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Elevated brain gamma-aminobutyric acid by MRS

MedGen UID:
1841957
•Concept ID:
C5826745
•
Finding
Synonym: Elevated brain GABA by MRS
 
HPO: HP:0034895

Definition

An increase in the level of gamma-aminobutyric acid (GABA) in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated brain gamma-aminobutyric acid by MRS

Professional guidelines

PubMed

Gamma-aminobutyric acid (GABA) levels in the midcingulate cortex and clozapine response in patients with treatment-resistant schizophrenia: A proton magnetic resonance spectroscopy ((1) H-MRS) study.
Ueno F, Nakajima S, Iwata Y, Honda S, Torres-Carmona E, Mar W, Tsugawa S, Truong P, Plitman E, Noda Y, Mimura M, Sailasuta N, Mikkelsen M, Edden RAE, De Luca V, Remington G, Gerretsen P, Graff-Guerrero A
Psychiatry Clin Neurosci 2022 Nov;76(11):587-594. Epub 2022 Sep 16 doi: 10.1111/pcn.13463. PMID: 36111425
Elevated prefrontal cortex GABA in patients with major depressive disorder after TMS treatment measured with proton magnetic resonance spectroscopy.
Dubin MJ, Mao X, Banerjee S, Goodman Z, Lapidus KA, Kang G, Liston C, Shungu DC
J Psychiatry Neurosci 2016 Apr;41(3):E37-45. doi: 10.1503/jpn.150223. PMID: 26900793Free PMC Article

Recent clinical studies

Etiology

Increased prefrontal GABA concentrations in adults with autism spectrum disorders.
Maier S, Düppers AL, Runge K, Dacko M, Lange T, Fangmeier T, Riedel A, Ebert D, Endres D, Domschke K, Perlov E, Nickel K, Tebartz van Elst L
Autism Res 2022 Jul;15(7):1222-1236. Epub 2022 May 19 doi: 10.1002/aur.2740. PMID: 35587691
Elevation of brain gamma-aminobutyric acid levels is associated with vigabatrin-associated brain abnormalities on magnetic resonance imaging.
Ikeda A, Tomiyasu M, Yamamoto A, Tsuyusaki Y, Kawai Y, Tanabe M, Tsuji M, Iai M, Aida N, Goto T
Epilepsy Res 2022 Mar;181:106881. Epub 2022 Feb 7 doi: 10.1016/j.eplepsyres.2022.106881. PMID: 35183975
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Hone-Blanchet A, Bohsali A, Krishnamurthy LC, Shahid S, Lin Q, Zhao L, Loring D, Goldstein F, John SE, Fleischer CC, Levey A, Lah J, Qiu D, Crosson B
Neurobiol Aging 2022 Jan;109:22-30. Epub 2021 Sep 20 doi: 10.1016/j.neurobiolaging.2021.09.016. PMID: 34638000Free PMC Article
Clinical characteristics and elevated ProGRP and positive oligoclonal bands of 13 Chinese cases with anti-GABABR encephalitis.
Wu H, Wang Y, Wei K, Qiao S, Liu L, Zhang R, Cao L, Wang S, Liu X
Int J Dev Neurosci 2021 Oct;81(6):492-501. Epub 2021 May 22 doi: 10.1002/jdn.10121. PMID: 33973258
Elevated striatal γ-aminobutyric acid in youth with major depressive disorder.
Bradley KA, Alonso CM, Mehra LM, Xu J, Gabbay V
Prog Neuropsychopharmacol Biol Psychiatry 2018 Aug 30;86:203-210. Epub 2018 Jun 8 doi: 10.1016/j.pnpbp.2018.06.004. PMID: 29890194Free PMC Article

Diagnosis

Effects of sex hormones on brain GABA and glutamate levels in a cis- and transgender cohort.
Spurny-Dworak B, Handschuh P, Spies M, Kaufmann U, Seiger R, Klöbl M, Konadu ME, Reed MB, Ritter V, Baldinger-Melich P, Bogner W, Kranz GS, Lanzenberger R
Psychoneuroendocrinology 2022 Apr;138:105683. Epub 2022 Feb 1 doi: 10.1016/j.psyneuen.2022.105683. PMID: 35176535
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Hone-Blanchet A, Bohsali A, Krishnamurthy LC, Shahid S, Lin Q, Zhao L, Loring D, Goldstein F, John SE, Fleischer CC, Levey A, Lah J, Qiu D, Crosson B
Neurobiol Aging 2022 Jan;109:22-30. Epub 2021 Sep 20 doi: 10.1016/j.neurobiolaging.2021.09.016. PMID: 34638000Free PMC Article
Clinical characteristics and elevated ProGRP and positive oligoclonal bands of 13 Chinese cases with anti-GABABR encephalitis.
Wu H, Wang Y, Wei K, Qiao S, Liu L, Zhang R, Cao L, Wang S, Liu X
Int J Dev Neurosci 2021 Oct;81(6):492-501. Epub 2021 May 22 doi: 10.1002/jdn.10121. PMID: 33973258
Imaging central neurochemical alterations in chronic pain with proton magnetic resonance spectroscopy.
Harris RE, Clauw DJ
Neurosci Lett 2012 Jun 29;520(2):192-6. Epub 2012 Mar 22 doi: 10.1016/j.neulet.2012.03.042. PMID: 22445845
Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders.
Chang L, Cloak CC, Ernst T
J Clin Psychiatry 2003;64 Suppl 3:7-14. PMID: 12662128

Therapy

Gamma-aminobutyric acid (GABA) levels in the midcingulate cortex and clozapine response in patients with treatment-resistant schizophrenia: A proton magnetic resonance spectroscopy ((1) H-MRS) study.
Ueno F, Nakajima S, Iwata Y, Honda S, Torres-Carmona E, Mar W, Tsugawa S, Truong P, Plitman E, Noda Y, Mimura M, Sailasuta N, Mikkelsen M, Edden RAE, De Luca V, Remington G, Gerretsen P, Graff-Guerrero A
Psychiatry Clin Neurosci 2022 Nov;76(11):587-594. Epub 2022 Sep 16 doi: 10.1111/pcn.13463. PMID: 36111425
Elevation of brain gamma-aminobutyric acid levels is associated with vigabatrin-associated brain abnormalities on magnetic resonance imaging.
Ikeda A, Tomiyasu M, Yamamoto A, Tsuyusaki Y, Kawai Y, Tanabe M, Tsuji M, Iai M, Aida N, Goto T
Epilepsy Res 2022 Mar;181:106881. Epub 2022 Feb 7 doi: 10.1016/j.eplepsyres.2022.106881. PMID: 35183975
Thalamic Gamma Aminobutyric Acid Level Changes in Major Depressive Disorder After a 12-Week Iyengar Yoga and Coherent Breathing Intervention.
Streeter CC, Gerbarg PL, Brown RP, Scott TM, Nielsen GH, Owen L, Sakai O, Sneider JT, Nyer MB, Silveri MM
J Altern Complement Med 2020 Mar;26(3):190-197. Epub 2020 Jan 14 doi: 10.1089/acm.2019.0234. PMID: 31934793Free PMC Article
Imaging central neurochemical alterations in chronic pain with proton magnetic resonance spectroscopy.
Harris RE, Clauw DJ
Neurosci Lett 2012 Jun 29;520(2):192-6. Epub 2012 Mar 22 doi: 10.1016/j.neulet.2012.03.042. PMID: 22445845
Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders.
Chang L, Cloak CC, Ernst T
J Clin Psychiatry 2003;64 Suppl 3:7-14. PMID: 12662128

Prognosis

Gamma-aminobutyric acid (GABA) levels in the midcingulate cortex and clozapine response in patients with treatment-resistant schizophrenia: A proton magnetic resonance spectroscopy ((1) H-MRS) study.
Ueno F, Nakajima S, Iwata Y, Honda S, Torres-Carmona E, Mar W, Tsugawa S, Truong P, Plitman E, Noda Y, Mimura M, Sailasuta N, Mikkelsen M, Edden RAE, De Luca V, Remington G, Gerretsen P, Graff-Guerrero A
Psychiatry Clin Neurosci 2022 Nov;76(11):587-594. Epub 2022 Sep 16 doi: 10.1111/pcn.13463. PMID: 36111425
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Hone-Blanchet A, Bohsali A, Krishnamurthy LC, Shahid S, Lin Q, Zhao L, Loring D, Goldstein F, John SE, Fleischer CC, Levey A, Lah J, Qiu D, Crosson B
Neurobiol Aging 2022 Jan;109:22-30. Epub 2021 Sep 20 doi: 10.1016/j.neurobiolaging.2021.09.016. PMID: 34638000Free PMC Article
Clinical characteristics and elevated ProGRP and positive oligoclonal bands of 13 Chinese cases with anti-GABABR encephalitis.
Wu H, Wang Y, Wei K, Qiao S, Liu L, Zhang R, Cao L, Wang S, Liu X
Int J Dev Neurosci 2021 Oct;81(6):492-501. Epub 2021 May 22 doi: 10.1002/jdn.10121. PMID: 33973258
Seven-tesla quantitative magnetic resonance spectroscopy of glutamate, γ-aminobutyric acid, and glutathione in the posterior cingulate cortex/precuneus in patients with epilepsy.
Gonen OM, Moffat BA, Desmond PM, Lui E, Kwan P, O'Brien TJ
Epilepsia 2020 Dec;61(12):2785-2794. Epub 2020 Oct 28 doi: 10.1111/epi.16731. PMID: 33111330
Impairment of Motor Function Correlates with Neurometabolite and Brain Iron Alterations in Parkinson's Disease.
Pesch B, Casjens S, Woitalla D, Dharmadhikari S, Edmondson DA, Zella MAS, Lehnert M, Lotz A, Herrmann L, Muhlack S, Kraus P, Yeh CL, Glaubitz B, Schmidt-Wilcke T, Gold R, van Thriel C, Brüning T, Tönges L, Dydak U
Cells 2019 Jan 29;8(2) doi: 10.3390/cells8020096. PMID: 30699914Free PMC Article

Clinical prediction guides

Gamma-aminobutyric acid (GABA) levels in the midcingulate cortex and clozapine response in patients with treatment-resistant schizophrenia: A proton magnetic resonance spectroscopy ((1) H-MRS) study.
Ueno F, Nakajima S, Iwata Y, Honda S, Torres-Carmona E, Mar W, Tsugawa S, Truong P, Plitman E, Noda Y, Mimura M, Sailasuta N, Mikkelsen M, Edden RAE, De Luca V, Remington G, Gerretsen P, Graff-Guerrero A
Psychiatry Clin Neurosci 2022 Nov;76(11):587-594. Epub 2022 Sep 16 doi: 10.1111/pcn.13463. PMID: 36111425
Elevation of brain gamma-aminobutyric acid levels is associated with vigabatrin-associated brain abnormalities on magnetic resonance imaging.
Ikeda A, Tomiyasu M, Yamamoto A, Tsuyusaki Y, Kawai Y, Tanabe M, Tsuji M, Iai M, Aida N, Goto T
Epilepsy Res 2022 Mar;181:106881. Epub 2022 Feb 7 doi: 10.1016/j.eplepsyres.2022.106881. PMID: 35183975
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Hone-Blanchet A, Bohsali A, Krishnamurthy LC, Shahid S, Lin Q, Zhao L, Loring D, Goldstein F, John SE, Fleischer CC, Levey A, Lah J, Qiu D, Crosson B
Neurobiol Aging 2022 Jan;109:22-30. Epub 2021 Sep 20 doi: 10.1016/j.neurobiolaging.2021.09.016. PMID: 34638000Free PMC Article
Seven-tesla quantitative magnetic resonance spectroscopy of glutamate, γ-aminobutyric acid, and glutathione in the posterior cingulate cortex/precuneus in patients with epilepsy.
Gonen OM, Moffat BA, Desmond PM, Lui E, Kwan P, O'Brien TJ
Epilepsia 2020 Dec;61(12):2785-2794. Epub 2020 Oct 28 doi: 10.1111/epi.16731. PMID: 33111330
Thalamic Gamma Aminobutyric Acid Level Changes in Major Depressive Disorder After a 12-Week Iyengar Yoga and Coherent Breathing Intervention.
Streeter CC, Gerbarg PL, Brown RP, Scott TM, Nielsen GH, Owen L, Sakai O, Sneider JT, Nyer MB, Silveri MM
J Altern Complement Med 2020 Mar;26(3):190-197. Epub 2020 Jan 14 doi: 10.1089/acm.2019.0234. PMID: 31934793Free PMC Article

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