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Decreased circulating sialic acid concentration

MedGen UID:
1841952
•Concept ID:
C5826784
•
Finding
HPO: HP:0034938

Definition

Concentration of sialic acid in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating sialic acid concentration

Recent clinical studies

Etiology

Immunopathology of desialylation: human plasma lipoprotein(a) and circulating anti-carbohydrate antibodies form immune complexes that recognize host cells.
Sabarinath PS, Appukuttan PS
Mol Cell Biochem 2015 May;403(1-2):13-23. Epub 2015 Jan 30 doi: 10.1007/s11010-015-2332-3. PMID: 25633186
The effect of laparoscopy on the IGF system in patients diagnosed with acute cholecystitis.
Baricević I, Jones DR, Malenković V, Nedić O
Clin Endocrinol (Oxf) 2006 Sep;65(3):373-9. doi: 10.1111/j.1365-2265.2006.02607.x. PMID: 16918959
Serum level of sialic acid (SA) and carbohydrate-deficient transferrin (CDT) in type 2 diabetes mellitus with microvascular complications.
Cylwik B, Chrostek L, Jakimiuk B, Popławska A, Szmitkowski M
J Clin Lab Anal 2006;20(2):68-73. doi: 10.1002/jcla.20099. PMID: 16538641Free PMC Article
Sialic acid is an indicator of inflammation due to cardiopulmonary bypass but not myocardial damage.
Berkan O, Göl MK, Günay L, Sagaban M
J Cardiovasc Surg (Torino) 2002 Aug;43(4):489-93. PMID: 12124560
Characterization of sex hormone-binding globulin isoforms in hypothyroid women.
Brenta G, Bedecarras P, Schnitman M, Gurfinkiel M, Damilano S, Campo S, Pisarev MA
Thyroid 2002 Feb;12(2):101-5. doi: 10.1089/105072502753522329. PMID: 11916278

Diagnosis

The effect of laparoscopy on the IGF system in patients diagnosed with acute cholecystitis.
Baricević I, Jones DR, Malenković V, Nedić O
Clin Endocrinol (Oxf) 2006 Sep;65(3):373-9. doi: 10.1111/j.1365-2265.2006.02607.x. PMID: 16918959
Characterization of sex hormone-binding globulin isoforms in hypothyroid women.
Brenta G, Bedecarras P, Schnitman M, Gurfinkiel M, Damilano S, Campo S, Pisarev MA
Thyroid 2002 Feb;12(2):101-5. doi: 10.1089/105072502753522329. PMID: 11916278

Therapy

Optical spectral diagnostics of the oxygenation level in periodontal tissues and photodynamic therapy using methylene blue in children with cerebral palsy.
Morozova NS, Kozlitina IA, Makarov VI, Loschenov VB, Grinin VM, Ivanov SY, Kashtanova MS
Front Public Health 2023;11:961066. Epub 2023 Jan 30 doi: 10.3389/fpubh.2023.961066. PMID: 36794072Free PMC Article
Reversible Shielding between Dual Ligands for Enhanced Tumor Accumulation of ZnPc-Loaded Micelles.
Cao J, Gao X, Cheng M, Niu X, Li X, Zhang Y, Liu Y, Wang W, Yuan Z
Nano Lett 2019 Mar 13;19(3):1665-1674. Epub 2019 Mar 1 doi: 10.1021/acs.nanolett.8b04645. PMID: 30801190
Sublethal mechanical trauma alters the electrochemical properties and increases aggregation of erythrocytes.
McNamee AP, Tansley GD, Simmonds MJ
Microvasc Res 2018 Nov;120:1-7. Epub 2018 May 24 doi: 10.1016/j.mvr.2018.05.008. PMID: 29803580
Pharmacokinetics and tolerability of human mouse chimeric anti-CD22 monoclonal antibody in Chinese patients with CD22-positive non-Hodgkin lymphoma.
Li S, Zhang D, Sun J, Li Z, Deng L, Zou B, Zhan J, Jiang W
MAbs 2012 Mar-Apr;4(2):256-66. Epub 2012 Mar 1 doi: 10.4161/mabs.4.2.19136. PMID: 22453099Free PMC Article
Continuous infusion of the anti-CD22 immunotoxin IgG-RFB4-SMPT-dgA in patients with B-cell lymphoma: a phase I study.
Sausville EA, Headlee D, Stetler-Stevenson M, Jaffe ES, Solomon D, Figg WD, Herdt J, Kopp WC, Rager H, Steinberg SM
Blood 1995 Jun 15;85(12):3457-65. PMID: 7780133

Prognosis

Serum level of sialic acid (SA) and carbohydrate-deficient transferrin (CDT) in type 2 diabetes mellitus with microvascular complications.
Cylwik B, Chrostek L, Jakimiuk B, Popławska A, Szmitkowski M
J Clin Lab Anal 2006;20(2):68-73. doi: 10.1002/jcla.20099. PMID: 16538641Free PMC Article
Continuous infusion of the anti-CD22 immunotoxin IgG-RFB4-SMPT-dgA in patients with B-cell lymphoma: a phase I study.
Sausville EA, Headlee D, Stetler-Stevenson M, Jaffe ES, Solomon D, Figg WD, Herdt J, Kopp WC, Rager H, Steinberg SM
Blood 1995 Jun 15;85(12):3457-65. PMID: 7780133

Clinical prediction guides

Pharmacokinetics and tolerability of human mouse chimeric anti-CD22 monoclonal antibody in Chinese patients with CD22-positive non-Hodgkin lymphoma.
Li S, Zhang D, Sun J, Li Z, Deng L, Zou B, Zhan J, Jiang W
MAbs 2012 Mar-Apr;4(2):256-66. Epub 2012 Mar 1 doi: 10.4161/mabs.4.2.19136. PMID: 22453099Free PMC Article
The effect of laparoscopy on the IGF system in patients diagnosed with acute cholecystitis.
Baricević I, Jones DR, Malenković V, Nedić O
Clin Endocrinol (Oxf) 2006 Sep;65(3):373-9. doi: 10.1111/j.1365-2265.2006.02607.x. PMID: 16918959
Serum level of sialic acid (SA) and carbohydrate-deficient transferrin (CDT) in type 2 diabetes mellitus with microvascular complications.
Cylwik B, Chrostek L, Jakimiuk B, Popławska A, Szmitkowski M
J Clin Lab Anal 2006;20(2):68-73. doi: 10.1002/jcla.20099. PMID: 16538641Free PMC Article
The role of sialic acid in the activation of platelets by wheat germ agglutinin.
Ganguly P, Fossett NG
Blood 1984 Jan;63(1):181-7. PMID: 6546297
Platelet sialic acid and platelet survival after aggregation by ADP.
Packham MA, Guccione MA, Kinlough-Rathbone RL, Mustard JF
Blood 1980 Nov;56(5):876-80. PMID: 7426751

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