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Focal necrotic thalamus lesion

MedGen UID:
1841892
•Concept ID:
C5826815
•
Finding
HPO: HP:0034988

Definition

A localized area of cell death, often accompanied by infiltration of inflammatory cells, in the thalamus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal necrotic thalamus lesion

Professional guidelines

PubMed

Percheron artery syndrome: variability in presentation and differential diagnosis.
de la Cruz-Cosme C, Márquez-Martínez M, Aguilar-Cuevas R, Romero-Acebal M, Valdivielso-Felices P
Rev Neurol 2011 Aug 16;53(4):193-200. PMID: 21780071
Dual phase FDG-PET imaging of brain metastases provides superior assessment of recurrence versus post-treatment necrosis.
Horky LL, Hsiao EM, Weiss SE, Drappatz J, Gerbaudo VH
J Neurooncol 2011 May;103(1):137-46. Epub 2010 Sep 14 doi: 10.1007/s11060-010-0365-8. PMID: 20838854

Recent clinical studies

Etiology

Characterizing Diaschisis-Related Thalamic Perfusion and Diffusion After Middle Cerebral Artery Infarction.
Xia C, Zhou J, Lu C, Wang Y, Tang T, Cai Y, Ju S
Stroke 2021 Jul;52(7):2319-2327. Epub 2021 May 11 doi: 10.1161/STROKEAHA.120.032464. PMID: 33971741
Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts.
Weaver NA, Kuijf HJ, Aben HP, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Del C Valdés-Hernández M, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biesbroek JM, Biessels GJ
Lancet Neurol 2021 Jun;20(6):448-459. Epub 2021 Apr 23 doi: 10.1016/S1474-4422(21)00060-0. PMID: 33901427
Confluent thalamic hyperintensities in CADASIL.
Jacqmin M, Hervé D, Viswanathan A, Guichard JP, During M, Dichgans M, Chabriat H
Cerebrovasc Dis 2010 Aug;30(3):308-13. Epub 2010 Jul 28 doi: 10.1159/000319607. PMID: 20664266
The pathology of "vascular dementia": a critical update.
Jellinger KA
J Alzheimers Dis 2008 May;14(1):107-23. doi: 10.3233/jad-2008-14110. PMID: 18525132
Leigh's syndrome.
Mannan AA, Sharma MC, Shrivastava P, Ralte AM, Gupta V, Behari M, Sarkar C
Indian J Pediatr 2004 Nov;71(11):1029-33. doi: 10.1007/BF02828121. PMID: 15572826

Diagnosis

Characterizing Diaschisis-Related Thalamic Perfusion and Diffusion After Middle Cerebral Artery Infarction.
Xia C, Zhou J, Lu C, Wang Y, Tang T, Cai Y, Ju S
Stroke 2021 Jul;52(7):2319-2327. Epub 2021 May 11 doi: 10.1161/STROKEAHA.120.032464. PMID: 33971741
Imaging characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL).
Stojanov D, Vojinovic S, Aracki-Trenkic A, Tasic A, Benedeto-Stojanov D, Ljubisavljevic S, Vujnovic S
Bosn J Basic Med Sci 2015 Feb 9;15(1):1-8. doi: 10.17305/bjbms.2015.247. PMID: 25725137Free PMC Article
Thalamic cramplike pain.
Sposato LA, Sharma HA, Khan AR, Bartha R, Hachinski V
J Neurol Sci 2014 Jan 15;336(1-2):269-72. Epub 2013 Oct 27 doi: 10.1016/j.jns.2013.10.026. PMID: 24210074
The pathology of "vascular dementia": a critical update.
Jellinger KA
J Alzheimers Dis 2008 May;14(1):107-23. doi: 10.3233/jad-2008-14110. PMID: 18525132
Leigh's syndrome.
Mannan AA, Sharma MC, Shrivastava P, Ralte AM, Gupta V, Behari M, Sarkar C
Indian J Pediatr 2004 Nov;71(11):1029-33. doi: 10.1007/BF02828121. PMID: 15572826

Therapy

Recessive twinkle mutations cause severe epileptic encephalopathy.
Lönnqvist T, Paetau A, Valanne L, Pihko H
Brain 2009 Jun;132(Pt 6):1553-62. Epub 2009 Mar 20 doi: 10.1093/brain/awp045. PMID: 19304794
Cerebral microbleeds in CADASIL: a gradient-echo magnetic resonance imaging and autopsy study.
Dichgans M, Holtmannspötter M, Herzog J, Peters N, Bergmann M, Yousry TA
Stroke 2002 Jan;33(1):67-71. doi: 10.1161/hs0102.100885. PMID: 11779891
A lesion of the anterior thalamus producing dystonic tremor of the hand.
Cho C, Samkoff LM
Arch Neurol 2000 Sep;57(9):1353-5. doi: 10.1001/archneur.57.9.1353. PMID: 10987904
Disorders of higher mental function due to single infarctions in the thalamus and in the area of the thalamofrontal tracts.
Kalashnikova LA, Gulevskaya TS, Kashina EM
Neurosci Behav Physiol 1999 Jul-Aug;29(4):397-403. doi: 10.1007/BF02461075. PMID: 10582221
Symptomatic dystonias associated with structural brain lesions: report of 16 cases.
Kostić VS, Stojanović-Svetel M, Kacar A
Can J Neurol Sci 1996 Feb;23(1):53-6. doi: 10.1017/s0317167100039184. PMID: 8673963

Prognosis

Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts.
Weaver NA, Kuijf HJ, Aben HP, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Del C Valdés-Hernández M, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biesbroek JM, Biessels GJ
Lancet Neurol 2021 Jun;20(6):448-459. Epub 2021 Apr 23 doi: 10.1016/S1474-4422(21)00060-0. PMID: 33901427
Recessive twinkle mutations cause severe epileptic encephalopathy.
Lönnqvist T, Paetau A, Valanne L, Pihko H
Brain 2009 Jun;132(Pt 6):1553-62. Epub 2009 Mar 20 doi: 10.1093/brain/awp045. PMID: 19304794
Inflammation in areas of remote changes following focal brain lesion.
Block F, Dihné M, Loos M
Prog Neurobiol 2005 Apr;75(5):342-65. doi: 10.1016/j.pneurobio.2005.03.004. PMID: 15925027
Leigh's syndrome.
Mannan AA, Sharma MC, Shrivastava P, Ralte AM, Gupta V, Behari M, Sarkar C
Indian J Pediatr 2004 Nov;71(11):1029-33. doi: 10.1007/BF02828121. PMID: 15572826
Thalamic stroke. Presentation and prognosis of infarcts and hemorrhages.
Steinke W, Sacco RL, Mohr JP, Foulkes MA, Tatemichi TK, Wolf PA, Price TR, Hier DB
Arch Neurol 1992 Jul;49(7):703-10. doi: 10.1001/archneur.1992.00530310045011. PMID: 1497496

Clinical prediction guides

Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts.
Weaver NA, Kuijf HJ, Aben HP, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Del C Valdés-Hernández M, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biesbroek JM, Biessels GJ
Lancet Neurol 2021 Jun;20(6):448-459. Epub 2021 Apr 23 doi: 10.1016/S1474-4422(21)00060-0. PMID: 33901427
Clinical and radiological characteristics of restless legs syndrome following acute lacunar infarction.
Tuo H, Tian Z, Ma X, Cui Y, Xue Y, Che J, Xu C, Chen K, Zhang Y, Zhang L, Bi H, Le W, Ondo W
Sleep Med 2019 Jan;53:81-87. Epub 2018 Jun 26 doi: 10.1016/j.sleep.2018.06.004. PMID: 30458382
Thalamic lesions: a radiological review.
Renard D, Castelnovo G, Campello C, Bouly S, Le Floch A, Thouvenot E, Waconge A, Taieb G
Behav Neurol 2014;2014:154631. Epub 2014 Jul 2 doi: 10.1155/2014/154631. PMID: 25100900Free PMC Article
Thalamic cramplike pain.
Sposato LA, Sharma HA, Khan AR, Bartha R, Hachinski V
J Neurol Sci 2014 Jan 15;336(1-2):269-72. Epub 2013 Oct 27 doi: 10.1016/j.jns.2013.10.026. PMID: 24210074
Inflammation in areas of remote changes following focal brain lesion.
Block F, Dihné M, Loos M
Prog Neurobiol 2005 Apr;75(5):342-65. doi: 10.1016/j.pneurobio.2005.03.004. PMID: 15925027

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