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Abnormal circulating thyroxine-binding globulin concentration

MedGen UID:
1841918
•Concept ID:
C5826502
•
Finding
HPO: HP:0034590

Definition

Any deviation from the normal concentration of thyroxine-binding globulin (TBG) in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating thyroxine-binding globulin concentration

Professional guidelines

PubMed

Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Recent clinical studies

Etiology

The role of thyroid autoimmunity in fertility and pregnancy.
Poppe K, Velkeniers B, Glinoer D
Nat Clin Pract Endocrinol Metab 2008 Jul;4(7):394-405. Epub 2008 May 27 doi: 10.1038/ncpendmet0846. PMID: 18506157
Pituitary dysfunction in recently post-menopausal women. Nottingham EPIC Study Group.
Lyons A, Ng C, Fielding K, Hosking D, Selby C, Lawson N
Clin Endocrinol (Oxf) 1997 Oct;47(4):431-8. doi: 10.1046/j.1365-2265.1997.2761083.x. PMID: 9404441
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Diagnosis

Resistance to thyroid hormone--an incidental finding.
Chantler D, Moran C, Schoenmakers E, Cleland S, Panarelli M
BMJ Case Rep 2012 Mar 27;2012 doi: 10.1136/bcr.12.2011.5375. PMID: 22605824Free PMC Article
Abnormal serum thyroid hormones concentration with healthy functional gland: a review on the metabolic role of thyroid hormones transporter proteins.
Azad RM
Pak J Biol Sci 2011 Mar 1;14(5):313-26. doi: 10.3923/pjbs.2011.313.326. PMID: 21874823
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574
Raised total thyroxine and free thyroxine index but normal free thyroxine. A serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein.
Hennemann G, Docter R, Krenning EP, Bos G, Otten M, Visser TJ
Lancet 1979 Mar 24;1(8117):639-42. doi: 10.1016/s0140-6736(79)91080-8. PMID: 85873

Therapy

Pituitary dysfunction in recently post-menopausal women. Nottingham EPIC Study Group.
Lyons A, Ng C, Fielding K, Hosking D, Selby C, Lawson N
Clin Endocrinol (Oxf) 1997 Oct;47(4):431-8. doi: 10.1046/j.1365-2265.1997.2761083.x. PMID: 9404441
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Clinical prediction guides

Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574
Raised total thyroxine and free thyroxine index but normal free thyroxine. A serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein.
Hennemann G, Docter R, Krenning EP, Bos G, Otten M, Visser TJ
Lancet 1979 Mar 24;1(8117):639-42. doi: 10.1016/s0140-6736(79)91080-8. PMID: 85873

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