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Dermal papillary IgA deposition

MedGen UID:
1842042
•Concept ID:
C5826552
•
Finding
Synonym: Granular IgA deposits at the dermal papillae
 
HPO: HP:0034642

Definition

Accumulation of immunoglobulin A (IgA) surrounding dermal papillae, which are specialized cells that support the hair follicle. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDermal papillary IgA deposition

Recent clinical studies

Etiology

A clinical, histopathological and laboratory study of 19 consecutive Italian paediatric patients with chilblain-like lesions: lights and shadows on the relationship with COVID-19 infection.
El Hachem M, Diociaiuti A, Concato C, Carsetti R, Carnevale C, Ciofi Degli Atti M, Giovannelli L, Latella E, Porzio O, Rossi S, Stracuzzi A, Zaffina S, Onetti Muda A, Zambruno G, Alaggio R
J Eur Acad Dermatol Venereol 2020 Nov;34(11):2620-2629. Epub 2020 Jul 2 doi: 10.1111/jdv.16682. PMID: 32474947Free PMC Article
Two Cases of Dermatitis Herpetiformis Successfully Treated with Tetracycline and Niacinamide.
Wang Y, Yang B, Zhou G, Zhang F
Acta Dermatovenerol Croat 2018 Oct;26(3):273-275. PMID: 30390734
Dermatitis Herpetiformis: A Review of Direct Immunofluorescence Findings.
Barnadas MA
Am J Dermatopathol 2016 Apr;38(4):283-8. doi: 10.1097/DAD.0000000000000420. PMID: 26630684
Neutrophil CD11b, L-selectin and Fc IgA receptors in patients with dermatitis herpetiformis.
Smith AD, Streilein RD, Hall RP 3rd
Br J Dermatol 2002 Dec;147(6):1109-17. doi: 10.1046/j.1365-2133.2002.05004.x. PMID: 12452859

Diagnosis

Fibrillar-type dermatitis herpetiformis.
Makino T, Shimizu T
Eur J Dermatol 2019 Apr 1;29(2):115-120. doi: 10.1684/ejd.2019.3533. PMID: 31106757
Approach to cutaneous vasculitides with special emphasis on small vessel vasculitis: histopathology and direct immunofluorescence.
Demirkesen C
Curr Opin Rheumatol 2017 Jan;29(1):39-44. doi: 10.1097/BOR.0000000000000346. PMID: 27787337
Neutrophil CD11b, L-selectin and Fc IgA receptors in patients with dermatitis herpetiformis.
Smith AD, Streilein RD, Hall RP 3rd
Br J Dermatol 2002 Dec;147(6):1109-17. doi: 10.1046/j.1365-2133.2002.05004.x. PMID: 12452859
Vesiculobullous systemic lupus erythematosus: a case with circulating IgG and IgA autoantibodies to type VII collagen.
Nitta Y, Kawamura C, Hashimoto T
J Am Acad Dermatol 2002 Nov;47(5 Suppl):S283-6. doi: 10.1067/mjd.2002.109251. PMID: 12399753
Recurrent pericarditis and dermatitis herpetiformis. Evidence for immune complex deposition in the pericardium.
Afrasiabi R, Sirop PA, Albini SM, Rosenbaum HM, Piscatelli RL
Chest 1990 Apr;97(4):1006-7. doi: 10.1378/chest.97.4.1006. PMID: 2323232

Therapy

Two Cases of Dermatitis Herpetiformis Successfully Treated with Tetracycline and Niacinamide.
Wang Y, Yang B, Zhou G, Zhang F
Acta Dermatovenerol Croat 2018 Oct;26(3):273-275. PMID: 30390734
Dermatitis herpetiformis sera or goat anti-transglutaminase-3 transferred to human skin-grafted mice mimics dermatitis herpetiformis immunopathology.
Zone JJ, Schmidt LA, Taylor TB, Hull CM, Sotiriou MC, Jaskowski TD, Hill HR, Meyer LJ
J Immunol 2011 Apr 1;186(7):4474-80. Epub 2011 Feb 18 doi: 10.4049/jimmunol.1003273. PMID: 21335491

Prognosis

The utility of the DNA microarray scanner to simplify the immunofluorescence evaluation of autoimmune bullous diseases.
Iwamoto S, Iwamoto AT, Cha J, Clark T, Lu M, Breen C, Bhawan J, Falanga V
Am J Dermatopathol 2009 May;31(3):218-22. doi: 10.1097/DAD.0b013e31818ffde1. PMID: 19384060Free PMC Article

Clinical prediction guides

A clinical, histopathological and laboratory study of 19 consecutive Italian paediatric patients with chilblain-like lesions: lights and shadows on the relationship with COVID-19 infection.
El Hachem M, Diociaiuti A, Concato C, Carsetti R, Carnevale C, Ciofi Degli Atti M, Giovannelli L, Latella E, Porzio O, Rossi S, Stracuzzi A, Zaffina S, Onetti Muda A, Zambruno G, Alaggio R
J Eur Acad Dermatol Venereol 2020 Nov;34(11):2620-2629. Epub 2020 Jul 2 doi: 10.1111/jdv.16682. PMID: 32474947Free PMC Article
Fibrillar-type dermatitis herpetiformis.
Makino T, Shimizu T
Eur J Dermatol 2019 Apr 1;29(2):115-120. doi: 10.1684/ejd.2019.3533. PMID: 31106757
A Case of Dermatitis Herpetiformis With Fibrillar Immunoglobulin A Deposition: A Rare Pattern Not to Be Missed.
Lilo MT, Yan S, Chapman MS, Linos K
Am J Dermatopathol 2019 Jul;41(7):511-513. doi: 10.1097/DAD.0000000000001380. PMID: 30839342
Dermatitis Herpetiformis: A Review of Direct Immunofluorescence Findings.
Barnadas MA
Am J Dermatopathol 2016 Apr;38(4):283-8. doi: 10.1097/DAD.0000000000000420. PMID: 26630684
The utility of the DNA microarray scanner to simplify the immunofluorescence evaluation of autoimmune bullous diseases.
Iwamoto S, Iwamoto AT, Cha J, Clark T, Lu M, Breen C, Bhawan J, Falanga V
Am J Dermatopathol 2009 May;31(3):218-22. doi: 10.1097/DAD.0b013e31818ffde1. PMID: 19384060Free PMC Article

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