secondary to thalamic infarction successfully treated with thalamotomy of the ventralis intermedius nucleus.
Álvarez M, Quintanal N, Díaz A, Prince J, García I, Carballo M, Rodríguez R, Maragoto C, Pedroso I, Macías R
Mov Disord 2014 Aug;29(9):1188-90. Epub 2014 May 17 doi: 10.1002/mds.25889. PMID: 24839270
Leigh's syndrome.
Mannan AA, Sharma MC, Shrivastava P, Ralte AM, Gupta V, Behari M, Sarkar C
Indian J Pediatr 2004 Nov;71(11):1029-33. doi: 10.1007/BF02828121. PMID: 15572826
Are white matter lesions directly associated with cognitive impairment in patients with lacunar infarcts?
van Swieten JC, Staal S, Kappelle LJ, Derix MM, van Gijn J
J Neurol 1996 Feb;243(2):196-200. doi: 10.1007/BF02444014. PMID: 8750560
CT of ischemic infarctions in the territory of the anterior choroidal artery: a review of 28 cases.
Paroni Sterbini GL, Agatiello LM, Stocchi A, Solivetti FM
AJNR Am J Neuroradiol 1987 Mar-Apr;8(2):229-32. PMID: 3105280Free PMC Article

Diagnosis

Thalamic hand dystonia: an MRI anatomoclinical study.
Deleu D, Lagopoulos M, Louon A
Acta Neurol Belg 2000 Dec;100(4):237-41. PMID: 11233679
A combined pattern of movement disorders resulting from posterolateral thalamic lesions of a vascular nature: a syndrome with clinico-radiologic correlation.
Lera G, Scipioni O, Garcia S, Cammarota A, Fischbein G, Gershanik O
Mov Disord 2000 Jan;15(1):120-6. doi: 10.1002/1531-8257(200001)15:1<120::aid-mds1018>3.0.co;2-v. PMID: 10634250
Utilization behavior after right thalamic infarction.
Hashimoto R, Yoshida M, Tanaka Y
Eur Neurol 1995;35(1):58-62. doi: 10.1159/000117092. PMID: 7737250
Diagnosis and treatment of deep cerebral vein thrombosis.
Erbguth F, Brenner P, Schuierer G, Druschky KF, Neundörfer B
Neurosurg Rev 1991;14(2):145-8. doi: 10.1007/BF00313042. PMID: 1870721
Secondary mania with focal cerebrovascular lesions.
Cummings JL, Mendez MF
Am J Psychiatry 1984 Sep;141(9):1084-7. doi: 10.1176/ajp.141.9.1084. PMID: 6465386

Therapy

Recessive twinkle mutations cause severe epileptic encephalopathy.
Lönnqvist T, Paetau A, Valanne L, Pihko H
Brain 2009 Jun;132(Pt 6):1553-62. Epub 2009 Mar 20 doi: 10.1093/brain/awp045. PMID: 19304794
Cerebral microbleeds in CADASIL: a gradient-echo magnetic resonance imaging and autopsy study.
Dichgans M, Holtmannspötter M, Herzog J, Peters N, Bergmann M, Yousry TA
Stroke 2002 Jan;33(1):67-71. doi: 10.1161/hs0102.100885. PMID: 11779891
A lesion of the anterior thalamus producing dystonic tremor of the hand.
Cho C, Samkoff LM
Arch Neurol 2000 Sep;57(9):1353-5. doi: 10.1001/archneur.57.9.1353. PMID: 10987904
Embolic pontine infarction in a nonhypertensive patient following coronary angioplasty.
Dibert SW, Asconapé J
J Neuroimaging 1995 Jul;5(3):194-5. doi: 10.1111/jon199553194. PMID: 7626830
Diagnosis and treatment of deep cerebral vein thrombosis.
Erbguth F, Brenner P, Schuierer G, Druschky KF, Neundörfer B
Neurosurg Rev 1991;14(2):145-8. doi: 10.1007/BF00313042. PMID: 1870721

Prognosis

Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts.
Weaver NA, Kuijf HJ, Aben HP, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Del C Valdés-Hernández M, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biesbroek JM, Biessels GJ
Lancet Neurol 2021 Jun;20(6):448-459. Epub 2021 Apr 23 doi: 10.1016/S1474-4422(21)00060-0. PMID: 33901427
Dystonia and tremor secondary to thalamic infarction successfully treated with thalamotomy of the ventralis intermedius nucleus.
Álvarez M, Quintanal N, Díaz A, Prince J, García I, Carballo M, Rodríguez R, Maragoto C, Pedroso I, Macías R
Mov Disord 2014 Aug;29(9):1188-90. Epub 2014 May 17 doi: 10.1002/mds.25889. PMID: 24839270
In utero development of symmetric thalamic and brainstem necrosis in a preterm hydropic stillborn.
Szekessy DP, Bamberg C, Blechschmidt C, Kaindl AM, Stoltenburg-Didinger G
Clin Neuropathol 2010 Nov-Dec;29(6):365-71. doi: 10.5414/npp29365. PMID: 21073840
Clinical lacunar syndromes as predictors of lacunar infarcts. A comparison of acute clinical lacunar syndromes and findings on diffusion-weighted MRI.
Lindgren A, Staaf G, Geijer B, Brockstedt S, Ståhlberg F, Holtås S, Norrving B
Acta Neurol Scand 2000 Feb;101(2):128-34. doi: 10.1034/j.1600-0404.2000.101002128.x. PMID: 10685861
Diagnosis and treatment of deep cerebral vein thrombosis.
Erbguth F, Brenner P, Schuierer G, Druschky KF, Neundörfer B
Neurosurg Rev 1991;14(2):145-8. doi: 10.1007/BF00313042. PMID: 1870721

Clinical prediction guides

Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts.
Weaver NA, Kuijf HJ, Aben HP, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Del C Valdés-Hernández M, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biesbroek JM, Biessels GJ
Lancet Neurol 2021 Jun;20(6):448-459. Epub 2021 Apr 23 doi: 10.1016/S1474-4422(21)00060-0. PMID: 33901427
Apraxic agraphia following thalamic damage: Three new cases.
Vandenborre D, van Dun K, Engelborghs S, Mariën P
Brain Lang 2015 Nov;150:153-65. Epub 2015 Nov 3 doi: 10.1016/j.bandl.2015.05.011. PMID: 26460984
Neural correlates of visual motion processing without awareness in patients with striate cortex and pulvinar lesions.
Barleben M, Stoppel CM, Kaufmann J, Merkel C, Wecke T, Goertler M, Heinze HJ, Hopf JM, Schoenfeld MA
Hum Brain Mapp 2015 Apr;36(4):1585-94. Epub 2014 Dec 19 doi: 10.1002/hbm.22725. PMID: 25529748Free PMC Article
Thalamic lesions: a radiological review.
Renard D, Castelnovo G, Campello C, Bouly S, Le Floch A, Thouvenot E, Waconge A, Taieb G
Behav Neurol 2014;2014:154631. Epub 2014 Jul 2 doi: 10.1155/2014/154631. PMID: 25100900Free PMC Article
Utilization behavior after right thalamic infarction.
Hashimoto R, Yoshida M, Tanaka Y
Eur Neurol 1995;35(1):58-62. doi: 10.1159/000117092. PMID: 7737250

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